|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
5-829 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 1020.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 5 ALPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVG 84
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 85 YHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQLREDLRIVVMSATLQG 164
Cdd:COG1643 89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPDLKLLVMSATLDA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 165 ERLAQFL-DAPRLTSEGRAYPVAITHFPARRDE-SLETHARRAIQHALDTHQGDVLTFLPGQREIARLQAILEKTLSPEL 242
Cdd:COG1643 169 ERFARLLgDAPVIESSGRTYPVEVRYRPLPADErDLEDAVADAVREALAEEPGDILVFLPGEREIRRTAEALRGRLPPDT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 243 HVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLAREPAYDPNTGFTRLDVVSITQASADQR 322
Cdd:COG1643 249 EILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQR 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 323 AGRAGRLAPGWAYRLWPQSQ--RLEAQRRPEMIQTELSGLALELTAWGS---STLRFIDPPPAGALSAARELLQRLGAIS 397
Cdd:COG1643 329 AGRAGRLAPGICYRLWSEEDfaRRPAFTDPEILRADLASLILELAAWGLgdpEDLPFLDPPPARAIADARALLQELGALD 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 398 NTSTLTPLGQRMLALGIHPRLAAMLLAPHDPQEQALACDLAALLDARDPLRGSGDA-LISRWRALAELRsSCLPHDTRRS 476
Cdd:COG1643 409 ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAGSdLLARLNLWRRLR-EQQREFLSYL 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 477 TLRAIDAATHQWRRRIRCDTTPPDAiEAHTLGNLLTHAFPERIAARHSSDPlYYVLANGRRMRLFDNSALHGEPWIIASE 556
Cdd:COG1643 488 RLREWRDLARQLRRLLGEGANEEPA-DYEAIGLLLALAYPDRIARRRGEGG-RYLLARGRGAALFPGSPLAKKEWLVAAE 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 557 LHHGIKDIQLLCGAPLDERRLHADFPERFIQHDVIRWETDKRALVAQRESCFDRIVLDVRPAGRIDPVQAANVLTGAVRT 636
Cdd:COG1643 566 LVGGAAEARIRLAAPIDPEWLEELAAHLIKRYSEPHWDKKRGRVVARERVRLGALVLVSRPLPGPDPEAAREALLRALRR 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 637 LGLDTLSWTEHLRQWQARAVALRHWMPElELPDLSNTTLLATLDTWLTPAFAGKTRLDALDEAAFEQAVKSLLSWTQHAL 716
Cdd:COG1643 646 EGLDLLPWSKAARQLRARVEFLERKLGE-RWPDVSDEALLATLEDWLAPYLTGVRSLKDLKRLDLLAALRALLPWEQQQR 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 717 IDRHAPARIIVPSGMERHIDYGladdgtPQPPVLAVKLQELFGLPDTPRIAKNRIPLTLHLLSPGGRPLQVTQDLKSFWT 796
Cdd:COG1643 725 LDELAPTHLTVPSGSRLPLDYS------ADGPPVAVRLQELFGLAETPGVADGRVPVPLHLLSPAGRPLQVTWDLPGFWR 798
|
810 820 830
....*....|....*....|....*....|...
gi 499196197 797 NTYPEVKKEMKGRYPKHPWPDDPWTATATHRTK 829
Cdd:COG1643 799 GSYAEVRKELRGRYPKHPWPDDPAAAAPTRRTK 831
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
6-832 |
0e+00 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 1015.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPwLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAP-GIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQLREDLRIVVMSATLQGE 165
Cdd:TIGR01970 80 RVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMSATLDGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 166 RLAQFL-DAPRLTSEGRAYPVAITHFPARRDESLETHARRAIQHALDTHQGDVLTFLPGQREIARLQAILEKTLSPELHV 244
Cdd:TIGR01970 160 RLSSLLpDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEIRRVQEQLAERLDSDVLI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 245 MPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLAREPAYDPNTGFTRLDVVSITQASADQRAG 324
Cdd:TIGR01970 240 CPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 325 RAGRLAPGWAYRLWPQSQ--RLEAQRRPEMIQTELSGLALELTAWGS---STLRFIDPPPAGALSAARELLQRLGAISNT 399
Cdd:TIGR01970 320 RAGRLEPGVCYRLWSEEQhqRLPAQDEPEILQADLSGLALELAQWGAkdpSDLRWLDAPPSVALAAARQLLQRLGALDAQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 400 STLTPLGQRMLALGIHPRLAAMLLAPHDPQEQALACDLAALLDARDPLRGSGDALISRWRALaelrssclpHDTRRSTLR 479
Cdd:TIGR01970 400 GRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGLPRQGGADLMNRLHRL---------QQGRQGRGQ 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 480 AIDAATHQWRRRIRCDTTPPDAIEAHTLGNLLTHAFPERIAARHSSdPLYYVLANGRRMRLFDNSALHGEPWIIASELHH 559
Cdd:TIGR01970 471 RAQQLAKKLRRRLRFSQADSGAIASHALGLLLALAFPDRIAKRRGQ-PGRYQLANGRGAVLSAEDALAREPWLVAADLGE 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 560 GI--KDIQLLCGAPLDERRLHADFPERFIQHDVIRWETDKRALVAQRESCFDRIVLDVRPAGRIDPVQAANVLTGAVRTL 637
Cdd:TIGR01970 550 GQgkTAARILLAAPVDEALLRQVLPDLVVQVDQVDWDETKGRLVAERQLRIGQLVLKSEPLANPDPAQIAAALLNYVRQK 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 638 GLDTLSWTEHLRQWQARAVALRHWMPELELPDLSNTTLLATLDTWLTPAFAGKTRLDALDEAAFEQAVKSLLSWTQHALI 717
Cdd:TIGR01970 630 GLSALNWTEELRQWRARVACARSWDPEADWPDLSDEALLARLETWLEPYLAGVTSLSGLQELDLYDALKNLLPWELQQAL 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 718 DRHAPARIIVPSGMERHIDYGLAddgtpQPPVLAVKLQELFGLPDTPRIAKNRIPLTLHLLSPGGRPLQVTQDLKSFWTN 797
Cdd:TIGR01970 710 DALLPTHWPVPTGNFIAIRYSLD-----GPPLLAVRLQELFGLAESPRVAQGRVPLTLELLSPAQRPLQVTRDLASFWAG 784
|
810 820 830
....*....|....*....|....*....|....*
gi 499196197 798 TYPEVKKEMKGRYPKHPWPDDPWTATATHRTKSPG 832
Cdd:TIGR01970 785 AYREVKKEMKGRYPKHVWPDDPANAAPTKRTKPRG 819
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
4-829 |
0e+00 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 724.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 4 HALPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRsIILLEPRRVAARNAALFMARQCGEEVGGLV 83
Cdd:PRK11664 2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-IIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 84 GYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQLREDLRIVVMSATLQ 163
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLLIMSATLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 164 GERLAQFL-DAPRLTSEGRAYPVAITHFPARRDESLETHARRAIQHALDTHQGDVLTFLPGQREIARLQAILEKTLSPEL 242
Cdd:PRK11664 161 NDRLQQLLpDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASRVASDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 243 HVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLAREPAYDPNTGFTRLDVVSITQASADQR 322
Cdd:PRK11664 241 LLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 323 AGRAGRLAPGWAYRLWPQSQ--RLEAQRRPEMIQTELSGLALELTAWG---SSTLRFIDPPPAGALSAARELLQRLGAIS 397
Cdd:PRK11664 321 AGRAGRLEPGICLHLYSKEQaeRAAAQSEPEILHSDLSGLLLELLQWGchdPAQLSWLDQPPAAALAAAKRLLQQLGALD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 398 NTSTLTPLGQRMLALGIHPRLAAMLLAPHDPQEQALACDLAALLDARDPLR-GSGDalisrwraLAELRSSCLPHDTRRs 476
Cdd:PRK11664 401 GQGRLTARGRKMAALGNDPRLAAMLVAAKEDDEAALATAAKLAAILEEPPRsGSSD--------LGVALSRKQPHWQQR- 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 477 tlraidaaTHQWRRRIRCDTTPPDaieAHTLGNLLTHAFPERIAARHSSDPlYYVLANGRRMRLFDNSALHGEPWIIASE 556
Cdd:PRK11664 472 --------AQQLLKRLNVRGGEAD---SSLIAPLLALAFPDRIARRRGQDG-RYQLANGMGAMLDADDALSRHEWLIAPL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 557 LHHGIK--DIQLLCGAPLDERRLHADFPERFIQHDVIRWETDKRALVAQRESCFDRIVLDVRPAGRIDPVQAANVLTGAV 634
Cdd:PRK11664 540 LLQGSAspDARILLALPLDIDELVQRCPQLVQQSDTVEWDEAKGTLRAWRRLQIGQLTVKVQPLAKPSEEELHQALLNWI 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 635 RTLGLDTLSWTEHLRQWQARAVALRHWMPELELPDLSNTTLLATLDTWLTPAFAGKTRLDALDEAAFEQAVKSLLSWTQH 714
Cdd:PRK11664 620 RRKGLSVLNWTPEAEQLRLRLLCAAKWLPEYDWPAVDDESLLASLETWLLPHMTGVRSLRGLKSLNIAQALRGLLDWPQR 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 715 ALIDRHAPARIIVPSGMERHIDYglaDDGtpQPPVLAVKLQELFGLPDTPRIAKNRIPLTLHLLSPGGRPLQVTQDLKSF 794
Cdd:PRK11664 700 QRLDSELPTHYTVPTGSRIAIRY---HED--NPPALAVRMQEMFGEAQSPTIAQGRVPLVLELLSPAQRPLQITRDLAAF 774
|
810 820 830
....*....|....*....|....*....|....*
gi 499196197 795 WTNTYPEVKKEMKGRYPKHPWPDDPWTATATHRTK 829
Cdd:PRK11664 775 WQGAYREVQKEMKGRYPKHVWPDDPANTAPTRRTK 809
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
6-173 |
2.87e-74 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 239.54 E-value: 2.87e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQLREDLRIVVMSATLQGE 165
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSATLDGD 160
|
....*...
gi 499196197 166 RLAQFLDA 173
Cdd:cd17990 161 GLAALLPE 168
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
6-424 |
2.57e-70 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 253.06 E-value: 2.57e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDApwlnGRSIILL----EPRRVAARNAALFMARQCGEEVGG 81
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLightQPRRLAARTVANRIAEELETELGG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 82 LVGYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLglalALDVQTQL---REDLRIVVM 158
Cdd:PRK11131 149 CVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDF----ILGYLKELlprRPDLKVIIT 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 159 SATLQGERLAQ-FLDAPRLTSEGRAYPVAITHFP-ARRDESLETHARRAIQHALDTHQ----GDVLTFLPGQREIARLQA 232
Cdd:PRK11131 225 SATIDPERFSRhFNNAPIIEVSGRTYPVEVRYRPiVEEADDTERDQLQAIFDAVDELGregpGDILIFMSGEREIRDTAD 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 233 ILEKTLSPELHVMPLHGELPLKEQARVLEPdqHGRQRIVLATNVAESSITLPGISVVIDSGLAREPAYDPNTGFTRLDVV 312
Cdd:PRK11131 305 ALNKLNLRHTEILPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 313 SITQASADQRAGRAGRLAPGWAYRLWPQSQRLE--AQRRPEMIQTELSGLALELTAWG---SSTLRFIDPPPAGALSAAR 387
Cdd:PRK11131 383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSrpEFTDPEILRTNLASVILQMTALGlgdIAAFPFVEAPDKRNIQDGV 462
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 499196197 388 ELLQRLGAISNTST-----LTPLGQRMLALGIHPRLAAMLLA 424
Cdd:PRK11131 463 RLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLE 504
|
|
| HrpB_C |
pfam08482 |
ATP-dependent helicase C-terminal; This domain is found near the C-terminus of bacterial ... |
689-818 |
5.92e-63 |
|
ATP-dependent helicase C-terminal; This domain is found near the C-terminus of bacterial ATP-dependent helicases such as HrpB.
Pssm-ID: 430021 [Multi-domain] Cd Length: 126 Bit Score: 207.29 E-value: 5.92e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 689 GKTRLDALDEAAFEQAVKSLLSWTQHALIDRHAPARIIVPSGMERHIDYGladdGTPQPPVLAVKLQELFGLPDTPRIAK 768
Cdd:pfam08482 1 GVRSLADLKRLDLLAALRALLPWEQQQRLDRLAPEHLTVPSGSRIRIDYS----AEGGAPVLAVRLQELFGLAETPRIAG 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 499196197 769 NRIPLTLHLLSPGGRPLQVTQDLKSFWTNTYPEVKKEMKGRYPKHPWPDD 818
Cdd:pfam08482 77 GRVPLTLHLLSPAGRPVQVTRDLASFWAGSYAEVRKEMRGRYPKHPWPED 126
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
183-338 |
4.35e-55 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 187.36 E-value: 4.35e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 183 YPVAITHFP-------ARRDESLETHARRAIQHALDTHQ----GDVLTFLPGQREIARLQAILEKTL----SPELHVMPL 247
Cdd:cd18791 1 FPVEVYYLEdilellgISSEKEDPDYVDAAVRLILQIHRteepGDILVFLPGQEEIERLCELLREELlspdLGKLLVLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 248 HGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLAREPAYDPNTGFTRLDVVSITQASADQRAGRAG 327
Cdd:cd18791 81 HSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAG 160
|
170
....*....|.
gi 499196197 328 RLAPGWAYRLW 338
Cdd:cd18791 161 RTRPGKCYRLY 171
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
22-177 |
4.00e-51 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 176.11 E-value: 4.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 22 HPRLILEAPPGAGKTTQVPLALLDAPWLNGR--SIILLEPRRVAARNAALFMARQCGEEVGGLVGYHIRFESKVSARTRI 99
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGkgRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499196197 100 QVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQtQLREDLRIVVMSATLQGERLAQFLD-APRLT 177
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLL-RKRPDLKVILMSATLDAEKFSSYFGgAPVIH 158
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
6-176 |
2.80e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 132.09 E-value: 2.80e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQLRE----DLRIVVMSAT 161
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklsPLKVIIMSAT 160
|
170
....*....|....*.
gi 499196197 162 LQGERLAQFLD-APRL 176
Cdd:cd17978 161 LDADLFSEYFNgAPVL 176
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
19-177 |
1.53e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 127.53 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 19 LSNHPRLILEAPPGAGKTTQVPLALLDA--PWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGYHIRFESKVSAR 96
Cdd:cd17973 26 LKNNQILVLVGETGSGKTTQIPQFVLDDelPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAK 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 97 TRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQlREDLRIVVMSATLQGERLAQ-FLDAPR 175
Cdd:cd17973 106 TILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRR-RPDLKLIVMSATLDAGKFQKyFDNAPL 184
|
..
gi 499196197 176 LT 177
Cdd:cd17973 185 LK 186
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
6-178 |
6.81e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 125.66 E-value: 6.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWL-NGRSIILLEPRRVAARNAALFMARQCGEEVGGLVG 84
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTaGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 85 YHIRFESKVS-ARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQtQLREDLRIVVMSATLQ 163
Cdd:cd17980 81 YCIRFDDCTDpQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQ-KKRGDLRLIVASATLD 159
|
170 180
....*....|....*....|.
gi 499196197 164 GERLAQFL------DAPRLTS 178
Cdd:cd17980 160 AEKFRDFFnqnetnDPSKDTA 180
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
6-174 |
4.75e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 122.61 E-value: 4.75e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLN-GRSIILLEPRRVAARNAALFMARQCGEEVGGLVG 84
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKgGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 85 YHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVqTQLREDLRIVVMSATLQG 164
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-ARFRPDLKLLISSATMDA 159
|
170
....*....|.
gi 499196197 165 ERLAQFLD-AP 174
Cdd:cd17974 160 EKFSAFFDdAP 170
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
14-177 |
4.63e-30 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 117.25 E-value: 4.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 14 AITTSLSNHPRLILEAPPGAGKTTQVPLALLDApWLNG-----RSIILLEPRRVAARNAALFMARQCGEEVGGLVGYHIR 88
Cdd:cd17985 9 TILELLEKHQVLVISGMTGCGKTTQIPQFILDN-SLQGpplpvANIICTQPRRISAISVAERVAQERAERVGQSVGYQIR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 89 FESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQlREDLRIVVMSATLQGERLA 168
Cdd:cd17985 88 LESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQ-RPDLKVILMSATLNAELFS 166
|
170
....*....|
gi 499196197 169 Q-FLDAPRLT 177
Cdd:cd17985 167 DyFNSCPVIH 176
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
5-177 |
2.50e-29 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 114.89 E-value: 2.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 5 ALPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVG 84
Cdd:cd17971 5 SLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEVG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 85 YHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALaLDVQTQLREDLRIVVMSATLQG 164
Cdd:cd17971 85 YTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGL-LKKTVQKRPDLKLIVTSATLDA 163
|
170
....*....|....
gi 499196197 165 ERLAQ-FLDAPRLT 177
Cdd:cd17971 164 VKFSQyFYEAPIFT 177
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
6-174 |
6.74e-29 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 113.69 E-value: 6.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDApwlNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAA---GFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTqLREDLRIVVMSATLQGE 165
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLR-LRPDLKLILMSATINIE 156
|
170
....*....|
gi 499196197 166 RLAQ-FLDAP 174
Cdd:cd17979 157 LFSGyFEGAP 166
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
6-176 |
8.81e-29 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 113.99 E-value: 8.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRS-----IILLEPRRVAArnaaLFMARQCGEEVG 80
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgmIGITQPRRVAA----VSMAKRVAEELN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 81 GL---VGYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLAL---------ALDVQTQ 148
Cdd:cd17982 77 VFgkeVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMlsrivplraKLYLQDQ 156
|
170 180
....*....|....*....|....*...
gi 499196197 149 LREDLRIVVMSATLqgeRLAQFLDAPRL 176
Cdd:cd17982 157 TVKPLKLVIMSATL---RVEDFTENKLL 181
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
6-174 |
2.45e-27 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 109.08 E-value: 2.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALaLDVQTQLREDLRIVVMSATLQGE 165
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGY-LKQLLPRRPDLKVIITSATIDAE 159
|
170
....*....|
gi 499196197 166 RLAQ-FLDAP 174
Cdd:cd17989 160 RFSRhFNNAP 169
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
6-170 |
2.66e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 106.42 E-value: 2.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGR----SIILLEPRRVAARNAALFMARQCGEEVGG 81
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRgarcNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 82 LVGYHIRFESKVSART-RIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQtQLREDLRIVVMSA 160
Cdd:cd17976 81 NVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVL-QLNPELRVVLMSA 159
|
170
....*....|
gi 499196197 161 TLQGERLAQF 170
Cdd:cd17976 160 TGDNQRLSRY 169
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
15-172 |
4.70e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 105.69 E-value: 4.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 15 ITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRS----IILLEPRRVAARNAALFMARQCGEEV--GGLVGYHIR 88
Cdd:cd17981 10 IINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGsscrIVCTQPRRISAISVAERVAAERAESCglGNSTGYQIR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 89 FESKVS-ARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTqLREDLRIVVMSATLQGERL 167
Cdd:cd17981 90 LESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLP-FRSDLKVILMSATLNAEKF 168
|
....*
gi 499196197 168 AQFLD 172
Cdd:cd17981 169 SDYFN 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
6-170 |
1.12e-25 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 104.55 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGY 85
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 86 HIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALaLDVQTQLR-----EDLRIVVMSA 160
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGL-LKKLFQEKspnrkEHLKVVVMSA 159
|
170
....*....|
gi 499196197 161 TLQGERLAQF 170
Cdd:cd17984 160 TLELAKLSAF 169
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
6-171 |
1.37e-25 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 104.61 E-value: 1.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGR-----SIILLEPRRVAARNAALFMARQCGEEVG 80
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGtaqkcNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 81 -----GLVGYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVqTQLREDLRI 155
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEI-LHKRSDLHL 159
|
170
....*....|....*.
gi 499196197 156 VVMSATLQGERLAQFL 171
Cdd:cd17975 160 ILMSATVDCEKFSSYF 175
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
25-177 |
1.45e-23 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 98.30 E-value: 1.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 25 LILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGYHIRFESKVSARTRIQVVTE 104
Cdd:cd17983 20 VIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKYMTD 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499196197 105 GILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVqTQLREDLRIVVMSATLQGERLAQFL-DAPRLT 177
Cdd:cd17983 100 GILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREV-VARRRDLKLIVTSATMDADKFADFFgNVPIFT 172
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
6-170 |
1.76e-23 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 99.91 E-value: 1.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGR----SIILLEPRRVAARNAALFMARQCGEEVGG 81
Cdd:cd17972 59 LPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecNIVVTQPRRISAVSVAERVAFERGEEVGK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 82 LVGYHIRFESkVSAR--TRIQVVTEGILTRIIQDDplLDGIGALLFDEFHERHLASDLGLALALDVqTQLREDLRIVVMS 159
Cdd:cd17972 139 SCGYSVRFES-VLPRphASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDV-VQAYPDLRVILMS 214
|
170
....*....|.
gi 499196197 160 ATLQGERLAQF 170
Cdd:cd17972 215 ATIDTSMFCEY 225
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
6-162 |
2.84e-23 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 97.59 E-value: 2.84e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGR--SIILLEPRRVAARNAALFMARQCGEEVGGLV 83
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIpcRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 84 GYHIRFESKVSARTRIQVVTEGILTRIIQD-DPLLDGIGALLFDEFHERHLASDLgLALALDVQTQLREDLRIVVMSATL 162
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDF-LLTKLRDILQKHPNLKLILSSAAL 159
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
6-174 |
1.01e-19 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 87.56 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGR--SIILLEPRRVAARNAALFMARQCGEEVGGLV 83
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKycNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 84 GYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLglaLALDVQTQLREDLR---IVVMSA 160
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDF---LLLVVRRLLRTNSRhvkIILMSA 157
|
170
....*....|....
gi 499196197 161 TLQGERLAQFLDAP 174
Cdd:cd17988 158 TISCKEFADYFTTP 171
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
14-190 |
8.14e-17 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 79.84 E-value: 8.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 14 AITTSLSNHPRLILEAPPGAGKTTQVPLALLDAPW-LNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGYH------ 86
Cdd:smart00487 16 AIEALLSGLRDVILAAPTGSGKTLAALLPALEALKrGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYggdskr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 87 IRFESKVSARTRIQVVTEGILTRIIQDDPL-LDGIGALLFDEFHERhLASDLGLALAlDVQTQLREDLRIVVMSATLQGE 165
Cdd:smart00487 96 EQLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRL-LDGGFGDQLE-KLLKLLPKNVQLLLLSATPPEE 173
|
170 180
....*....|....*....|....*...
gi 499196197 166 R---LAQFLDAPRLTSEGRAYPVAITHF 190
Cdd:smart00487 174 IenlLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
204-328 |
6.18e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 68.39 E-value: 6.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 204 RAIQHALDTHQGD-VLTFLPGQREIArLQAILEKtlsPELHVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSIT 282
Cdd:pfam00271 4 EALLELLKKERGGkVLIFSQTKKTLE-AELLLEK---EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 499196197 283 LPGISVVIDSGLAREPaydpntgftrldvvsitqASADQRAGRAGR 328
Cdd:pfam00271 80 LPDVDLVINYDLPWNP------------------ASYIQRIGRAGR 107
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
25-174 |
4.62e-13 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 68.00 E-value: 4.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 25 LILEAPPGAGKTTQVP-----LALldAPWLNGRSIILLEPRRVAARNAALFMARQCGEEVGGLVGYHIRFESKVSARTRI 99
Cdd:cd17986 21 VLVSGEPGSGKSTQVPqwcaeFAL--SRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTIL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499196197 100 QVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQlREDLRIVVMSATLQGERLAQFLDAP 174
Cdd:cd17986 99 RFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQ-RPELRVVVVTSPALEPKLRAFWGNP 172
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
6-167 |
1.31e-12 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 66.77 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 6 LPIDPLLPAITTSLSNHPRLILEAPPGAGKTTQVPL----ALLDAPWLNGrSIILLEPRRVAARNAALFMARQCGEEVGG 81
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSAHYQHG-VVVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 82 LVGYHIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHERHLASDLGLALALDVQTQlREDLRIVVMSAT 161
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLS-RPELKLVIITCP 158
|
....*.
gi 499196197 162 LQGERL 167
Cdd:cd17977 159 HLSSKL 164
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
233-328 |
1.54e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.77 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 233 ILEKTL-SPELHVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLarepaydpntgftrldv 311
Cdd:smart00490 2 ELAELLkELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL----------------- 64
|
90
....*....|....*..
gi 499196197 312 vSITQASADQRAGRAGR 328
Cdd:smart00490 65 -PWSPASYIQRIGRAGR 80
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
20-332 |
1.36e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 64.66 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 20 SNHPRLILEAPPGAGKTTqvpLALLDAPWL-NGRSIILLEPRRVAARNAAlfmarqcgEEVGGLVGYHIRFESKVSARTR 98
Cdd:COG1061 98 RGGGRGLVVAPTGTGKTV---LALALAAELlRGKRVLVLVPRRELLEQWA--------EELRRFLGDPLAGGGKKDSDAP 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 99 IQVVTEGILTRIIQDDPLLDGIGALLFDEFHerHLASDLGLALALDVQtqlreDLRIVVMSATL-----QGERLAQF--- 170
Cdd:COG1061 167 ITVATYQSLARRAHLDELGDRFGLVIIDEAH--HAGAPSYRRILEAFP-----AAYRLGLTATPfrsdgREILLFLFdgi 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 171 ---LDAPRLTSEG-------RAYPVAITHFPARRDE----------SLETHARRAIQHALDTHQGD--VLTFLPGQREIA 228
Cdd:COG1061 240 vyeYSLKEAIEDGylappeyYGIRVDLTDERAEYDAlserlrealaADAERKDKILRELLREHPDDrkTLVFCSSVDHAE 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 229 RLQAILEKtlsPELHVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIdsgLARepaydpNTGFTR 308
Cdd:COG1061 320 ALAELLNE---AGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI---LLR------PTGSPR 387
|
330 340
....*....|....*....|....
gi 499196197 309 LDVvsitqasadQRAGRAGRLAPG 332
Cdd:COG1061 388 EFI---------QRLGRGLRPAPG 402
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
121-332 |
9.95e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 58.84 E-value: 9.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 121 GALLFDEFHERHLASDLGLALALDVQTQLREdlrIVVMSATLQG--ERLAQFLDAP--------RLTSEGRAYPVAITHF 190
Cdd:PHA02653 293 GTVIIDEVHEHDQIGDIIIAVARKHIDKIRS---LFLMTATLEDdrDRIKEFFPNPafvhipggTLFPISEVYVKNKYNP 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 191 PARRDESLEThaRRAIQHALDTHQGD----VLTFLPGQREIARLQAILEKTLsPELHVMPLHGELPlkEQARVLEpDQHG 266
Cdd:PHA02653 370 KNKRAYIEEE--KKNIVTALKKYTPPkgssGIVFVASVSQCEEYKKYLEKRL-PIYDFYIIHGKVP--NIDEILE-KVYS 443
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499196197 267 RQR--IVLATNVAESSITLPGISVVIDSGLAREPAydPNTGFTRLdvvsITQASADQRAGRAGRLAPG 332
Cdd:PHA02653 444 SKNpsIIISTPYLESSVTIRNATHVYDTGRVYVPE--PFGGKEMF----ISKSMRTQRKGRVGRVSPG 505
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
14-162 |
2.70e-08 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 54.17 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 14 AITTSLSNHpRLILEAPPGAGKTT--QVPLALLDAPWLNGRSIILLEPRRV-------AARNAALFMARQCGEEVGGLVg 84
Cdd:pfam00270 7 AIPAILEGR-DVLVQAPTGSGKTLafLLPALEALDKLDNGPQALVLAPTRElaeqiyeELKKLGKGLGLKVASLLGGDS- 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499196197 85 yhIRFESKVSARTRIQVVTEGILTRIIQDDPLLDGIGALLFDEFHeRHLASDLGLALALDVqTQLREDLRIVVMSATL 162
Cdd:pfam00270 85 --RKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEIL-RRLPKKRQILLLSATL 158
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
386-424 |
1.04e-07 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 50.70 E-value: 1.04e-07
10 20 30
....*....|....*....|....*....|....*....
gi 499196197 386 ARELLQRLGAISNTSTLTPLGQRMLALGIHPRLAAMLLA 424
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLA 39
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
392-424 |
4.06e-07 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 48.42 E-value: 4.06e-07
10 20 30
....*....|....*....|....*....|...
gi 499196197 392 RLGAISNTSTLTPLGQRMLALGIHPRLAAMLLA 424
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLA 33
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
22-161 |
2.36e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 47.78 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 22 HPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVaarnaalfMARQCGEEVGGLVGYHIRFESKVSART---- 97
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKA--------LALQTAERLRELFGPGIRVAVLVGGSSaeer 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499196197 98 --------RIQVVTEG-ILTRIIQDDPL-LDGIGALLFDEFHERHLASDLGLALALDVQTQLREDLRIVVMSAT 161
Cdd:cd00046 73 eknklgdaDIIIATPDmLLNLLLREDRLfLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
18-173 |
8.78e-06 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 47.21 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 18 SLSNHPRLILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEPRRVAARNAALFMARqCGEEVGGLV-GYHI---RFESKV 93
Cdd:cd18026 29 GLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKKALFVLPYVSIVQEKVDALSP-LFEELGFRVeGYAGnkgRSPPKR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 94 SARTRIQVVT----EGILTRIIQDDPLLDgIGALLFDEFH---ERHLASDLGLALaldvqTQL----REDLRIVVMSATL 162
Cdd:cd18026 108 RKSLSVAVCTiekaNSLVNSLIEEGRLDE-LGLVVVDELHmlgDGHRGALLELLL-----TKLlyaaQKNIQIVGMSATL 181
|
170
....*....|..
gi 499196197 163 QG-ERLAQFLDA 173
Cdd:cd18026 182 PNlEELASWLRA 193
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
201-335 |
1.71e-05 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 45.19 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 201 HARRAIQHALDTHQGD-VLTFLPGQREIARLQAILEKTlspELHVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAES 279
Cdd:cd18787 13 KKLLLLLLLLEKLKPGkAIIFVNTKKRVDRLAELLEEL---GIKVAALHGDLSQEERERALKKFRSGKVRVLVATDVAAR 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499196197 280 SITLPGISVVIDsglarepaYD-PNtgftrldvvsitqaSADQ---RAGRAGRL-APGWAY 335
Cdd:cd18787 90 GLDIPGVDHVIN--------YDlPR--------------DAEDyvhRIGRTGRAgRKGTAI 128
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
25-172 |
5.49e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 41.86 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 25 LILEAPPGAGKTTQVPLALLDAPWLNGRSIILLEP-RRVAARNAALF--MARQCGEEVGGLVGyHIRFESKVSARTRIQV 101
Cdd:cd17921 20 VLVSAPTSSGKTLIAELAILRALATSGGKAVYIAPtRALVNQKEADLreRFGPLGKNVGLLTG-DPSVNKLLLAEADILV 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499196197 102 VT----EGILTRIIQDdpLLDGIGALLFDEFHERHlASDLGLALALDVQTQLR--EDLRIVVMSATLQG-ERLAQFLD 172
Cdd:cd17921 99 ATpeklDLLLRNGGER--LIQDVRLVVVDEAHLIG-DGERGVVLELLLSRLLRinKNARFVGLSATLPNaEDLAEWLG 173
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
270-335 |
7.17e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.84 E-value: 7.17e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499196197 270 IVLATNVAESSITLPGISVVIDsglarepaYDPntgftrldvvSITQASADQRAGRAGRLAPGWAY 335
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIF--------FDP----------PSSAASYIQRVGRAGRGGKDEGE 72
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|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
217-298 |
6.59e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 39.90 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499196197 217 VLTFLPGQREIARLQailEKTLSPELHVMPLHGELPLKEQARVLEPDQHGRQRIVLATNVAESSITLPGISVVIDSGLAR 296
Cdd:PRK01297 338 VMVFANRKDEVRRIE---ERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPE 414
|
..
gi 499196197 297 EP 298
Cdd:PRK01297 415 DP 416
|
|
| |
