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Conserved domains on  [gi|499384902|ref|WP_011072393|]
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class Ia ribonucleoside-diphosphate reductase subunit beta [Shewanella oneidensis]

Protein Classification

ribonucleotide-diphosphate reductase subunit beta( domain architecture ID 10793142)

ribonucleotide-diphosphate reductase subunit beta catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, providing the precursors necessary for DNA synthesis

CATH:  1.10.620.20
EC:  1.17.4.1
Gene Ontology:  GO:0009263|GO:0006260|GO:0046872|GO:0004748|GO:0005971
PubMed:  34461093|16756507
SCOP:  4000846

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


:

Pssm-ID: 181647  Cd Length: 376  Bit Score: 866.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   1 MTYSTFCQTPNDATREPMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  81 QTLLDSIQGRSPNVAFLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVIFDDIVVNHEILRRATDIAEFYDH 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 161 LIKLTQIYHLLGEGTHVIDGEPVEVNTRTLKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 241 LHLNSTQHILTIMQGGKDDPEMGEIAIECQQEAYNLFLKAAEQEKEWAKYLFKDGSMIGLNEQILCQYVEYITNQRMKSV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499384902 321 NLPQPYAEQTNPLPWMKNWLESDAVQVAPQEVEVSSYLVGQIDAAVDSDEFLDFDL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 866.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   1 MTYSTFCQTPNDATREPMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  81 QTLLDSIQGRSPNVAFLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVIFDDIVVNHEILRRATDIAEFYDH 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 161 LIKLTQIYHLLGEGTHVIDGEPVEVNTRTLKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 241 LHLNSTQHILTIMQGGKDDPEMGEIAIECQQEAYNLFLKAAEQEKEWAKYLFKDGSMIGLNEQILCQYVEYITNQRMKSV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499384902 321 NLPQPYAEQTNPLPWMKNWLESDAVQVAPQEVEVSSYLVGQIDAAVDSDEFLDFDL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 16-369 3.46e-134

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 386.06  E-value: 3.46e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  16 EPMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVA 95
Cdd:COG0208    3 EPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  96 FLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVIFDDIVVNHEILRRATDIAEFYDHLikltqiyhllgegt 175
Cdd:COG0208   83 LYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL-------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 176 hvidgepvevNTRTLKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQg 255
Cdd:COG0208  149 ----------GTRETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTIR- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 256 gKDDPEMgeIAIECQQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNPLPW 335
Cdd:COG0208  218 -EENPEL--FTEELKEEIYELLKEAVELEKEYADDLFPDG-ILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPFPW 293

                        330       340       350
                 ....*....|....*....|....*....|....
gi 499384902 336 MKNWLESDAvQVAPQEVEVSSYLVGQIDAAVDSD 369
Cdd:COG0208  294 MSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-339 1.01e-75

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 235.98  E-value: 1.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  29 YDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETW 108
Cdd:cd01049    3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 109 IETWSFSETIHSRSYTHIIRNIVNDPSV--IFDDIVVNHEILRRATDIAEFYDHLIKLTqiyhllgegthvidgepvevn 186
Cdd:cd01049   83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 187 trtlKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQGGKDDpemgEIA 266
Cdd:cd01049  142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPE----LFT 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499384902 267 IECQQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPY-AEQTNPLPWMKNW 339
Cdd:cd01049  214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFnVEDKNPFDWMELI 286
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-332 5.32e-44

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 153.42  E-value: 5.32e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   33 KYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWIETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  113 SFSETIHSRSYTHIIRNIVNDPS---VIFDDIVVNHEILRRATDIAEFYDHLikltqiyhllgegthviDGEPVEvntrt 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPEeidELFNWIETNPALQKKAEWILKWYQDF-----------------DSDFLE----- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  190 lKKALYLCmmsvnaLEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQgGKDDPEMGEiaiEC 269
Cdd:pfam00268 146 -RLVAFAI------LEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLK-EENPELETK---EL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499384902  270 QQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNP 332
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 866.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   1 MTYSTFCQTPNDATREPMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  81 QTLLDSIQGRSPNVAFLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVIFDDIVVNHEILRRATDIAEFYDH 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 161 LIKLTQIYHLLGEGTHVIDGEPVEVNTRTLKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 241 LHLNSTQHILTIMQGGKDDPEMGEIAIECQQEAYNLFLKAAEQEKEWAKYLFKDGSMIGLNEQILCQYVEYITNQRMKSV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499384902 321 NLPQPYAEQTNPLPWMKNWLESDAVQVAPQEVEVSSYLVGQIDAAVDSDEFLDFDL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 16-369 3.46e-134

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 386.06  E-value: 3.46e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  16 EPMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVA 95
Cdd:COG0208    3 EPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  96 FLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVIFDDIVVNHEILRRATDIAEFYDHLikltqiyhllgegt 175
Cdd:COG0208   83 LYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL-------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 176 hvidgepvevNTRTLKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQg 255
Cdd:COG0208  149 ----------GTRETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTIR- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 256 gKDDPEMgeIAIECQQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNPLPW 335
Cdd:COG0208  218 -EENPEL--FTEELKEEIYELLKEAVELEKEYADDLFPDG-ILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPFPW 293

                        330       340       350
                 ....*....|....*....|....*....|....
gi 499384902 336 MKNWLESDAvQVAPQEVEVSSYLVGQIDAAVDSD 369
Cdd:COG0208  294 MSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-339 1.01e-75

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 235.98  E-value: 1.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  29 YDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETW 108
Cdd:cd01049    3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 109 IETWSFSETIHSRSYTHIIRNIVNDPSV--IFDDIVVNHEILRRATDIAEFYDHLIKLTqiyhllgegthvidgepvevn 186
Cdd:cd01049   83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 187 trtlKKALYLCMMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQGGKDDpemgEIA 266
Cdd:cd01049  142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPE----LFT 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499384902 267 IECQQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPY-AEQTNPLPWMKNW 339
Cdd:cd01049  214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFnVEDKNPFDWMELI 286
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 17-369 1.63e-45

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 158.84  E-value: 1.63e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  17 PMFFGQSVNVARYDQQKYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAF 96
Cdd:PRK09614   2 KIIGGNTYSAINWNKIEDPWDYEAWKRLTANFWLPEEVPLSNDLKDWKKLSDEEKNLYTRVFGGLTLLDTLQNNNGMPNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  97 LPLVSLPELETWIETWSFSETIHSRSYTHIIRNIvNDPSVIFD--DIVVNHEIL-RRATDIAEFYDHLIKltqiyhllge 173
Cdd:PRK09614  82 MPDITTPEEEAVLANIAFMEAVHAKSYSYIFSTL-CSPEEIDEafEWAEENPYLqKKADIIQDFYEPLKK---------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 174 gthvidgepvevntrtlKKALYLCMMSVnALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQH-ILTI 252
Cdd:PRK09614 151 -----------------KILRKAAVASV-FLEGFLFYSGFYYPLYLARQGKMTGTAQIIRLIIRDESLHGYYIGYlFQEG 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 253 MQggkddpEMGEI-AIECQQEAYNLFLKAAEQEKEWAKYLFKDgsmIGLNEQILcQYVEYITNQRMKSVNLPQPY-AEQT 330
Cdd:PRK09614 213 LE------ELPELeQEELKDEIYDLLYELYENEEAYTELLYDI---VGLAEDVK-KYIRYNANKRLMNLGLEPLFpEEEE 282

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 499384902 331 NPLPWMkNWLESDAVQVAPQ-EVEVSSYLVGQIDAAVDSD 369
Cdd:PRK09614 283 VNPIWL-NGLSNNADENHDFfEGKGTSYVKGATEATEDDD 321
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-332 5.32e-44

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 153.42  E-value: 5.32e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   33 KYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWIETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  113 SFSETIHSRSYTHIIRNIVNDPS---VIFDDIVVNHEILRRATDIAEFYDHLikltqiyhllgegthviDGEPVEvntrt 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPEeidELFNWIETNPALQKKAEWILKWYQDF-----------------DSDFLE----- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  190 lKKALYLCmmsvnaLEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQgGKDDPEMGEiaiEC 269
Cdd:pfam00268 146 -RLVAFAI------LEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLK-EENPELETK---EL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499384902  270 QQEAYNLFLKAAEQEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNP 332
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 49-336 5.00e-26

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 107.39  E-value: 5.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  49 WRPEEVDVSRDkI----DYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWIETWSFSETIHSRSYT 124
Cdd:PRK07209  71 WMPQEVNMSRD-IalwkSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQ 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 125 HIIRNIVNDPSVIFDdivVNHEIlRRATDIAEFydhLIKLTQiyHLLGEGTHVIDGEpvevNTRTLKKAL--YLCMMsvn 202
Cdd:PRK07209 150 YIVESLGLDEGEIFN---MYHEV-PSIRAKDEF---LIPFTR--SLTDPNFKTGTPE----NDQKLLRNLiaFYCIM--- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 203 alEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTqhILTIMQGGKDDPEMGeiAIECQQEAYNLFLKAAE 282
Cdd:PRK07209 214 --EGIFFYVGFTQILSLGRQNKMTGIAEQYQYILRDESMHLNFG--IDLINQIKLENPHLW--TAEFQAEIRELIKEAVE 287

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499384902 283 QEKEWAKYLFKDGsMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNPLPWM 336
Cdd:PRK07209 288 LEYRYARDTMPRG-VLGLNASMFKDYLRFIANRRLQQIGLKPQYPGTENPFPWM 340
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 1-369 3.28e-17

