NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|492517312|ref|WP_005872680|]
View 

ABC transporter permease [Schaalia georgiae]

Protein Classification

ABC transporter permease( domain architecture ID 11427312)

ABC transporter permease similar to ABC oligopeptide transporter permease proteins (OppB, AppB, and AmiC), the transmembrane subunits (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Gene Ontology:  GO:0055085
PubMed:  18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-308 4.84e-116

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 337.04  E-value: 4.84e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAALGGDRgLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:COG0601    1 MLRYILRRLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPR-ATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AF-NGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:COG0601   80 SFvYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTASNAV------TLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPV 233
Cdd:COG0601  160 GWLPVSGRVSPwedfldALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492517312 234 ATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-308 4.84e-116

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 337.04  E-value: 4.84e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAALGGDRgLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:COG0601    1 MLRYILRRLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPR-ATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AF-NGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:COG0601   80 SFvYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTASNAV------TLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPV 233
Cdd:COG0601  160 GWLPVSGRVSPwedfldALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492517312 234 ATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
1-308 5.87e-62

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 199.65  E-value: 5.87e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAALGGDRGLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:PRK10914   1 MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AFNGQ-QVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:PRK10914  81 SLKSRiPVWDEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTA----------SNAVT-------------------LESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTA 210
Cdd:PRK10914 161 NLTPVSGrvsdmvflddSNPLTgfmlidtaiwgedgnfidaVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 211 RAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVA 290
Cdd:PRK10914 241 RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILV 320

                        330
                 ....*....|....*...
gi 492517312 291 NLLVDLLYAVLDPRIRYE 308
Cdd:PRK10914 321 NLLVDLLYGVVNPRIRHK 338
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 113-307 6.09e-22

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 90.82  E-value: 6.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  113 GITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVklgwlpttasnaVTLESLTMPAMVLGGVSLAYVIR 192
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAIL------------SILGHGILPAIILALLGWAGYAR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  193 LTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGE 272
Cdd:pfam00528  69 LIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYD 148

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 492517312  273 PQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRY 307
Cdd:pfam00528 149 YPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 95-296 1.44e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.77  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  95 FPVTIRLALYAMAIETVLGITLGVIAGVKRGgWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKLGWLpttasnavTLES 174
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWG--------ILPG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 175 LTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGI 254
Cdd:cd06261   72 LGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 492517312 255 FNIHGVGGTLWNAIIKgepQTVVSVTTVLVLVYIVANLLVDL 296
Cdd:cd06261  152 GGGEAPGPGTGLLLIF---AILFPGDLGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-308 4.84e-116

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 337.04  E-value: 4.84e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAALGGDRgLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:COG0601    1 MLRYILRRLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPR-ATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AF-NGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:COG0601   80 SFvYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTASNAV------TLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPV 233
Cdd:COG0601  160 GWLPVSGRVSPwedfldALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492517312 234 ATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
1-308 5.87e-62

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 199.65  E-value: 5.87e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAALGGDRGLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:PRK10914   1 MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AFNGQ-QVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:PRK10914  81 SLKSRiPVWDEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTA----------SNAVT-------------------LESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTA 210
Cdd:PRK10914 161 NLTPVSGrvsdmvflddSNPLTgfmlidtaiwgedgnfidaVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 211 RAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVA 290
Cdd:PRK10914 241 RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILV 320

                        330
                 ....*....|....*...
gi 492517312 291 NLLVDLLYAVLDPRIRYE 308
Cdd:PRK10914 321 NLLVDLLYGVVNPRIRHK 338
PRK10352 PRK10352
nickel transporter permease NikB; Provisional
 1-306 7.55e-58

