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Conserved domains on  [gi|493997585|ref|WP_006940217|]
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ActS/PrrB/RegB family redox-sensitive histidine kinase [Roseibium aggregatum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ActS_PrrB_HisK super family cl41438
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


The actual alignment was detected with superfamily member NF033792:

Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 604.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  12 PHRRLKLDTLVRLRWLAVGGQSAALLVVHVGLGYPMPAGPAFAMVALSAWLNIFLKIRWPSAMRLSERAAALQLAYDILQ 91
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  92 MSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVS 171
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 172 TLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVAL 251
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 252 IRSQAERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVDPHRGTGVAIH-STGTGTGAEPVGTRNAAIRYGLGNLLENA 330
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEvVVAGDPGEEPVIRRNPEILYGLGNLIENA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 331 VDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPqRGTGGGLGLGIFIAKTLLERTGAKLHLE 410
Cdd:NF033792 324 VDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEER-RPGGGGLGLGLFIAKTLLERSGATVTFA 402

                        410       420
                 ....*....|....*....|.
gi 493997585 411 NSAPPQTGAHIRVSWPRQVFE 431
Cdd:NF033792 403 NRPPPEGGAVVTVRWPRAALE 423
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 604.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  12 PHRRLKLDTLVRLRWLAVGGQSAALLVVHVGLGYPMPAGPAFAMVALSAWLNIFLKIRWPSAMRLSERAAALQLAYDILQ 91
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  92 MSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVS 171
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 172 TLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVAL 251
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 252 IRSQAERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVDPHRGTGVAIH-STGTGTGAEPVGTRNAAIRYGLGNLLENA 330
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEvVVAGDPGEEPVIRRNPEILYGLGNLIENA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 331 VDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPqRGTGGGLGLGIFIAKTLLERTGAKLHLE 410
Cdd:NF033792 324 VDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEER-RPGGGGLGLGLFIAKTLLERSGATVTFA 402

                        410       420
                 ....*....|....*....|.
gi 493997585 411 NSAPPQTGAHIRVSWPRQVFE 431
Cdd:NF033792 403 NRPPPEGGAVVTVRWPRAALE 423
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
106-428 1.44e-25

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 106.53  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 106 FAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVSTLGFMAIYAFRVAE 185
Cdd:COG0642    6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 186 EARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDefEAGDPRGEDVALIRSQAERCRSILRQ 265
Cdd:COG0642   86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLE--ELDEEQREYLETILRSADRLLRLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 266 LTSLSSEEDRTY----QRMPVSQLLEDVVDPHRGT----GVAIHSTGTGtGAEPVGTRNAAIRYGLGNLLENAVDFAK-- 335
Cdd:COG0642  164 LLDLSRLEAGKLelepEPVDLAELLEEVVELFRPLaeekGIELELDLPD-DLPTVRGDPDRLRQVLLNLLSNAIKYTPeg 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 336 TRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQrgtggglglgiFIAKTLLERTGAKLHLENSapP 415
Cdd:COG0642  243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGgtg-----lglAIVKRIVELHGGTIEVESE--P 315

                        330
                 ....*....|...
gi 493997585 416 QTGAHIRVSWPRQ 428
Cdd:COG0642  316 GKGTTFTVTLPLA 328
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 323-428 2.53e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 66.13  E-value: 2.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585   323 LGNLLENAVDFAK--TRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSpqrgtggglglGI------- 393
Cdd:smart00387  10 LSNLLDNAIKYTPegGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSR-----------KIggtglgl 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 493997585   394 FIAKTLLERTGAKLHLENSapPQTGAHIRVSWPRQ 428
Cdd:smart00387  79 SIVKKLVELHGGEISVESE--PGGGTTFTITLPLE 111
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 169-359 1.26e-11

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 66.41  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 169 LVSTLGFMAIYAFRVAEEARQMADALAATELV-LAR--EQHLNALDGLA------TAAAHELGTPLATIyLVAKELSDEf 239
Cdd:PRK11100 206 LNRSIRRLTRYADAVTEGKPVPLPKLGSSELReLAQalESMRVKLEGKAyveqyvQTLTHELKSPLAAI-RGAAELLQE- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 240 eagDPRGEDVAL----IRSQAERCRSILRQLTSLSSEEDR----TYQRMPVSQLLEDVVDPH------RGTGVAIHSTGT 305
Cdd:PRK11100 284 ---DPPPEDRARftgnILTQSARLQQLIDRLLELARLEQRqeleVLEPVALAALLEELVEAReaqaaaKGITLRLRPDDA 360

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493997585 306 GTGAEPVGTRNAairygLGNLLENAVDFA--KTRVDVSATWDETTLSISILDDGPG 359
Cdd:PRK11100 361 RVLGDPFLLRQA-----LGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVEDQGPG 411
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 323-428 1.93e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 57.76  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  323 LGNLLENAVDFA--KTRVDVSATWDETtLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQRgtggglGLGIFIAKTLL 400
Cdd:pfam02518  10 LSNLLDNALKHAakAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGT------GLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*...
gi 493997585  401 ERTGAKLHLENSapPQTGAHIRVSWPRQ 428
Cdd:pfam02518  83 ELLGGTITVESE--PGGGTTVTLTLPLA 108
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 207-270 3.06e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 50.29  E-value: 3.06e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493997585 207 LNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVALIRSQAERCRSILRQLTSLS 270
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 12-431 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 604.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  12 PHRRLKLDTLVRLRWLAVGGQSAALLVVHVGLGYPMPAGPAFAMVALSAWLNIFLKIRWPSAMRLSERAAALQLAYDILQ 91
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  92 MSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVS 171
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 172 TLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVAL 251
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 252 IRSQAERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVDPHRGTGVAIH-STGTGTGAEPVGTRNAAIRYGLGNLLENA 330
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEvVVAGDPGEEPVIRRNPEILYGLGNLIENA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 331 VDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPqRGTGGGLGLGIFIAKTLLERTGAKLHLE 410
Cdd:NF033792 324 VDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEER-RPGGGGLGLGLFIAKTLLERSGATVTFA 402

                        410       420
                 ....*....|....*....|.
gi 493997585 411 NSAPPQTGAHIRVSWPRQVFE 431
Cdd:NF033792 403 NRPPPEGGAVVTVRWPRAALE 423
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
106-428 1.44e-25

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 106.53  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 106 FAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVSTLGFMAIYAFRVAE 185
Cdd:COG0642    6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 186 EARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDefEAGDPRGEDVALIRSQAERCRSILRQ 265
Cdd:COG0642   86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLE--ELDEEQREYLETILRSADRLLRLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 266 LTSLSSEEDRTY----QRMPVSQLLEDVVDPHRGT----GVAIHSTGTGtGAEPVGTRNAAIRYGLGNLLENAVDFAK-- 335
Cdd:COG0642  164 LLDLSRLEAGKLelepEPVDLAELLEEVVELFRPLaeekGIELELDLPD-DLPTVRGDPDRLRQVLLNLLSNAIKYTPeg 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 336 TRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQrgtggglglgiFIAKTLLERTGAKLHLENSapP 415
Cdd:COG0642  243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGgtg-----lglAIVKRIVELHGGTIEVESE--P 315

                        330
                 ....*....|...
gi 493997585 416 QTGAHIRVSWPRQ 428
Cdd:COG0642  316 GKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
201-427 9.65e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 96.51  E-value: 9.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 201 LAREQHLNAL-DGLATAAAHELGTPLATIYLVAKELSDEFEAGDP-RGEDVALIRSQAERCRSILRQLTSLSSEEDRTY- 277
Cdd:COG2205    6 LEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEeRRELLEIIRESAERLLRLIEDLLDLSRLESGKLs 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 278 ---QRMPVSQLLEDVVDPHRGT----GVAIHSTGTGTGAEpVGTRNAAIRYGLGNLLENAVDF--AKTRVDVSATWDETT 348
Cdd:COG2205   86 lelEPVDLAELLEEAVEELRPLaeekGIRLELDLPPELPL-VYADPELLEQVLANLLDNAIKYspPGGTITISARREGDG 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493997585 349 LSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQrgtggglglgiFIAKTLLERTGAKLHLENSapPQTGAHIRVSWPR 427
Cdd:COG2205  165 VRISVSDNGPGIPEEELERIFERFYRGDNSRGEGgtg-----lglAIVKRIVEAHGGTIWVESE--PGGGTTFTVTLPL 236
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 197-428 1.09e-18

