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Conserved domains on  [gi|499180067|ref|WP_010877607|]
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MULTISPECIES: tungstate ABC transporter permease WtpB [Archaeoglobus]

Protein Classification

ABC transporter permease( domain architecture ID 11426120)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
tungstate_WtpB super family cl46186
tungstate ABC transporter permease WtpB;
19-254 1.43e-106

tungstate ABC transporter permease WtpB;


The actual alignment was detected with superfamily member NF040839:

Pssm-ID: 468778  Cd Length: 250  Bit Score: 308.49  E-value: 1.43e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQlfNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIP 98
Cdd:NF040839  16 FILLPIITMLLNQ--DPGDLSKALHDPEVIKSLLVSLYAALIATLIALIFGVPLGYILARKDFKGKSFVEAIIDIPIVIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  99 HTVAGIALLVVFGSSGLIG-SFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVS 177
Cdd:NF040839  94 HSVVGIMLLVVFYGTGIGGaSKIGLKIVDNFWGIVVAMLFVSAPFMINSARDGFLSVDEELEHVARTLGASKLRTFFTIS 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499180067 178 LPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGRE 254
Cdd:NF040839 174 LPLAKRSIVSGAIMTWARGISEVGAILIVAYYPKTAPVLIYERFNNFGLSASKPIAVILILISLALFVILRLLIGRK 250
 
Name Accession Description Interval E-value
tungstate_WtpB NF040839
tungstate ABC transporter permease WtpB;
19-254 1.43e-106

tungstate ABC transporter permease WtpB;


Pssm-ID: 468778  Cd Length: 250  Bit Score: 308.49  E-value: 1.43e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQlfNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIP 98
Cdd:NF040839  16 FILLPIITMLLNQ--DPGDLSKALHDPEVIKSLLVSLYAALIATLIALIFGVPLGYILARKDFKGKSFVEAIIDIPIVIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  99 HTVAGIALLVVFGSSGLIG-SFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVS 177
Cdd:NF040839  94 HSVVGIMLLVVFYGTGIGGaSKIGLKIVDNFWGIVVAMLFVSAPFMINSARDGFLSVDEELEHVARTLGASKLRTFFTIS 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499180067 178 LPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGRE 254
Cdd:NF040839 174 LPLAKRSIVSGAIMTWARGISEVGAILIVAYYPKTAPVLIYERFNNFGLSASKPIAVILILISLALFVILRLLIGRK 250
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 19-253 1.00e-69

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 215.38  E-value: 1.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVT-LQLFNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVI 97
Cdd:COG0555   23 IVLLPLAALVLkAAGLGWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFAL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  98 PHTVAGIALLVVFGSSGLIGSFSP---LKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFF 174
Cdd:COG0555  103 PTAVAGIALLLLFGPNGWLGQLLAplgIKVAFTPLGIVLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFR 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 175 TVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYY-PM---IAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRII 250
Cdd:COG0555  183 RVILPLLLPALLTGFALAFARALGEFGAVIFIAGNlPMkteILPLLIYLKLEEGDYAGATAIALVLLLISFLLLLLINLL 262


                 ...
gi 499180067 251 VGR 253
Cdd:COG0555  263 QRR 265
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 34-237 8.83e-42

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 142.54  E-value: 8.83e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   34 NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSS 113
Cdd:TIGR01581   6 GGSHILSALTDPENIKALRLSLATSLASLLLAVIIGIPTAYVLARVRFPLKKLLDTLLDLPMVLPPLVAGLALLLLFGRN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  114 GLIGSF-----SPLKFVDAlpGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAG 188
Cdd:TIGR01581  86 GLLGPYleaagIQVIFSTL--GVVLAQTFVASPYYVRVARSTFKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAG 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499180067  189 AIMSWARGISEFGAVVVIA----YYPMIAPTLIYERYLSEGLSAAMPVAAILI 237
Cdd:TIGR01581 164 LVLAWARALGEFGATLMFAgsiqGKTRTLPLAIYLNIQSDNIEAAVASALLLL 216
modB PRK09421
molybdate ABC transporter permease subunit;
45-202 6.06e-36

