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Conserved domains on  [gi|493690402|ref|WP_006640437|]
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MULTISPECIES: cysteine hydrolase family protein [Bacillus]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10003554)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

CATH:  3.40.50.850
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 7-173 2.02e-42

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 139.65  E-value: 2.02e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFqFDMGEALSKQTEEMTADLLALKKHAGNMNWPIIYINDHF---GIWQADIAAIIKKC-RNAKSERIIER 82
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHppdGSEFAEFDLWPPHCvPGTPGAELVPE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  83 LEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALT 162
Cdd:COG1335   80 LAPLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAALA 159

                        170
                 ....*....|.
gi 493690402 163 IMKDiLFAKIT 173
Cdd:COG1335  160 RLRA-AGATVV 169
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 7-173 2.02e-42

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 139.65  E-value: 2.02e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFqFDMGEALSKQTEEMTADLLALKKHAGNMNWPIIYINDHF---GIWQADIAAIIKKC-RNAKSERIIER 82
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHppdGSEFAEFDLWPPHCvPGTPGAELVPE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  83 LEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALT 162
Cdd:COG1335   80 LAPLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAALA 159

                        170
                 ....*....|.
gi 493690402 163 IMKDiLFAKIT 173
Cdd:COG1335  160 RLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 7-165 3.75e-40

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 133.55  E-value: 3.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFQFDMGEALSkQTEEMTADLLALKKHAGNMNWPIIYINDHFGIWQADIAAIIKK---CRNAKSERIIERL 83
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLLP-GADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAELLWPphcVKGTEGAELVPEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  84 EPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALTI 163
Cdd:cd00431   80 APLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHEAALER 159


                 ..
gi 493690402 164 MK 165
Cdd:cd00431  160 LA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 6-176 2.03e-37

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 127.13  E-value: 2.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402    6 TALIIVDIINDFqFDMGEALSKQTEEMTADLLALKKHAGNMNWPIIYINDHFGIWQADIAAIIKKCRNAKSE----RIIE 81
Cdd:pfam00857   1 TALLVIDMQNDF-VDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGttgaELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   82 RLEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYAL 161
Cdd:pfam00857  80 ELAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAAL 159

                         170
                  ....*....|....*
gi 493690402  162 TIMKDIlFAKITTAE 176
Cdd:pfam00857 160 ERLAQR-GAEVTTTE 173
PRK11440 PRK11440
putative hydrolase; Provisional
 83-154 1.77e-07

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 48.96  E-value: 1.77e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493690402  83 LEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKD-CIASNTE 154
Cdd:PRK11440  90 LGKTDSDIEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDaCSAASAE 162
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 7-173 2.02e-42

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 139.65  E-value: 2.02e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFqFDMGEALSKQTEEMTADLLALKKHAGNMNWPIIYINDHF---GIWQADIAAIIKKC-RNAKSERIIER 82
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHppdGSEFAEFDLWPPHCvPGTPGAELVPE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  83 LEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALT 162
Cdd:COG1335   80 LAPLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAALA 159

                        170
                 ....*....|.
gi 493690402 163 IMKDiLFAKIT 173
Cdd:COG1335  160 RLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 7-165 3.75e-40

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 133.55  E-value: 3.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFQFDMGEALSkQTEEMTADLLALKKHAGNMNWPIIYINDHFGIWQADIAAIIKK---CRNAKSERIIERL 83
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLLP-GADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAELLWPphcVKGTEGAELVPEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  84 EPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALTI 163
Cdd:cd00431   80 APLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHEAALER 159


                 ..
gi 493690402 164 MK 165
Cdd:cd00431  160 LA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 6-176 2.03e-37

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 127.13  E-value: 2.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402    6 TALIIVDIINDFqFDMGEALSKQTEEMTADLLALKKHAGNMNWPIIYINDHFGIWQADIAAIIKKCRNAKSE----RIIE 81
Cdd:pfam00857   1 TALLVIDMQNDF-VDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGttgaELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   82 RLEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYAL 161
Cdd:pfam00857  80 ELAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAAL 159

                         170
                  ....*....|....*
gi 493690402  162 TIMKDIlFAKITTAE 176
Cdd:pfam00857 160 ERLAQR-GAEVTTTE 173
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
6-179 4.89e-29

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 106.47  E-value: 4.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   6 TALIIVDIINDF--QFDMGEALSkqtEEMTADLLALKKHAGNMNWPIIY--------------INDhfgIWQADIAAiik 69
Cdd:COG1535   20 AALLIHDMQNYFlrPYDPDEPPI---RELVANIARLRDACRAAGIPVVYtaqpgdqtpedrglLND---FWGPGLTA--- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  70 kcrNAKSERIIERLEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCI 149
Cdd:COG1535   91 ---GPEGQEIVDELAPAPGDTVLTKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAV 167

