|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
1-444 |
0e+00 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 965.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 1 MFTRVANFCRKVLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKD 80
Cdd:PRK11623 8 IFTRVANFCRKVLSREESEAEQAVARPQMTVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 81 FDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQR 160
Cdd:PRK11623 88 FDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNESDRNTSQRGQNGMLLRDNIFGSIEEDAQR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 161 RDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLND 240
Cdd:PRK11623 168 RDFTINSLYYSVADFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLND 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 241 IPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAA 320
Cdd:PRK11623 248 IPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 321 MFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAA 400
Cdd:PRK11623 328 MFWYPLLEHAQKIAQESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAA 407
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 498414173 401 YDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEE 444
Cdd:PRK11623 408 YDLLALRAEVENNAELQRLAQWWGEFQVSAPPQQKGMLNELDDD 451
|
|
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
31-443 |
7.40e-167 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 476.21 E-value: 7.40e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 31 VIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAH 110
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 111 VMFGPEIIEVATFRGHHEGNVsdrttsqrGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDG 190
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSV--------NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 191 VIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYH 270
Cdd:TIGR01942 153 RLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 271 LFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQEsGLTYHDAFALAMN 350
Cdd:TIGR01942 233 LLEPLFPSVAYALRESPKFESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQ-GVMPYPAVFDAIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 351 DVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERnaELQRLVKWWGEFQVSA 430
Cdd:TIGR01942 312 DFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGR--ENAVLGEWWTPYQLAS 389
|
410
....*....|...
gi 498414173 431 PPDQKGMLNELDE 443
Cdd:TIGR01942 390 EEERTEMTRSAAR 402
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
43-431 |
1.98e-127 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 374.92 E-value: 1.98e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 43 DISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFR---NCRLVGRRFRLAHVMFGPEIIE 119
Cdd:COG0617 1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 120 VATFRGHHEgnvsdrttSQRGQNGmllrDNIFG-SIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNP 198
Cdd:COG0617 81 VATARTERY--------YGDGRRP----FVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 199 ETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLfpt 278
Cdd:COG0617 149 EERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 279 itryftengdspmeriieqvlkntdtrihndmrvnpAFLFAAMFwYPLLETAQKiaqESGLTYHDAFALAMNDVLDEACR 358
Cdd:COG0617 226 ------------------------------------ALRLAALL-HDLGKPATR---EDGLPTFHGHEEAGAELAEALLK 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498414173 359 SLAIPKRLTTLTRDIWQLQLRMSRRQGKRAW---KLLEHpKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAP 431
Cdd:COG0617 266 RLRLPNRERKLVRELVELHLRFHGLGELRDSavrRLLER-GPEALEDLLLLRENGLEYPELQERLAELLEAAWRRF 340
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
62-193 |
8.18e-53 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 173.62 E-value: 8.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 62 AWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLV----GRRFRLAHVMFGPEIIEVATFRGHH-EGNVSDRTT 136
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFGNQILEVATFRIEFdESDFRNPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 498414173 137 SQRGqngmllrdnifGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIR 193
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
45-189 |
5.50e-43 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 148.51 E-value: 5.50e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 45 SENALKVMYRLNKA-GYEAWLVGGGVRDLLLGKKPKDFDVTTNA-TPEQVRKLFR--NCRLVGR--RFRLAHVMFGPEII 118
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiGGRVVGLgeEFGTATVVINGLTI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498414173 119 EVATFRghhegnvSDRTTSqrgqNGMLLRDNIFGsIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKD 189
Cdd:cd05398 81 DVATLR-------TETYTD----PGRRPPVVGFT-IEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
1-444 |
0e+00 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 965.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 1 MFTRVANFCRKVLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKD 80
Cdd:PRK11623 8 IFTRVANFCRKVLSREESEAEQAVARPQMTVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 81 FDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQR 160
Cdd:PRK11623 88 FDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNESDRNTSQRGQNGMLLRDNIFGSIEEDAQR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 161 RDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLND 240
Cdd:PRK11623 168 RDFTINSLYYSVADFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLND 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 241 IPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAA 320
Cdd:PRK11623 248 IPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 321 MFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAA 400
Cdd:PRK11623 328 MFWYPLLEHAQKIAQESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAA 407
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 498414173 401 YDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEE 444
Cdd:PRK11623 408 YDLLALRAEVENNAELQRLAQWWGEFQVSAPPQQKGMLNELDDD 451
|
|
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
31-443 |
7.40e-167 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 476.21 E-value: 7.40e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 31 VIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAH 110
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 111 VMFGPEIIEVATFRGHHEGNVsdrttsqrGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDG 190
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSV--------NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 191 VIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYH 270
Cdd:TIGR01942 153 RLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 271 LFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQEsGLTYHDAFALAMN 350
Cdd:TIGR01942 233 LLEPLFPSVAYALRESPKFESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQ-GVMPYPAVFDAIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 351 DVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERnaELQRLVKWWGEFQVSA 430
Cdd:TIGR01942 312 DFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGR--ENAVLGEWWTPYQLAS 389
|
410
....*....|...