nickel transporter permease NikB; Provisional


Pssm-ID: 182400 [Multi-domain]  Cd Length: 314  Bit Score: 188.37  E-value: 7.55e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPvaALGGDRgLS-----EAAAAQIRAQYNLDKPFWMQYLLYLKGVFT 75
Cdd:PRK10352   1 MLRYILRRLLLLIPMLLAASVIIFLMLRLGTGDP--ALDYLR-LSnlpptPEMLASTRTMLGLDQPLYVQYGTWLWKALH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  76 LDFGKAF-NGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFF 154
Cdd:PRK10352  78 LDFGISFaTQRPVLDDLLNFLPATLELAGAALVLILLTSVPLGIWAARHRDRLPDFAVRFIAFLGVSMPNFWLAFLLVMA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 155 LGVKLGWLPttASNAVTLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVA 234
Cdd:PRK10352 158 FSVYLQWLP--AMGYGGWQHIILPAVSIAFMSLAINARLLRASMLEVAGQRHVTWARLRGLSERQVERRHILRNASLPMI 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492517312 235 TFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIR 306
Cdd:PRK10352 236 TAVGMHIGELIGGTMIIENIFAWPGVGRYAVSAIFNRDYPVIQCFTLMMVVVFVVCNLIVDLLNAALDPRIR 307
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 1-308 1.49e-57

glutathione ABC transporter permease GsiC; Provisional


Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 187.61  E-value: 1.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPvAALGGDRGLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:PRK15081   1 MLNYVIKRLLGLIPTLLIVAVLVFLFVHLLPGDP-ARLAAGPEADAQVVALVRQQLGLDQPLPHQFWHYISNALQGDFGT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AFNGQQ-VIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:PRK15081  80 SMVSRRpVSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVEL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTASNavTLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGG 239
Cdd:PRK15081 160 GWLPTVGAD--SWQHYILPSLTLGAAVAAVMARFTRASFVEVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGL 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492517312 240 DLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:PRK15081 238 QFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPAIRYK 306
oppB PRK09471
oligopeptide ABC transporter permease OppB;
1-307 1.23e-54

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 179.88  E-value: 1.23e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPVAalgGDRGLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGK 80
Cdd:PRK09471   1 MLKFILRRCLEAIPTLFILITISFFMMRLAPGSPFT---GERTLPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  81 AFN--GQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVK 158
Cdd:PRK09471  78 SFKykDYSVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAIT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 159 LGWLPTTASNAVTLESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLG 238
Cdd:PRK09471 158 LHWLPGGGWNGGALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMG 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492517312 239 GDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRY 307
Cdd:PRK09471 238 PAFVGIITGSMVIETIFGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKIRY 306
YejB COG4174
ABC-type microcin C transport system, permease component YejB [Secondary metabolites ...
 1-308 2.49e-36

ABC-type microcin C transport system, permease component YejB [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443333 [Multi-domain]  Cd Length: 363  Bit Score: 133.39  E-value: 2.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPV------------AALG----------------------GDRGLSE 46
Cdd:COG4174    1 MGAYILRRLLLMIPTLLGIMLINFVIVQFAPGGPVeqviaqlqgtggGATGrisggggdagggaaagggskyrGARGLDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  47 AAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGKA-FNGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRG 125
Cdd:COG4174   81 EFIAELEKQYGFDKPAHERFLLMLKNYLRFDFGESyFRDISVIDLILEKLPVSISLGLWSTLLTYLISIPLGIRKAVRDG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 126 GWFD---STVLVLSLAlisVPTFVLGFVLQFFL--GVKLGWLPT---TASNAVTLE----------SLTMP--AMVLGGv 185
Cdd:COG4174  161 SRFDvwtSTVIIVGYA---IPGFLFAILLIVLFagGSYFDWFPLrglTSDNWDQLSwwgkildylwHLTLPvtAMVIGG- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 186 sLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPV-ATFLGGDLGALMGGAIITEGIFNIHGVGGTL 264
Cdd:COG4174  237 -FATLTLLTKNSFLDEIRKQYVLTARAKGLSERRVLYGHVFRNAMLIViAGFPAAFIGAFFTGSLLIETIFSLDGLGLLG 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 492517312 265 WNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:COG4174  316 FEAVVNRDYPVVFGTLYIFTLIGLVLKLISDLTYVLVDPRIDFE 359
PRK15110 PRK15110
peptide ABC transporter permease SapB;
1-303 4.13e-31

peptide ABC transporter permease SapB;


Pssm-ID: 185065 [Multi-domain]  Cd Length: 321  Bit Score: 118.64  E-value: 4.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPvaalggdrgLSEAAaaqiraqynldkpFWMQYLLYLKGVFTLDFG- 79
Cdd:PRK15110   1 MIIFTLRRLLLLIVTLFLLTLVGFSLSYFTPHAP---------LQGAS-------------LWDAWVFWFNGLLHWDFGv 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  80 KAFNGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKL 159
Cdd:PRK15110  59 SSINGQPISEQLKEVFPATMELCILAFGFALLVGIPVGIIAGVTRHKWQDNLISALALLGFSIPVFWLALLLTLFFSLTL 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 160 GWLPTTAS-------NAVT----------------------LESLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTA 210
Cdd:PRK15110 139 GWLPVSGRfdllyevKPVTgfalidawlsdspwrdemimsaIRHMILPVITLAVAPTTEVIRLMRISTIEVYDQNYVKAA 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 211 RAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGEPQTVVSVTTVLVLVYIVA 290
Cdd:PRK15110 219 ATRGLSRFTILRRHVLHNALPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIIV 298

                        330
                 ....*....|...
gi 492517312 291 NLLVDLLYAVLDP 303
Cdd:PRK15110 299 NVLSDILGAMANP 311
PRK15133 PRK15133
microcin C ABC transporter permease YejB; Provisional
 1-308 4.47e-26

microcin C ABC transporter permease YejB; Provisional


Pssm-ID: 185087 [Multi-domain]  Cd Length: 364  Bit Score: 105.98  E-value: 4.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312   1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPV---------------------------AALG----------GDRG 43
Cdd:PRK15133   1 MGAYLIRRLLLVIPTLWAIITINFFIVQIAPGGPVdqaiaaiefgqagglpgaggegvrashAQTGvgnisdsnyrGGRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  44 LSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFTLDFGKA-FNGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGV 122
Cdd:PRK15133  81 LDPEVIAEITHRYGFDKPLHERYFKMLWDYIRFDFGDSlFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGIRKAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 123 KRGGWFD---STVLVLSLAlisVPTFVLGFVLQFFL--GVKLGWLPT---TASNAVTLE----------SLTMP--AMVL 182
Cdd:PRK15133 161 RNGSRFDvwsSAFIIIGYA---IPAFLFAILLIVFFagGSYFDLFPLrglVSANFDSLPwyqkitdylwHITLPvlATVI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 183 GGvsLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNS-LIPVATFLGGDLGALMGGAIITEGIFNIHGVG 261
Cdd:PRK15133 238 GG--FAALTMLTKNSFLDEIRKQYVVTARAKGVSEKNILWKHVFRNAmLLVIAGFPATFISMFFTGSLLIEVMFSLNGLG 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 492517312 262 GTLWNAIIKGEPQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRYE 308
Cdd:PRK15133 316 LLGYEATVSRDYPVMFGTLYIFTLIGLLLNIVSDISYTLVDPRIDFE 362
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 113-307 6.09e-22

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 90.82  E-value: 6.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  113 GITLGVIAGVKRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVklgwlpttasnaVTLESLTMPAMVLGGVSLAYVIR 192
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAIL------------SILGHGILPAIILALLGWAGYAR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  193 LTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGIFNIHGVGGTLWNAIIKGE 272
Cdd:pfam00528  69 LIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYD 148

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 492517312  273 PQTVVSVTTVLVLVYIVANLLVDLLYAVLDPRIRY 307
Cdd:pfam00528 149 YPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 90-252 1.36e-15

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 75.15  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  90 VIAGAfPVTIRLALYAMAIETVLGITLGVIAGVkRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVklgwlpttasna 169
Cdd:COG1173   74 LLYGA-RISLLVGLLAVLIALVIGVLLGLLAGY-FGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGP------------ 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 170 vtleSLTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDlgalMGGAI 249
Cdd:COG1173  140 ----GLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLG----IASAI 211


                 ...
gi 492517312 250 ITE 252
Cdd:COG1173  212 LAE 214
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 95-296 1.44e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.77  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  95 FPVTIRLALYAMAIETVLGITLGVIAGVKRGgWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKLGWLpttasnavTLES 174
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWG--------ILPG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 175 LTMPAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALMGGAIITEGI 254
Cdd:cd06261   72 LGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 492517312 255 FNIHGVGGTLWNAIIKgepQTVVSVTTVLVLVYIVANLLVDL 296
Cdd:cd06261  152 GGGEAPGPGTGLLLIF---AILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1_N pfam19300
Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal ...
 1-102 2.08e-13

Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal transmembrane domain of the Binding-protein-dependent transport system inner membrane component.


