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Conserved domains on  [gi|49457147|emb|CAG46894|]
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LGALS3, partial [Homo sapiens]

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 117-244 1.06e-54

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.05  E-value: 1.06e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147 117 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 195
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 49457147 196 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 9-113 9.96e-08

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 9.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    9 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK07764 619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         90       100
                 ....*....|....*....|....*.
gi 49457147   88 AYPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07764 699 AQPAPAPAATPPAGQADDPAAQPPQA 724
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 117-244 1.06e-54

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.05  E-value: 1.06e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147 117 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 195
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 49457147 196 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 123-244 7.52e-54

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 169.69  E-value: 7.52e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    123 PGGVVPRMLITILGTVKPNANRIALDFQRG--NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPFKI 200
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG---TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 49457147    201 QVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTS 120
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 123-244 1.19e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 156.65  E-value: 1.19e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   123 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 198
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 49457147   199 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-113 9.96e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 9.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    9 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK07764 619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         90       100
                 ....*....|....*....|....*.
gi 49457147   88 AYPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07764 699 AQPAPAPAATPPAGQADDPAAQPPQA 724
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 42-122 3.03e-04

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 41.06  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    42 PGAYPGQapPGAYPGQAPPGAYPGAPGAYPGAPA------PGVYPGPPSGPGAYPSSGQPSAP--GAYPATGPygaPAGP 113
Cdd:pfam15991 147 QQAYYKQ--PAFSPGYAEHGQQKHDDGRRGYDVArfgswnKSTAQYPPSGQLFYPTHQYLPPPqtQGQADARL---QTIY 221


                  ....*....
gi 49457147   114 LIVPYNLPL 122
Cdd:pfam15991 222 PQPGYALPL 230
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
2-127 3.80e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   2 ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYP-GAPAPGVYP 80
Cdd:COG3469  91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATgGTTTTSTTT 170

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 49457147  81 GPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNLPLPGGVV 127
Cdd:COG3469 171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHVL 217
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 27-123 1.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    27 GNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAP--PGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPAT 104
Cdd:TIGR01628 382 MRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLgwPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQP 461

                          90
                  ....*....|....*....
gi 49457147   105 GPYGAPAGPLIVPYNLPLP 123
Cdd:TIGR01628 462 VMYPPNYQSLPLSQDLPQP 480
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 37-124 3.54e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 38.06  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   37 PGASYPGAYPGQAPPGAY-PGQAPPGAYPGAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLI 115
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASqPATPPPPAAPPSPPGDPPEPPA---PEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVR 92


                 ....*....
gi 49457147  116 VPYNLPLPG 124
Cdd:NF041121  93 VPAPPALPN 101
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 117-244 1.06e-54

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.05  E-value: 1.06e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147 117 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 195
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 49457147 196 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 123-244 7.52e-54

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 169.69  E-value: 7.52e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    123 PGGVVPRMLITILGTVKPNANRIALDFQRG--NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPFKI 200
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG---TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 49457147    201 QVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTS 120
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 118-247 3.57e-53

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 168.18  E-value: 3.57e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    118 YNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGK 196
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGdDIALHFNPRFNEN---KIVCNSKLNGSWGSEEREGGFPFQPGQ 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 49457147    197 PFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTSASY 247
Cdd:smart00276  78 PFDLTIIVQPDHFQIFVNGVHITTFPHRL-PLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 123-244 1.19e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 156.65  E-value: 1.19e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   123 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 198
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 49457147   199 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 244
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-113 9.96e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 9.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    9 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK07764 619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         90       100
                 ....*....|....*....|....*.
gi 49457147   88 AYPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07764 699 AQPAPAPAATPPAGQADDPAAQPPQA 724
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 12-114 1.39e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   12 SGSGNPNPQGWPGAWGNQPAGAGGYPGAsypgAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPS 91
Cdd:PRK07764 643 PAPGVAAPEHHPKHVAVPDASDGGDGWP----AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPA 718

                         90       100
                 ....*....|....*....|...
gi 49457147   92 SGQPSAPGAYPATGPYGAPAGPL 114
Cdd:PRK07764 719 AQPPQAAQGASAPSPAADDPVPL 741
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 10-113 4.35e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   10 ALSGSGNPNPQGW-PGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGaypgaPGAYPGAPAPGVYPGPPSGPGA 88
Cdd:PRK07764 594 AAGGEGPPAPASSgPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPG-----VAAPEHHPKHVAVPDASDGGDG 668

                         90       100
                 ....*....|....*....|....*
gi 49457147   89 YPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07764 669 WPAKAGGAAPAAPPPAPAPAAPAAP 693
PHA03378 PHA03378
EBNA-3B; Provisional
 17-150 9.83e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 9.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   17 PNPQGWPGAwGNQPAGAGGypGASYPGAYPGQA-PPGAYPGQAPPGAypGAPG-AYPGAPAPGVYPGPPSGPGAYPSSGQ 94
Cdd:PHA03378 705 RPPAAPPGR-AQRPAAATG--RARPPAAAPGRArPPAAAPGRARPPA--AAPGrARPPAAAPGRARPPAAAPGAPTPQPP 779

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49457147   95 PSAP---------GAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILgTVKPNANRIALDFQ 150
Cdd:PHA03378 780 PQAPpapqqrprgAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLL-TGGVKRGRPSLKKP 843
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 27-113 1.21e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   27 GNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPG--APGAYPGAPAPGVYPGPPSGPGAYPSSGQPS-APGAYPA 103
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAApaPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSpPPAAAPS 463

                         90
                 ....*....|
gi 49457147  104 TGPYGAPAGP 113
Cdd:PRK07764 464 AQPAPAPAAA 473
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 23-105 2.17e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.06  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   23 PGAWGNQPAGAGGYPGASYPGAypGQAPPgayPGQAPPGAYPGAPG-----AYPGAPAPGVYPGP-------PSGPGAY- 89
Cdd:PRK14959 373 PSGGGASAPSGSAAEGPASGGA--ATIPT---PGTQGPQGTAPAAGmtpssAAPATPAPSAAPSPrvpwddaPPAPPRSg 447

                         90
                 ....*....|....*..
gi 49457147   90 -PSSGQPSAPGAYPATG 105
Cdd:PRK14959 448 iPPRPAPRMPEASPVPG 464
PHA03378 PHA03378
EBNA-3B; Provisional
 16-129 2.96e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   16 NPNPQGWPGAWGNQPAGAGGYPGASYPG-AYPGQAPPG-AYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSG 93
Cdd:PHA03378 675 QPSPTGANTMLPIQWAPGTMQPPPRAPTpMRPPAAPPGrAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA 754

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 49457147   94 QPSAPGAYPATGPYGAPAGPLIVPynlPLPGGVVPR 129
Cdd:PHA03378 755 RPPAAAPGRARPPAAAPGAPTPQP---PPQAPPAPQ 787
PHA03247 PHA03247
large tegument protein UL36; Provisional
 17-128 3.36e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    17 PNPQGWPGAWGNQPAGAGgyPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAyPGAPAPGVYPGPPSGPG-AYPSSGQP 95
Cdd:PHA03247 2748 PATPGGPARPARPPTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-PSPWDPADPPAAVLAPAaALPPAASP 2824

                          90       100       110
                  ....*....|....*....|....*....|....
gi 49457147    96 SAPGAYPATG-PYGAPAGPLIVPYNLPLPGGVVP 128
Cdd:PHA03247 2825 AGPLPPPTSAqPTAPPPPPGPPPPSLPLGGSVAP 2858
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 10-113 3.86e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   10 ALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAyPGQAPPGAYPGQAPPGAYPGAPGAYPGA---------PAPGVYP 80
Cdd:PRK07764 671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP-AATPPAGQADDPAAQPPQAAQGASAPSPaaddpvplpPEPDDPP 749

