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Conserved domains on  [gi|497558032|ref|WP_009872216|]
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class I SAM-dependent methyltransferase [Chlamydia trachomatis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10353326)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 57-189 1.07e-47

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


:

Pssm-ID: 429214  Cd Length: 137  Bit Score: 152.18  E-value: 1.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497558032   57 VY--DIQQEALDRATANFQSGLLAEEraiIEMKLCSHEYLQE---QGAKLFHYNLGYLPSGDKQITTCSESTVTSIYKAL 131
Cdd:pfam06962   1 VYafDIQEEALENTRERLEEEGLEER---VELILDGHENLDEyvpGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 497558032  132 ELVAPSGIVSVVCYPGHQEGAAELCCVEQVAADLDPSMWEVCTHYSVNRRNAPRLFLF 189
Cdd:pfam06962  78 ELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVL 135
Methyltransf_31 super family cl48233
Methyltransferase domain; This family appears to have methyltransferase activity.
 26-74 2.08e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


The actual alignment was detected with superfamily member pfam13847:

Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497558032   26 EPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATANFQS 74
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK 50
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 57-189 1.07e-47

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 152.18  E-value: 1.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497558032   57 VY--DIQQEALDRATANFQSGLLAEEraiIEMKLCSHEYLQE---QGAKLFHYNLGYLPSGDKQITTCSESTVTSIYKAL 131
Cdd:pfam06962   1 VYafDIQEEALENTRERLEEEGLEER---VELILDGHENLDEyvpGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 497558032  132 ELVAPSGIVSVVCYPGHQEGAAELCCVEQVAADLDPSMWEVCTHYSVNRRNAPRLFLF 189
Cdd:pfam06962  78 ELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVL 135
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 26-74 2.08e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497558032   26 EPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATANFQS 74
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK 50
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 25-71 2.50e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 46.31  E-value: 2.50e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATAN 71
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKN 135
PRK08317 PRK08317
hypothetical protein; Provisional
 25-70 1.80e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.99  E-value: 1.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATA 70
Cdd:PRK08317  17 VQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKE 62
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 25-143 6.47e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.28  E-value: 6.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRG-KGHLVvyDIQQEALDRATANFQ-SGLlaEER-AIIEMKLCshEYLQEQGAKL 101
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMLAQRSPGaRITGV--EIQPEAAELARRNVAlNGL--EDRiTVIHGDLK--EFAAELPPGS 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497558032 102 FHY---------NLGYLPSGDKQITT-CSESTVT---SIYKALELVAPSGIVSVV 143
Cdd:COG4123  109 FDLvvsnppyfkAGSGRKSPDEARAIaRHEDALTledLIRAAARLLKPGGRFALI 163
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 57-189 1.07e-47

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 152.18  E-value: 1.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497558032   57 VY--DIQQEALDRATANFQSGLLAEEraiIEMKLCSHEYLQE---QGAKLFHYNLGYLPSGDKQITTCSESTVTSIYKAL 131
Cdd:pfam06962   1 VYafDIQEEALENTRERLEEEGLEER---VELILDGHENLDEyvpGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 497558032  132 ELVAPSGIVSVVCYPGHQEGAAELCCVEQVAADLDPSMWEVCTHYSVNRRNAPRLFLF 189
Cdd:pfam06962  78 ELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVL 135
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 26-74 2.08e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497558032   26 EPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATANFQS 74
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK 50
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 25-71 2.50e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 46.31  E-value: 2.50e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATAN 71
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKN 135
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 25-74 1.73e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.98  E-value: 1.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLlrgKGHLVVYDIQQEALDRATANFQS 74
Cdd:COG2226   20 LRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAE 66
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 31-73 1.77e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.39  E-value: 1.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 497558032   31 IVDATCGNGKDALFLAQllRGKGHLVVYDIQQEALDRATANFQ 73
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR--RGGARVTGVDLSPEMLERARERAA 41
PRK08317 PRK08317
hypothetical protein; Provisional
 25-70 1.80e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.99  E-value: 1.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRGKGHLVVYDIQQEALDRATA 70
Cdd:PRK08317  17 VQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKE 62
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 26-74 1.90e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.59  E-value: 1.90e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 497558032  26 EPGDTIVDATCGNGKDALFLAQllRGKGHLVVYDIQQEALDRATANFQS 74
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAA--RFGGRVIGIDLSPEAIALARARAAK 71
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 18-73 2.67e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.53  E-value: 2.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497558032  18 HSIFRQVVEPGDTIVDATCGNGKDALFLAQLlrgkGHLVV-YDIQQEALDRATANFQ 73
Cdd:COG2227   15 AALLARLLPAGGRVLDVGCGTGRLALALARR----GADVTgVDISPEALEIARERAA 67
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 25-143 6.47e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.28  E-value: 6.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQLLRG-KGHLVvyDIQQEALDRATANFQ-SGLlaEER-AIIEMKLCshEYLQEQGAKL 101
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMLAQRSPGaRITGV--EIQPEAAELARRNVAlNGL--EDRiTVIHGDLK--EFAAELPPGS 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497558032 102 FHY---------NLGYLPSGDKQITT-CSESTVT---SIYKALELVAPSGIVSVV 143
Cdd:COG4123  109 FDLvvsnppyfkAGSGRKSPDEARAIaRHEDALTledLIRAAARLLKPGGRFALI 163
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 25-79 9.46e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 35.29  E-value: 9.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497558032  25 VEPGDTIVDATCGNGKDALFLAQllRGKGHLVVYDIQQEALDRATANFQSGLLAE 79
Cdd:COG2230   49 LKPGMRVLDIGCGWGGLALYLAR--RYGVRVTGVTLSPEQLEYARERAAEAGLAD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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