gi 498414173 431 PPDQKGMLNELDE 443
Cdd:TIGR01942 390 EEERTEMTRSAAR 402
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
43-431 |
1.98e-127 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 374.92 E-value: 1.98e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 43 DISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFR---NCRLVGRRFRLAHVMFGPEIIE 119
Cdd:COG0617 1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 120 VATFRGHHEgnvsdrttSQRGQNGmllrDNIFG-SIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNP 198
Cdd:COG0617 81 VATARTERY--------YGDGRRP----FVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 199 ETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLfpt 278
Cdd:COG0617 149 EERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 279 itryftengdspmeriieqvlkntdtrihndmrvnpAFLFAAMFwYPLLETAQKiaqESGLTYHDAFALAMNDVLDEACR 358
Cdd:COG0617 226 ------------------------------------ALRLAALL-HDLGKPATR---EDGLPTFHGHEEAGAELAEALLK 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498414173 359 SLAIPKRLTTLTRDIWQLQLRMSRRQGKRAW---KLLEHpKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAP 431
Cdd:COG0617 266 RLRLPNRERKLVRELVELHLRFHGLGELRDSavrRLLER-GPEALEDLLLLRENGLEYPELQERLAELLEAAWRRF 340
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
62-193 |
8.18e-53 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 173.62 E-value: 8.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 62 AWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLV----GRRFRLAHVMFGPEIIEVATFRGHH-EGNVSDRTT 136
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFGNQILEVATFRIEFdESDFRNPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 498414173 137 SQRGqngmllrdnifGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIR 193
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
42-273 |
4.56e-50 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 175.03 E-value: 4.56e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 42 KDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVA 121
Cdd:PRK13299 3 PSEFQKALPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVDVGIEHGTVLVLENGEEYEVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 122 TFRGhhEGNVSD-RTTSQ----RgqngmllrdnifgSIEEDAQRRDFTINSLYYSvADFTVRDYVGGMKDLKDGVIRLIG 196
Cdd:PRK13299 83 TFRT--ESEYVDyRRPSEvtfvR-------------SLEEDLKRRDFTINAIAMD-ENGEIIDLFDGLEDLKNRLIRAVG 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498414173 197 NPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQ 273
Cdd:PRK13299 147 NAEERFQEDALRMMRAVRFASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKLLIETGLYN 223
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
337-444 |
5.54e-44 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 150.04 E-value: 5.54e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 337 SGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERnaEL 416
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGE--VL 78
|
90 100
....*....|....*....|....*...
gi 498414173 417 QRLVKWWGEFQVSAPPDQKGMLNELDEE 444
Cdd:pfam12626 79 QELAEWWTRFQEADEAEREAMIAELGAD 106
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
45-189 |
5.50e-43 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 148.51 E-value: 5.50e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 45 SENALKVMYRLNKA-GYEAWLVGGGVRDLLLGKKPKDFDVTTNA-TPEQVRKLFR--NCRLVGR--RFRLAHVMFGPEII 118
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiGGRVVGLgeEFGTATVVINGLTI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498414173 119 EVATFRghhegnvSDRTTSqrgqNGMLLRDNIFGsIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKD 189
Cdd:cd05398 81 DVATLR-------TETYTD----PGRRPPVVGFT-IEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
220-283 |
9.51e-20 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 82.53 E-value: 9.51e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498414173 220 GMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYF 283
Cdd:pfam12627 1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
63-229 |
2.57e-16 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 80.67 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 63 WLVGGGVRDLLLGKKPKDFD-VTTNATPEQVrkLFRNCRLVGRRFRlahVMFGPEIievatfrghHEGNVSDRT--TSQR 139
Cdd:PRK10885 4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEM--LAQGYQQVGKDFP---VFLHPKT---------HEEYALARTerKSGR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 140 GQNGMllrdnIFG-----SIEEDAQRRDFTINSLYYSvADFTVRDYVGGMKDLKDGVIRLIGNPetrYREDPVRMLRAVR 214
Cdd:PRK10885 70 GYTGF-----TCYaapdvTLEEDLIRRDLTINAMAQD-DDGELIDPYGGQRDLEARLLRHVSPA---FAEDPLRVLRVAR 140
|
170
....*....|....*...