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 127.73  E-value: 6.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  45 PAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSF----S 120
Cdd:PRK09421   5 DPEWQAVLLSLKVSSVAVLFSLPFGILVAWLLARCRFPGKSLLDSLLHLPLVLPPVVTGYLLLISMGRRGFIGQWlyewF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 121 PLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEF 200
Cdd:PRK09421  85 GISFAFSWRGAALAAAVMAFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAGTVLAFARSLGEF 164


                 ..
gi 499180067 201 GA 202
Cdd:PRK09421 165 GA 166
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 52-245 6.83e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.86  E-value: 6.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  52 LTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSPLkfvdALPGI 131
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGL----GLPAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 132 VVAMLFVSVPIYINQAkEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPM 211
Cdd:cd06261   78 ILALLLIAPFARLIRR-AALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEA 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 499180067 212 IAPTLIYERYLSEGLSAAMPVAAILILLSLAVFV 245
Cdd:cd06261  157 PGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
ABC_perm1 NF038017
ABC transporter permease; Proteins of this family are the permease subunit of an ABC ...
 54-206 8.14e-09

ABC transporter permease; Proteins of this family are the permease subunit of an ABC transporter complex, which may be involved in tungstate uptake.


Pssm-ID: 411610 [Multi-domain]  Cd Length: 184  Bit Score: 53.70  E-value: 8.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  54 TYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSpLKFVDAlpGIVV 133
Cdd:NF038017   1 SLRVSGTATLIAALIGIPLGALLALRRFPGRRLVISLLNTLMGLPPVVVGLIVYLLLSRSGPLGFLG-LLYTPT--AMII 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499180067 134 AMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVsLPLSVRHIVAGAIMSWARGISEFGAVVVI 206
Cdd:NF038017  78 AQAVLALPIVAGLTLAAVQGLDPELRLQILSLGATRWQALWTL-LKEARFALLAAVLAGFGRAISEVGAVMMV 149
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 69-253 3.04e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   69 GTPLAYILARK-SFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFsplkfvdaLPGIVVAMLFVSVPIYINQA 147
Cdd:pfam00528   1 GIPLGIIAALRrGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI--------LPAIILALLGWAGYARLIRR 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  148 kEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIA---PTLIYERYLSE 224
Cdd:pfam00528  73 -AALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGlllIEAILGYDYPE 151

                         170       180
                  ....*....|....*....|....*....
gi 499180067  225 GLSAAMPVAAILILLSLAVFVALRIIVGR 253
Cdd:pfam00528 152 IQGPVLAAALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
tungstate_WtpB NF040839
tungstate ABC transporter permease WtpB;
19-254 1.43e-106

tungstate ABC transporter permease WtpB;


Pssm-ID: 468778  Cd Length: 250  Bit Score: 308.49  E-value: 1.43e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQlfNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIP 98
Cdd:NF040839  16 FILLPIITMLLNQ--DPGDLSKALHDPEVIKSLLVSLYAALIATLIALIFGVPLGYILARKDFKGKSFVEAIIDIPIVIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  99 HTVAGIALLVVFGSSGLIG-SFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVS 177
Cdd:NF040839  94 HSVVGIMLLVVFYGTGIGGaSKIGLKIVDNFWGIVVAMLFVSAPFMINSARDGFLSVDEELEHVARTLGASKLRTFFTIS 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499180067 178 LPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGRE 254
Cdd:NF040839 174 LPLAKRSIVSGAIMTWARGISEVGAILIVAYYPKTAPVLIYERFNNFGLSASKPIAVILILISLALFVILRLLIGRK 250
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 19-253 1.00e-69

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 215.38  E-value: 1.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVT-LQLFNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVI 97
Cdd:COG0555   23 IVLLPLAALVLkAAGLGWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFAL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  98 PHTVAGIALLVVFGSSGLIGSFSP---LKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFF 174
Cdd:COG0555  103 PTAVAGIALLLLFGPNGWLGQLLAplgIKVAFTPLGIVLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFR 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 175 TVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYY-PM---IAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRII 250
Cdd:COG0555  183 RVILPLLLPALLTGFALAFARALGEFGAVIFIAGNlPMkteILPLLIYLKLEEGDYAGATAIALVLLLISFLLLLLINLL 262