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 81.74  E-value: 3.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902   1 MTYSTFCQTPND-ATREPMFFGQSVNVARYDQQK-YEVFEKLIEKqlsfFWRPEEVDVSRDKIDYNSLPDHEKHIFISNL 78
Cdd:PRK13965   1 QSYYDRSQSPIEyALSETQKPLRSINWNYLNDDKdLEVWNRVTQN----FWLPEKVPVSNDLNSWRSLGEDWQQLITRTF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  79 KYQTLLDSIQGRSPNVAFLPlVSLPELETWIET-WSFSETIHSRSYTHIIRNIVNDPSV--IFDDIVVNHEILRRATDIA 155
Cdd:PRK13965  77 TGLTLLDTVQATVGDVAQIP-HSQTDHEQVIYTnFAFMVAIHARSYGTIFSTLCSSEQIeeAHEWVVSTESLQRRARVLI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 156 EFYDhlikltqiyhllGEgthvidgEPvevntrtLKKALYLCMMSvnaleAIRFYVSFACSFAFAERKLMEGNAKIIRLI 235
Cdd:PRK13965 156 PYYT------------GD-------DP-------LKSKVAAAMMP-----GFLLYGGFYLPFYLSARGKLPNTSDIIRLI 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 236 ARDEALH-----LNSTQHIltimqggkdDPEMGEIAIECQQEAYNLFLKAAEQEKEWAKYLFKDgsmIGLNEQILcQYVE 310
Cdd:PRK13965 205 LRDKVIHnyysgYKYQQKV---------ARLSPEKQAEMKAFVFDLLYELIDLEKAYLRELYAG---FDLAEDAI-RFSL 271

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499384902 311 YITNQRMKSVNLPQPYAEQTNPLpwmknwleSDAV--QVAPQEVEV--------SSYLVGQIDAAVDSD 369
Cdd:PRK13965 272 YNAGKFLQNLGYESPFTEEETRV--------SPEVfaQLSARADENhdffsgngSSYVMGITEETTDDD 332
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 33-336 1.29e-16

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 79.81  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  33 KYEVFEKLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKHiFISN-LKYQTLLDSIQGRSPNVAFLPLVSLPELETWiet 111
Cdd:PTZ00211  28 KYPDIWRMYKKAEASFWTAEEIDLGNDLKDWEKLNDGERH-FIKHvLAFFAASDGIVLENLAQRFMREVQVPEARCF--- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 112 WSFS---ETIHSRSYTHIIRNIVNDPS---VIFDDIVVNHEILRRA-------TDIAEFYDHLIKLTqiyhllgegthvi 178
Cdd:PTZ00211 104 YGFQiamENIHSETYSLLIDTYITDEEekdRLFHAIETIPAIKKKAewaakwiNSSNSFAERLVAFA------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 179 dgepvevntrtlkkalylcmmsvnALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQGGKD 258
Cdd:PTZ00211 171 ------------------------AVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYSHLKNKLP 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 259 DPEMGEI---AIECQQEaynlFLKAAeqekewakyLFKDgsMIGLNEQILCQYVEYITNQRMKSVNLPQPYaEQTNPLPW 335
Cdd:PTZ00211 227 RERVQEIikeAVEIERE----FICDA---------LPVD--LIGMNSRLMAQYIEFVADRLLVALGVPKIY-NSKNPFDW 290


                 .
gi 499384902 336 M 336
Cdd:PTZ00211 291 M 291
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 49-367 2.36e-15

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 76.99  E-value: 2.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  49 WRPEEVDVSRDKIDYNS--LPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWIETWSFSETIHSRSYThi 126
Cdd:PRK12759 120 WIEDEIDLSEDVTDWKNgkITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAYA-- 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 127 irnIVNDPSVIFDDIVVNHEILRRATDIAEFydhlikltqiyhllgegthVIDGEPvevntrTLKKALYLCMMSVNALEA 206
Cdd:PRK12759 198 ---LLNDTLGLPDSEYHAFLEYKAMTDKIDF-------------------MMDADP------TTRRGLGLCLAKTVFNEG 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 207 IRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMqgGKDDPEMgeIAIECQQEAYNLFLKAAEQEKE 286
Cdd:PRK12759 250 VALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIY--CQENPYI--VDNEFKKEIYLMASKAVELEDR 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 287 WAKYLFKDGSMIGLNEQILCQYVEYITNQRMKSVNLPQPYAEQTNPLPWMKnWLESDAVQVAPQEVEVSSYLVGQIDAAV 366
Cdd:PRK12759 326 FIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLE-WILNGADHTNFFENRVTEYEVAGLTGSW 404


                 .
gi 499384902 367 D 367
Cdd:PRK12759 405 D 405
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 30-317 8.14e-15

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 74.37  E-value: 8.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  30 DQQKYEVFEKLIEKqlsfFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWI 109
Cdd:PRK13966  21 DEKDAEVWDRLTGN----FWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 110 ETWSFSETIHSRSYTHIIRNIVNDPSVifDDIV----VNHEILRRATDIAEFYDhlikltqiyhllgegthviDGEPVEv 185
Cdd:PRK13966  97 TNIAFMESVHAKSYSQIFSTLCSTAEI--DDAFrwseENRNLQRKAEIVLQYYR-------------------GDEPLK- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 186 ntRTLKKALylcmmsvnaLEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHlnstqhilTIMQGGKDDPEMGEI 265
Cdd:PRK13966 155 --RKVASTL---------LESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVH--------GYYIGYKFQRGLALV 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499384902 266 AIECQQE----AYNLFLKAAEQEKEWAKYLFKDgsmIGLNEQILcQYVEYITNQRM 317
Cdd:PRK13966 216 DDVTRAElkdyTYELLFELYDNEVEYTQDLYDE---VGLTEDVK-KFLRYNANKAL 267
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 30-242 4.49e-11

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 63.21  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  30 DQQKYEVFEKLIEKqlsfFWRPEEVDVSRDKIDYNSLPDHEKHIFISNLKYQTLLDSIQGRSPNVAFLPLVSLPELETWI 109
Cdd:PRK13967  19 DAKDLQVWERLTGN----FWLPEKIPLSNDLASWQTLSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 110 ETWSFSETIHSRSYTHIIRNIVNDPSV--IFDDIVVNHEILRRATDIAEFY--DHLIKltqiyhllgegthvidgepvev 185
Cdd:PRK13967  95 TNMAFMESVHAKSYSSIFSTLCSTKQIddAFDWSEQNPYLQRKAQIIVDYYrgDDALK---------------------- 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499384902 186 ntrtlKKAlylcmmSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALH 242
Cdd:PRK13967 153 -----RKA------SSVMLESFLFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVH 198
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 48-336 2.02e-10

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 61.22  E-value: 2.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  48 FWRPEEVDVSRDKIDYNSLPDHEKHiFISN-LKYQTLLDSIQGRSPNVAFLPLVSLPELETWietWSFS---ETIHSRSY 123
Cdd:PLN02492  32 FWTAEEVDLSADLKDWEKLTDDERH-FISHvLAFFAASDGIVLENLAARFMKEVQVPEARAF---YGFQiaiENIHSEMY 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 124 THIIRNIVNDPSVifddivvnheilrratdiaefYDHLIkltqiyhllgegtHVIdgEPVEVNTRTLKKALYLC------ 197
Cdd:PLN02492 108 SLLLDTYIKDPKE---------------------KDRLF-------------NAI--ETIPCVAKKADWALRWIdssasf 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 198 ---MMSVNALEAIRFYVSFACSFAFAERKLMEGNAKIIRLIARDEALHLNSTQHILTIMQGGKDDPEMGEIAIEcqqeay 274
Cdd:PLN02492 152 aerLVAFACVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCE------ 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499384902 275 nlflkAAEQEKEWAKylfkDG---SMIGLNEQILCQYVEYITNQRMKSVNLPQPYaEQTNPLPWM 336
Cdd:PLN02492 226 -----AVEIEKEFVC----DAlpcALVGMNADLMSQYIEFVADRLLVALGYEKVY-NVVNPFDWM 280
PRK08326 PRK08326
R2-like ligand-binding oxidase;
39-243 6.36e-03

R2-like ligand-binding oxidase;


Pssm-ID: 236242  Cd Length: 311  Bit Score: 38.06  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902  39 KLIEKQLSFFWRPEEVDVSRDKIDYNSLPDHEKhIFISNLKYQtlldsIQGRSPNVA--FLPLVS-LPEL-----ETWIE 110
Cdd:PRK08326  29 KLFAKGNAKFWNPADIDFSRDAEDWEKLSDEER-DYATRLCAQ-----FIAGEEAVTldIQPLISaMAAEgrledEMYLT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499384902 111 TWSFSETIHsrsyTHIIRnivndpsvIFDDIVVNHEILRRATDIAEFYDHLikltqIYHLLGEGTHVIDGEPVEVNtrtL 190
Cdd:PRK08326 103 QFAFEEAKH----TEAFR--------RWFDAVGVTEDLSVYTDDNPSYRQI-----FYEELPAALNRLSTDPSPEN---Q 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499384902 191 KKALYLCMMSVNALEAIRFYVSFAcsFAFAERKLMEGNAKIIRLIARDEALHL 243
Cdd:PRK08326 163 VRASVTYNHVVEGVLAETGYYAWR--KICVTRGILPGLQELVRRIGDDERRHI 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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