NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499906042|ref|WP_011586776|]
View 

substrate-binding domain-containing protein [Cytophaga hutchinsonii]

Protein Classification

substrate-binding domain-containing protein( domain architecture ID 10194536)

substrate-binding domain-containing protein belonging to the type 2 periplasmic-binding protein (PBP2) fold superfamily, similar to Ca3427 protein from Candida albicans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PBP2_Ca3427_like cd13637
The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; ...
 2-271 6.74e-140

The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; This group includes the Ca3427 protein from candida albicans, which is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8, and other related hypothetical proteins. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ca3427 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


:

Pssm-ID: 270355  Cd Length: 273  Bit Score: 394.63  E-value: 6.74e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMCQDLRADIIDIATLLTEGAITDIA-NGNPSTIDSVYV 80
Cdd:cd13637    1 TLRIGGVPEHFNTPWHLAIEEGFFAEHGINVEWVDFPGGTGAMIKALRNGEIDIAIGLTEGFVADIAkGGNPYKIVGTYV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  81 SSPLIWGIHTGAQSQHSNPDTPGLIKYAVSRMGSGSHLMALVDRIQRGLSLTDASWELIQNLDGARVSLQKNDSDYFLWE 160
Cdd:cd13637   81 ASPLNWAIHTGANSDYNSIEDLKGTKIGISRIGSGSHLMAYVLALQQGWDTEDLKFEVLNNFDGLRDAVNDGKADAFMWE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 161 KNMTAPYVYNGELRRIGECPTPWPSVVITITKK-ASARIGNLSGMYRALEKAIHFIQQLP-DPVQTIASVYDLKIEDAKD 238
Cdd:cd13637  161 HFTTKPYVDSGEFKRIGEIPTPWPSFVIAASDElLEENPEALKAFLDALNQGIAYFKAHPeEAVEYIAKRYDYKEEDARE 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 499906042 239 WYSRIEWAINTPLTEKDFDTTCHALVEAGILKE 271
Cdd:cd13637  241 WLKTVKWASQRQVSEKVLENTLDVLKEAGVLKE 273
 
Name Accession Description Interval E-value
PBP2_Ca3427_like cd13637
The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; ...
 2-271 6.74e-140

The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; This group includes the Ca3427 protein from candida albicans, which is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8, and other related hypothetical proteins. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ca3427 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270355  Cd Length: 273  Bit Score: 394.63  E-value: 6.74e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMCQDLRADIIDIATLLTEGAITDIA-NGNPSTIDSVYV 80
Cdd:cd13637    1 TLRIGGVPEHFNTPWHLAIEEGFFAEHGINVEWVDFPGGTGAMIKALRNGEIDIAIGLTEGFVADIAkGGNPYKIVGTYV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  81 SSPLIWGIHTGAQSQHSNPDTPGLIKYAVSRMGSGSHLMALVDRIQRGLSLTDASWELIQNLDGARVSLQKNDSDYFLWE 160
Cdd:cd13637   81 ASPLNWAIHTGANSDYNSIEDLKGTKIGISRIGSGSHLMAYVLALQQGWDTEDLKFEVLNNFDGLRDAVNDGKADAFMWE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 161 KNMTAPYVYNGELRRIGECPTPWPSVVITITKK-ASARIGNLSGMYRALEKAIHFIQQLP-DPVQTIASVYDLKIEDAKD 238
Cdd:cd13637  161 HFTTKPYVDSGEFKRIGEIPTPWPSFVIAASDElLEENPEALKAFLDALNQGIAYFKAHPeEAVEYIAKRYDYKEEDARE 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 499906042 239 WYSRIEWAINTPLTEKDFDTTCHALVEAGILKE 271
Cdd:cd13637  241 WLKTVKWASQRQVSEKVLENTLDVLKEAGVLKE 273
TauA COG0715
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ...
 2-273 2.12e-17

ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];


Pssm-ID: 440479 [Multi-domain]  Cd Length: 297  Bit Score: 80.05  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAITDIANGNPSTIDSVYVS 81
Cdd:COG0715   23 TLRLGWLPNTDHAPLYVAKEKGYFKKEGLDVELVEFAGGAAAL-EALAAGQADFGVAGAPPALAARAKGAPVKAVAALSQ 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  82 SPLiWGIHTGAQSQHSNP-DTPGLiKYAVSRmGSGSHLM--ALVDriQRGLSLTDASWELIQNLDgARVSLQKNDSDYF- 157
Cdd:COG0715  102 SGG-NALVVRKDSGIKSLaDLKGK-KVAVPG-GSTSHYLlrALLA--KAGLDPKDVEIVNLPPPD-AVAALLAGQVDAAv 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 158 LWEKNMTApYVYNGELRRIGECPTPWP----SVVITITKKASARIGNLSGMYRALEKAIHFIQQLPDPV-QTIASVYDLK 232
Cdd:COG0715  176 VWEPFESQ-AEKKGGGRVLADSADLVPgypgDVLVASEDFLEENPEAVKAFLRALLKAWAWAAANPDEAaAILAKATGLD 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 499906042 233 IEDAKDWYSRiEWAINTPLT---EKDFDTTCHALVEAGILKEKP 273
Cdd:COG0715  255 PEVLAAALEG-DLRLDPPLGapdPARLQRVADFLVELGLLPKDV 297
 
