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Conserved domains on  [gi|49257479|gb|AAH73816|]
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Beta-1,4-mannosyltransferase-like [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 1-156 6.44e-64

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03816:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 411  Bit Score: 202.12  E-value: 6.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479   1 MERSAFMEL----DAGSRLVMHLREWPALLVSSTGWT-------------EFEQLTLDGH-NLPSLVCVITG-------- 54
Cdd:cd03816 202 EKHELFLELalfrELAEGAVSYKEGRPALLVSSTSWTpdedfsilldalkAYESSAATEPaLLPSLLCIITGkgplkemy 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479  55 -----------------------------SVDLGVCLHMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLV 105
Cdd:cd03816 282 lelikelklkkvtirtpwlsaedyprllaSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLV 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 49257479 106 FEDSEELAA-LQMLFSNFpdPAGKLNQFWKDLRESQQLRWDESWVQTVLPLV 156
Cdd:cd03816 362 FGDSEELAEqLIDLLSDF--DRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
 
Name Accession Description Interval E-value
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 1-156 6.44e-64

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 202.12  E-value: 6.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479   1 MERSAFMEL----DAGSRLVMHLREWPALLVSSTGWT-------------EFEQLTLDGH-NLPSLVCVITG-------- 54
Cdd:cd03816 202 EKHELFLELalfrELAEGAVSYKEGRPALLVSSTSWTpdedfsilldalkAYESSAATEPaLLPSLLCIITGkgplkemy 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479  55 -----------------------------SVDLGVCLHMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLV 105
Cdd:cd03816 282 lelikelklkkvtirtpwlsaedyprllaSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLV 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 49257479 106 FEDSEELAA-LQMLFSNFpdPAGKLNQFWKDLRESQQLRWDESWVQTVLPLV 156
Cdd:cd03816 362 FGDSEELAEqLIDLLSDF--DRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
PLN02275 PLN02275
transferase, transferring glycosyl groups
 35-119 6.45e-34

transferase, transferring glycosyl groups


Pssm-ID: 215155 [Multi-domain]  Cd Length: 371  Bit Score: 123.24  E-value: 6.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479   35 FEQLTLDGHNLPSLVcvitGSVDLGVCLHMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAA 114
Cdd:PLN02275 290 FRTMWLEAEDYPLLL----GSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNGLLFSSSSELAD 365


                 ....*.
gi 49257479  115 -LQMLF 119
Cdd:PLN02275 366 qLLELL 371
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 43-121 6.13e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 40.74  E-value: 6.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479  43 HNLPSLVCVITGSVDLGVclhMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELA-ALQMLF 119
Cdd:COG0438   8 KGLDLLLEALLAAADVFV---LPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAeAILRLL 84


                ..
gi 49257479 120 SN 121
Cdd:COG0438  85 ED 86
 
Name Accession Description Interval E-value
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 1-156 6.44e-64

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 202.12  E-value: 6.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479   1 MERSAFMEL----DAGSRLVMHLREWPALLVSSTGWT-------------EFEQLTLDGH-NLPSLVCVITG-------- 54
Cdd:cd03816 202 EKHELFLELalfrELAEGAVSYKEGRPALLVSSTSWTpdedfsilldalkAYESSAATEPaLLPSLLCIITGkgplkemy 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479  55 -----------------------------SVDLGVCLHMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLV 105
Cdd:cd03816 282 lelikelklkkvtirtpwlsaedyprllaSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLV 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 49257479 106 FEDSEELAA-LQMLFSNFpdPAGKLNQFWKDLRESQQLRWDESWVQTVLPLV 156
Cdd:cd03816 362 FGDSEELAEqLIDLLSDF--DRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
PLN02275 PLN02275
transferase, transferring glycosyl groups
 35-119 6.45e-34

transferase, transferring glycosyl groups


Pssm-ID: 215155 [Multi-domain]  Cd Length: 371  Bit Score: 123.24  E-value: 6.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479   35 FEQLTLDGHNLPSLVcvitGSVDLGVCLHMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAA 114
Cdd:PLN02275 290 FRTMWLEAEDYPLLL----GSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNGLLFSSSSELAD 365


                 ....*.
gi 49257479  115 -LQMLF 119
Cdd:PLN02275 366 qLLELL 371
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 43-121 6.13e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 40.74  E-value: 6.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49257479  43 HNLPSLVCVITGSVDLGVclhMSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELA-ALQMLF 119
Cdd:COG0438   8 KGLDLLLEALLAAADVFV---LPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAeAILRLL 84


                ..
gi 49257479 120 SN 121
Cdd:COG0438  85 ED 86
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 71-121 5.85e-03

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 36.75  E-value: 5.85e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 49257479  71 LPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELA-ALQMLFSN 121
Cdd:cd03801 280 FGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPpdDVEALAdALLRLLAD 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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