                 ...
gi 499180067 251 VGR 253
Cdd:COG0555  263 QRR 265
ModB COG4149
ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and ...
 44-253 1.38e-54

ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, permease component ModB is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 443320 [Multi-domain]  Cd Length: 223  Bit Score: 175.24  E-value: 1.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  44 DPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSPLK 123
Cdd:COG4149    2 SPEDWSALWLSLKVALIATLLLLLLGIPLAWWLARTRFRGKGLLEALVTLPLVLPPTVLGFYLLLLFGRNGPLGQLLEEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 124 FVDALP----GIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISE 199
Cdd:COG4149   82 FGISLVftwtGAVLASVVVSLPLMVQPLRAAFEAVDPRLEEAARTLGASPWRVFFRVTLPLAKPGILAGAVLAFARALGE 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499180067 200 FGAVVVIA-YYPM---IAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGR 253
Cdd:COG4149  162 FGATLMFAgNIPGktqTLPLAIYDAVEAGDYAAAHALSLILLAISFVVLLLLNLLNRR 219
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 34-237 8.83e-42

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 142.54  E-value: 8.83e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   34 NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSS 113
Cdd:TIGR01581   6 GGSHILSALTDPENIKALRLSLATSLASLLLAVIIGIPTAYVLARVRFPLKKLLDTLLDLPMVLPPLVAGLALLLLFGRN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  114 GLIGSF-----SPLKFVDAlpGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAG 188
Cdd:TIGR01581  86 GLLGPYleaagIQVIFSTL--GVVLAQTFVASPYYVRVARSTFKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAG 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499180067  189 AIMSWARGISEFGAVVVIA----YYPMIAPTLIYERYLSEGLSAAMPVAAILI 237
Cdd:TIGR01581 164 LVLAWARALGEFGATLMFAgsiqGKTRTLPLAIYLNIQSDNIEAAVASALLLL 216
modB_ABC TIGR02141
molybdate ABC transporter, permease protein; This model describes the permease protein, ModB, ...
 58-253 1.66e-41

molybdate ABC transporter, permease protein; This model describes the permease protein, ModB, of the molybdate ABC transporter. This system has been characterized in E. coli, Staphylococcus carnosus, Rhodobacter capsulatus and Azotobacter vinlandii. Molybdate is chemically similar to sulfate, thiosulfate, and selenate. These related substrates, and sometimes molybdate itself, can be transported by the homologous sulfate receptor. Some apparent molybdenum transport operons include a permease related to this ModB, although less similar than some sulfate permease proteins and not included in this model. [Transport and binding proteins, Anions]


Pssm-ID: 273993 [Multi-domain]  Cd Length: 208  Bit Score: 141.23  E-value: 1.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   58 ALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIG---SFSPLKFVDALPGIVVA 134
Cdd:TIGR02141   7 AVIATLLLLPLGIPVAWLLARSRFRGKPLLEVLVTLPLVLPPTVLGFYLLIAFGPNGPIGkllELFGISLVFTFTGAVLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  135 MLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYY----P 210
Cdd:TIGR02141  87 SVIVSFPLMVQPIRAAFEAVDPDLEEAARTLGASESQTFLKVTLPLAFPGLLAGAVLSFARALGEFGATLMFAGNipgeT 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 499180067  211 MIAPTLIYErYLSEGLSAAMPVAAILILLSLAVFVALRIIVGR 253
Cdd:TIGR02141 167 QTIPLAIYD-AVESDYELAHQLSLVLLAISLIVLLLVELLNKR 208
permease_CysT TIGR02139
sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two ...
 20-253 3.09e-36

sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysW (TIGR02140). The sulfate transporter has been described in E. coli as transporting sulfate, thiosulfate, selenate, and selenite. Sulfate transporters may also transport molybdate ion if a specific molybdate transporter is not present. [Transport and binding proteins, Anions]


Pssm-ID: 131194  Cd Length: 265  Bit Score: 129.37  E-value: 3.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   20 VLLPVAATV--TLQLfNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVI 97
Cdd:TIGR02139  20 VLLPLAALFlkASQL-GWAGFWQIITEPRVLAAYKLSFGTALIAALINAVFGTLLAWVLVRYRFPGKRIVDALVDLPFAL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   98 PHTVAGIALLVVFGSSGLIGSF-SPL--KFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFF 174
Cdd:TIGR02139  99 PTAVAGIALATLYSPNGWIGSFlAPLgiKIAFTPLGIVIALVFVSLPFVVRTVQPVLEEIEKELEEAAASLGASRWQTFW 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  175 TVSLPLSVRHIVAGAIMSWARGISEFGAVVVIA----YYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRII 250
Cdd:TIGR02139 179 RVILPALLPALLTGFALAFARAVGEYGSVIFIAgnlpMKTEIAPLLIFQKLEQYDYAGATAIASVMLIISFVILLFINLL 258


                  ...
gi 499180067  251 VGR 253
Cdd:TIGR02139 259 QWW 261
modB PRK09421
molybdate ABC transporter permease subunit;
45-202 6.06e-36

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 127.73  E-value: 6.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  45 PAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSF----S 120
Cdd:PRK09421   5 DPEWQAVLLSLKVSSVAVLFSLPFGILVAWLLARCRFPGKSLLDSLLHLPLVLPPVVTGYLLLISMGRRGFIGQWlyewF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 121 PLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEF 200
Cdd:PRK09421  85 GISFAFSWRGAALAAAVMAFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAGTVLAFARSLGEF 164


                 ..
gi 499180067 201 GA 202
Cdd:PRK09421 165 GA 166
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
19-261 4.17e-34

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 128.74  E-value: 4.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQLF-NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVI 97
Cdd:COG1178   23 LVLLPLLALLLRAFTdGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLAL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  98 PHTVAGIALLVVFGSSGLIGSFSPLKF------VDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLR 171
Cdd:COG1178  103 PPYVVALAWIALFGPNGLLNTLLRALFgleppdIYGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWR 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 172 VFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAY-YPMIApTLIYERYLSEG-LSAAMPVAAILILLSLAVFVALRI 249
Cdd:COG1178  183 AFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVLGGgYTTLT-TAIYQAWLGDFdLGAAAALALVLLLLVLLLLLLERR 261

                        250
                 ....*....|..
gi 499180067 250 IVGREDVSEGQG 261
Cdd:COG1178  262 LRRRRRYATVGG 273
3a0106s02 TIGR00969
sulfate ABC transporter, permease protein; This model describes a subfamily of both CysT and ...
 19-245 1.27e-33

sulfate ABC transporter, permease protein; This model describes a subfamily of both CysT and CysW, paralogous and generally tandemly encoded permease proteins of the sulfate ABC transporter. [Transport and binding proteins, Anions]


Pssm-ID: 273370  Cd Length: 271  Bit Score: 122.85  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   19 FVLLPVAATVTLQLF--NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVV 96
Cdd:TIGR00969  28 LILILPVAALFVQAFskGLGQFWQNATDPIAVSAYNLTLLMALIAVPLNGVFGLLIAWVLTRYQFPGRKLLDALIDLPFA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   97 IPHTVAGIALLVVFGSSGLIGSFSP---LKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVF 173
Cdd:TIGR00969 108 LSPVVAGLTLALLYGSNGWLGSWLAsfgIQIIFTWPGMALAMIFVSLPFVVREVQPVLEELGTEAEEAAATLGASGWQTF 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499180067  174 FTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIA----YYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFV 245
Cdd:TIGR00969 188 WRVTLPSIRWALLYGVVLTFARALGEFGAVVVVSgnipGKTLTLPLLIEERLEQYDYPGAYVIAAVLLLVSLVTLF 263
cysT CHL00187
sulfate transport protein; Provisional
 34-221 5.34e-30

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 112.42  E-value: 5.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  34 NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSS 113
Cdd:CHL00187  40 PWSDFLQKATEPIALSAYSLTLSMALIAALINGFFGLLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLATVYGDN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 114 GLIG---SFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAI 190
Cdd:CHL00187 120 GWIGhllSHLGIQIVFTKLGVLLAMIFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLA 199

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 499180067 191 MSWARGISEFGAVVVIA----YYPMIAPTLIYERY 221
Cdd:CHL00187 200 LTFSRAIGEYGSIVIISsnipFKDLVASVLIFQSL 234
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
19-253 9.47e-29

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 113.72  E-value: 9.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTL-------QLFNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIV 91
Cdd:COG1178  301 GLLLPLLALLLWsltkaldDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLA 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  92 DLPVVIPHTVAGIALLVVFgssgliGSFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLR 171
Cdd:COG1178  381 MLPYAVPGIVLGLGLLLLF------NRPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLR 454

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 172 VFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYP-MIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRII 250
Cdd:COG1178  455 TLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGfETLAVLIYQLASSGRYGEAAALALLLVLVSLLPVLLLERL 534


                 ...
gi 499180067 251 VGR 253
Cdd:COG1178  535 LGR 537
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 33-253 1.04e-28

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 109.43  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  33 FNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGS 112
Cdd:COG1177   45 FTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 113 SGLIGSFsplkfvdalPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMS 192
Cdd:COG1177  125 LGLSGGL---------WGLILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLA 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499180067 193 WARGISEFG-AVVVIAYYPMIAPTLIYErYLSEGLS-AAMPVAAILILLSLAVFVALRIIVGR 253
Cdd:COG1177  196 FTLSFDEFViTLFLAGPGVTTLPVYIYS-MIRRGISpEINALSTLLILLSLLLLLLAERLRRR 257
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 33-259 1.02e-26

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 104.84  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  33 FNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGS 112
Cdd:COG1176   51 FTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGR 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 113 SGLIGSF--------SPLKFVDALPGIVVAML-----FVSVPIYINqakegFASVDVRLEHVARTLGSSPLRVFFTVSLP 179
Cdd:COG1176  131 NGLLNSLllalglidEPLRLLYTEFAVVIGLVyvylpFMVLPLYAA-----LEKIDPSLLEAARDLGASPWQTFRRVILP 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 180 LSVRHIVAGAIMSWARGISEFGAVVVI--AYYPMIApTLIYERYLSE---GLSAAMpvAAILILLSLAVFVALRIIVGRE 254
Cdd:COG1176  206 LSLPGIIAGSLLVFIPALGAFVTPALLggGKVLMIG-NLIYQQFLSAlnwPLAAAL--AVVLLLIVLLVLLLYLRLLRRR 282


                 ....*
gi 499180067 255 DVSEG 259
Cdd:COG1176  283 RLLGG 287
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
20-253 2.38e-23

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 95.59  E-value: 2.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  20 VLLPVAATVT-LQLFNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIP 98
Cdd:PRK10971  28 LLLPLSALVMqLSQMSWAQYWEVITNPQVVAAYKVTLLSAFVASIFNAVFGLLMAWILTRYRFPGRTLLDALMDLPFALP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  99 HTVAGIALLVVFGSSGLIGSFSP---LKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFT 175
Cdd:PRK10971 108 TAVAGLTLASLFSVNGWYGEWLAkfdIKVTYTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRK 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 176 VSLPLSVRHIVAGAIMSWARGISEFGAVVVI----AYYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIV 251
Cdd:PRK10971 188 VVLPELSPALLAGVALSFTRSLGEFGAVIFIagniAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSINTLQ 267


                 ..
gi 499180067 252 GR 253
Cdd:PRK10971 268 SR 269
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 19-254 5.14e-18

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 81.59  E-value: 5.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQLFN-----FDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDL 93
Cdd:PRK15050  38 LVVYPLVRVVLQSLTGehglgLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVLGVLLALVLAFVPFPGASLVGRFIDT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  94 PVVIPHTVAGIALLVVFGSSGLIG---------SFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVART 164
Cdd:PRK15050 118 FVAFPSFLITLAFTFLYGSAGSVNialqrlfglEAPPLDFLYSPGGVILAEITFYTPFVVRPLLAAFAQLDARQLEAAAS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 165 LGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIA-PTLIYERYLSE-GLSAAMPVAAILILLSLA 242
Cdd:PRK15050 198 LGASPWRVARRVILPEAWPALAAGGSLCLLLTLNEFGIVLFTGAKDVVTlPVLIYSKAIVDfDYPTACAIAVVNLALSLG 277