Name Accession Description Interval E-value
PBP2_Ca3427_like cd13637
The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; ...
 2-271 6.74e-140

The conserved hypothetical protein Ca3427 exhibits the type 2 periplasmic-binding protein fold; This group includes the Ca3427 protein from candida albicans, which is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8, and other related hypothetical proteins. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ca3427 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270355  Cd Length: 273  Bit Score: 394.63  E-value: 6.74e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMCQDLRADIIDIATLLTEGAITDIA-NGNPSTIDSVYV 80
Cdd:cd13637    1 TLRIGGVPEHFNTPWHLAIEEGFFAEHGINVEWVDFPGGTGAMIKALRNGEIDIAIGLTEGFVADIAkGGNPYKIVGTYV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  81 SSPLIWGIHTGAQSQHSNPDTPGLIKYAVSRMGSGSHLMALVDRIQRGLSLTDASWELIQNLDGARVSLQKNDSDYFLWE 160
Cdd:cd13637   81 ASPLNWAIHTGANSDYNSIEDLKGTKIGISRIGSGSHLMAYVLALQQGWDTEDLKFEVLNNFDGLRDAVNDGKADAFMWE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 161 KNMTAPYVYNGELRRIGECPTPWPSVVITITKK-ASARIGNLSGMYRALEKAIHFIQQLP-DPVQTIASVYDLKIEDAKD 238
Cdd:cd13637  161 HFTTKPYVDSGEFKRIGEIPTPWPSFVIAASDElLEENPEALKAFLDALNQGIAYFKAHPeEAVEYIAKRYDYKEEDARE 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 499906042 239 WYSRIEWAINTPLTEKDFDTTCHALVEAGILKE 271
Cdd:cd13637  241 WLKTVKWASQRQVSEKVLENTLDVLKEAGVLKE 273
TauA COG0715
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ...
 2-273 2.12e-17

ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];


Pssm-ID: 440479 [Multi-domain]  Cd Length: 297  Bit Score: 80.05  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAITDIANGNPSTIDSVYVS 81
Cdd:COG0715   23 TLRLGWLPNTDHAPLYVAKEKGYFKKEGLDVELVEFAGGAAAL-EALAAGQADFGVAGAPPALAARAKGAPVKAVAALSQ 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  82 SPLiWGIHTGAQSQHSNP-DTPGLiKYAVSRmGSGSHLM--ALVDriQRGLSLTDASWELIQNLDgARVSLQKNDSDYF- 157
Cdd:COG0715  102 SGG-NALVVRKDSGIKSLaDLKGK-KVAVPG-GSTSHYLlrALLA--KAGLDPKDVEIVNLPPPD-AVAALLAGQVDAAv 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 158 LWEKNMTApYVYNGELRRIGECPTPWP----SVVITITKKASARIGNLSGMYRALEKAIHFIQQLPDPV-QTIASVYDLK 232
Cdd:COG0715  176 VWEPFESQ-AEKKGGGRVLADSADLVPgypgDVLVASEDFLEENPEAVKAFLRALLKAWAWAAANPDEAaAILAKATGLD 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 499906042 233 IEDAKDWYSRiEWAINTPLT---EKDFDTTCHALVEAGILKEKP 273
Cdd:COG0715  255 PEVLAAALEG-DLRLDPPLGapdPARLQRVADFLVELGLLPKDV 297
PBP2_SsuA_like_1 cd13556
Substrate binding domain of putative sulfonate binding protein, a member of the type 2 ...
 25-239 3.31e-06

Substrate binding domain of putative sulfonate binding protein, a member of the type 2 periplasmic binding fold superfamily; This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270274  Cd Length: 265  Bit Score: 47.46  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  25 FSAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAITDIANGNPstIDSVYVSSPLIWgihTGAQSQHSNP----- 99
Cdd:cd13556   26 FQKDGVKVTWVLSQGSNKAL-EFLNSGSVDFGSTAGLAALLAKANGNP--IKTVYVYSRPEW---TALVVRKDSPirsva 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042 100 DTPGLiKYAVSRmGSGSHLMALVDRIQRGLSLTDASWELIQNLDGaRVSLQKNDSDyfLW---EKNMTAPYVYNGElrRI 176
Cdd:cd13556  100 DLKGK-KVAVTK-GTDPYIFLLRALNTAGLSKNDIEIVNLQHADG-RTALEKGDVD--AWaglDPFMAQTELENGS--RL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499906042 177 gecptpwpsvvitITKKASArigNLSGMYRALEKaihFIQQLPDPVQTIASVYdlkiEDAKDW 239
Cdd:cd13556  173 -------------FYRNPDF---NTYGVLNVRED---FAKRHPDAVRRVLKVY----EKARKW 212
PBP2_SsuA_like_6 cd13563
Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 ...
 2-75 1.50e-05

Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 periplasmic binding protein fold; This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270281 [Multi-domain]  Cd Length: 208  Bit Score: 44.92  E-value: 1.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAITDIANGNPSTI 75
Cdd:cd13563    1 PLKIGISTWPGYGPWYLADEKGFFKKEGLDVELVWFESYSDSM-AALASGQIDAAATTLDDALAMAAKGVPVKI 73
PBP2_NrtA_SsuA_CpmA_like cd01008
Substrate binding domain of ABC-type nitrate/sulfonate/bicarbonate transporters, a member of ...
 18-160 2.72e-04

Substrate binding domain of ABC-type nitrate/sulfonate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily; This family represents the periplasmic binding proteins involved in nitrate, alkanesulfonate, and bicarbonate transport. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates. Other closest homologs involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB) are also included in this family. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270229 [Multi-domain]  Cd Length: 212  Bit Score: 41.12  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  18 VAIEQGYF--SAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAITDIANGNPSTIDSVYVSSPLIWGIHTGAQSQ 95
Cdd:cd01008   17 VAKEKGLFekEKEGIDVEWVEFTSGPPAL-EALAAGSLDFGTGGDTPALLAAAGGVPVVLIAALSRSPNGNGIVVRKDSG 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499906042  96 HSNP-DTPGLiKYAVSRmGSGSHlMALVDRIQR-GLSLTDAswELIqNLD--GARVSLQKNDSD-YFLWE 160
Cdd:cd01008   96 ITSLaDLKGK-KIAVTK-GTTGH-FLLLKALAKaGLSVDDV--ELV-NLGpaDAAAALASGDVDaWVTWE 159
PBP2_NrtA_CpmA_like cd13553
Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 ...
 18-94 1.70e-03

Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily; This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270271 [Multi-domain]  Cd Length: 212  Bit Score: 38.71  E-value: 1.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499906042  18 VAIEQGYFSAEGIEFEWIDYKGGTGAMcQDLRADIIDIATLLTEGAItDIANGNPSTIDSVYvsspliwGIHTGAQS 94
Cdd:cd13553   17 VAKEKGFFEKEGLDVELVKFPSWADLR-DALAAGELDAAHVLAPMPA-AATYGKGAPIKVVA-------GLHRNGSA 84
PBP2_ThiY_THI5_like_1 cd13652
Putative substrate binding domain of an ABC-type transporter similar to ThiY/THI5; the type 2 ...
 2-75 2.86e-03

Putative substrate binding domain of an ABC-type transporter similar to ThiY/THI5; the type 2 periplasmic binding protein fold; This subfamily is phylogenetically similar to ThiY, which is the periplasmic N-formyl-4-amino-5-(aminomethyl)-2-methylpyrimidine (FAMP) binding component of the ABC transport system (ThiXYZ). FAMP is imported into cell by the transporter, where it is then incorporated into the thiamin biosynthetic pathway. The closest structural homologs of ThiY are THI5, which is responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate (HMP-P) in the thiamin biosynthetic pathway of eukaryotes, and periplasmic binding proteins involved in alkanesulfonate/nitrate and bicarbonate transport. After binding the ligand, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ThiY/THI5 proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270370 [Multi-domain]  Cd Length: 217  Bit Score: 38.14  E-value: 2.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499906042   2 KIRCGGVPEHFNYPWHVAIEQGYFSAEGIEFEWIDYKGGTgAMCQDLRADIIDIAtLLTEGAIT--DIANGNPSTI 75
Cdd:cd13652    3 KVKFGQIPISDFAPVYIAAEKGYFKEEGLDVEITRFASGA-EILAALASGQVDVA-GSSPGASLlgALARGADLKI 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH