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Conserved domains on  [gi|49522668|gb|AAH73890|]
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Ribosomal protein L7-like 1 [Homo sapiens]

Protein Classification

uL30 family ribosomal protein( domain architecture ID 11492225)

uL30 family ribosomal protein binds to G-rich structures in 28S rRNA and in mRNAs, plays a regulatory role in the translation apparatus and inhibits cell-free translation of mRNAs

Gene Ontology:  GO:0003735|GO:0003723
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 14-246 1.72e-105

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


:

Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 304.67  E-value: 1.72e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    14 ENLLKKRKAYQALKATQAKQALLAKKEQKKGKGLRFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPDKHSLAFVVRI 93
Cdd:TIGR01310   1 ELLLKKRKANQELAVAAAKQAKAKKKANKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    94 ERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVI 173
Cdd:TIGR01310  81 KGINGIPPKPRKVLRLLRLKQVHNGVFVKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAII 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522668   174 EEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLS--VARHATKNRVGFLKEMGTPGYRGERINQLIRQLN 246
Cdd:TIGR01310 161 EQHLGKYGIICIEDLIHEIYTVGPHFKEVNNFLWPFKLSspVKGFGKRKKVKHFIEGGDFGNREDHINELIKKMN 235
 
Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 14-246 1.72e-105

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 304.67  E-value: 1.72e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    14 ENLLKKRKAYQALKATQAKQALLAKKEQKKGKGLRFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPDKHSLAFVVRI 93
Cdd:TIGR01310   1 ELLLKKRKANQELAVAAAKQAKAKKKANKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    94 ERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVI 173
Cdd:TIGR01310  81 KGINGIPPKPRKVLRLLRLKQVHNGVFVKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAII 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522668   174 EEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLS--VARHATKNRVGFLKEMGTPGYRGERINQLIRQLN 246
Cdd:TIGR01310 161 EQHLGKYGIICIEDLIHEIYTVGPHFKEVNNFLWPFKLSspVKGFGKRKKVKHFIEGGDFGNREDHINELIKKMN 235
Ribosomal_L7_archeal_euk cd01657
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds ...
 87-246 1.58e-57

Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L7 members have an N-terminal extension not found in the archeal L7 orthologs. L7 is closely related to the ribosomal L30 protein found in eukaryotes and prokaryotes.


Pssm-ID: 100099  Cd Length: 159  Bit Score: 180.03  E-value: 1.58e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668  87 LAFVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIP 166
Cdd:cd01657   1 LYAVVRIRGIVGVPPKIRKTLQLLRLRRINNAVFVKLTKATIGMLKKVEPYVTWGEPNLETLRELIYKRGRLKGNGQRIP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668 167 LTDNTVIEEHLgKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSVARHATKNRVGFLKEMGTPGYRGERINQLIRQLN 246
Cdd:cd01657  81 LTDNYLVEKTL-KKGIICIEDLAHEIYTGGPNFKEVNNFLPPFRLHPPRGGFKGKKRHFSEGGELGYRGEDINELIRRMI 159
Ribosomal_L30_N pfam08079
Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal ...
 12-83 1.81e-21

Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018.


Pssm-ID: 462360  Cd Length: 72  Bit Score: 84.56  E-value: 1.81e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49522668    12 VPENLLKKRKAYQALKATQAKQALLAKKEQKKGKGLRFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPD 83
Cdd:pfam08079   1 VPESLLKKRKRNEKLKAERAKKALARKKANKKKRKLIFKRAEKYVKEYRRKERDEIRLKREAKKAGNFYVPA 72
rpl30p PRK06049
50S ribosomal protein L30P; Reviewed
 90-243 1.67e-14

50S ribosomal protein L30P; Reviewed


Pssm-ID: 235683  Cd Length: 154  Bit Score: 68.68  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668   90 VVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQaKVKNKtiPLTD 169
Cdd:PRK06049   5 VIRIRGRVNVPRDIADTLKMLRLHRVNHCVLVPETPSYKGMLQKVKDYVTWGEIDADTLAELLRKRGR-LEGNK--KLTD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49522668  170 nTVIEEHLGKFGViclEDLIHEIAfPGK-HFQEISWFLCPFHLSVAR--HATKNRvgFLKEMGTPGYRGERINQLIR 243
Cdd:PRK06049  82 -EYVKENTGYDSI---EELAEALV-EGEiKLKDLPGLKPVFRLHPPRggFGGIKR--PFKEGGELGYRGEKINELLR 151
RpmD COG1841
Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 103-141 1.75e-04

Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L30/L7E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441446  Cd Length: 58  Bit Score: 38.48  E-value: 1.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 49522668 103 VQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWG 141
Cdd:COG1841  19 QRATLKALGLRKINHTVELPDTPAIRGMINKVKHLVTVE 57
 
Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 14-246 1.72e-105

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 304.67  E-value: 1.72e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    14 ENLLKKRKAYQALKATQAKQALLAKKEQKKGKGLRFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPDKHSLAFVVRI 93
Cdd:TIGR01310   1 ELLLKKRKANQELAVAAAKQAKAKKKANKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668    94 ERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVI 173
Cdd:TIGR01310  81 KGINGIPPKPRKVLRLLRLKQVHNGVFVKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAII 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522668   174 EEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLS--VARHATKNRVGFLKEMGTPGYRGERINQLIRQLN 246
Cdd:TIGR01310 161 EQHLGKYGIICIEDLIHEIYTVGPHFKEVNNFLWPFKLSspVKGFGKRKKVKHFIEGGDFGNREDHINELIKKMN 235
Ribosomal_L7_archeal_euk cd01657
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds ...
 87-246 1.58e-57

Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L7 members have an N-terminal extension not found in the archeal L7 orthologs. L7 is closely related to the ribosomal L30 protein found in eukaryotes and prokaryotes.


Pssm-ID: 100099  Cd Length: 159  Bit Score: 180.03  E-value: 1.58e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668  87 LAFVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIP 166
Cdd:cd01657   1 LYAVVRIRGIVGVPPKIRKTLQLLRLRRINNAVFVKLTKATIGMLKKVEPYVTWGEPNLETLRELIYKRGRLKGNGQRIP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668 167 LTDNTVIEEHLgKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSVARHATKNRVGFLKEMGTPGYRGERINQLIRQLN 246
Cdd:cd01657  81 LTDNYLVEKTL-KKGIICIEDLAHEIYTGGPNFKEVNNFLPPFRLHPPRGGFKGKKRHFSEGGELGYRGEDINELIRRMI 159
Ribosomal_L30_N pfam08079
Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal ...
 12-83 1.81e-21

Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018.


Pssm-ID: 462360  Cd Length: 72  Bit Score: 84.56  E-value: 1.81e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49522668    12 VPENLLKKRKAYQALKATQAKQALLAKKEQKKGKGLRFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPD 83
Cdd:pfam08079   1 VPESLLKKRKRNEKLKAERAKKALARKKANKKKRKLIFKRAEKYVKEYRRKERDEIRLKREAKKAGNFYVPA 72
rpl30p PRK06049
50S ribosomal protein L30P; Reviewed
 90-243 1.67e-14

50S ribosomal protein L30P; Reviewed


Pssm-ID: 235683  Cd Length: 154  Bit Score: 68.68  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522668   90 VVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQaKVKNKtiPLTD 169
Cdd:PRK06049   5 VIRIRGRVNVPRDIADTLKMLRLHRVNHCVLVPETPSYKGMLQKVKDYVTWGEIDADTLAELLRKRGR-LEGNK--KLTD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49522668  170 nTVIEEHLGKFGViclEDLIHEIAfPGK-HFQEISWFLCPFHLSVAR--HATKNRvgFLKEMGTPGYRGERINQLIR 243
Cdd:PRK06049  82 -EYVKENTGYDSI---EELAEALV-EGEiKLKDLPGLKPVFRLHPPRggFGGIKR--PFKEGGELGYRGEKINELLR 151
Ribosomal_L30_like cd00355
Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one ...
 89-141 2.23e-11

Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L30 members have N- and/or C-terminal extensions not found in their prokaryotic orthologs. L30 is closely related to the ribosomal L7 protein found in eukaryotes and archaea.


Pssm-ID: 100098 [Multi-domain]  Cd Length: 53  Bit Score: 57.42  E-value: 2.23e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 49522668  89 FVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWG 141
Cdd:cd00355   1 KVTRVRSLIGRPPKQRKTLKALGLRKINQTVFVKDTPSIRGMLRKVKHLVTVG 53
Ribosomal_L30 pfam00327
Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.
 88-138 4.40e-08

Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.


Pssm-ID: 459762 [Multi-domain]  Cd Length: 51  Bit Score: 48.46  E-value: 4.40e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 49522668    88 AFVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYV 138
Cdd:pfam00327   1 LKVTRIRSIIGRPPKQRKTLKALGLRKINGVVVKEDTPSIRGMLRKVKHLV 51
RpmD COG1841
Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 103-141 1.75e-04

Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L30/L7E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441446  Cd Length: 58  Bit Score: 38.48  E-value: 1.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 49522668 103 VQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWG 141
Cdd:COG1841  19 QRATLKALGLRKINHTVELPDTPAIRGMINKVKHLVTVE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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