NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500053787|ref|WP_011733704|]
View 

MULTISPECIES: helix-turn-helix transcriptional regulator [Francisella]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-95 4.36e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 4.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500053787   4 MQMKDNASKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPS 83
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|..
gi 500053787  84 VTKILEALYSIY 95
Cdd:COG0640   81 LAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-95 4.36e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 4.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500053787   4 MQMKDNASKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPS 83
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|..
gi 500053787  84 VTKILEALYSIY 95
Cdd:COG0640   81 LAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 1.03e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 80.58  E-value: 1.03e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500053787  13 ASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPSVTKIL 88
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-91 1.97e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 67.24  E-value: 1.97e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 500053787    36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPSVTKILEAL 91
Cdd:smart00418  10 ELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 36-80 1.04e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 60.50  E-value: 1.04e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSIN 80
Cdd:NF033789  21 DMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLN 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-81 2.70e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 59.62  E-value: 2.70e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSIND 81
Cdd:cd00090   20 PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 36-66 1.12e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 44.36  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 500053787   36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLV 66
Cdd:pfam01022  15 ELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 36-79 7.29e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 35.95  E-value: 7.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSI 79
Cdd:PRK10141  30 ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-95 4.36e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 4.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500053787   4 MQMKDNASKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPS 83
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|..
gi 500053787  84 VTKILEALYSIY 95
Cdd:COG0640   81 LAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 1.03e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 80.58  E-value: 1.03e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500053787  13 ASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPSVTKIL 88
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-91 1.97e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 67.24  E-value: 1.97e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 500053787    36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPSVTKILEAL 91
Cdd:smart00418  10 ELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 36-80 1.04e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 60.50  E-value: 1.04e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSIN 80
Cdd:NF033789  21 DMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLN 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-81 2.70e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 59.62  E-value: 2.70e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSIND 81
Cdd:cd00090   20 PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 36-66 1.12e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 44.36  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 500053787   36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLV 66
Cdd:pfam01022  15 ELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
37-82 5.28e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 44.87  E-value: 5.28e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500053787  37 MTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDP 82
Cdd:COG3398  112 ATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
4-71 4.66e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 38.79  E-value: 4.66e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500053787   4 MQMKDNAsKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKE 71
Cdd:COG4189    1 MVVLDDE-ESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 36-71 4.84e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 37.90  E-value: 4.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 500053787   36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKE 71
Cdd:pfam12840  24 PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
36-84 9.28e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 38.09  E-value: 9.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNV-----YYSINDPSV 84
Cdd:COG1777   30 PAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDgrarkYYRLSAFRL 83
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 36-79 7.29e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 35.95  E-value: 7.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 500053787  36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSI 79
Cdd:PRK10141  30 ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-67 2.96e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 500053787   36 EMTVGELAEYSSLSQSAFSQHLSVLRNNGLVK 67
Cdd:pfam12802  19 GLTVAELARRLGISKQTVSRLVKRLEAKGLVE 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH