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Conserved domains on  [gi|492014357|ref|WP_005717623|]
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MULTISPECIES: shikimate kinase AroK [Pasteurella]

Protein Classification

shikimate kinase( domain architecture ID 10792380)

shikimate kinase catalyzes the specific phosphorylation of the 3-hydroxylgroup of shikimic acid using ATP as a cosubstrate

EC:  2.7.1.71

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
aroK PRK05057
shikimate kinase AroK;
1-170 1.72e-112

shikimate kinase AroK;


:

Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 317.04  E-value: 1.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   1 MAEKRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLST 80
Cdd:PRK05057   1 MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  81 GGGAVLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAK 160
Cdd:PRK05057  81 GGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQ-VDDPREVLEALANERNPLYEEIADVTIRTDDQSAK 159

                        170
                 ....*....|
gi 492014357 161 VMATQIVDLI 170
Cdd:PRK05057 160 VVANQIIHML 169
 
Name Accession Description Interval E-value
aroK PRK05057
shikimate kinase AroK;
1-170 1.72e-112

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 317.04  E-value: 1.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   1 MAEKRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLST 80
Cdd:PRK05057   1 MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  81 GGGAVLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAK 160
Cdd:PRK05057  81 GGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQ-VDDPREVLEALANERNPLYEEIADVTIRTDDQSAK 159

                        170
                 ....*....|
gi 492014357 161 VMATQIVDLI 170
Cdd:PRK05057 160 VVANQIIHML 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-170 1.05e-82

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 241.19  E-value: 1.05e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVL 86
Cdd:COG0703    1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  87 SKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAKVMATQI 166
Cdd:COG0703   81 SPENRELLKEHGTVVYLDASPETLLERLRRDDNRPLLQ-GEDPRERLEELLAEREPLYREVADITVDTDGRSPEEVVDEI 159


                 ....
gi 492014357 167 VDLI 170
Cdd:COG0703  160 LEAL 163
SKI pfam01202
Shikimate kinase;
13-170 3.17e-71

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 212.06  E-value: 3.17e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   13 MGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVLSKENRN 92
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492014357   93 HLSARGIVIYLETTVEKQYQRTQRDKKRPLLQEVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAKVMATQIVDLI 170
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKRDKTRPLLQNKDPEEELLELLFEERDPLYEEAADIVIDTDESSPEEVATEILEAL 158
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 6-158 8.89e-69

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 205.87  E-value: 8.89e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   6 NIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAV 85
Cdd:cd00464    1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492014357  86 LSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQevEDPRQVLEDLAKIRNPLYEEIADITLPTDEQS 158
Cdd:cd00464   81 LREENRRLLLENGIVVWLDASPEELLERLARDKTRPLLQ--DEDPERLRELLEEREPLYREVADLTIDTDELS 151
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 4-78 8.14e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.12  E-value: 8.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357     4 KRNIFLIGPMGAGKSTIGRQLAQLLSMD-----FVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVL 78
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDV 81
 
Name Accession Description Interval E-value
aroK PRK05057
shikimate kinase AroK;
1-170 1.72e-112

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 317.04  E-value: 1.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   1 MAEKRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLST 80
Cdd:PRK05057   1 MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  81 GGGAVLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAK 160
Cdd:PRK05057  81 GGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQ-VDDPREVLEALANERNPLYEEIADVTIRTDDQSAK 159

                        170
                 ....*....|
gi 492014357 161 VMATQIVDLI 170
Cdd:PRK05057 160 VVANQIIHML 169
aroK PRK00131
shikimate kinase; Reviewed
 1-174 1.84e-92

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 266.28  E-value: 1.84e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   1 MAEKRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLST 80
Cdd:PRK00131   1 MLKGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVIST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  81 GGGAVLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAK 160
Cdd:PRK00131  81 GGGAVLREENRALLRERGTVVYLDASFEELLRRLRRDRNRPLLQ-TNDPKEKLRDLYEERDPLYEEVADITVETDGRSPE 159