                         90       100       110
                 ....*....|....*....|....*....|...
gi 49457147   81 GPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07764 750 DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
13-123 5.15e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   13 GSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPG-APGAYPGAPAPGVYPGPPSGPGAYPS 91
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAaAPARRSPAPEALAAARQASARGPGGA 447

                         90       100       110
                 ....*....|....*....|....*....|..
gi 49457147   92 SGQPSAPGAYPATGPYGAPAGPLIVPYNLPLP 123
Cdd:PRK12323 448 PAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA 479
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-139 1.13e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    4 NFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPP 83
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49457147   84 SGPGAYPS-----SGQPSAPGAYPATGPYGAPAGPliVPYNLPLPGGVVPRMLITILGTVK 139
Cdd:PRK07764 466 PAPAPAAApeptaAPAPAPPAAPAPAAAPAAPAAP--AAPAGADDAATLRERWPEILAAVP 524
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 37-111 1.86e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49457147   37 PGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVyPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPA 111
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAP-AAAASAPAAPPAAAPPAPVAAPAAAAPAAAPA 439
PHA03247 PHA03247
large tegument protein UL36; Provisional
 42-125 2.32e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    42 PGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSG---PGAYPSSGQPSAPGAYPATGPYGAPAGPliVPY 118
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatPGGPARPARPPTTAGPPAPAPPAAPAAG--PPR 2781


                  ....*..
gi 49457147   119 NLPLPGG 125
Cdd:PHA03247 2782 RLTRPAV 2788
dnaA PRK14086
chromosomal replication initiator protein DnaA;
9-113 2.79e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.73  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    9 DALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPgAPAPGVYPGPPSgpga 88
Cdd:PRK14086  89 DPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQ-RPEPGAWPRAAD---- 163

                         90       100
                 ....*....|....*....|....*
gi 49457147   89 ypSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PRK14086 164 --DYGWQQQRLGFPPRAPYASPASY 186
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 42-122 3.03e-04

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 41.06  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    42 PGAYPGQapPGAYPGQAPPGAYPGAPGAYPGAPA------PGVYPGPPSGPGAYPSSGQPSAP--GAYPATGPygaPAGP 113
Cdd:pfam15991 147 QQAYYKQ--PAFSPGYAEHGQQKHDDGRRGYDVArfgswnKSTAQYPPSGQLFYPTHQYLPPPqtQGQADARL---QTIY 221


                  ....*....
gi 49457147   114 LIVPYNLPL 122
Cdd:pfam15991 222 PQPGYALPL 230
PHA03247 PHA03247
large tegument protein UL36; Provisional
 17-128 3.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    17 PNPQGWPGAWGNQPAGAGGypGASYPGAYPGQAPPGAYPGQAPPG--AYPGAPGAYPGAPAPGVYPGPPSGPGayPSSGQ 94
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAA--RQASPALPAAPAPPAVPAGPATPGgpARPARPPTTAGPPAPAPPAAPAAGPP--RRLTR 2785

                          90       100       110
                  ....*....|....*....|....*....|....
gi 49457147    95 PSAPGAYPATGPYGAPAGPLIVPYNLPLPGGVVP 128
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 10-106 3.79e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.20  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   10 ALSGSGNPNPQGW-------PGAWGNQPA--GAGGYPGASYPGA-YPGQAPPGAYP-GQAPPGAYPGAPGAYPGAPAPGV 78
Cdd:PRK14959 380 APSGSAAEGPASGgaatiptPGTQGPQGTapAAGMTPSSAAPATpAPSAAPSPRVPwDDAPPAPPRSGIPPRPAPRMPEA 459