                        250
                 ....*....|..
gi 499180067 243 VFVALRIIVGRE 254
Cdd:PRK15050 278 LYALYRRVNRRA 289
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 19-206 6.30e-18

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 82.81  E-value: 6.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   19 FVLLPVAATVTLQLFN-------FDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIV 91
Cdd:TIGR03262  17 FLLLPLLALLTKSVYDsdgdfigLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGKGAFRLVA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   92 DLPVVIPHTVAGIALLVVFGSSGLIGSFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLR 171
Cdd:TIGR03262  97 LLPLLAPSLLPAISLIYLFGNQGLLKGLLGGFSIYGFWGIVIGEVFYTFPHALMILVTALSLADGRLYEAARAMGASPWR 176

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 499180067  172 VFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVI 206
Cdd:TIGR03262 177 TFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVI 211
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 52-245 6.83e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.86  E-value: 6.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  52 LTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSPLkfvdALPGI 131
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGL----GLPAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 132 VVAMLFVSVPIYINQAkEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPM 211
Cdd:cd06261   78 ILALLLIAPFARLIRR-AALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEA 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 499180067 212 IAPTLIYERYLSEGLSAAMPVAAILILLSLAVFV 245
Cdd:cd06261  157 PGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
cysW PRK11602
sulfate/thiosulfate ABC transporter permease CysW;
46-207 1.42e-15

sulfate/thiosulfate ABC transporter permease CysW;


Pssm-ID: 183225  Cd Length: 283  Bit Score: 74.40  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  46 AVWKVVLTtyyaALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSF---SPL 122
Cdd:PRK11602  65 AIWLTVLI----ALIAVPVNLVFGILLAWLVTRFNFPGRQLLLTLLDIPFAVSPVVAGLVYLLFYGSNGPLGGWldeHNL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 123 KFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGA 202
Cdd:PRK11602 141 QLMFSWPGMVLVTIFVTCPFVVRELVPVMLSQGSQEDEAAILLGASGWQMFRRVTLPNIRWALLYGVVLTNARAIGEFGA 220


                 ....*
gi 499180067 203 VVVIA 207
Cdd:PRK11602 221 VSVVS 225
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 33-192 9.51e-13

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 66.27  E-value: 9.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  33 FNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGS 112
Cdd:COG0395   58 FTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQ 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 113 SGLIGSFsplkfvdalPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMS 192
Cdd:COG0395  138 LGLLNTY---------WGLILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFT 208
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 41-179 5.79e-12

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 65.24  E-value: 5.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  41 AASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFs 120
Cdd:PRK09433  36 VWQDSYLWHVLRFSFWQAFLSALLSVLPAIPLARALYRRRFPGRGLLLRLCAMTLVLPVLVAVFGLLSVYGRSGWLAQL- 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 121 pLKFVDA--------LPGIVVAMLFVSVPI---YINQAKEGFASVDVRLehvARTLGSSPLRVFFTVSLP 179
Cdd:PRK09433 115 -LQALGLewpfsiygLQGILLAHVFFNLPLatrLLLQALESIPAEQRQL---AAQLGMRGWQFFRLVEWP 180
thiP TIGR01253
thiamine ABC transporter, permease protein; The model describes thiamine ABC transporter, ...
 36-261 3.04e-09

thiamine ABC transporter, permease protein; The model describes thiamine ABC transporter, permease protein in bacteria. The protein belongs to the larger ABC transport system. It consists of atleast three components: the inner mebrane permease; thiamine binding protein; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP). [Transport and binding proteins, Other]


Pssm-ID: 130320 [Multi-domain]  Cd Length: 519  Bit Score: 56.85  E-value: 3.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   36 DEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGL 115
Cdd:TIGR01253  34 DDWRAVFQDDYLQHLILFSFGQAFLSALLSIFFAIFLARALFRKPFLGKKALLKLCALTFILPALVAIFGIIGIYGRQGW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  116 IGSFSPLKFVD------ALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGA 189
Cdd:TIGR01253 114 LATLANLFGLEwqfhiyGLQGILIAHLFFNIPLAAQLFLQALENIPGEQRQLAAQLGLQGWHFFKFVEWPVFRQQCLPTA 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499180067  190 IMSWARGISEFGAVVVIAYYPMiAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGREDVSEGQG 261
Cdd:TIGR01253 194 ALIFMLCFASFATVLSLGGGPQ-ATTIELAIYQAILFDFDLAKAALFALLQFVCCLGLFLLSQRFSKAIANG 264
ABC_perm1 NF038017
ABC transporter permease; Proteins of this family are the permease subunit of an ABC ...
 54-206 8.14e-09