                        170
                 ....*....|....
gi 492014357 161 VMATQIVDLIDNLH 174
Cdd:PRK00131 160 EVVNEILEKLEAAW 173
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-170 1.05e-82

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 241.19  E-value: 1.05e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVL 86
Cdd:COG0703    1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  87 SKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAKVMATQI 166
Cdd:COG0703   81 SPENRELLKEHGTVVYLDASPETLLERLRRDDNRPLLQ-GEDPRERLEELLAEREPLYREVADITVDTDGRSPEEVVDEI 159


                 ....
gi 492014357 167 VDLI 170
Cdd:COG0703  160 LEAL 163
SKI pfam01202
Shikimate kinase;
13-170 3.17e-71

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 212.06  E-value: 3.17e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   13 MGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVLSKENRN 92
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492014357   93 HLSARGIVIYLETTVEKQYQRTQRDKKRPLLQEVEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAKVMATQIVDLI 170
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKRDKTRPLLQNKDPEEELLELLFEERDPLYEEAADIVIDTDESSPEEVATEILEAL 158
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 6-158 8.89e-69

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 205.87  E-value: 8.89e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   6 NIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAV 85
Cdd:cd00464    1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492014357  86 LSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQevEDPRQVLEDLAKIRNPLYEEIADITLPTDEQS 158
Cdd:cd00464   81 LREENRRLLLENGIVVWLDASPEELLERLARDKTRPLLQ--DEDPERLRELLEEREPLYREVADLTIDTDELS 151
PRK13946 PRK13946
shikimate kinase; Provisional
 4-172 7.06e-51

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 161.25  E-value: 7.06e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   4 KRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGG 83
Cdd:PRK13946  10 KRTVVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARLLKGGPLVLATGGG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  84 AVLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEiADITLPTDEQSAKVMA 163
Cdd:PRK13946  90 AFMNEETRAAIAEKGISVWLKADLDVLWERVSRRDTRPLLR-TADPKETLARLMEERYPVYAE-ADLTVASRDVPKEVMA 167


                 ....*....
gi 492014357 164 TQIVDLIDN 172
Cdd:PRK13946 168 DEVIEALAA 176
PRK13947 PRK13947
shikimate kinase; Provisional
 5-175 1.57e-38

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 129.44  E-value: 1.57e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   5 RNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGA 84
Cdd:PRK13947   2 KNIVLIGFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEKLLVKKLARLKNLVIATGGGV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  85 VLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKKRPLLQeVEDPRQVLEDLAKIRNPLYeEIADITLPTDEQSAKVMAT 164
Cdd:PRK13947  82 VLNPENVVQLRKNGVVICLKARPEVILRRVGKKKSRPLLM-VGDPEERIKELLKEREPFY-DFADYTIDTGDMTIDEVAE 159

                        170
                 ....*....|.
gi 492014357 165 QIVDLIDNLHG 175
Cdd:PRK13947 160 EIIKAYLKLKN 170
aroL PRK03731
shikimate kinase AroL;
7-170 8.89e-36

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 122.36  E-value: 8.89e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQrQGIVLSTGGGAVL 86
Cdd:PRK03731   5 LFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTA-PSTVIATGGGIIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  87 SKENRNHLSARGIVIYLETTVEKQYQRTQRDKK---------RPLLQEVEDprqVLEDlakiRNPLYEEIADITLPTDeQ 157
Cdd:PRK03731  84 TEENRHFMRNNGIVIYLCAPVSVLANRLEANPEedqrptltgKPISEEVAE---VLAE----REALYREVAHHIIDAT-Q 155