Pssm-ID: 437132 [Multi-domain]  Cd Length: 114  Bit Score: 65.32  E-value: 2.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312    1 MLRYIGRRLLQTIPVFFGATFLIFAMVYLMPGDPvAALGGDRGLSEAAAAQIRAQYNLDKPFWMQYLLYLKGVFT-LDF- 78
Cdd:pfam19300   1 MLRFLVRRTLGAVVILLIISAVTFFLFYAIPRDP-ARLACGKNCTPETLALIRHNLGLDKPIPVQYWHFLSGIFAgRDFg 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 492517312   79 ----------GKAF-NGQQVIDVIAGAFPVTIRLA 102
Cdd:pfam19300  80 avghcpapclGYSFaNNEPVWDTIMDRFPTTLSLA 114
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 95-237 1.08e-07

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 52.46  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  95 FPVTIRLALYAMAIETVLGITLGVIAGVkRGGWFD----------STVLVLSLALISVPTFVLGFVLQFFLGVKLGWlpt 164
Cdd:COG4239  140 FRISVLFGLALTVISSVIGVAAGAVQGY-FGGRVDllfqrfieiwSSMPELYLLIILSSIFQPSFWLLLGILLLFGW--- 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492517312 165 tasnavtlesltmpamvlggVSLAYVIRL----TRQsvsqnvsADYVRTARAKGLPGGVVMTRHILRNSLIPVATFL 237
Cdd:COG4239  216 --------------------MGLVGVVRAeflrARN-------LEYVRAARALGVSDRRIMFRHILPNAMVATLTFL 265
nikC PRK10417
nickel transporter permease NikC; Provisional
 91-245 1.28e-04

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 42.73  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  91 IAGAfPVTIRLALYAMAIETVLGITLGVIAGVkRGGWFDSTVLVLSLALISVPTFVLGFvlqFFLGVklgwLPTTASNAV 170
Cdd:PRK10417  63 MAGT-RVSLGSVMACLLLVLALGLVIGGSAGL-LGGRVDQATMRVADMFMTFPTSILAF---FMVGV----LGTGLTNVI 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492517312 171 TLESLTmpamvlggvSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGALM 245
Cdd:PRK10417 134 IAIALS---------HWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATLDIGHMM 199
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
111-233 1.81e-04

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 42.46  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 111 VLGITLGVIAGVkRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGVKLGwlptTASNAVTLesltmpamvlggVSLAYV 190
Cdd:PRK10913 114 VMGVILGLIAGY-FGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIV----NAALALTF------------VALPHY 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 492517312 191 IRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPV 233
Cdd:PRK10913 177 VRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPL 219
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
98-249 3.82e-03

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 38.26  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  98 TIRLALYAMAIETVLGITLGVIAGVkRGGWFDSTVLVLSLALISVPTFVLGFVLQFFLGvklgwlpttasnavtlESLTM 177
Cdd:PRK09881  96 SILAGLVVVAIAGMIGSLLGCLSGV-LGGRADAIIMRIMDIMLSIPSLVLTMALAAALG----------------PSLFN 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492517312 178 PAMVLGGVSLAYVIRLTRQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVATFLGGDLGA--LMGGAI 249
Cdd:PRK09881 159 AMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSaiLMAATL 232
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 78-237 5.88e-03

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 38.04  E-value: 5.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312  78 FGKAFNGQQVIDVIAGAFPVTIRLALYAMAIETVLGITLGVIAGVKRGG---WFDSTVLVLSlaliSVPTFVLGFVLQFF 154
Cdd:PRK15021 123 LGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKvdlWGQRFIEVWS----GMPTLFLIILLSSV 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492517312 155 LGVKLGWLPttasnAVTLesltmpamVLGGVSLAYVIRltrQSVSQNVSADYVRTARAKGLPGGVVMTRHILRNSLIPVA 234
Cdd:PRK15021 199 VQPNFWWLL-----AITV--------LFGWMSLVGVVR---AEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATL 262


                 ...
gi 492517312 235 TFL 237
Cdd:PRK15021 263 TFL 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH