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Conserved domains on  [gi|492005131|gb|AGL16451|]
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two-component system histidine kinase [Actinoplanes sp. N902-109]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
197-397 3.31e-23

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 97.38  E-value: 3.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 197 RVAIARDLHDTISHHVSAVGVVAAAARLSLGtpqlAGTGKTTGFLEQIEASGRAALGDLRRMLDLLHGNDADGVrqpGLT 276
Cdd:COG4585   54 RRRIARELHDGVGQSLSAIKLQLEAARRLLD----ADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDL---GLA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 277 -ALDELVEG-TRRAGLNVDLRLAGlRPEHLPDSLNLAAYRVIQEMLTNALRYGDG-HLDLGVTQTATELRLEATNR---M 350
Cdd:COG4585  127 aALEELAERlLRAAGIRVELDVDG-DPDRLPPEVELALYRIVQEALTNALKHAGAtRVTVTLEVDDGELTLTVRDDgvgF 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 492005131 351 TGGSGRGTGRGLDGIRHRVSLFGGSVTAGPAPDRPstWRTAIVLPLQ 397
Cdd:COG4585  206 DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGG--TRVRATLPLA 250
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
197-397 3.31e-23

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 97.38  E-value: 3.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 197 RVAIARDLHDTISHHVSAVGVVAAAARLSLGtpqlAGTGKTTGFLEQIEASGRAALGDLRRMLDLLHGNDADGVrqpGLT 276
Cdd:COG4585   54 RRRIARELHDGVGQSLSAIKLQLEAARRLLD----ADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDL---GLA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 277 -ALDELVEG-TRRAGLNVDLRLAGlRPEHLPDSLNLAAYRVIQEMLTNALRYGDG-HLDLGVTQTATELRLEATNR---M 350
Cdd:COG4585  127 aALEELAERlLRAAGIRVELDVDG-DPDRLPPEVELALYRIVQEALTNALKHAGAtRVTVTLEVDDGELTLTVRDDgvgF 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 492005131 351 TGGSGRGTGRGLDGIRHRVSLFGGSVTAGPAPDRPstWRTAIVLPLQ 397
Cdd:COG4585  206 DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGG--TRVRATLPLA 250
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-395 9.97e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 46.39  E-value: 9.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 312 AYRVIQEMLTNALRYGDG-HLDLGVTQTATELRLEATNRMTGGSGRGTGRG----LDGIRHRVSLFGGSVTAGPAPDRps 386
Cdd:cd16917    1 LYRIVQEALTNALKHAGAsRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGggfgLLGMRERAELLGGTLTIGSRPGG-- 78


                 ....*....
gi 492005131 387 TWRTAIVLP 395
Cdd:cd16917   79 GTRVTARLP 87
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 197-263 4.40e-03

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 35.67  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492005131  197 RVAIARDLHDTISHHVSAVGVVAAAARLSLgtPQLAGTGKTTgfLEQIEASGRAALGDLRRMLDLLH 263
Cdd:pfam07730   2 RNRIARELHDSVGQSLTAIKLQLELARRLL--DRDPEEAREQ--LDAIRELAREALQELRRLLGDLR 64
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
197-397 3.31e-23

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 97.38  E-value: 3.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 197 RVAIARDLHDTISHHVSAVGVVAAAARLSLGtpqlAGTGKTTGFLEQIEASGRAALGDLRRMLDLLHGNDADGVrqpGLT 276
Cdd:COG4585   54 RRRIARELHDGVGQSLSAIKLQLEAARRLLD----ADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDL---GLA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 277 -ALDELVEG-TRRAGLNVDLRLAGlRPEHLPDSLNLAAYRVIQEMLTNALRYGDG-HLDLGVTQTATELRLEATNR---M 350
Cdd:COG4585  127 aALEELAERlLRAAGIRVELDVDG-DPDRLPPEVELALYRIVQEALTNALKHAGAtRVTVTLEVDDGELTLTVRDDgvgF 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 492005131 351 TGGSGRGTGRGLDGIRHRVSLFGGSVTAGPAPDRPstWRTAIVLPLQ 397
Cdd:COG4585  206 DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGG--TRVRATLPLA 250
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-395 9.97e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 46.39  E-value: 9.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 312 AYRVIQEMLTNALRYGDG-HLDLGVTQTATELRLEATNRMTGGSGRGTGRG----LDGIRHRVSLFGGSVTAGPAPDRps 386
Cdd:cd16917    1 LYRIVQEALTNALKHAGAsRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGggfgLLGMRERAELLGGTLTIGSRPGG-- 78


                 ....*....
gi 492005131 387 TWRTAIVLP 395
Cdd:cd16917   79 GTRVTARLP 87
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 197-375 5.52e-05

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 45.00  E-value: 5.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 197 RVAIARDLHDTISHHVSAVGVVAAAARLSLGTPQLAGTGKTTGFL-EQIEASGRAALGDLR-RMLDLLhgndadgvrqpG 274
Cdd:COG3851  293 RREIARELHDEIGQNITAIRTQASILKRLAPQPEIEQSAQSIESLaLRIYDTTRRLLDRLRpAVLDEL-----------G 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492005131 275 L-TALDELVEGTRRA--GLNVDLRLAGlRPEHLPDSLNLAAYRVIQEMLTNALRYGD-GHLDLGVTQTATELRLEATNRM 350
Cdd:COG3851  362 LeEALRELPRELAFEepGISCQLDLRG-DPSLLDDTLQLTLYRLVQEALTNILKHAEaSQIRISLSQDKRLLSLEIRDDG 440

                        170       180
                 ....*....|....*....|....*..
gi 492005131 351 TGGSGRGTGRG--LDGIRHRVSLFGGS 375
Cdd:COG3851  441 IGLPPELRAKGfgLRGMRERVRALGGD 467
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 197-263 4.40e-03

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 35.67  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492005131  197 RVAIARDLHDTISHHVSAVGVVAAAARLSLgtPQLAGTGKTTgfLEQIEASGRAALGDLRRMLDLLH 263
Cdd:pfam07730   2 RNRIARELHDSVGQSLTAIKLQLELARRLL--DRDPEEAREQ--LDAIRELAREALQELRRLLGDLR 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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