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 88.10  E-value: 1.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 197 TELVlaREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGED-----VALIRSQAERCRSILRQLTSLSS 271
Cdd:COG5000  190 TELL--RAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREdleraLDTIIRQVDRLKRIVDEFLDFAR 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 272 EEDRTYQRMPVSQLLEDVVD----PHRGTGVAIHSTGTGTGAEPVGTRNAaIRYGLGNLLENAVDFAKT--RVDVSATWD 345
Cdd:COG5000  268 LPEPQLEPVDLNELLREVLAlyepALKEKDIRLELDLDPDLPEVLADRDQ-LEQVLINLLKNAIEAIEEggEIEVSTRRE 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 346 ETTLSISILDDGPGFSVEILGKIGDPYVSVRG-----GKSpqrgtggglglgifIAKTLLERTGAKLHLENSapPQTGAH 420
Cdd:COG5000  347 DGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPkgtglGLA--------------IVKKIVEEHGGTIELESR--PGGGTT 410


                 ....*...
gi 493997585 421 IRVSWPRQ 428
Cdd:COG5000  411 FTIRLPLA 418
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 73-374 5.53e-17

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 82.15  E-value: 5.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  73 AMRLSERAAALQLAYDILQMSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVG 152
Cdd:COG4191    6 LLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 153 ADFSLPIVYSVGIWIALVSTLGFMAIYAFRVAEeARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVA 232
Cdd:COG4191   86 LLLLLEALLLLLLAALDAEENAELEELERDITE-LERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 233 KELSDEFEAGDPRG---EDVALIRSQAERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVD---PH-RGTGVAIHsTGT 305
Cdd:COG4191  165 ELLRRRLEDEPDPEelrEALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALEllrPRlKARGIEVE-LDL 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493997585 306 GTGAEPVGTRNAAIRYGLGNLLENAVD-FAKT---RVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVS 374
Cdd:COG4191  244 PPDLPPVLGDPGQLEQVLLNLLINAIDaMEEGeggRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFT 316
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
52-427 1.80e-15

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 78.06  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  52 AFAMVALSAWLNIFLKIRWPSAMRLSERAAALQLAYDILQMSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGI 131
Cdd:COG5002    6 LLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 132 LATVCASLVAIFHLPLPWPVGADFSLPIVYSVGIWIALVSTLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNAL- 210
Cdd:COG5002   86 LALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMr 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 211 DGLATAAAHELGTPLATIYLVAKELSDEfEAGDP--RGEDVALIRSQAERCRSILRQLTSLS----SEEDRTYQRMPVSQ 284
Cdd:COG5002  166 REFVANVSHELRTPLTSIRGYLELLLDG-AADDPeeRREYLEIILEEAERLSRLVNDLLDLSrlesGELKLEKEPVDLAE 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 285 LLEDVVDPHRGT----GVAIHSTGTGTGAEPVGTRNAaIRYGLGNLLENAVDFAK--TRVDVSATWDETTLSISILDDGP 358
Cdd:COG5002  245 LLEEVVEELRPLaeekGIELELDLPEDPLLVLGDPDR-LEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRISVRDTGI 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493997585 359 GFSVEILGKIGDPYVsvRGGKSPQRGTggglglgIFIAKTLLERTGAKLHLENSapPQTGAHIRVSWPR 427
Cdd:COG5002  324 GIPEEDLPRIFERFY--RVDKSRSRETggt-glgLAIVKHIVEAHGGRIWVESE--PGKGTTFTITLPL 387
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 323-428 2.53e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 66.13  E-value: 2.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585   323 LGNLLENAVDFAK--TRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSpqrgtggglglGI------- 393
Cdd:smart00387  10 LSNLLDNAIKYTPegGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSR-----------KIggtglgl 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 493997585   394 FIAKTLLERTGAKLHLENSapPQTGAHIRVSWPRQ 428
Cdd:smart00387  79 SIVKKLVELHGGEISVESE--PGGGTTFTITLPLE 111
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 169-359 1.26e-11

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 66.41  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 169 LVSTLGFMAIYAFRVAEEARQMADALAATELV-LAR--EQHLNALDGLA------TAAAHELGTPLATIyLVAKELSDEf 239
Cdd:PRK11100 206 LNRSIRRLTRYADAVTEGKPVPLPKLGSSELReLAQalESMRVKLEGKAyveqyvQTLTHELKSPLAAI-RGAAELLQE- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 240 eagDPRGEDVAL----IRSQAERCRSILRQLTSLSSEEDR----TYQRMPVSQLLEDVVDPH------RGTGVAIHSTGT 305
Cdd:PRK11100 284 ---DPPPEDRARftgnILTQSARLQQLIDRLLELARLEQRqeleVLEPVALAALLEELVEAReaqaaaKGITLRLRPDDA 360

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493997585 306 GTGAEPVGTRNAairygLGNLLENAVDFA--KTRVDVSATWDETTLSISILDDGPG 359
Cdd:PRK11100 361 RVLGDPFLLRQA-----LGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVEDQGPG 411
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 323-428 1.93e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 57.76  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  323 LGNLLENAVDFA--KTRVDVSATWDETtLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQRgtggglGLGIFIAKTLL 400
Cdd:pfam02518  10 LSNLLDNALKHAakAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGT------GLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*...
gi 493997585  401 ERTGAKLHLENSapPQTGAHIRVSWPRQ 428
Cdd:pfam02518  83 ELLGGTITVESE--PGGGTTVTLTLPLA 108
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 73-368 2.33e-10

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 62.50  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  73 AMRLSERAAALQLAYDILQMSGLLFLTGGLGNPFAFLLMAPVMVSATGLSARYTILLGILATVCASLVAIFHLPLPWPVG 152
Cdd:COG4251  134 LLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLL 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 153 ADFSLPIVYSVGIWIALVSTLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNA-----------LDGLATAAAHEL 221
Cdd:COG4251  214 EAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEErtaelersneeLEQFAYVASHDL 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 222 GTPLATIYLVAKELSDEFEAG-DPRGED-VALIRSQAERCRSILRQLTSLS--SEEDRTYQRMPVSQLLEDVVD----PH 293
Cdd:COG4251  294 REPLRKISGFSQLLEEDYGDKlDEEGREyLERIRDAAERMQALIDDLLAYSrvGRQELEFEPVDLNELLEEVLEdlepRI 373

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493997585 294 RGTGVAIHstgTGTGAEPVGTRnAAIRYGLGNLLENAVDFAKT----RVDVSATWDETTLSISILDDGPGFSVEILGKI 368
Cdd:COG4251  374 EERGAEIE---VGPLPTVRGDP-TLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKI 448
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
181-378 1.99e-09

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 59.09  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 181 FRVAEEARQMadalaatELVLAREQHLNALDGLATAAAHELGTPLATIY----LVAKELSDefeagDPRGEDVALIRSQA 256
Cdd:COG3852  113 LRDITERKRL-------ERELRRAEKLAAVGELAAGLAHEIRNPLTGIRgaaqLLERELPD-----DELREYTQLIIEEA 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 257 ERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVdphrgtgvaihstgtgTGAEPVGTRNAAIRYGLG------------ 324
Cdd:COG3852  181 DRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVL----------------ELLRAEAPKNIRIVRDYDpslpevlgdpdq 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493997585 325 ------NLLENAVDfA---------KTRVDVSATWDETT----LSISILDDGPGFSVEILGKIGDPYVSVRGG 378
Cdd:COG3852  245 liqvllNLVRNAAE-AmpeggtitiRTRVERQVTLGGLRprlyVRIEVIDNGPGIPEEILDRIFEPFFTTKEK 316
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
159-377 2.84e-08

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 55.95  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 159 IVYSVGIWIALVSTLGFMaiYAFRVAEEARQMADALAatelvlaREQHLNALDGLATAAAHELGTPLATIYLVAKELSDE 238
Cdd:PRK10364 195 IILFALATVLLASLLAFF--WYRRYLRSRQLLQDEMK-------RKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAER 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 239 FEAGdprGEDVAL---IRSQAERCRSILRQLTSLSSEEDRTYQRMPVSQLLED----VVDPHRGTGVAIHStgtgTGAEP 311
Cdd:PRK10364 266 APAG---GEAHQLaqvMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHslqlVSQDANSREIQLRF----TANDT 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493997585 312 VGTRNA-AIRYG--LGNLLENAVDF--AKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRG 377
Cdd:PRK10364 339 LPEIQAdPDRLTqvLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA 409
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 207-270 3.06e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 50.29  E-value: 3.06e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493997585 207 LNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVALIRSQAERCRSILRQLTSLS 270
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-423 3.65e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 51.86  E-value: 3.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 323 LGNLLENAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDpyvsvRGgkspQRGTGGGLGLGI--FIAKTLL 400
Cdd:cd16954   42 LGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQ-----RG----QRLDEQRPGQGLglAIAKEIV 112

                         90       100
                 ....*....|....*....|...
gi 493997585 401 ERTGAKLHLENSapPQTGAHIRV 423
Cdd:cd16954  113 EQYGGELSLSDS--PLGGARFEV 133
PRK10337 PRK10337
sensor protein QseC; Provisional
 182-370 1.88e-07

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 53.11  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 182 RVAEEARQMADAL----AATELVLAREQHLNaldglaTAAAHELGTPLATIYL---VAkELSDEfeagDPRGEDVALIRS 254
Cdd:PRK10337 211 GVPSEVRPLVEALnqlfARTHAMMVRERRFT------SDAAHELRSPLAALKVqteVA-QLSDD----DPQARKKALLQL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 255 QA--ERCRSILRQLTSLS---SEEDR-TYQRMPVSQLLEDVVdphrgtgVAIHSTGTGTGAEPVGTRNA--AIRYG---- 322
Cdd:PRK10337 280 HAgiDRATRLVDQLLTLSrldSLDNLqDVAEIPLEDLLQSAV-------MDIYHTAQQAGIDVRLTLNAhpVIRTGqpll 352

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 493997585 323 ----LGNLLENAVDFAKTRVDVSATWDETTLSIsiLDDGPGFSVEILGKIGD 370
Cdd:PRK10337 353 lsllVRNLLDNAIRYSPQGSVVDVTLNARNFTV--RDNGPGVTPEALARIGE 402
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 209-273 2.93e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 47.59  E-value: 2.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493997585  209 ALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRgEDVALIRSQAERCRSILRQLTSLSSEE 273
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSRIE 64
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 209-273 3.02e-07

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 47.56  E-value: 3.02e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493997585   209 ALDGLATAAAHELGTPLATIYLVAKELSDEfEAGDPRGEDVALIRSQAERCRSILRQLTSLSSEE 273
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDT-ELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 197-374 8.21e-07

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 51.27  E-value: 8.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 197 TELVLAREQHLNALDGLATAAAHELGTPLATI----YLVAKELSDEFEAGDprgedvaLIRSQAERCRSILRQLTSLSSE 272
Cdd:COG5805  274 AEELMARSEKLSIAGQLAAGIAHEIRNPLTSIkgflQLLQPGIEDKEEYFD-------IMLSELDRIESIISEFLALAKP 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 273 EDRTYQRMPVSQLLEDVVdPHRGT-----GVAIHSTGTGTGAEPVGTRNAaIRYGLGNLLENAVDFAKT--RVDVSATWD 345
Cdd:COG5805  347 QAVNKEKENINELIQDVV-TLLETeailhNIQIRLELLDEDPFIYCDENQ-IKQVFINLIKNAIEAMPNggTITIHTEEE 424

                        170       180
                 ....*....|....*....|....*....
gi 493997585 346 ETTLSISILDDGPGFSVEILGKIGDPYVS 374
Cdd:COG5805  425 DNSVIIRVIDEGIGIPEERLKKLGEPFFT 453
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 185-399 9.32e-07

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 51.23  E-value: 9.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 185 EEARQMADALAATELVLAREQHLNALDGLATAAAHELGTPL--ATIYLVAKELSDEFEAGDPRGEDVALIRSQAERCRSI 262
Cdd:COG4192  408 EERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLnaMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKI 487

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 263 LRQLTSLSSEEDRTYQRMPVSQLLED----VVDPHRGTGVAIHSTGtgtgaEPVGTRNA-AIRYGLGNLLENAVDFAKTR 337
Cdd:COG4192  488 IKSLRQFSRKSDTPLQPVDLRQVIEQawelVESRAKPQQITLHIPD-----DLMVQGDQvLLEQVLVNLLVNALDAVATQ 562

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493997585 338 VDVSATWDETT--LSISILDDGPGFsvEILGKIGDPYVSVRG-----GKSPQRGTGGGLGLGIFIAKTL 399
Cdd:COG4192  563 PQISVDLLSNAenLRVAISDNGNGW--PLVDKLFTPFTTTKEvglglGLSICRSIMQQFGGDLYLASTL 629
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 318-426 1.86e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 46.38  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 318 AIRYGLGNLLENAVDFAK--------TRVDVSATWDETtLSISILDDGPGFSVEILGKIGDPYVSVRggkspqrgtGGGL 389
Cdd:cd16944    4 QISQVLTNILKNAAEAIEgrpsdvgeVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYVTTR---------PKGT 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 493997585 390 GLGIFIAKTLLERTGAKLHLENSapPQTGAHIRVSWP 426
Cdd:cd16944   74 GLGLAIVKKIMEEHGGRISLSNR--EAGGACIRIILP 108
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 323-379 3.82e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 49.08  E-value: 3.82e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493997585 323 LGNLLENAVD------FAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGK 379
Cdd:COG3290  286 LGNLLDNAIEaveklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGE 348
PRK10490 PRK10490
sensor protein KdpD; Provisional
 182-426 4.19e-06

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 49.26  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 182 RVAEEARQMADalaatelvlaREQHLNALdgLAtAAAHELGTPLATIYLVAKELS-DEFEAGDPRGEDVALIRSQAERCR 260
Cdd:PRK10490 649 ASEEQARLASE----------REQLRNAL--LA-ALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQQVLNTT 715

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 261 SILRQLTSLSSEEDRTYQRMPVSQLLEDVVdphrgtGVAIHSTGTGTGAEPVGTRNAA-----------IRYGLGNLLEN 329
Cdd:PRK10490 716 RLVNNLLDMARIQSGGFNLRKEWLTLEEVV------GSALQMLEPGLSGHPINLSLPEpltlihvdgplFERVLINLLEN 789

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 330 AVDFA--KTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYvsVRGGKspqRGTGGGLGLGIFIAKTLLERTGAKL 407
Cdd:PRK10490 790 AVKYAgaQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF--ARGNK---ESAIPGVGLGLAICRAIVEVHGGTI 864

                        250
                 ....*....|....*....
gi 493997585 408 HLENsaPPQTGAHIRVSWP 426
Cdd:PRK10490 865 WAEN--RPEGGACFRVTLP 881
envZ PRK09467
osmolarity sensor protein; Provisional
 219-426 6.05e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 48.37  E-value: 6.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 219 HELGTPLATIYLVAKELSDEfeagdprgeDVAL---IRSQAERCRSILRQLTSLSseedRTYQRMP-----VSQLLEDVV 290
Cdd:PRK09467 238 HDLRTPLTRIRLATEMMSEE---------DGYLaesINKDIEECNAIIEQFIDYL----RTGQEMPmemadLNALLGEVI 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 291 DPHRGTGVAIHsTGTGTGAEPVGTRNAAIRYGLGNLLENAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGD 370
Cdd:PRK09467 305 AAESGYEREIE-TALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQ 383

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 493997585 371 PYV---SVRGGkspqrgtgGGLGLGIFIAKTLLERTGAKLHLENSapPQTGAHIRVSWP 426
Cdd:PRK09467 384 PFTrgdSARGS--------SGTGLGLAIVKRIVDQHNGKVELGNS--EEGGLSARAWLP 432
PRK10604 PRK10604
sensor protein RstB; Provisional
 189-373 6.13e-06

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 48.45  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 189 QMADALAAteLVLAREQHLNALdglataaAHELGTPLATI-YLVakELSDEFEAGdprgEDVALIRSqaercrsiLRQLT 267
Cdd:PRK10604 200 QMADNINA--LIASKKQLIDGI-------AHELRTPLVRLrYRL--EMSDNLSAA----ESQALNRD--------IGQLE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 268 SLSsEEDRTYQRMPVSQL----------------LEDV--VDPHRGTGVAIHSTG-TGTGAEPVGTRnaairyGLGNLLE 328
Cdd:PRK10604 257 ALI-EELLTYARLDRPQNelhlsepdlpawlsthLADIqaVTPEKTVRLDTPHQGdYGALDMRLMER------VLDNLLN 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 493997585 329 NAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYV 373
Cdd:PRK10604 330 NALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFV 374
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-427 7.28e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 44.73  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 323 LGNLLENAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSPQrgtGGGLGLGIFIAKTLLER 402
Cdd:cd16939    5 LDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRA---TGGFGLGLAIVHRVALW 81

                         90       100
                 ....*....|....*....|....*
gi 493997585 403 TGAKLHLENSapPQTGAHIRVSWPR 427
Cdd:cd16939   82 HGGHVECDDS--ELGGACFRLTWPR 104
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
157-369 7.85e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 47.31  E-value: 7.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 157 LPIVYSVGIWIALVSTLGFMAIYAFRVAEEARQMADALAATELVLAREQHLNALdglataaAHEL----GTPLATIYLVA 232
Cdd:COG4585    4 LALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEERRRI-------ARELhdgvGQSLSAIKLQL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 233 KELSDEFEAGDPR-GEDVALIRSQAERC----RSILRQLTSLSSEEDRTYQRmpVSQLLEDVvdpHRGTGVAIHSTGTGT 307
Cdd:COG4585   77 EAARRLLDADPEAaREELEEIRELAREAlaelRRLVRGLRPPALDDLGLAAA--LEELAERL---LRAAGIRVELDVDGD 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493997585 308 GAEPVGTRNAAIRYGLGNLLENAVDFAK-TRVDVSATWDETTLSISILDDGPGFSVEILGKIG 369
Cdd:COG4585  152 PDRLPPEVELALYRIVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGG 214
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-423 9.34e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 44.37  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 325 NLLENAVDFAKTR--VDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVsvRGGKSpqRGTGGGLGLGIFIAKTLLER 402
Cdd:cd16975   11 NIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFY--RDDTS--RRSGGHYGMGLYIAKNLVEK 86

                         90       100
                 ....*....|....*....|.
gi 493997585 403 TGAKLHLENSAppQTGAHIRV 423
Cdd:cd16975   87 HGGSLIIENSQ--KGGAEVTV 105
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-426 2.07e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 43.47  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 325 NLLENAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYV---SVRGGKSPqrgtggGLGLGIFIAKTLLE 401
Cdd:cd16949    7 NVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDRESG------GTGLGLAIAERAIE 80

                         90       100
                 ....*....|....*....|....*
gi 493997585 402 RTGAKLHLENSAPPqtGAHIRVSWP 426
Cdd:cd16949   81 QHGGKIKASNRKPG--GLRVRIWLP 103
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 319-413 2.81e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 42.82  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 319 IRYGLGNLLENAVDFAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYV---SVRGGKSpqrgtgggLGLGIFI 395
Cdd:cd16950    1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdNARGTSG--------TGLGLAI 72

                         90
                 ....*....|....*...
gi 493997585 396 AKTLLERTGAKLHLENSA 413
Cdd:cd16950   73 VQRISDAHGGSLTLANRA 90
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
198-372 1.35e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 44.15  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 198 ELVLAREQHLNALDGLATAAAHELGTPL-----ATIYLVAKElsdefeagdprGEDVAL--IRSQAERCRSILRQLTSLS 270
Cdd:PRK09470 231 QMVTALERMMTSQQRLLSDISHELRTPLtrlqlATALLRRRQ-----------GESKELerIETEAQRLDSMINDLLVLS 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 271 -----SEEDRtyQRMPVSQLLEDVVD------PHRGTGVAIHstgTGTGAEPVGTRNAAIRYGLGNLLENAVDFAKTRVD 339
Cdd:PRK09470 300 rnqqkNHLER--ETFKANSLWSEVLEdakfeaEQMGKSLTVS---APPGPWPINGNPNALASALENIVRNALRYSHTKIE 374

                        170       180       190
                 ....*....|....*....|....*....|...
gi 493997585 340 VSATWDETTLSISILDDGPGFSVEILGKIGDPY 372
Cdd:PRK09470 375 VAFSVDKDGLTITVDDDGPGVPEEEREQIFRPF 407
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
176-378 1.40e-04

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 44.28  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 176 MAIYAFRVAEEARQMADALAATELVLAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEFEAGDPRGEDVALIRSQ 255
Cdd:PRK13837 416 LALDCLAHAIERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISA 495

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 256 AERCRSILRQLTSLSSEEDRTYQRMPVSQLLEDVVDPHR---GTGVAIHSTGTGTGAEPVGTRnAAIRYGLGNLLENA-- 330
Cdd:PRK13837 496 GARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRvslPPGVELDFDQDQEPAVVEGNP-AELQQVLMNLCSNAaq 574

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493997585 331 -------VDFAKTRVDVSATwdeTTLS-----------ISILDDGPGFSVEILGKIGDPYVSVRGG 378
Cdd:PRK13837 575 amdgagrVDISLSRAKLRAP---KVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRAG 637
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
186-443 2.71e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 43.57  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  186 EARQMADAL-----AATELVLAREQHLNALdglataaAHELGTPLATIYLVAKELSDEFEAGDPRGEDVALIRSQAERCR 260
Cdd:PRK09959  690 ETRDLIHALevernKAINATVAKSQFLATM-------SHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLL 762

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  261 SILRQLTSLSSEEDRTYQRMP----VSQLLEDVVDPH----RGTGVAIHSTGTGTGAEPVGTRNAAIRYGLGNLLENAVD 332
Cdd:PRK09959  763 GLIGEILDVDKIESGNYQLQPqwvdIPTLVQNTCHSFgaiaASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALK 842

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585  333 F-AKTRVDVSATW-----DETTLSISILDDGPGFSVEILGKIGDPYVSVRGGKSpqrgtGGGLGLGIFIAKTLLERTGAK 406
Cdd:PRK09959  843 FtTEGAVKITTSLghiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ-----QTGSGLGLMICKELIKNMQGD 917

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 493997585  407 LHLENSapPQTGAHIRVSWPRQVFEQDGRVDETAFTP 443
Cdd:PRK09959  918 LSLESH--PGIGTTFTITIPVEISQQVATVEAKAEQP 952
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 197-372 2.86e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 43.04  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 197 TELVLAREQHLNALDGLATAAAHELGTPLATI-----YLVAKELSDE---FEagdprgedvaLIRSQAERCRSILRQLTS 268
Cdd:COG5809  257 LEELLRKSEKLSVVGELAAGIAHEIRNPLTSLkgfiqLLKDTIDEEQktyLD----------IMLSELDRIESIISEFLV 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 269 LSSEEDRTYQRMPVSQLLEDVVD---PHrgtgvAIHstgtgtgaepvgtRNAAIRYGLG------------------NLL 327
Cdd:COG5809  327 LAKPQAIKYEPKDLNTLIEEVIPllqPQ-----ALL-------------KNVQIELELEddipdilgdenqlkqvfiNLL 388

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 493997585 328 ENAVDFAKT----RVDVSATwDETTLSISILDDGPGFSVEILGKIGDPY 372
Cdd:COG5809  389 KNAIEAMPEggniTIETKAE-DDDKVVISVTDEGCGIPEERLKKLGEPF 436
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 323-410 3.01e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 43.36  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 323 LGNLLENAVDFA----KTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGgksPQRgtggglGLGIFIAKT 398
Cdd:PRK11086 438 LGNLIENALEAVggeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKG---SNR------GVGLYLVKQ 508

                         90
                 ....*....|..
gi 493997585 399 LLERTGAKLHLE 410
Cdd:PRK11086 509 SVENLGGSIAVE 520
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-376 3.04e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 40.13  E-value: 3.04e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493997585 325 NLLENAVD----FAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVR 376
Cdd:cd16976    7 NLLQNALDamgkVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTK 62
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
201-376 3.08e-04

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 43.03  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 201 LAREQHLNALDGLATAAAHELGTPLATIYLVAKELSDEfEAGDPRGEDVALIRSQAERCRSILRQLTSLSSEEDRTYQRM 280
Cdd:PRK11360 381 VARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQ-TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPV 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 281 PVSQLLEDVV----DPHRGTGVAIHsTGTGTGAEPVGTRNAAIRYGLGNLLENAVDFAKTRVDVS-ATWDET--TLSISI 353
Cdd:PRK11360 460 SLNALVEEVLqlfqTAGVQARVDFE-TELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRiRTWQYSdgQVAVSI 538

                        170       180
                 ....*....|....*....|...
gi 493997585 354 LDDGPGFSVEILGKIGDPYVSVR 376
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTTK 561
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-376 3.52e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 39.71  E-value: 3.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493997585 325 NLLENAV----DFAKTRVDVSATWDEttLSISILDDGPGFSVEILGKIGDPYVSVR 376
Cdd:cd16943   10 NLLVNAAqameGRGRITIRTWAHVDQ--VLIEVEDTGSGIDPEILGRIFDPFFTTK 63
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
323-359 2.45e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 40.39  E-value: 2.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 493997585 323 LGNLLENAVDFAKTRVDVSATWDETTLSISILDDGPG 359
Cdd:PRK10815 383 MGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPG 419
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-426 3.02e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 37.55  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 323 LGNLLENAVDFA---KTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRggkSPQRGTGGGLGLGIFIAKTL 399
Cdd:cd16953    5 LRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTER---PANEAFGQHSGLGLSISRQI 81

                         90       100
                 ....*....|....*....|....*....
gi 493997585 400 LERTGAKLHLENSAPPQ--TGAHIRVSWP 426
Cdd:cd16953   82 IEAHGGISVAENHNQPGqvIGARFTVQLP 110
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-425 6.06e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 36.62  E-value: 6.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493997585 323 LGNLLENAVDF--AKTRVDVSATWDETTLsISILDDGPGFSVEILGKIGDPYVsvrggKSPQRGTGGGLgLGIFIAKTLL 400
Cdd:cd16940   18 LRNLVDNAVRYspQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFY-----RSDGQNYGGSG-LGLSIVKRIV 90

                         90       100
                 ....*....|....*....|....*
gi 493997585 401 ERTGAKLHLENSapPQTGAHIRVSW 425
Cdd:cd16940   91 ELHGGQIFLGNA--QGGGLEAWVRL 113
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-379 7.13e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.11  E-value: 7.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493997585 323 LGNLLENAVD------FAKTRVDVSATWDETTLSISILDDGPGFSVEILGKIGDPYVSVRGGK 379
Cdd:cd16915    5 VGNLIDNALDalaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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