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Conserved domains on  [gi|49902519|gb|AAH74842|]
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Cytotoxic T-lymphocyte-associated protein 4 [Homo sapiens]

Protein Classification

IgV_CTLA-4 domain-containing protein( domain architecture ID 10146090)

IgV_CTLA-4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 1.20e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


:

Pssm-ID: 409386  Cd Length: 115  Bit Score: 249.15  E-value: 1.20e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519  39 HVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 49902519 119 LRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
 
Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 1.20e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 249.15  E-value: 1.20e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519  39 HVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 49902519 119 LRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
IGv smart00406
Immunoglobulin V-Type;
58-131 2.04e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 49.69  E-value: 2.04e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49902519     58 CEYaSPGKATEVRVTVLRQADSQVTEVCAatYMMGNELTFLDDSI-----CTGTSSGNQVNLTIQGLRAMDTGLYICKV 131
Cdd:smart00406   6 CKF-SGSTFSSYYVSWVRQPPGKGLEWLG--YIGSNGSSYYQESYkgrftISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 42-151 4.28e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 4.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519    42 QPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSIC-TGTSSGNQVNLTIQGLR 120
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSgRGDPSNGDGSLTIQNLT 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 49902519   121 AMDTGLYICKVelmyPPPYYLGIGNGTQIYV 151
Cdd:pfam07686  82 LSDSGTYTCAV----IPSGEGVFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 1.20e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 249.15  E-value: 1.20e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519  39 HVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 49902519 119 LRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
IgV_CD28 cd20925
Immunoglobulin Variable (IgV) domain Cluster of Differentiation (CD) 28; The members here are ...
 40-151 5.39e-14

Immunoglobulin Variable (IgV) domain Cluster of Differentiation (CD) 28; The members here are composed of the immunoglobulin variable region (IgV) of Cluster of Differentiation (CD) 28). CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. CD28 consists of a paired V-set of immunoglobulin (Ig) superfamily domains attached to single-transmembrane domains and cytoplasmic domains that contain the MYPPY motif, which is involved in binding B7.1 or B7.2. CD28 is very similar to CTLA-4 (cytotoxic T-lymphocyte-associated protein 4, also known as CD152 (cluster of differentiation 152)), which is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 also binds the B7 molecules (B7.1 and B7.2) with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The N-terminal Ig-like domain of CD28 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other. However, each CD28-B7 family member is slightly different, some have an IgV domain which lacks an A' or C" strand.


Pssm-ID: 409519  Cd Length: 117  Bit Score: 66.12  E-value: 5.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519  40 VAQPAVVLASSRGiASFVCEYASPGKATEVRVTVLRQADSQVtEVCAATYMMGNELTFLDDS--ICTGTSSGNQVNLTIQ 117
Cdd:cd20925   3 VKQSPMLVVYNNA-VNLSCKYTYNLFSKEFRASLHKGLDSAV-EVCVVYGNYSQQLQVYSNTgfNCDGKLGNESVTFYLW 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 49902519 118 GLRAMDTGLYICKVELMYPPPY-YLGIGNGTQIYV 151
Cdd:cd20925  81 NLYVNQTDIYFCKIEVMYPPPYlDNEKSNGTIIHV 115
IGv smart00406
Immunoglobulin V-Type;
58-131 2.04e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 49.69  E-value: 2.04e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49902519     58 CEYaSPGKATEVRVTVLRQADSQVTEVCAatYMMGNELTFLDDSI-----CTGTSSGNQVNLTIQGLRAMDTGLYICKV 131
Cdd:smart00406   6 CKF-SGSTFSSYYVSWVRQPPGKGLEWLG--YIGSNGSSYYQESYkgrftISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 42-151 4.28e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 4.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519    42 QPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSIC-TGTSSGNQVNLTIQGLR 120
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSgRGDPSNGDGSLTIQNLT 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 49902519   121 AMDTGLYICKVelmyPPPYYLGIGNGTQIYV 151
Cdd:pfam07686  82 LSDSGTYTCAV----IPSGEGVFGKGTRLTV 108
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 37-151 2.86e-06

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 44.97  E-value: 2.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519  37 AMHVAQPAVVLASSRGIASFVCEY-ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDS--ICtgtssGNQVN 113
Cdd:cd20926   1 ALWVSQPPEIRTLEGSSAFLPCSFnASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSrfLR-----DHQAE 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 49902519 114 LTIQGLRAMDTGLYICKVELMyppPYYLGIGNGTQIYV 151
Cdd:cd20926  76 LHIWDVRGHDAGIYVCRVEVL---GLGVGTGNGTRLVV 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-132 1.21e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49902519     43 PAVVLASSRGIASFVCEYASPgkaTEVRVTVLRQADSQVTEvcaatymmgneltfldDSICTGTSSGNQVNLTIQGLRAM 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS---PPPEVTWYKQGGKLLAE----------------SGRFSVSRSGSTSTLTISNVTPE 61

                           90
                   ....*....|
gi 49902519    123 DTGLYICKVE 132
Cdd:smart00410  62 DSGTYTCAAT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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