|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
1-459 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 763.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 1 MAHLPKEYDFSIESLGESKIPSPIYLSHTLGDFIpNYVSDNEYISHELSARLG-ETVGPFTHKNLMERAGPRQKIFFNPH 79
Cdd:PRK06830 1 FMMKVTELDFAIETLGECKIPSPLIYSLAAGDTT-HFVSDSDRVLFDVSLSLIkEEDAPGTEPPSFEKAGPREKIYFDPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 80 HVHAGIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLLPDYNFDILPLTPEVIDNCHKTGGSLLGTSRGGg 159
Cdd:PRK06830 80 KVKAAIVTCGGLCPGLNDVIRAIVLELHHHYGVRRILGIRYGYQGLIPRYGHDPVELTPEVVADIHEFGGTILGSSRGP- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 160 NRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:PRK06830 159 QDPEEIVDTLERMNINILFVIGGDGTLRGASAIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQINGIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDGPNGLLAHLEKRIALRKHAVLVVAEGAGQDLM 319
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALASKDVNFVLIPEVPFDLEGPNGLLAALEKRLAERGHAVIVVAEGAGQELF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 320 vnadgvpsgdsqggslRVSSGTDASGNKRLADIGLFLKEKIGVYFKEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERLG 399
Cdd:PRK06830 319 ----------------DDTGETDASGNPKLGDIGLFLKDRIKEYFKARGIPINLKYIDPSYIIRSVPANANDSVYCGFLG 382
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 400 NNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDALDATGQPIVMKN 459
Cdd:PRK06830 383 QNAVHAAMAGKTGMVVGRWNNRFVHLPIDLAVSKRKKVNPEGDLWRSVLESTGQPRSMGN 442
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
82-448 |
1.34e-110 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 330.11 E-value: 1.34e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 82 HAGIVTCGGLCPGLNDVIRAIVRCLWgRYGVkRISGIRFGYKGLLPDynfDILPLTPEVIDNCHKTGGSLLGTSRGGGNR 161
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAI-KYGI-EVYGIRDGYEGLLEG---DIIDLTREDVSGILQRGGTILGSSRSKPFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 162 VVD----IVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVA 237
Cdd:COG0205 78 TEEgrekALENLKKLGIDALVVIGGDGSLDGAAKLAEE-----YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAID 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 238 AAHMEARSqINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDgpnGLLAHLEKRIA-LRKHAVLVVAEGAGQ 316
Cdd:COG0205 153 RLRDTAAS-HERVFVVEVMGRHAGWLALAAGLAGG-ADLILIPEVPFDLD---KLLEKLKERRKrGKGYSIIVVAEGAGD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 317 DlmvnadgvpsgdsqGGSLRVSSGTDASGNKRLADIGLFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCE 396
Cdd:COG0205 228 E--------------DGEAVLEADTDAFGHVRLGGIGEYLAKEI-----EERTGIETRVTVLGHLQRGGSPSAFDRVLAS 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 499184017 397 RLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDAL 448
Cdd:COG0205 289 RLGAAAVELLLEGKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSPLIQLAR 340
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
84-404 |
5.91e-64 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 207.58 E-value: 5.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVR-CLwgRYGVKrISGIRFGYKGLLpdyNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRV 162
Cdd:pfam00365 3 GILTSGGDAPGMNAAIRAVVRtAI--YRGHE-VYGIRNGYEGLV---EGDIDELTWRDVSGILNRGGTILGTSRSKPFKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 163 VD----IVDGIERLNLHILFIIGGDGSQKGAKEIADEIKhrnlkISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAA 238
Cdd:pfam00365 77 EEgrekIAENLKKLGIDALVVIGGDGSLTGANKLSEERG-----IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 239 AHMEARSQiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDgpnGLLAHLEKRIALRKHAVLVVAEGAgqdl 318
Cdd:pfam00365 152 IRDTASSH-NRVFVVEVMGRHCGWLALMAGLAG-GADAILIPEIPFDIE---ELCEKIKELRKGKRFSIIVVAEGA---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 319 mvnadgvpsgdsqggslrvsSGTDasgnkrladiglFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERL 398
Cdd:pfam00365 223 --------------------SDGE------------FLAKLI-----EEGTGIETRVTVLGHVQRGGTPSAFDRILATRL 265
|
....*.
gi 499184017 399 GNNAVH 404
Cdd:pfam00365 266 GVKAVE 271
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
84-431 |
1.12e-54 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 185.20 E-value: 1.12e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRIsGIRFGYKGLLpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGG----- 158
Cdd:TIGR02483 3 GVLTGGGDCPGLNAVIRGVVRRAIAEYGWEVI-GIRDGWRGLL--EGDTVPLLDLEDVRGILPRGGTILGSSRTNpfkye 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 159 GNRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnlKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAA 238
Cdd:TIGR02483 80 EDGDDKIVANLKELGLDALIAIGGDGTLGIARRLADK------GLPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALDR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 239 AHMEARSQiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDgpnGLLAHLEKRI-ALRKHAVLVVAEGAgqd 317
Cdd:TIGR02483 154 LHTTAESH-HRVMVVEVMGRHAGWIALHSGIAG-GADVILIPEIPFDID---SVCEKVRERFaRGKRFAIVVVAEGA--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 318 lmvnadgvpsgDSQGGSLRVSSGT-DASGNKRLADIGLFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCE 396
Cdd:TIGR02483 226 -----------KPKGGEMVVQEGVkDAFGHVRLGGIGNWLAEEI-----ERRTGIETRATVLGHLQRGGSPSAFDRVLAT 289
|
330 340 350
....*....|....*....|....*....|....*
gi 499184017 397 RLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVV 431
Cdd:TIGR02483 290 RFGVAAVDLVHEGQFGHMVALRGTDIVYVPIAEAV 324
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-427 |
7.54e-46 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 162.08 E-value: 7.54e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWgRYGVKRIsGIRFGYKGLlpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVV 163
Cdd:cd00363 4 GVLTSGGDAPGMNAAIRGVVRSAI-AEGLEVY-GIYEGYAGL---VEGDIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 164 DI----VDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:cd00363 79 EGrakaAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQiNGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDGPNGLLAHLEKRIAL-RKHAVLVVAEGAGQDL 318
Cdd:cd00363 159 RDTASSH-QRTFVVEVMGRHCGDIALEAGLATG-ADIIFIPEEPAADEWEEEMVDVIKKRRERgKRHGIVIVAEGAIDFI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 319 MVNADGvpsgdsqggslrvssgtdasgnkrlADIGLFLKEKIGVyfkEKRIHInLKYIDpsyliRSAVAAPIDSIYCERL 398
Cdd:cd00363 237 PKPITE-------------------------KLLAKLVEERLGF---DTRATV-LGHVQ-----RGGTPTAFDRILASRL 282
|
330 340 350
....*....|....*....|....*....|..
gi 499184017 399 GNNAVHAAMCGKTKMIIGLV---HNKFVHLPI 427
Cdd:cd00363 283 GAEAVELLLEGTGGTPVGIQnlnENQVVRHPL 314
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
1-459 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 763.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 1 MAHLPKEYDFSIESLGESKIPSPIYLSHTLGDFIpNYVSDNEYISHELSARLG-ETVGPFTHKNLMERAGPRQKIFFNPH 79
Cdd:PRK06830 1 FMMKVTELDFAIETLGECKIPSPLIYSLAAGDTT-HFVSDSDRVLFDVSLSLIkEEDAPGTEPPSFEKAGPREKIYFDPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 80 HVHAGIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLLPDYNFDILPLTPEVIDNCHKTGGSLLGTSRGGg 159
Cdd:PRK06830 80 KVKAAIVTCGGLCPGLNDVIRAIVLELHHHYGVRRILGIRYGYQGLIPRYGHDPVELTPEVVADIHEFGGTILGSSRGP- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 160 NRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:PRK06830 159 QDPEEIVDTLERMNINILFVIGGDGTLRGASAIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQINGIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDGPNGLLAHLEKRIALRKHAVLVVAEGAGQDLM 319
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALASKDVNFVLIPEVPFDLEGPNGLLAALEKRLAERGHAVIVVAEGAGQELF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 320 vnadgvpsgdsqggslRVSSGTDASGNKRLADIGLFLKEKIGVYFKEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERLG 399
Cdd:PRK06830 319 ----------------DDTGETDASGNPKLGDIGLFLKDRIKEYFKARGIPINLKYIDPSYIIRSVPANANDSVYCGFLG 382
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 400 NNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDALDATGQPIVMKN 459
Cdd:PRK06830 383 QNAVHAAMAGKTGMVVGRWNNRFVHLPIDLAVSKRKKVNPEGDLWRSVLESTGQPRSMGN 442
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
11-454 |
5.75e-166 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 475.69 E-value: 5.75e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 11 SIESLGESKIPSPIYLshtlGDFIPN--YVSDNEYISHelSARLGETVGPFTHKnLMERAGPRQKIFFNPHHVHAGIVTC 88
Cdd:PTZ00286 23 VNPDLGECNLRGVFGG----NGFLPReaFVDTNSYILS--TPRFGPDDVIVNTK-RWLRAGPRKHLYFNPKEVKAGIVTC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 89 GGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLlpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVVdIVDG 168
Cdd:PTZ00286 96 GGLCPGLNVVIRELVMNLINNYGVKTIYGAKYGYKGL---YKEDWIKLDPKDVKTIHRLGGTILGSSRGGFDPKV-MVDT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 169 IERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAAHMEARSQIN 248
Cdd:PTZ00286 172 LIRHGINILFTLGGDGTHRGALAIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKN 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 249 GIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDgpnGLLAHLEKRIALRKHAVLVVAEGAGQDLMvnaDGVPSG 328
Cdd:PTZ00286 252 GVGIVKLMGRDSGFIALHASVASADVNVCLIPEFDIPLE---GVLEYIEQRLQKKGHCVIVVAEGAGQSLK---DADLDL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 329 dsqggslrvssGTDASGNKRLADIGLFLKEKIGVYFKEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERLGNNAVHAAMC 408
Cdd:PTZ00286 326 -----------GTDASGNKKLWDIGVYLKDEITKYLKKKKPEHTVKYIDPSYMIRAVPANAADAKFCTQLAQNAVHGAMA 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 499184017 409 GKTKMIIGLVHNKFVHLPIDVVVCQ-RKHVNPEGSLWRDALDATGQP 454
Cdd:PTZ00286 395 GFTGFIIGHVHNNYVMIPIKEMSGNyRRRVNPEGRLWQRMLAITGQP 441
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
67-459 |
5.61e-151 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 438.41 E-value: 5.61e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 67 RAGPRQKIFFNPHHVHAGIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLlpdYNFDILPLTPEVIDNCHK 146
Cdd:PLN02564 74 RAGPRQKVYFESDEVRACIVTCGGLCPGLNTVIREIVCGLSYMYGVTRILGIDGGYRGF---YSRNTIPLTPKVVNDIHK 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 147 TGGSLLGTSRGGGNrVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFD 226
Cdd:PLN02564 151 RGGTILGTSRGGHD-TSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEIRRRGLKVAVAGIPKTIDNDIPVIDKSFGFD 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 227 TAIVKATEAVAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDGPNGLLAHLEKRIALRKHA 306
Cdd:PLN02564 230 TAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASRDVDCCLIPESPFYLEGKGGLFEFIEKRLKENGHM 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 307 VLVVAEGAGQDLMVNadgvpsgdsqggSLRVSSGTDASGNKRLADIGLFLKEKIGVYF-KEKRIHINLKYIDPSYLIRSA 385
Cdd:PLN02564 310 VIVVAEGAGQDLIAE------------SMESSDLQDASGNKLLLDVGLWLSQKIKDHFtKVKKMPINLKYIDPTYMIRAI 377
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499184017 386 VAAPIDSIYCERLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDALDATGQPIVMKN 459
Cdd:PLN02564 378 PSNASDNVYCTLLAHSAVHGAMAGYTGFTVGPVNGRHAYIPFYRITEKQNKVVITDRMWARLLSSTNQPSFLSP 451
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
67-454 |
8.01e-145 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 419.99 E-value: 8.01e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 67 RAGPRQKIFFNPHHVHAGIVTCGGLCPGLNDVIRAIVRCLwGRYGVKRISGIRFGYKGLLPDYNFDIlPLTPEVIDNCHK 146
Cdd:PLN02884 40 RAGPRKKIYFEPEEVKAAIVTCGGLCPGLNDVIRQIVFTL-EIYGVKNIVGIPFGYRGFFEKGLSEM-PLSRKVVQNIHL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 147 TGGSLLGTSRGGGNrVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFD 226
Cdd:PLN02884 118 SGGSLLGVSRGGAK-TSDIVDSIEARGINMLFVLGGNGTHAGANAIHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 227 TAIVKATEAVAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDGPNGLLAHLEKRIALRKHA 306
Cdd:PLN02884 197 TAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGQVDICLIPEVPFTLDGPNGVLRHLEHLIETKGSA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 307 VLVVAEGAGQDLMVNadgvpsgdsqggslrvSSGTDASGNKRLADIGLFLKEKIGVYFKEKRIHINLKYIDPSYLIRSAV 386
Cdd:PLN02884 277 VVCVAEGAGQDLLQK----------------TNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPADVKYIDPTYMIRACR 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499184017 387 AAPIDSIYCERLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDALDATGQP 454
Cdd:PLN02884 341 ANASDAILCTVLGQNAVHGAFAGFSGITVGICNTHYVYLPIPEVIAYPRRVDPNSRMWHRCLTSTGQP 408
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
82-448 |
1.34e-110 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 330.11 E-value: 1.34e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 82 HAGIVTCGGLCPGLNDVIRAIVRCLWgRYGVkRISGIRFGYKGLLPDynfDILPLTPEVIDNCHKTGGSLLGTSRGGGNR 161
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAI-KYGI-EVYGIRDGYEGLLEG---DIIDLTREDVSGILQRGGTILGSSRSKPFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 162 VVD----IVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVA 237
Cdd:COG0205 78 TEEgrekALENLKKLGIDALVVIGGDGSLDGAAKLAEE-----YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAID 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 238 AAHMEARSqINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDgpnGLLAHLEKRIA-LRKHAVLVVAEGAGQ 316
Cdd:COG0205 153 RLRDTAAS-HERVFVVEVMGRHAGWLALAAGLAGG-ADLILIPEVPFDLD---KLLEKLKERRKrGKGYSIIVVAEGAGD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 317 DlmvnadgvpsgdsqGGSLRVSSGTDASGNKRLADIGLFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCE 396
Cdd:COG0205 228 E--------------DGEAVLEADTDAFGHVRLGGIGEYLAKEI-----EERTGIETRVTVLGHLQRGGSPSAFDRVLAS 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 499184017 397 RLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDAL 448
Cdd:COG0205 289 RLGAAAVELLLEGKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSPLIQLAR 340
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
84-404 |
5.91e-64 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 207.58 E-value: 5.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVR-CLwgRYGVKrISGIRFGYKGLLpdyNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRV 162
Cdd:pfam00365 3 GILTSGGDAPGMNAAIRAVVRtAI--YRGHE-VYGIRNGYEGLV---EGDIDELTWRDVSGILNRGGTILGTSRSKPFKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 163 VD----IVDGIERLNLHILFIIGGDGSQKGAKEIADEIKhrnlkISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAA 238
Cdd:pfam00365 77 EEgrekIAENLKKLGIDALVVIGGDGSLTGANKLSEERG-----IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 239 AHMEARSQiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDgpnGLLAHLEKRIALRKHAVLVVAEGAgqdl 318
Cdd:pfam00365 152 IRDTASSH-NRVFVVEVMGRHCGWLALMAGLAG-GADAILIPEIPFDIE---ELCEKIKELRKGKRFSIIVVAEGA---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 319 mvnadgvpsgdsqggslrvsSGTDasgnkrladiglFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERL 398
Cdd:pfam00365 223 --------------------SDGE------------FLAKLI-----EEGTGIETRVTVLGHVQRGGTPSAFDRILATRL 265
|
....*.
gi 499184017 399 GNNAVH 404
Cdd:pfam00365 266 GVKAVE 271
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
84-431 |
1.12e-54 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 185.20 E-value: 1.12e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRIsGIRFGYKGLLpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGG----- 158
Cdd:TIGR02483 3 GVLTGGGDCPGLNAVIRGVVRRAIAEYGWEVI-GIRDGWRGLL--EGDTVPLLDLEDVRGILPRGGTILGSSRTNpfkye 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 159 GNRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnlKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAA 238
Cdd:TIGR02483 80 EDGDDKIVANLKELGLDALIAIGGDGTLGIARRLADK------GLPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALDR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 239 AHMEARSQiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDgpnGLLAHLEKRI-ALRKHAVLVVAEGAgqd 317
Cdd:TIGR02483 154 LHTTAESH-HRVMVVEVMGRHAGWIALHSGIAG-GADVILIPEIPFDID---SVCEKVRERFaRGKRFAIVVVAEGA--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 318 lmvnadgvpsgDSQGGSLRVSSGT-DASGNKRLADIGLFLKEKIgvyfkEKRIHINLKYIDPSYLIRSAVAAPIDSIYCE 396
Cdd:TIGR02483 226 -----------KPKGGEMVVQEGVkDAFGHVRLGGIGNWLAEEI-----ERRTGIETRATVLGHLQRGGSPSAFDRVLAT 289
|
330 340 350
....*....|....*....|....*....|....*
gi 499184017 397 RLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVV 431
Cdd:TIGR02483 290 RFGVAAVDLVHEGQFGHMVALRGTDIVYVPIAEAV 324
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
84-440 |
1.29e-53 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 182.20 E-value: 1.29e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRclwgrYGVKR---ISGIRFGYKGLLPDynfDILPLTPEVIDNCHKTGGSLLGTSRGGGN 160
Cdd:PRK03202 5 GVLTSGGDAPGMNAAIRAVVR-----TAISEgleVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 161 RVVD----IVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnlKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAV 236
Cdd:PRK03202 77 KDEEgrakAIENLKKLGIDALVVIGGDGSYMGAKRLTEH------GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 237 ------AAAHmearsqiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDgpnGLLAHLEKRIAL-RKHAVLV 309
Cdd:PRK03202 151 drlrdtASSH-------ERVFIVEVMGRHAGDLALHAGIAG-GAEVILIPEVPFDIE---ELCAKIKKGRERgKKHAIIV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 310 VAEGAGqdlmvNADGvpsgdsqggslrvssgtdasgnkrLADIglfLKEKIGvyfKEKRIHInLKYIDpsyliRSAVAAP 389
Cdd:PRK03202 220 VAEGVM-----PAEE------------------------LAKE---IEERTG---LETRVTV-LGHIQ-----RGGSPTA 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 499184017 390 IDSIYCERLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPE 440
Cdd:PRK03202 259 FDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDK 309
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-427 |
7.54e-46 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 162.08 E-value: 7.54e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWgRYGVKRIsGIRFGYKGLlpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVV 163
Cdd:cd00363 4 GVLTSGGDAPGMNAAIRGVVRSAI-AEGLEVY-GIYEGYAGL---VEGDIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 164 DI----VDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:cd00363 79 EGrakaAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQiNGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDGPNGLLAHLEKRIAL-RKHAVLVVAEGAGQDL 318
Cdd:cd00363 159 RDTASSH-QRTFVVEVMGRHCGDIALEAGLATG-ADIIFIPEEPAADEWEEEMVDVIKKRRERgKRHGIVIVAEGAIDFI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 319 MVNADGvpsgdsqggslrvssgtdasgnkrlADIGLFLKEKIGVyfkEKRIHInLKYIDpsyliRSAVAAPIDSIYCERL 398
Cdd:cd00363 237 PKPITE-------------------------KLLAKLVEERLGF---DTRATV-LGHVQ-----RGGTPTAFDRILASRL 282
|
330 340 350
....*....|....*....|....*....|..
gi 499184017 399 GNNAVHAAMCGKTKMIIGLV---HNKFVHLPI 427
Cdd:cd00363 283 GAEAVELLLEGTGGTPVGIQnlnENQVVRHPL 314
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
84-447 |
9.64e-44 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 157.15 E-value: 9.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRIsGIRFGYKGLL---PDYnfdiLPLTPEVIDNCHKTGGSLLGTSRGGG- 159
Cdd:PRK14071 8 GILTSGGDCAGLNAVIRAVVHRARGTYGWEVI-GIRDATQGLMarpPQY----IELDLDQVDDLLRMGGTILGTTNKGDp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 160 -----------NRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEikhrnLKISIIGIPKTVDNDISFVQKSFGFDTA 228
Cdd:PRK14071 83 fafpmpdgslrDRSQEIIDGYHSLGLDALIGIGGDGSLAILRRLAQQ-----GGINLVGIPKTIDNDVGATEVSIGFDTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 229 IVKATEAVAAAHMEARSQiNGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDGpngllahLEKRIALRKhavl 308
Cdd:PRK14071 158 VNIATEALDRLHFTAASH-NRVMILEVMGRDAGHIALAAGIAGG-ADVILIPEIPYTLEN-------VCKKIRERQ---- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 309 vvAEGAGQDLMVNADGVPSGDsqGGSLRVssgTDASGNKRLADIGLFLKEKIGVYF-KEKRIHInLKYIDpsyliRSAVA 387
Cdd:PRK14071 225 --EEGKNFCLVVVSEAVRTEE--GEQVTK---TQALGEDRYGGIGQYLAEQIAERTgAETRVTV-LGHIQ-----RGGIP 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 388 APIDSIYCERLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDA 447
Cdd:PRK14071 292 SPRDRLLASAFGVAAVDLIAQGKFDRMVAWQNRQVVSVPIAEAIATYRAVDPEGTLVKTA 351
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
84-427 |
3.02e-36 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 135.55 E-value: 3.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWgRYGVKrISGIRFGYKGLLpdyNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVV 163
Cdd:TIGR02482 3 GILTSGGDAPGMNAAIRAVVRTAI-YHGFE-VYGIRRGYKGLI---NGKIEPLESKNVSGIIHRGGTILGTARCPEFKTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 164 DI----VDGIERLNLHILFIIGGDGSQKGAKEIadeikHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:TIGR02482 78 EVrekaVENLKKLGIEGLVVIGGDGSYTGAQKL-----YEEGGIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQiNGIGLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDGPNGLLahLEKRIALRKHAVLVVAEGagqdlm 319
Cdd:TIGR02482 153 RDTATSH-ERAFVIEVMGRHAGDLALYAGIAT-GAEIIIIPEFDYDIDELIQRL--KEQHEAGKKHSIIIVAEG------ 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 320 vnadgvpsgdSQGGSLRvssgtdasgnkrlaDIGLFLKEKIGVyfkEKRIHInLKYIDpsyliRSAVAAPIDSIYCERLG 399
Cdd:TIGR02482 223 ----------NIVGSAK--------------EVAKKIEEKTGI---ETRVTV-LGHTQ-----RGGSPSAFDRVLASRLG 269
|
330 340
....*....|....*....|....*...
gi 499184017 400 NNAVHAAMCGKTKMIIGLVHNKFVHLPI 427
Cdd:TIGR02482 270 AKAVELLLEGKGGVMIGIQNNKIVTHPI 297
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-427 |
7.03e-33 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 126.76 E-value: 7.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRyGVKRIsGIRFGYKGLlpdYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVV 163
Cdd:cd00763 4 GVLTSGGDAPGMNAAIRGVVRSAIAE-GLEVY-GIRDGYAGL---IAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 164 DI-VDGIERLNLH---ILFIIGGDGSQKGAKEIADEikhrnlKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAA 239
Cdd:cd00763 79 EGqAKAIEQLKKHgidALVVIGGDGSYMGAMRLTEH------GFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 240 HMEARSQiNGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDldgPNGLLAHLEKRIAL-RKHAVLVVAEGAGqdl 318
Cdd:cd00763 153 RDTSSSH-QRISVVEVMGRHCGDIALAAGIAGG-AEFIVIPEAEFD---REEVANRIKAGIERgKKHAIVVVAEGVY--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 319 mvnadgvpSGDSQGGSLRVSSGTDAsgnkRLADIGlflkekigvyfkekriHINlkyidpsyliRSAVAAPIDSIYCERL 398
Cdd:cd00763 225 --------DVDELAKEIEEATGFET----RATVLG----------------HIQ----------RGGSPTAFDRILASRM 266
|
330 340
....*....|....*....|....*....
gi 499184017 399 GNNAVHAAMCGKTKMIIGLVHNKFVHLPI 427
Cdd:cd00763 267 GAYAVELLLAGKGGLAVGIQNEQLVHHDI 295
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
112-418 |
2.68e-25 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 107.25 E-value: 2.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 112 VKRISGIRFGYKGLLpDYNF-DILPLTPEVIDNCHKTGGSLLGTSR-------GGGNRVVDIVDGIERLNLHILFIIGGD 183
Cdd:PRK14072 35 IGKVYGARNGIIGIL-DEDLiDLSKESDEALAALAHTPSGALGSCRyklksleEDRAEYERLLEVFKAHDIGYFFYNGGN 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 184 GSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAAHMEARSQING--IGLVKLMGRESG 261
Cdd:PRK14072 114 DSMDTALKVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVLEAALDVAAMANTskVFILEVMGRHAG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 262 FIATYTAIASHETN----FVLIPEVSFDLDgpnGLLAHLEKRIALRKHAVLVVAEGAgqdlmVNADGVPSGDSQggslrv 337
Cdd:PRK14072 194 WLAAAAALAKQNPDdaphLIYLPERPFDEE---KFLADVRAIVKRYGYCVVVVSEGI-----RDADGKFIAEAG------ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 338 sSGTDASGNKRLADIGLFLKEKIgvyfKEKRIHiNLKYIDPSYLIRSAV--AAPIDSIYCERLGNNAVHAAMCGKTKMII 415
Cdd:PRK14072 260 -LAEDAFGHAQLGGVAPVLANLI----KEKLGK-KVHWAVLDYLQRAARhiASKTDVEEAYAVGKAAVEYALAGKNGVMP 333
|
...
gi 499184017 416 GLV 418
Cdd:PRK14072 334 AIR 336
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
84-438 |
1.39e-21 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 97.80 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRClwGRYGVKRISGIRFGYKGLLpDYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVV 163
Cdd:TIGR02478 4 AVLTSGGDAQGMNAAVRAVVRM--AIYVGCRVYAIREGYQGLV-DGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 164 D---------IVDGIERlnlhiLFIIGGDGSQKGA-----------KEIADEIK--------HRNLkiSIIGIPKTVDND 215
Cdd:TIGR02478 81 PgrlkaarnlVSNGIDA-----LVVIGGDGSLTGAdlfreewpsllEELVDTGKitaeqaeeHRHL--TIVGLVGSIDND 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 216 ISFVQKSFGFDTA---IVKATEAVAA-AHMEARSQIngiglVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDGPNG 291
Cdd:TIGR02478 154 MCGTDMTIGADSAlhrICEAIDAISStAQSHQRAFV-----VEVMGRHCGYLALMAAIAT-GADYVFIPERPPEEGWEDQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 292 LLAHLEK-RIALRKHAVLVVAEGAgqdlmvnadgvpsgdsqggslrvssgTDASGNKRLA-DIGLFLKEKIGVyfkEKRI 369
Cdd:TIGR02478 228 LCHKLKRnRKAGKRKTIVIVAEGA--------------------------IDRDLNPITSeDVKDVLVERLGL---DTRI 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499184017 370 HInLKYIDpsyliRSAVAAPIDSIYCERLGNNAVHAAMCGKTKMI---IGLVHNKFVHLPIDVVVCQRKHVN 438
Cdd:TIGR02478 279 TV-LGHVQ-----RGGAPSAFDRILATRQGVEAVLAVLESTPETPspvISLRGNKIVRKPLVEAVAQTKTVA 344
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
84-314 |
1.63e-21 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 97.80 E-value: 1.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVR-CLWGRYgvkRISGIRFGYKGLLpdyNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRV 162
Cdd:TIGR02478 393 AIIHVGAPAGGMNAATRSAVRyALARGH---TVIAIHNGFSGLA---RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDD 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 163 VD-IVDGIERLNLHILFIIGGDGSQKGAKEIADE-IKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAAH 240
Cdd:TIGR02478 467 LGtIAYYFQQHKIDGLIIIGGFEAFEALYQLDAArEKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIK 546
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499184017 241 MEARSQINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDGPNGLLAHLEKRIAL-RKHAVLVVAEGA 314
Cdd:TIGR02478 547 QSASASKRRVFVVETMGGYSGYLATMAGLATG-ADAAYIPEEGISLKDLQEDIEHLKETFAEgRAGKLILRNEKA 620
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
84-313 |
7.09e-20 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 93.18 E-value: 7.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRcLWGRYGVK-RISGIRFGYKGLlpdYNFDILPLTPEVIDNCHKTGG-SLLGTSRG---G 158
Cdd:PTZ00287 181 GIILSGGPAPGGHNVISGIYD-YAKRYNEQsQVIGFLGGIDGL---YSKNYVTITDSLMNRFRNLGGfNMLWSGRGkvrN 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 159 GNRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDI--SFVQKSFGFDTAIVKATEAV 236
Cdd:PTZ00287 257 KDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISEYFAERQIPISIIGIPKTIDGDLksEAIEISFGFDTATKTYSEVI 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 237 AAAHMEARSQINGIGLVKLMGRESGFIATYTAIAShETNFVLIPE----VSFDL-DGPNGLLAHLEKRIALRK-HAVLVV 310
Cdd:PTZ00287 337 GNLCTDVKTGHNVYHVVRVMGRSASHVVLECALQT-RPNIVLIGEevekENLSLkDIVSNIVNTILKRRSLNKnYGVILI 415
|
...
