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Conserved domains on  [gi|49388099|dbj|BAD25232|]
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putative cytochrome [Oryza sativa Japonica Group]

Protein Classification

cytochrome b family protein( domain architecture ID 581032)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Ontology:  GO:0046872|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrome_b_N super family cl23723
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-239 5.60e-95

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


The actual alignment was detected with superfamily member PLN02810:

Pssm-ID: 474033  Cd Length: 231  Bit Score: 278.24  E-value: 5.60e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099    1 MGLGVRAAPFTYVAHALAVAAATMVLVWCIHFRGGLAFEATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEA 80
Cdd:PLN02810   1 MAVGINALPLTFVAHALAVIGAIMVLVWSIYYRGGLAWEATNKNLIFN---------------LHPVLMLIGLIIIGGEA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099   81 IMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRA 160
Cdd:PLN02810  66 IMSYKSLPL-KKEVKKLIHLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGG 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49388099  161 SPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQSSGLDKYGAEAFLVNFTALIVVLFGASVVVAAVSPARVEE 239
Cdd:PLN02810 145 STNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKLTFLESGGLDKYGSEALLVNFTAIITILYGAFVVLTALAQSPSDE 223
 
Name Accession Description Interval E-value
PLN02810 PLN02810
carbon-monoxide oxygenase
 1-239 5.60e-95

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 278.24  E-value: 5.60e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099    1 MGLGVRAAPFTYVAHALAVAAATMVLVWCIHFRGGLAFEATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEA 80
Cdd:PLN02810   1 MAVGINALPLTFVAHALAVIGAIMVLVWSIYYRGGLAWEATNKNLIFN---------------LHPVLMLIGLIIIGGEA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099   81 IMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRA 160
Cdd:PLN02810  66 IMSYKSLPL-KKEVKKLIHLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGG 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49388099  161 SPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQSSGLDKYGAEAFLVNFTALIVVLFGASVVVAAVSPARVEE 239
Cdd:PLN02810 145 STNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKLTFLESGGLDKYGSEALLVNFTAIITILYGAFVVLTALAQSPSDE 223
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 40-199 3.48e-72

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 217.17  E-value: 3.48e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  40 ATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEAIMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCAFK 119
Cdd:cd08766   1 SDNKGLIFN---------------VHPVLMVIGFIFLAGEAILAYKTVPG-SREVQKAVHLTLHLVALVLGIVGIYAAFK 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099 120 FHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQ 199
Cdd:cd08766  65 FHNEVGIPNLYSLHSWLGIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTFLQ 144
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 64-198 3.45e-55

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 173.56  E-value: 3.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099    64 VHPVLMLIGYIILGSEAIMVYKVLPTWK--HDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTI 141
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRlsKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 49388099   142 CLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFL 198
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 64-191 8.48e-41

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 136.59  E-value: 8.48e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099     64 VHPVLMLIGYIILGSEAIMVYKVL-PTWKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTIC 142
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLtRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 49388099    143 LYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGF 191
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
 
Name Accession Description Interval E-value
PLN02810 PLN02810
carbon-monoxide oxygenase
 1-239 5.60e-95

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 278.24  E-value: 5.60e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099    1 MGLGVRAAPFTYVAHALAVAAATMVLVWCIHFRGGLAFEATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEA 80
Cdd:PLN02810   1 MAVGINALPLTFVAHALAVIGAIMVLVWSIYYRGGLAWEATNKNLIFN---------------LHPVLMLIGLIIIGGEA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099   81 IMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRA 160
Cdd:PLN02810  66 IMSYKSLPL-KKEVKKLIHLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGG 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49388099  161 SPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQSSGLDKYGAEAFLVNFTALIVVLFGASVVVAAVSPARVEE 239
Cdd:PLN02810 145 STNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKLTFLESGGLDKYGSEALLVNFTAIITILYGAFVVLTALAQSPSDE 223
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 40-199 3.48e-72

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 217.17  E-value: 3.48e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  40 ATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEAIMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCAFK 119
Cdd:cd08766   1 SDNKGLIFN---------------VHPVLMVIGFIFLAGEAILAYKTVPG-SREVQKAVHLTLHLVALVLGIVGIYAAFK 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099 120 FHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQ 199
Cdd:cd08766  65 FHNEVGIPNLYSLHSWLGIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTFLQ 144
PLN02680 PLN02680
carbon-monoxide oxygenase
 24-235 2.94e-59

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 187.31  E-value: 2.94e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099   24 MVLVWCIHFRGGLAFEATNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEAIMVYKVLPTWKhDTTKLIHLILH 103
Cdd:PLN02680  24 LVLTWTVHYRGGLALSSDNKDLIFN---------------VHPVLMVIGLVLLNGEAMLAYKTVPGTK-NLKKLVHLTLQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  104 AIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILA 183
Cdd:PLN02680  88 FLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALA 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 49388099  184 LATAELGFLEKLTFLQSSG-LDKYGAEAFLVNFTALIVVLFGASVVVAAVSPA 235
Cdd:PLN02680 168 VATATTGILEKATFLQSNKvISRYSTEAMLVNSLGILIVVLGGFVILAIVTPL 220
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 64-198 3.45e-55