gi 498414173 215 FAAK---LGMRISPETAE 229
Cdd:PRK10885 141 FAARfahLGFRIAPETLA 158
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
58-249 |
4.34e-15 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 76.57 E-value: 4.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 58 AGYEAWLVGGGVRDLLLGKKPKDFD-VTTNATPEQVRKlfRNCRLVGRRFRlahVMFGPEIIE-VATFRGHHEgnvsdrt 135
Cdd:PRK13297 10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMAR--RGFIPVGGDFP---VFLHPRTKEeYALARTERK------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 136 tSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVrDYVGGMKDLKDGVIRLIGNPetrYREDPVRMLRAVRF 215
Cdd:PRK13297 78 -SGRGYKGFTFYTGADVTLEQDLQRRDLTVNAIARTPQGELV-DPLDGVADVRARVLRHVGEA---FAEDPVRILRLGRF 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 498414173 216 AAKLG-MRISPETAEPIPRL--ATLLNDIPPARLFEE 249
Cdd:PRK13297 153 AARFGdFSIAPETMQLCRRMveAGEADALVPERVWKE 189
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
61-227 |
5.06e-15 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 76.69 E-value: 5.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 61 EAWLVGGGVRDLLLGKKPKDFD-VTTNATPEQVrkLFRNCRLVGRRFRlahVMFGPEiievatfrgHHEGNVSDRT--TS 137
Cdd:PRK13298 2 KIYLVGGAVRDSLLNLPVKDKDwVVVGGTPKIL--LSINFQQVGKDFP---VFLHPE---------THEEYALARTerKS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 138 QRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSvADFTVRDYVGGMKDLKDGVIRLIGNPetrYREDPVRMLRAVRFAA 217
Cdd:PRK13298 68 GVGYTGFITDTSSDVTLEEDLIRRDLTINAIAQD-ENGNYIDPFQGKKDIQLRLLRHVSES---FIEDPLRVLRVARFAA 143
|
170
....*....|...
gi 498414173 218 K---LGMRISPET 227
Cdd:PRK13298 144 LlvhLGFKIAKET 156
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
61-350 |
6.40e-13 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 70.01 E-value: 6.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 61 EAWLVGGGVRDLLLGKKPKDFD-VTTNATPEQVRKlfrncrlVGRRFRLAH--VMFGPEII-EVATFRghhegnvSDRTT 136
Cdd:PRK13296 2 KFYLVGGAVRDMLLGITPKDKDwVVVGATEDEMLA-------NGFIKIAANfpVFIHPQTKqEYALAR-------SEKKT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 137 SqRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSvADFTVRDYVGGMKDLKDGVIRligNPETRYREDPVRMLRAVRFA 216
Cdd:PRK13296 68 A-SGYHGFEVNFSKYITLEDDLKRRDLTINSIAID-QNNKVIDPFNGQADLQNRILR---HTSIAFIEDPLRVVRLARFK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 217 AKLG---MRISPETAEPIPRLATL--LNDIPPARLFEESLKLLQAGYGYetYKLLCEYHLFQPLFPTIT--------RYF 283
Cdd:PRK13296 143 AQLSnfnFSIAQEMLALIKELVKTgeLNHLTRERLHIEFVKALNNPKIF--FTTLKELEALKIIFPNIScilplipnKSF 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498414173 284 TENG---DSPMERIIEQVLKNTDTRIHNDMRVNpafLFAAMFWYPLLETA---QKIAQESGLTYHDAFALAMN 350
Cdd:PRK13296 221 FENPiykGSNINEKITLCLLKIPQQQLDDIRKE---LLLTNKHYKLLKASiaiSKILEDRSITAEEIFQLIKN 290
|
|
| PHA01806 |
PHA01806 |
hypothetical protein |
31-218 |
7.52e-04 |
|
hypothetical protein
Pssm-ID: 222838 Cd Length: 200 Bit Score: 40.64 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 31 VIPREQHaISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNA-TPEQVRKLFrNCRLvgrrfrla 109
Cdd:PHA01806 8 LLEGTKE-IPEGLIAKALLLRLYSDARHSEGVALAGGAARDLMHGAEPKDIDIALYGmDDRQAELLI-GCIL-------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498414173 110 hVMFGPEIIEVATFRG-HHEGNVSDRTTSQ------RGQNGMLLRDNIF--GSIEEDAQRRDFTINSLyysVADFTVRDY 180
Cdd:PHA01806 78 -PKLVSRFLRDGGWSQeYHDGGDGGIFKGVvslkgcRGLEGMDVDFNYYdtDSVGEVMESFDYTINQV---GIAYNWPDP 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 498414173 181 VGG-------MKDLKDGVIRlignpetRYREDPVRMLRAVRFAAK 218
Cdd:PHA01806 154 EGGprlgaylHKDVTWGVNK-------ELRAGSRLPERAEKMRAK 191
|
|
| |