                         90       100       110
                 ....*....|....*....|....*....|....
gi 49457147   79 YPGP------PSGPGAYPSSGQPSAPGAYPATGP 106
Cdd:PRK14959 460 SPVPgapdsvASASDAPPTLGDPSDTAEHTPSGP 493
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
2-127 3.80e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   2 ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYP-GAPAPGVYP 80
Cdd:COG3469  91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATgGTTTTSTTT 170

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 49457147  81 GPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNLPLPGGVV 127
Cdd:COG3469 171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHVL 217
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
10-114 4.08e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   10 ALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAP-PGAYPGAPGAYPGAPAPGVYPGPPSGPGA 88
Cdd:PRK07003 361 AVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALaPKAAAAAAATRAEAPPAAPAPPATADRGD 440

                         90       100
                 ....*....|....*....|....*.
gi 49457147   89 YPSSGQPSAPGAYPATGPYGAPAGPL 114
Cdd:PRK07003 441 DAADGDAPVPAKANARASADSRCDER 466
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
12-123 5.97e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 5.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   12 SGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAP----PGAYPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrsPAPEALAAARQASARGPGGAPAPAPAPA 455

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 49457147   88 AYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNLPLP 123
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 8-125 6.87e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    8 HDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK07764 653 HPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS 732

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 49457147   88 AYPSSGQP--SAPGAYPATGPYGAPAGPLIVPYNLPLPGG 125
Cdd:PRK07764 733 PAADDPVPlpPEPDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 16-131 7.49e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 7.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   16 NPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGP-------GA 88
Cdd:PRK14951 382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPaqaapetVA 461

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 49457147   89 YPSSGQPSAPGAYPATGPYGAPAGPLIVPYNL-PLPGGVVPRML 131
Cdd:PRK14951 462 IPVRVAPEPAVASAAPAPAAAPAAARLTPTEEgDVWHATVQQLA 505
PHA03247 PHA03247
large tegument protein UL36; Provisional
 50-113 7.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49457147    50 PPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGP 113
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 37-117 8.72e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.26  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    37 PGASYPGAYPGQAPPGAYPGQAP-PGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLI 115
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAaPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEV 117


                  ..
gi 49457147   116 VP 117
Cdd:PRK12270  118 TP 119
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
31-113 1.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   31 AGAGGYPGASYPGAYPGQAPPgayPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAP 110
Cdd:PRK12323 439 ASARGPGGAPAPAPAPAAAPA---AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515


                 ...
gi 49457147  111 AGP 113
Cdd:PRK12323 516 AAP 518
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 27-123 1.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    27 GNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAP--PGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPAT 104
Cdd:TIGR01628 382 MRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLgwPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQP 461

                          90
                  ....*....|....*....
gi 49457147   105 GPYGAPAGPLIVPYNLPLP 123
Cdd:TIGR01628 462 VMYPPNYQSLPLSQDLPQP 480
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
29-129 1.40e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   29 QPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYG 108
Cdd:PRK12323 364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443

                         90       100
                 ....*....|....*....|.
gi 49457147  109 APAGPLIVPYNLPLPGGVVPR 129
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARP 464
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 12-114 1.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   12 SGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGA----YPGAPGAYPGAPAPGVYPGPPSGPG 87
Cdd:PRK07764 692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPpepdDPPDPAGAPAQPPPPPAPAPAAAPA 771

                         90       100
                 ....*....|....*....|....*..
gi 49457147   88 AYPSSGQPSAPGAYPATGPYGAPAGPL 114
Cdd:PRK07764 772 AAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 31-128 2.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   31 AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGayPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAP 110
Cdd:PRK07764 586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA--PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663

                         90
                 ....*....|....*...
gi 49457147  111 AGPLIVPYNLPLPGGVVP 128
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAP 681
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
17-113 2.82e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 38.68  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   17 PNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPP---SGPGAYPSSG 93
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPpaaPAPPATADRG 439