                        170
                 ....*....|...
gi 492014357 158 SAKVMATQIVDLI 170
Cdd:PRK03731 156 PPSQVVSEILSAL 168
PRK13948 PRK13948
shikimate kinase; Provisional
 9-168 6.57e-33

shikimate kinase; Provisional


Pssm-ID: 184413 [Multi-domain]  Cd Length: 182  Bit Score: 115.66  E-value: 6.57e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   9 LIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVLSK 88
Cdd:PRK13948  15 LAGFMGTGKSRIGWELSRALMLHFIDTDRYIERVTGKSIPEIFRHLGEAYFRRCEAEVVRRLTRLDYAVISLGGGTFMHE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  89 ENRNHLSARGIVIYLETTVEKQYQRTqRDKKRPLLQeVEDPRQVLEDLAKIRNPLYEEiADITLPTDEQSAKVMATQIVD 168
Cdd:PRK13948  95 ENRRKLLSRGPVVVLWASPETIYERT-RPGDRPLLQ-VEDPLGRIRTLLNEREPVYRQ-ATIHVSTDGRRSEEVVEEIVE 171
PRK13949 PRK13949
shikimate kinase; Provisional
 5-173 1.30e-30

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 109.05  E-value: 1.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   5 RNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGA 84
Cdd:PRK13949   2 ARIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  85 VLSKENRNHLSARGIVIYLETTVEKQYQRTQRDKK-RPLLQEVEDPR---QVLEDLAKiRNPLYEEiADITLPTDEQsak 160
Cdd:PRK13949  82 PCFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQqRPLLKGKSDEElldFIIEALEK-RAPFYRQ-AKIIFNADKL--- 156

                        170
                 ....*....|...
gi 492014357 161 VMATQIVDLIDNL 173
Cdd:PRK13949 157 EDESQIEQLVQRL 169
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
7-162 1.66e-27

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 106.91  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVL 86
Cdd:PRK13951   3 IFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLRELVERDNVVVATGGGVVI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  87 SKENRNHLSARGiVIYLETTVEKQYQRTQRDkKRPLLQE-VEDPRQVLEDlakiRNPLYEEI--ADITLPTD-EQSAKVM 162
Cdd:PRK13951  83 DPENRELLKKEK-TLFLYAPPEVLMERVTTE-NRPLLREgKERIREIWER----RKQFYTEFrgIDTSKLNEwETTALVV 156
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 9-171 3.41e-26

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 103.79  E-value: 3.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   9 LIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVLSK 88
Cdd:PRK14021  11 IIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDFDGIFSLGGGAPMTP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  89 ENRNHLSAR----GIVIYLETTVEKQYQRTQRDKKRPLLQevEDPRQVLEDLAKIRNPLYEEIADITLPTDEQSAKVMAT 164
Cdd:PRK14021  91 STQHALASYiahgGRVVYLDADPKEAMERANRGGGRPMLN--GDANKRWKKLFKQRDPVFRQVANVHVHTRGLTPQAAAK 168


                 ....*..
gi 492014357 165 QIVDLID 171
Cdd:PRK14021 169 KLIDMVA 175
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 2-170 9.93e-26

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 100.03  E-value: 9.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   2 AEKRNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQG-IVLST 80
Cdd:PRK08154 131 ARRRRIALIGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYRRLERRALERLIAEHEeMVLAT 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  81 GGGAVLSKENRNHLSARGIVIYLETTVEKQYQRT--QRDkKRPLlqevEDPRQVLEDLAKI---RNPLYEEiADITLPTD 155
Cdd:PRK08154 211 GGGIVSEPATFDLLLSHCYTVWLKASPEEHMARVraQGD-LRPM----ADNREAMEDLRRIlasREPLYAR-ADAVVDTS 284

                        170
                 ....*....|....*
gi 492014357 156 EQSAKVMATQIVDLI 170
Cdd:PRK08154 285 GLTVAQSLARLRELV 299
PLN02199 PLN02199
shikimate kinase
 5-125 1.34e-19

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 83.59  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   5 RNIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRA-GADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGG 83
Cdd:PLN02199 103 RSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMnGTSVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGG 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 492014357  84 AVLSKENRNHLSaRGIVIYLETTVEKQYQRTQR--DKKRPLLQE 125
Cdd:PLN02199 183 AVIRPINWKYMH-KGISIWLDVPLEALAHRIAAvgTDSRPLLHD 225
PRK00625 PRK00625
shikimate kinase; Provisional
 6-156 2.18e-14