                        170       180       190
                 ....*....|....*....|....*....|
gi 493690402 150 ASNTEKDNEYALTIMkDILFAKITTAENLI 179
Cdd:COG1535  168 ADFSREEHRMALEYV-AGRCGVVVTTDEVL 196
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 7-151 2.00e-16

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 72.24  E-value: 2.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFQF-DMGEALSKQTEEMTADLLAlkkHAGNMNWPIIYINDHFGiwqADIAAiikkCRNAKSERIIERLEP 85
Cdd:cd01014    1 ALLVIDVQNGYFDgGLPPLNNEAALENIAALIA---AARAAGIPVIHVRHIDD---EGGSF----APGSEGWEIHPELAP 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493690402  86 NENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIAS 151
Cdd:cd01014   71 LEGETVIEKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACAT 136
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 7-151 1.24e-12

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 62.80  E-value: 1.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   7 ALIIVDIINDFQFD---MGEALSKQTEEmTADLLALKKHAGnmnWPIIYIN--------DHfGIWQADIAAIIKKCRNAK 75
Cdd:cd01015    1 ALLVIDLVEGYTQPgsyLAPGIAAALEN-VQRLLAAARAAG---VPVIHTTvvydpdgaDG-GLWARKVPAMSDLVEGSP 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493690402  76 SERIIERLEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIAS 151
Cdd:cd01015   76 LAAICDELAPQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVRECVGD 151
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 77-162 4.17e-12

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 61.97  E-value: 4.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  77 ERIIERLEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKD 156
Cdd:cd01013  105 TKIVTELAPQPDDTVLTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLEE 184


                 ....*.
gi 493690402 157 NEYALT 162
Cdd:cd01013  185 HRMALK 190
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 94-181 1.46e-07

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 48.74  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  94 KPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEYALTIMKDIlFAKIT 173
Cdd:cd01012   68 KTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQA-GAVLT 146


                 ....*...
gi 493690402 174 TAENLINE 181
Cdd:cd01012  147 TSESVLFE 154
PRK11440 PRK11440
putative hydrolase; Provisional
 83-154 1.77e-07

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 48.96  E-value: 1.77e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493690402  83 LEPNENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKD-CIASNTE 154
Cdd:PRK11440  90 LGKTDSDIEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDaCSAASAE 162
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
97-165 7.75e-07

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 47.29  E-value: 7.75e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493690402  97 HSAFYG------TALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKD-CIASN-TEKDNEYALTIMK 165
Cdd:PRK11609 119 YSAFFDnghrqkTALDDWLREHGITELIVMGLATDYCVKFTVLDALALGYQVNVITDgCRGVNlQPQDSAHAFMEMS 195
PLN02621 PLN02621
nicotinamidase
 80-161 8.55e-07

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 47.08  E-value: 8.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  80 IERLEpnENDYFLIKPKHSAFYGTALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPKDCIASNTEKDNEY 159
Cdd:PLN02621  95 IGRVT--GPDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANEELHEA 172


                 ..
gi 493690402 160 AL 161
Cdd:PLN02621 173 TL 174
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 2-148 1.77e-06

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 46.21  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402   2 SNSDTALIIVDIINDF------QFDMGEALSKQTEEMTA----DLLALKK--HAGN--------------------MNWP 49
Cdd:PTZ00331   9 SSTNDALIIVDVQNDFckggslAVPDAEEVIPVINQVRQshhfDLVVATQdwHPPNhisfasnhgkpkilpdgttqGLWP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  50 IIYIND------HFGIWQADIAAIIKKCRNAKSEriierlepnendyflikpKHSAFYG-----TALETLLSELSISHLI 118
Cdd:PTZ00331  89 PHCVQGtkgaqlHKDLVVERIDIIIRKGTNRDVD------------------SYSAFDNdkgskTGLAQILKAHGVRRVF 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 493690402 119 ITGIAGNICVLFTANDAYMREYDITIPKDC 148
Cdd:PTZ00331 151 ICGLAFDFCVLFTALDAVKLGFKVVVLEDA 180
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 79-166 3.28e-05

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 42.64  E-value: 3.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493690402  79 IIERLEPNENDYFLIK------PKHSAFYG------TALETLLSELSISHLIITGIAGNICVLFTANDAYMREYDITIPK 146
Cdd:cd01011   91 LHPGLPVPDIDLIVRKgtnpdiDSYSAFFDndrrssTGLAEYLRERGIDRVDVVGLATDYCVKATALDALKAGFEVRVLE 170

                         90       100
                 ....*....|....*....|
gi 493690402 147 DCIASNTEKDNEYALTIMKD 166
Cdd:cd01011  171 DACRAVDPETIERAIEEMKE 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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