                         90       100
                 ....*....|....*....|
gi 49457147   94 QPSAPGAYPATGPYGAPAGP 113
Cdd:PRK07003 440 DDAADGDAPVPAKANARASA 459
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 37-124 3.54e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 38.06  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   37 PGASYPGAYPGQAPPGAY-PGQAPPGAYPGAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLI 115
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASqPATPPPPAAPPSPPGDPPEPPA---PEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVR 92


                 ....*....
gi 49457147  116 VPYNLPLPG 124
Cdd:NF041121  93 VPAPPALPN 101
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
30-113 3.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   30 PAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPgAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSAPGAYPATGPYGA 109
Cdd:PRK12323 473 AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA-SPAPAQPDAAP---AGWVAESIPDPATADPDDAFETLAPAPAAA 548


                 ....
gi 49457147  110 PAGP 113
Cdd:PRK12323 549 PAPR 552
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 30-100 5.54e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 37.95  E-value: 5.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49457147    30 PAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGA 100
Cdd:PRK12270   40 STAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAA 110
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 44-123 5.99e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 37.15  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   44 AYPGQAPPGAYPGQAPPGAYPGAPGAY-PGAPAPGVYPGPPSGPGAYPSSGQPSAPgAYPATGPYGAPAG-PLIVPYNLP 121
Cdd:PHA02682  94 ACPACAPAAPAPAVTCPAPAPACPPATaPTCPPPAVCPAPARPAPACPPSTRQCPP-APPLPTPKPAPAAkPIFLHNQLP 172


                 ..
gi 49457147  122 LP 123
Cdd:PHA02682 173 PP 174
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 29-113 6.09e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 37.66  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   29 QPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPG--APAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGP 106
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAgaAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666


                 ....*..
gi 49457147  107 YGAPAGP 113
Cdd:PRK07764 667 DGWPAKA 673
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 19-111 6.38e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 37.56  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    19 PQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAypgAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAP 98
Cdd:PRK12270   39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAA---PPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115

                          90
                  ....*....|...
gi 49457147    99 GAYPATGPYGAPA 111
Cdd:PRK12270  116 EVTPLRGAAAAVA 128
PHA03247 PHA03247
large tegument protein UL36; Provisional
 6-103 6.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147     6 SLHDALSGSGNPnPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPA---PGVYPGP 82
Cdd:PHA03247  364 SLEDLSAGRHHP-KRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPAtplPSAEPGS 442

                          90       100
                  ....*....|....*....|.
gi 49457147    83 PSGPgAYPSSGQPSAPGAYPA 103
Cdd:PHA03247  443 DDGP-APPPERQPPAPATEPA 462
PHA03185 PHA03185
UL14 tegument protein; Provisional
 75-113 6.87e-03

UL14 tegument protein; Provisional


Pssm-ID: 177553 [Multi-domain]  Cd Length: 214  Bit Score: 36.93  E-value: 6.87e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 49457147   75 APGVYPGPPSGPGAYPSS-----GQPSAPGAYPATGPYGAPAGP 113
Cdd:PHA03185 157 APAVRPGDLSGPGSRPTSgpvagGLPGGGAPAPPTPPRPGPTDP 200
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 27-114 7.23e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 37.56  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147    27 GNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGvyPGPPSGPGAYPSSGQPSAPGAYPATGP 106
Cdd:PRK12270   35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                  ....*...
gi 49457147   107 YGAPAGPL 114
Cdd:PRK12270  113 VEDEVTPL 120
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
19-129 8.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.16  E-value: 8.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457147   19 PQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAypgAPGAYPGAPAPGVYPGPPS-GPGAYPSSGQPSA 97
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAA---APAAAAAARAVAAAPARRSpAPEALAAARQASA 441

                         90       100       110
                 ....*....|....*....|....*....|..
gi 49457147   98 PGAYPATGPYGAPAgPLIVPYNLPLPGGVVPR 129
Cdd:PRK12323 442 RGPGGAPAPAPAPA-AAPAAAARPAAAGPRPV 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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