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 67.09  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   6 NIFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADI----SWIFDVEGEDGFRKREERIINELTQRQGIVlSTG 81
Cdd:PRK00625   2 QIFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLIVSNYHGALysspKEIYQAYGEEGFCREEFLALTSLPVIPSIV-ALG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492014357  82 GGAVLSKENRNHLSARGIVIYLETTVEKQYQRTQrdkKRPLLQEVEDPRQvLEDLAKIRNPLYEEIADITLPTDE 156
Cdd:PRK00625  81 GGTLMIEPSYAHIRNRGLLVLLSLPIATIYQRLQ---KRGLPERLKHAPS-LEEILSQRIDRMRSIADYIFSLDH 151
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 7-136 2.79e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 47.30  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357    7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISWIfdvegeDGFRKREERIINELTQRQGIVLSTGGGAV- 85
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSI------SYYTDATDRTYERLHELARIALRAGRPVIl 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492014357   86 ----LSKENR-------NHLSARGIVIYLETTVEKQYQRT-QRDKKRPLLQEVedPRQVLEDL 136
Cdd:pfam13671  76 datnLRRDERarllalaREYGVPVRIVVFEAPEEVLRERLaARARAGGDPSDV--PEEVLDRQ 136
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
11-95 1.34e-06

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 46.36  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  11 GPMGAGKSTIGRQLAQLLSMDFVDSD--NEIEQRAGADISWI------------FDVEGEDGFRKREERIINELTQRQGI 76
Cdd:COG1102    7 REPGSGGTTIAKRLAEKLGLPLYDGEilREAAKERGLSEEEFekldekapsllyRDTAEEDEIDRALDKVIRELARKGNC 86

                         90
                 ....*....|....*....
gi 492014357  77 VLSTGGGAVLSKENRNHLS 95
Cdd:COG1102   87 VIVGRLADWILRDRPNVLK 105
AAA_18 pfam13238
AAA domain;
7-132 2.55e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 44.73  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357    7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEqragADISWIFDVEGEDGFRKREERIINELTQRQGIVLSTGGGAVL 86
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALE----NGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGNLI 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 492014357   87 SKENRNHLSARGIV----IYLETTVEKQYQR-TQRDKKRPLLQEVEDPRQV 132
Cdd:pfam13238  77 IDGHLAELEPERAKdlvgIVLRASPEELLERlEKRGYEEAKIKENEEAEIL 127
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
7-121 5.26e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.13  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSDNEIEQRAGADISwifdveGEDGFRKREERIINELTQRQGIVLSTGGGAVL 86
Cdd:COG0645    2 ILVCGLPGSGKSTLARALAERLGAVRLRSDVVRKRLFGAGLA------PLERSPEATARTYARLLALARELLAAGRSVIL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 492014357  87 -----SKENRNHL----SARGI---VIYLETTVEKQYQR-TQRDKKRP 121
Cdd:COG0645   76 datflRRAQREAFralaEEAGApfvLIWLDAPEEVLRERlEARNAEGG 123
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 7-36 2.15e-05

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 42.24  E-value: 2.15e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSD 36
Cdd:cd02021    2 IVVMGVSGSGKSTVGKALAERLGAPFIDGD 31
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-155 8.13e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 40.55  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357  11 GPMGAGKSTIGRQLAQLLSMDFVDS----DNEIEQRAGAdISWIFDVegedgfRKREERIINELTQRQGIVL-STGGGAV 85
Cdd:cd02020    6 GPAGSGKSTVAKLLAKKLGLPYLDTggirTEEVGKLASE-VAAIPEV------RKALDERQRELAKKPGIVLeGRDIGTV 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492014357  86 LSKENRnhlsargIVIYLETTVEKQYQRtqRDKKRPLLQEVEDPRQVLEDLAKiR---------NPLYEEIADITLPTD 155
Cdd:cd02020   79 VFPDAD-------LKIFLTASPEVRAKR--RAKQLQAKGEGVDLEEILAEIIE-RderdstryvAPLKLAEDAIVIDTS 147
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 13-97 1.91e-04

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 39.92  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   13 MGAGKSTIGRQLAQLLSMDFVDSD--NEIEQRAGADISWI----------------------FDVEGEDGFRKREERIIN 68
Cdd:pfam13189   8 YGSGGTTIAKKLAEKLGYPFYDREilDEIAKELGISEEEFelfdeksrlssflyslaggrvrGDALSDDRLFDAQSKVIR 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 492014357   69 ELT-QRQGIVLSTGGGAVLsKENRNHLSAR 97
Cdd:pfam13189  88 ELAaEDNCVIVGRGADYIL-KDIPNVLRVF 116
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 7-36 1.97e-04

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 39.73  E-value: 1.97e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLLSMDFVDSD 36
Cdd:COG3265    4 IVVMGVSGSGKSTVGQALAERLGWPFIDGD 33
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 4-78 8.14e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.12  E-value: 8.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357     4 KRNIFLIGPMGAGKSTIGRQLAQLLSMD-----FVDSDNEIEQRAGADISWIFDVEGEDGFRKREERIINELTQRQGIVL 78
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDV 81
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 7-28 9.00e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 36.16  E-value: 9.00e-04
                         10        20
                 ....*....|....*....|..
gi 492014357   7 IFLIGPMGAGKSTIGRQLAQLL 28
Cdd:cd02019    2 IAITGGSGSGKSTVAKKLAEQL 23
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
 5-56 1.03e-03

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 38.77  E-value: 1.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492014357   5 RNIFLIGPMGAGKSTigrqLAQLLSMDFvdsdneieQRAGADIsWIFDVEGE 56
Cdd:COG3451  205 GNTLILGPSGSGKSF----LLKLLLLQL--------LRYGARI-VIFDPGGS 243
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
11-35 1.27e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 38.08  E-value: 1.27e-03
                         10        20
                 ....*....|....*....|....*
gi 492014357  11 GPMGAGKSTIGRQLAQLLSMDFVDS 35
Cdd:COG0283    7 GPAGSGKSTVAKALAKRLGYHYLDT 31
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
1-78 2.61e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 36.88  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   1 MAEKRnIFLIGPMGAGKSTIGRQLAQllsmDFVDSDNE---IeqraGADIS-------------WIFDVEGEDGFRKREE 64
Cdd:COG1100    1 MGEKK-IVVVGTGGVGKTSLVNRLVG----DIFSLEKYlstN----GVTIDkkelkldgldvdlVIWDTPGQDEFRETRQ 71

                         90
                 ....*....|....
gi 492014357  65 RIINELTQRQGIVL 78
Cdd:COG1100   72 FYARQLTGASLYLF 85
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 5-33 3.85e-03

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 36.20  E-value: 3.85e-03
                         10        20
                 ....*....|....*....|....*....
gi 492014357   5 RNIFLIGPMGAGKSTIGRQLAQLLSMDFV 33
Cdd:cd19498   47 KNILMIGPTGVGKTEIARRLAKLAGAPFI 75
COG4639 COG4639
Predicted kinase [General function prediction only];
7-146 4.95e-03

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 35.58  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492014357   7 IFLIGPMGAGKSTIGRQLA---QLLSMDFVD---SDNEIEQRAGADIswifdvegedgFRKREERIINELTQRQGIVL-S 79
Cdd:COG4639    5 VVLIGLPGSGKSTFARRLFaptEVVSSDDIRallGGDENDQSAWGDV-----------FQLAHEIARARLRAGRLTVVdA 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492014357  80 TGggavLSKENRNHL-------SARGIVIYLETTVEKQYQRtQRDKKRPLlqevedPRQVLEDLAKI--RNPLYEE 146
Cdd:COG4639   74 TN----LQREARRRLlalarayGALVVAVVLDVPLEVCLAR-NAARDRQV------PEEVIRRMLRRlrRPPLPEE 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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