ABC transporter permease; Proteins of this family are the permease subunit of an ABC transporter complex, which may be involved in tungstate uptake.


Pssm-ID: 411610 [Multi-domain]  Cd Length: 184  Bit Score: 53.70  E-value: 8.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  54 TYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSpLKFVDAlpGIVV 133
Cdd:NF038017   1 SLRVSGTATLIAALIGIPLGALLALRRFPGRRLVISLLNTLMGLPPVVVGLIVYLLLSRSGPLGFLG-LLYTPT--AMII 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499180067 134 AMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVsLPLSVRHIVAGAIMSWARGISEFGAVVVI 206
Cdd:NF038017  78 AQAVLALPIVAGLTLAAVQGLDPELRLQILSLGATRWQALWTL-LKEARFALLAAVLAGFGRAISEVGAVMMV 149
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 31-192 2.14e-08

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 53.45  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  31 QLFNFDEFLKAAsdpavWKVVLTTYYAALISTLIavifGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVF 110
Cdd:PRK09500  48 LLFNNDSLLQAA-----QHSLTMAVFSATFATLI----GSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLF 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 111 GSSGLigsfsPLKFVDALPG-IVVAMLFVSVPIYINqakegFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGA 189
Cdd:PRK09500 119 MLLGI-----QLGFWSLLFAhITFCLPFVVVTVYSR-----LKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAGW 188


                 ...
gi 499180067 190 IMS 192
Cdd:PRK09500 189 LLS 191
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 35-194 2.76e-08

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 53.23  E-value: 2.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  35 FDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARkSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGssg 114
Cdd:COG0600   47 LAALVELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLALAPLLILWFG--- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 115 ligsfsplkfVDALPGIVVAMLFVSVPIYINqAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWA 194
Cdd:COG0600  123 ----------IGEASKIFVIFLGAFFPILLN-TAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALG 191
PRK10683 PRK10683
putrescine transporter subunit: membrane component of ABC superfamily; Provisional
 34-200 1.67e-06

putrescine transporter subunit: membrane component of ABC superfamily; Provisional


Pssm-ID: 182646  Cd Length: 317  Bit Score: 48.17  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  34 NFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSS 113
Cdd:PRK10683  82 NLGNFLQLTDDPLYFDAYLQSLQVAAISTLCCLLIGYPLAWAVAHSKPSTRNILLLLVILPSWTSFLIRVYAWMGILKNN 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 114 GLIGSF--------SPLKFVDA----LPGIVVAML-FVSVPIYInqakeGFASVDVRLEHVARTLGSSPLRVFFTVSLPL 180
Cdd:PRK10683 162 GVLNNFllwlgvidQPLTILHTnlavYIGIVYAYLpFMVLPIYT-----ALTRIDYSLVEAALDLGARPLKTFFSVIVPL 236

                        170       180
                 ....*....|....*....|
gi 499180067 181 SVRHIVAGAIMSWARGISEF 200
Cdd:PRK10683 237 TKGGIIAGSMLVFIPAVGEF 256
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 33-191 1.87e-06

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 48.15  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  33 FNFDEFLKAAsDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGS 112
Cdd:PRK09497  48 FTLDNYTRLL-DPLYAEVLLHSLNMALIATLACLVLGYPFAWFLAKLPHKVRPLLLFLLIVPFWTNSLIRIYGLKIFLST 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 113 SGLIGSF--------SPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRH 184
Cdd:PRK09497 127 KGYLNEFllwlgvidTPIRIMFTESAVIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIPLTMPG 206