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 173.56  E-value: 3.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099    64 VHPVLMLIGYIILGSEAIMVYKVLPTWK--HDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTI 141
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRlsKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 49388099   142 CLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFL 198
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 23-249 4.36e-48

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 157.88  E-value: 4.36e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  23 TMVLVWCIHFRGGLAFeaTNKNLIFNrfksvahisnvetlqVHPVLMLIGYIILGSEAIMVYKVLPTWKHDTTKLIHLIL 102
Cdd:cd08764   2 VLVGIWLGKFRGGFSW--TGPGLQFN---------------WHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVL 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099 103 HAIALVFGAVGIYCAFKFHN--ESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVY 180
Cdd:cd08764  65 HLLAFILAVIGLKAVFDSHNlaKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIF 144

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49388099 181 ILALATAELGFLEKLTFLQSSgLDKYGAEAFLVNFTALIVVLFGASVV--VAAVSPARVEEPHEYAPIPES 249
Cdd:cd08764 145 VLAVATALLGITEKAFFSLNK-YSNLPAEGVLGNFIGIVLVIFGGLVVylVTEPDYKRIELPEEEELLIQN 214
PLN02351 PLN02351
cytochromes b561 family protein
 64-234 4.94e-41

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 140.81  E-value: 4.94e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099   64 VHPVLMLIGYIILGSEAIMVYKVLPTwKHDTTKLIHLILHAIALVFGAVGIYCafKFHNESGI-ANLYSLHSWLGIGTIC 142
Cdd:PLN02351  53 LHPLLMVIGFILISGEAILVHRWLPG-SRKTKKSVHLWLQGLALASGVFGIWT--KFHGQDGIvANFYSLHSWMGLICVS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  143 LYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQSS-GLDKYGAEAFLVNFTALIVV 221
Cdd:PLN02351 130 LFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVFLGLYTYGLAVATAETGLLEKLTFLQTKrNVSKHGSESMVVNGLGLGLA 209

                        170
                 ....*....|...
gi 49388099  222 LFGASVVVAAVSP 234
Cdd:PLN02351 210 LLSGIVILAAVLP 222
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 64-191 8.48e-41

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 136.59  E-value: 8.48e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099     64 VHPVLMLIGYIILGSEAIMVYKVL-PTWKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTIC 142
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLtRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 49388099    143 LYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGF 191
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 62-191 6.81e-35

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 121.62  E-value: 6.81e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  62 LQVHPVLMLIGYIILGSEAIMVYKVLPTWKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTI 141
Cdd:cd08554   2 FNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLATV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 49388099 142 CLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGF 191
Cdd:cd08554  82 LLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 64-197 1.08e-31

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 113.76  E-value: 1.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  64 VHPVLMLIGYIILGSEAIMVYKVLPTWKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICL 143
Cdd:cd08763   9 VHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSWCGILTFVL 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 49388099 144 YGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTF 197
Cdd:cd08763  89 YFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 24-197 1.09e-30

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 112.27  E-value: 1.09e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  24 MVLVWCIHFRGGLAFEATNKNliFNRfksvahisnvetlqvHPVLMLIGYIILGSEAIMVYKVLPTWKHDTT--KLIHLI 101
Cdd:cd08762  14 LVVHWNQMWRGGFAWDGSSKN--FNW---------------HPVLMVTGMVVLYGNAALVYRIPLTWGGPKLpwKLLHAG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099 102 LHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYI 181
Cdd:cd08762  77 LLLLAFILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILV 156

                       170
                ....*....|....*.
gi 49388099 182 LALATAELGFLEKLTF 197
Cdd:cd08762 157 LSIASCISGINEKLFF 172
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 65-197 8.46e-29

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 106.52  E-value: 8.46e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  65 HPVLMLIGYIILGSEAIMVYKVLPTWK--HDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTIC 142
Cdd:cd08765  15 HPVLMVIGFIFIQGIAIIVYRLPWTWKcsKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNMYSLHSWVGLAAVI 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 49388099 143 LYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTF 197
Cdd:cd08765  95 LYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIF 149
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 65-193 4.38e-15

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 71.17  E-value: 4.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  65 HPVLMLIGYIILGSEAIMVYKVLPTWKHDTTK---LIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTI 141
Cdd:cd08761  24 HPLLMSLGFLLLMTEALLLLQPTSSLTKLARKtkvRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGLVTV 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 49388099 142 CLYGIQWIFGFVAFFFPRASPSVRKGVLPW--HILFGLFVYILALATAELGFLE 193
Cdd:cd08761 104 ILIVLQALGGLALLYPPGLRRGESKAKKLKkyHRLSGYVAYLLGLATLVLGLET 157
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 62-191 3.07e-09

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 55.04  E-value: 3.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49388099  62 LQVHPVLMLIGYIILGSEAIMV----YKVLPTWKHdttklIHLILHAIALVFGAVGIYCAFKfHNESGIANLYSLHSWLG 137
Cdd:cd08760  36 IKAHGVLMAIAWGILMPIGALLaryfLLGDPVWFY-----LHAGLQLLAVLLAIAGFVLGIV-LVQGGGGSLNNAHAILG 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 49388099 138 IGTICLYGIQWIFGFvafFFPRASPSVRKGVLPWHILFGLFVYILALATAELGF 191
Cdd:cd08760 110 IIVLALAILQPLLGL---LRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGL 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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