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Conserved domains on  [gi|49227854|ref|NP_115662|]
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mediator of RNA polymerase II transcription subunit 10 [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 10( domain architecture ID 10560945)

mediator of RNA polymerase II transcription subunit 10 is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 9-126 1.86e-54

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


:

Pssm-ID: 462879  Cd Length: 119  Bit Score: 166.53  E-value: 1.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227854     9 EEHLEKFVENIRQLGIIVSDFQP-SSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLER 87
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGtESQEVLNQKINTLVSSLQELDKLKSDLQDIQVPLEVIQYIDDGRNPDIYTREFVEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 49227854    88 ALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRS 126
Cdd:pfam09748  81 VRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 9-126 1.86e-54

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


Pssm-ID: 462879  Cd Length: 119  Bit Score: 166.53  E-value: 1.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227854     9 EEHLEKFVENIRQLGIIVSDFQP-SSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLER 87
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGtESQEVLNQKINTLVSSLQELDKLKSDLQDIQVPLEVIQYIDDGRNPDIYTREFVEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 49227854    88 ALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRS 126
Cdd:pfam09748  81 VRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 9-126 1.86e-54

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


Pssm-ID: 462879  Cd Length: 119  Bit Score: 166.53  E-value: 1.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227854     9 EEHLEKFVENIRQLGIIVSDFQP-SSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLER 87
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGtESQEVLNQKINTLVSSLQELDKLKSDLQDIQVPLEVIQYIDDGRNPDIYTREFVEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 49227854    88 ALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRS 126
Cdd:pfam09748  81 VRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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