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Conserved domains on  [gi|499809790|ref|WP_011490524|]
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TOBE domain-containing protein [Paraburkholderia xenovorans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10676 super family cl28684
DNA-binding transcriptional regulator ModE; Provisional
 33-274 1.61e-45

DNA-binding transcriptional regulator ModE; Provisional


The actual alignment was detected with superfamily member PRK10676:

Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 154.04  E-value: 1.61e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  33 RIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVRLTGGKGGGGTTLTPRAVKLIETFRAVER-EHRRF 111
Cdd:PRK10676  21 RISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYGERLIQLYDLLAQiQQKAF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 112 ---------LERAGAAiegfatdwdlIGRIGVKTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSV-ITHESTETLG 181
Cdd:PRK10676 101 dvldddalpLDSLLAA----------ISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKVaITAQSAERLG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 182 LVEGAAAFALIKASWVVLFVDNQSGVplklSARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGG 261
Cdd:PRK10676 171 LDEGKEVLVLIKAPWVGITQDPAVAQ----AADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAARLSLQQGD 246

                        250
                 ....*....|...
gi 499809790 262 NAVAVFKASSVIL 274
Cdd:PRK10676 247 AVTAYFNADRVII 259
 
Name Accession Description Interval E-value
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
 33-274 1.61e-45

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 154.04  E-value: 1.61e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  33 RIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVRLTGGKGGGGTTLTPRAVKLIETFRAVER-EHRRF 111
Cdd:PRK10676  21 RISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYGERLIQLYDLLAQiQQKAF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 112 ---------LERAGAAiegfatdwdlIGRIGVKTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSV-ITHESTETLG 181
Cdd:PRK10676 101 dvldddalpLDSLLAA----------ISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKVaITAQSAERLG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 182 LVEGAAAFALIKASWVVLFVDNQSGVplklSARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGG 261
Cdd:PRK10676 171 LDEGKEVLVLIKAPWVGITQDPAVAQ----AADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAARLSLQQGD 246

                        250
                 ....*....|...
gi 499809790 262 NAVAVFKASSVIL 274
Cdd:PRK10676 247 AVTAYFNADRVII 259
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
135-278 5.60e-42

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 140.98  E-value: 5.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 135 KTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLVEGAAAFALIKASWVVLFVDNqsgvPLKLSAR 214
Cdd:COG3585    2 TSSRNNQFGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDD----AMKLSAR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499809790 215 NQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGGNAVAVFKASSVILGVKD 278
Cdd:COG3585   78 NQLKGTVTRIERGAVNSEVVLDLGGGTTLTAVITNESVEELGLKEGDEVTALFKASSVILAVDA 141
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 209-276 1.94e-18

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 77.40  E-value: 1.94e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499809790  209 LKLSARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGGNAVAVFKASSVILGV 276
Cdd:TIGR00638   1 LQTSARNQLKGKVVAIEDGDVNAEVDLLLGGGTKLTAVITLESVAELGLKPGKEVYAVIKAPWVILAV 68
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 138-197 2.33e-09

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 52.28  E-value: 2.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  138 ARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLVEGAAAFALIKASWV 197
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLTLTARITRDSAEELGLAPGDEVWALIKATKV 60
 
Name Accession Description Interval E-value
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
 33-274 1.61e-45

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 154.04  E-value: 1.61e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  33 RIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVRLTGGKGGGGTTLTPRAVKLIETFRAVER-EHRRF 111
Cdd:PRK10676  21 RISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYGERLIQLYDLLAQiQQKAF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 112 ---------LERAGAAiegfatdwdlIGRIGVKTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSV-ITHESTETLG 181
Cdd:PRK10676 101 dvldddalpLDSLLAA----------ISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKVaITAQSAERLG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 182 LVEGAAAFALIKASWVVLFVDNQSGVplklSARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGG 261
Cdd:PRK10676 171 LDEGKEVLVLIKAPWVGITQDPAVAQ----AADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAARLSLQQGD 246

                        250
                 ....*....|...
gi 499809790 262 NAVAVFKASSVIL 274
Cdd:PRK10676 247 AVTAYFNADRVII 259
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
135-278 5.60e-42

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 140.98  E-value: 5.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 135 KTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLVEGAAAFALIKASWVVLFVDNqsgvPLKLSAR 214
Cdd:COG3585    2 TSSRNNQFGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDD----AMKLSAR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499809790 215 NQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGGNAVAVFKASSVILGVKD 278
Cdd:COG3585   78 NQLKGTVTRIERGAVNSEVVLDLGGGTTLTAVITNESVEELGLKEGDEVTALFKASSVILAVDA 141
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
12-122 1.22e-31

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 113.38  E-value: 1.22e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  12 TLELGGSVWFQAGAQTLGGASRIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVRLTGGKGGGGTTLT 91
Cdd:COG2005    2 SMKLRLKLWLELDGGVFLGPGRIELLEAIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERQTGGKGGGGARLT 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 499809790  92 PRAVKLIETFRAVEREHRRFLERAGAAIEGF 122
Cdd:COG2005   82 PEGRRLLALYRRLEAEAQRALAALFEELFAL 112
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
105-202 7.75e-20

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 83.20  E-value: 7.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790 105 EREHRRFLERAGAAIEGFATDWDLIGRI-GVKTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLV 183
Cdd:COG3585   42 SSAELLGLVGGKEVAALKKASVVILATDdAMKLSARNQLKGTVTRIERGAVNSEVVLDLGGGTTLTAVITNESVEELGLK 121

                         90
                 ....*....|....*....
gi 499809790 184 EGAAAFALIKASWVVLFVD 202
Cdd:COG3585  122 EGDEVTALFKASSVILAVD 140
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 209-276 1.94e-18

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 77.40  E-value: 1.94e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499809790  209 LKLSARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGGNAVAVFKASSVILGV 276
Cdd:TIGR00638   1 LQTSARNQLKGKVVAIEDGDVNAEVDLLLGGGTKLTAVITLESVAELGLKPGKEVYAVIKAPWVILAV 68
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 134-202 4.68e-16

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 70.85  E-value: 4.68e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499809790  134 VKTSARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLVEGAAAFALIKASWVVLFVD 202
Cdd:TIGR00638   1 LQTSARNQLKGKVVAIEDGDVNAEVDLLLGGGTKLTAVITLESVAELGLKPGKEVYAVIKAPWVILAVD 69
ModE_repress TIGR00637
ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the ...
 30-106 4.74e-16

ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this model and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This model also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins. [Regulatory functions, Other]


Pssm-ID: 273188 [Multi-domain]  Cd Length: 99  Bit Score: 71.70  E-value: 4.74e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499809790   30 GASRIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVRLTGGKGGGGTTLTPRAVKLIETFRAVER 106
Cdd:TIGR00637   3 DPRRVALLKAIARMGSISQAAKDAGISYKSAWDYIRAMNNLSGEPLVERATGGKGGGGAVLTEYGQRLIQLYDLLER 79
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 138-197 2.33e-09

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 52.28  E-value: 2.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  138 ARNQLYGTVSAITRGTVNDEVTLVLPGGHAIVSVITHESTETLGLVEGAAAFALIKASWV 197
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLTLTARITRDSAEELGLAPGDEVWALIKATKV 60
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 213-272 1.93e-08

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 49.97  E-value: 1.93e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499809790  213 ARNQLRGTVQSVKRGAVNAEVSLVLAGGAVITAVVTNESVDTLGLVEGGNAVAVFKASSV 272
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLTLTARITRDSAEELGLAPGDEVWALIKATKV 60
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
33-78 4.79e-05

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 40.45  E-value: 4.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 499809790   33 RIALLAAIGETGSITSAAKAVGMSYKGAWDAIDTMNNLAGEPLVVR 78
Cdd:pfam00126   3 QLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFER 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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