gi 499184017 311 AEG 313
Cdd:PTZ00287 416 PEG 418
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-281 |
2.93e-18 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 87.23 E-value: 2.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLLPDynfDILPLTPEVIDNCHKTGG-SLLGTSRG---GG 159
Cdd:cd00765 76 GIVLSGGQAPGGHNVISGLFDYLKERAKGSTLYGFKGGPAGILKC---DYIELNAEYIQPYRNTGGfDMICSGRTkieTE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 160 NRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDI--SFVQKSFGFDTAIVKATEAVA 237
Cdd:cd00765 153 DQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENFRSKGLKTRVIGVPKTIDGDLknKEIETSFGFDTATKIYSELIG 232
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 499184017 238 AAHMEARSQINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPE 281
Cdd:cd00765 233 NVMRDARSTGKYWHFVKLMGRSASHIALECALKTH-PNICIISE 275
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
84-320 |
7.32e-18 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 85.06 E-value: 7.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNdvirAIVRCLWGRYGVK----RISGIRFGYKGLLPDYNFDIlplTPEVIDNC---HKTGGSLLGTSR 156
Cdd:PRK06555 7 ALLTAGGLAPCLS----SAVGGLIERYTEIapevEIIAYRSGYQGLLLGDSIEI---TPAVRANAgllHRYGGSPIGNSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 157 GGGNRVVDIVD-GI------------ERL---NLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQ 220
Cdd:PRK06555 80 VKLTNVADCVKrGLvkegenplkvaaERLaadGVDILHTIGGDDTNTTAADLAAYLAENGYDLTVVGLPKTIDNDVVPIR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 221 KSFGFDTAivkATE-AVAAAHMEARSQINGIGLV--KLMGRESGFIATYTAIASHE-------------------TNFVL 278
Cdd:PRK06555 160 QSLGAWTA---AEQgARFFDNVINEHSANPRMLIihEVMGRNCGWLTAATARAYREwldrqeyvpgfglsaerwdIHAVY 236
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 499184017 279 IPEVSFDLDGPnglLAHLEKRIALRKHAVLVVAEGAGQDLMV 320
Cdd:PRK06555 237 LPEMAFDLEAE---AERLKAVMDEVGNVNIFLSEGAGLDAIV 275
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
84-281 |
1.89e-16 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 81.51 E-value: 1.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIraivrclWGRY-GVKRIS------GIRFGYKGLLPDYNFDIlplTPEVIDNCHKTGG-SLLGTS 155
Cdd:PRK07085 74 GVILSGGQAPGGHNVI-------AGLFdGLKKLNpdsklfGFIGGPLGLLNGKYIEI---TEEVIDEYRNTGGfDMIGSG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 156 RGG------GNRVVDIVdgiERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDI--SFVQKSFGFDT 227
Cdd:PRK07085 144 RTKieteeqKEACLETV---KKLKLDGLVIIGGDDSNTNAAILAEYFAKHGCKTQVIGVPKTIDGDLknEFIETSFGFDT 220
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 499184017 228 AIVKATEAVAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPE 281
Cdd:PRK07085 221 ATKTYSEMIGNISRDALSAKKYWHFIKLMGRSASHIALECALQTH-PNICLISE 273
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-326 |
7.85e-15 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 76.79 E-value: 7.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRClwGRYGVKRISGIRFGYKGLLP--DYnfdILPLTPEVIDNCHKTGGSLLGTSR----- 156
Cdd:cd00764 7 AVLTSGGDAQGMNAAVRAVVRM--GIYVGAKVFFVYEGYEGLVKggDY---IKQAEWESVSNWLQEGGTIIGSARckefr 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 157 ---GGGNRVVDIVD-GIERlnlhiLFIIGGDGSQKGAK-----------------EIADEIKHRNLKISIIGIPKTVDND 215
Cdd:cd00764 82 ereGRLQAAYNLIQrGITN-----LCVIGGDGSLTGADlfrsewpslleelvkdgKITEEEVAKYQHLNIVGMVGSIDND 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 216 ISFVQKSFGFDTAIVKATEAVAAAHMEARSQINGIgLVKLMGRESGFIATYTAIAShETNFVLIPEVSFDLDGPNGLLAH 295
Cdd:cd00764 157 FCGTDMTIGTDSALHRICEVVDAITTTAQSHQRTF-VLEVMGRHCGYLALVSGLAT-GADWIFIPERPPEDGWEDQMCRR 234
|
250 260 270
....*....|....*....|....*....|..
gi 499184017 296 L-EKRIALRKHAVLVVAEGAgqdlmVNADGVP 326
Cdd:cd00764 235 LsEHRSRGKRLNIIIVAEGA-----IDDQLKP 261
|
|
| PLN02251 |
PLN02251 |
pyrophosphate-dependent phosphofructokinase |
84-281 |
5.59e-14 |
|
pyrophosphate-dependent phosphofructokinase
Pssm-ID: 215140 Cd Length: 568 Bit Score: 74.06 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 84 GIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLLpdyNFDILPLTPEVIDNCHKTGGSLLGTSrgGGNRV- 162
Cdd:PLN02251 100 GVVLSGGQAPGGHNVISGIFDYLQEHAKGSVLYGFKGGPAGIM---KCKYVELTAEFIYPYRNQGGFDMICS--GRDKIe 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 163 -----VDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISF--VQKSFGFDTAIVKATEA 235
Cdd:PLN02251 175 tpeqfKQAEETATKLDLDGLVVIGGDDSNTNACLLAEYFRAKNLKTRVIGCPKTIDGDLKSkeVPTSFGFDTACKIYSEM 254
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 499184017 236 VAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPE 281
Cdd:PLN02251 255 IGNVMIDARSTGKYYHFVRLMGRAASHITLECALQTH-PNITIIGE 299
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
170-281 |
4.22e-13 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 71.93 E-value: 4.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 170 ERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDI--SFVQKSFGFDTAIVKATEAVAAAHMEARSQI 247
Cdd:PTZ00468 193 EKLKLHGLVVIGGDDSNTNAAVLAEYFKRNSSSTVVVGCPKTIDGDLknEVIETSFGYDTAVKTYSEQIGSIMDAIKTEG 272
|
90 100 110
....*....|....*....|....*....|....
gi 499184017 248 NGIGLVKLMGRESGFIATYTAIASHeTNFVLIPE 281
Cdd:PTZ00468 273 YGYYFVRLMGRSASHITLECGLQTR-ANMILIGE 305
|
|
| PLN03028 |
PLN03028 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
39-313 |
1.31e-12 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 215543 Cd Length: 610 Bit Score: 69.80 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 39 SDNEYISHELSARLGEtvgPFTHKNLMERAGPRQKIFFNPHHVHAGIVTCGGLCPGLNDVIraivrclWGRYGVKRIS-- 116
Cdd:PLN03028 41 ADAHAISRAFPHTYGQ---PLAHFLRATAKVPDAQVITEHPAVRVGVVFCGRQSPGGHNVI-------WGLHDALKAHnp 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 117 -----GIRFGYKGLLPDYNFDIlplTPEVIDNCHKTGG-SLLGTSRG---GGNRVVDIVDGIERLNLHILFIIGGDGSQK 187
Cdd:PLN03028 111 nsvllGFLGGTEGLFAQKTLEI---TDDVLSTYKNQGGyDLLGRTKDqirTTEQVNAALAACEALKLDGLVIIGGVTSNT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 188 GAKEIADEIKHRNLKISIIGIPKTVDNDI--SFVQKSFGFDTAIVKATEAVAAAHMEARSQINGIGLVKLMGRESGFIAT 265
Cdd:PLN03028 188 DAAQLAETFAEAKCKTKVVGVPVTLNGDLknQFVETNVGFDTICKVNSQLISNVCTDALSAEKYYYFIRLMGRKASHVAL 267
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 499184017 266 YTAIASHETNFVLIPEVSFD----LDGPNGLLAHLEKRIALRK-HAVLVVAEG 313
Cdd:PLN03028 268 ECALQSHPNMVILGEEVAASkltlFDITKQICDAVQARAEQDKnHGVILIPEG 320
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
80-307 |
6.72e-11 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 64.46 E-value: 6.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 80 HVHAGIVTCGGLCPGLNDVIRAIVRclwgrYGV---KRISGIRFGYKGLLPDynfDILPLTPEVIDNCHKTGGSLLGTSR 156
Cdd:cd00764 389 NLNIAIVNVGAPAAGMNAAVRSAVR-----YGLahgHRPYAIYDGFEGLAKG---QIVELGWIDVGGWTGRGGSELGTKR 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499184017 157 G-GGNRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIAD-EIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATE 234
Cdd:cd00764 461 TlPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREaREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMK 540
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499184017 235 AVAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHeTNFVLIPEVSFDLDGPNGLLAHLEKRIalrKHAV 307
Cdd:cd00764 541 YCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLAVG-ADAAYVFEEPFNIRDLQENVEHLTEKM---KTTI 609
|
|
| |
