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Conserved domains on  [gi|499188980|ref|WP_010886520|]
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MULTISPECIES: outer spore coat protein CotM [Bacillus]

Protein Classification

Hsp20/alpha crystallin family protein( domain architecture ID 10157978)

Hsp20/alpha crystallin family protein is a small, stress-induced protein, between 12-43 kDa, which functions as an ATP-independent chaperone that prevents aggregation and protects against cell stress, induced by heat, osmotic, or acid shock

CATH:  2.60.40.790
Gene Ontology:  GO:0006950
PubMed:  10950306|11875128|16165157|11908065|7723051
SCOP:  4002439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 43-115 8.97e-07

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


:

Pssm-ID: 107221  Cd Length: 88  Bit Score: 43.70  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499188980  43 DLYETSQQYIIEADLTFLQPTQVTVTLSGCefILTVK-----------------SSGQTFEKQMMLPFYFNDKNIQVECE 105
Cdd:cd06464    1 DVYETDDAYVVEADLPGFKKEDIKVEVEDG--VLTISgereeeeeeeenylrreRSYGSFSRSFRLPEDVDPDKIKASLE 78

                         90
                 ....*....|
gi 499188980 106 NQILTVAVNK 115
Cdd:cd06464   79 NGVLTITLPK 88
 
Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 43-115 8.97e-07

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 43.70  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499188980  43 DLYETSQQYIIEADLTFLQPTQVTVTLSGCefILTVK-----------------SSGQTFEKQMMLPFYFNDKNIQVECE 105
Cdd:cd06464    1 DVYETDDAYVVEADLPGFKKEDIKVEVEDG--VLTISgereeeeeeeenylrreRSYGSFSRSFRLPEDVDPDKIKASLE 78

                         90
                 ....*....|
gi 499188980 106 NQILTVAVNK 115
Cdd:cd06464   79 NGVLTITLPK 88
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 42-118 2.62e-04

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 37.82  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499188980  42 IDLYETSQQYIIEADLTFLQPTQVTVTLSGCefILTVK-------------------SSGQtFEKQMMLPFYFNDKNIQV 102
Cdd:COG0071    2 VDIEETDDAYVITADLPGVDKEDIDVTVEGN--VLTISgerkeeeeeegenylrrerRYGS-FERSFTLPDDVDVDKIEA 78

                         90
                 ....*....|....*.
gi 499188980 103 ECENQILTVAVNKETE 118
Cdd:COG0071   79 SYENGVLTITLPKAEE 94
 
Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 43-115 8.97e-07

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 43.70  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499188980  43 DLYETSQQYIIEADLTFLQPTQVTVTLSGCefILTVK-----------------SSGQTFEKQMMLPFYFNDKNIQVECE 105
Cdd:cd06464    1 DVYETDDAYVVEADLPGFKKEDIKVEVEDG--VLTISgereeeeeeeenylrreRSYGSFSRSFRLPEDVDPDKIKASLE 78

                         90
                 ....*....|
gi 499188980 106 NQILTVAVNK 115
Cdd:cd06464   79 NGVLTITLPK 88
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 45-115 2.67e-05

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 39.88  E-value: 2.67e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499188980  45 YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKS--------SGQTFEKQMMLPFYFNDKNIQVECENQILTVAVNK 115
Cdd:cd00298    2 YQTDDEVVVTVDLPGVKKEDIKVEVEDNVLTISGKReeeeererSYGEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 42-118 2.62e-04

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 37.82  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499188980  42 IDLYETSQQYIIEADLTFLQPTQVTVTLSGCefILTVK-------------------SSGQtFEKQMMLPFYFNDKNIQV 102
Cdd:COG0071    2 VDIEETDDAYVITADLPGVDKEDIDVTVEGN--VLTISgerkeeeeeegenylrrerRYGS-FERSFTLPDDVDVDKIEA 78

                         90
                 ....*....|....*.
gi 499188980 103 ECENQILTVAVNKETE 118
Cdd:COG0071   79 SYENGVLTITLPKAEE 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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