                 ....*..
gi 499180067 185 IVAGAIM 191
Cdd:PRK09497 207 IIAGCLL 213
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 69-253 3.04e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067   69 GTPLAYILARK-SFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFsplkfvdaLPGIVVAMLFVSVPIYINQA 147
Cdd:pfam00528   1 GIPLGIIAALRrGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI--------LPAIILALLGWAGYARLIRR 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  148 kEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIA---PTLIYERYLSE 224
Cdd:pfam00528  73 -AALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGlllIEAILGYDYPE 151

                         170       180
                  ....*....|....*....|....*....
gi 499180067  225 GLSAAMPVAAILILLSLAVFVALRIIVGR 253
Cdd:pfam00528 152 IQGPVLAAALILLLLNLLVDILQRLLDPR 180
YnjC COG4135
ABC-type uncharacterized transport system YnjBCD, permease component [General function ...
 43-198 9.93e-05

ABC-type uncharacterized transport system YnjBCD, permease component [General function prediction only];


Pssm-ID: 443310 [Multi-domain]  Cd Length: 564  Bit Score: 43.32  E-value: 9.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  43 SDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPhtvaGIALL----VVFGSSGLIGS 118
Cdd:COG4135  350 AAPGLLEPLGNTLLLALASALIALVLVLACLEAEARRGRRPGRRALWLLYLPLLVP----QIAFLfglqVLLLRLGLDGT 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 119 FSPLkfvdalpgIVVAMLFVSVPIYINQAkEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVagaiMSWARGIS 198
Cdd:COG4135  426 WLAV--------IWAHLVFVLPYVFLSLA-GPWRALDPRYAQVAASLGASPWRVFWRVKLPLLLRPIL----TAAAVGFA 492
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
48-213 1.92e-04

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 42.00  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  48 WKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKsVVEGIVDLPVVIPHTVAGIALLVVFGssglIGSfsplkfvda 127
Cdd:PRK10952 143 WSQAMVTLALVLTALLFCIVIGLPLGIWLARSPRAAK-IIRPLLDAMQTTPAFVYLVPIVMLFG----IGN--------- 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 128 LPGIVVAMLFVSVPIyINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISefgaVVVIA 207
Cdd:PRK10952 209 VPGVVVTIIFALPPI-VRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALS----MVVIA 283


                 ....*.
gi 499180067 208 yyPMIA 213
Cdd:PRK10952 284 --SMIA 287
PRK10592 PRK10592
putrescine transporter subunit: membrane component of ABC superfamily; Provisional
 44-193 6.69e-03

putrescine transporter subunit: membrane component of ABC superfamily; Provisional


Pssm-ID: 182574  Cd Length: 281  Bit Score: 37.14  E-value: 6.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  44 DPAVWKVVLTTYYAALISTLIAVIFGTPLAYILAR-KSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSPL 122
Cdd:PRK10592  58 DDAMMSAVGLSLTIAACAATAAAILGTIAAVVMVRfGRFRGSNGFAFMITAPLVMPDVITGLSLLLLFVALAHAIGWPAD 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499180067 123 K--FVDALPGIVVAMLFVSVPIyinqaKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSW 193
Cdd:PRK10592 138 RgmLTIWLAHVTFCTAYVAVVI-----SSRLRELDRSIEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAF 205
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 19-255 7.81e-03

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 37.51  E-value: 7.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  19 FVLLPVAATVTLQLFNfdEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIP 98
Cdd:PRK09433 291 LLLPPLLAVVVSGLNA--SLLRVLAQPALWQALWTSLRIALAAALLAVVLTMMLLWSSRELRLRQRKLAAQALELSGMLI 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067  99 HTVAGIALlvvfgSSGLIGSFSPLKFVDALPGIVVAML--FVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTV 176
Cdd:PRK09433 369 LAMPGIVL-----ATGLFLLLRNTTDLPASALGIVILTnaLMALPYALRVLEPPMRDIAARYGRLCQSLGIRGWSRLRLI 443

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499180067 177 SLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIA-PTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGRED 255
Cdd:PRK09433 444 ELRALRRPLAQAFAFACALSLGDFGVIALFGSQDFRTlPFLLYQQLGSYRSQDAAVTALLLLLLCLLLFTLIERLPGRHA 523
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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