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Conserved domains on  [gi|491559916|ref|WP_005417502|]
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MULTISPECIES: calcium/sodium antiporter [Aliivibrio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10734 super family cl32565
putative calcium/sodium:proton antiporter; Provisional
 19-320 6.33e-117

putative calcium/sodium:proton antiporter; Provisional


The actual alignment was detected with superfamily member PRK10734:

Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 340.08  E-value: 6.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:PRK10734  16 VYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  99 ISSAIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFACFIIAMLYIS-KNEQQNGDILLEEQESEIPEGVANGKA 177
Cdd:PRK10734  96 VHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIArLAERQGNDSLTREQLAELPREGGLPVA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 178 LFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAV 257
Cdd:PRK10734 176 FLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIV 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916 258 MGIPALINPSEISPDLMGRDFYVMLGVSILLLIMALGKSRSINRIEGGILVTCFCVYQGYLFL 320
Cdd:PRK10734 256 LGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYW 318
 
Name Accession Description Interval E-value
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 19-320 6.33e-117

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 340.08  E-value: 6.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:PRK10734  16 VYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  99 ISSAIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFACFIIAMLYIS-KNEQQNGDILLEEQESEIPEGVANGKA 177
Cdd:PRK10734  96 VHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIArLAERQGNDSLTREQLAELPREGGLPVA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 178 LFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAV 257
Cdd:PRK10734 176 FLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIV 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916 258 MGIPALINPSEISPDLMGRDFYVMLGVSILLLIMALGKSRSINRIEGGILVTCFCVYQGYLFL 320
Cdd:PRK10734 256 LGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYW 318
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
22-318 1.54e-101

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 299.74  E-value: 1.54e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  22 ADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLAISS 101
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 102 AIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFACFIIAMLYISKNEQQNGDillEEQESEIPEGVANGKALFWV 181
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEE---VEEELEEKPKMSLWKALLLL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 182 VVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAVMGIP 261
Cdd:COG0530  158 VLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491559916 262 ALINPSEISPDLMGRDFYVMLGVSILLLIMALGKsRSINRIEGGILVTCFCVYQGYL 318
Cdd:COG0530  238 ALITPIPVDPAVLSFDLPVMLAATLLLLGLLRTG-GRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 19-314 3.55e-68

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 215.27  E-value: 3.55e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:TIGR00367  15 IYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPII 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   99 ISSAIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFacfIIAMLYISKNEQQ-NGDILLEEQESEIPEGVANGKA 177
Cdd:TIGR00367  95 VDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILY---IVYLLFLVKNERWvKYDTYTEENLDENNRRPQIFFS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  178 LFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAV 257
Cdd:TIGR00367 172 LVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVG 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491559916  258 MGIPALINPSEISPDLMGRDFYVMLGVSILLLIMALgKSRSINRIEGGILVTCFCVY 314
Cdd:TIGR00367 252 LGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFK-TSMKLGRWEGILLLALYIAY 307
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 176-314 5.17e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 89.97  E-value: 5.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  176 KALFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNIL 255
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916  256 AVMGIPALINPSEISPDLMGRDFYVMLGVSILLLIMAL----GKSRSINRIEGGILVTCFCVY 314
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLllllPLFGRLSRFEGLVLLLLYIVY 143
 
Name Accession Description Interval E-value
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 19-320 6.33e-117

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 340.08  E-value: 6.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:PRK10734  16 VYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  99 ISSAIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFACFIIAMLYIS-KNEQQNGDILLEEQESEIPEGVANGKA 177
Cdd:PRK10734  96 VHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIArLAERQGNDSLTREQLAELPREGGLPVA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 178 LFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAV 257
Cdd:PRK10734 176 FLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIV 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916 258 MGIPALINPSEISPDLMGRDFYVMLGVSILLLIMALGKSRSINRIEGGILVTCFCVYQGYLFL 320
Cdd:PRK10734 256 LGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYW 318
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
22-318 1.54e-101

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 299.74  E-value: 1.54e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  22 ADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLAISS 101
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 102 AIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFACFIIAMLYISKNEQQNGDillEEQESEIPEGVANGKALFWV 181
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEE---VEEELEEKPKMSLWKALLLL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 182 VVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAVMGIP 261
Cdd:COG0530  158 VLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491559916 262 ALINPSEISPDLMGRDFYVMLGVSILLLIMALGKsRSINRIEGGILVTCFCVYQGYL 318
Cdd:COG0530  238 ALITPIPVDPAVLSFDLPVMLAATLLLLGLLRTG-GRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 19-314 3.55e-68

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 215.27  E-value: 3.55e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:TIGR00367  15 IYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPII 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   99 ISSAIIRRELPLMLMVTLLAGGIMFNNYLGFYEGLLLIGLFacfIIAMLYISKNEQQ-NGDILLEEQESEIPEGVANGKA 177
Cdd:TIGR00367  95 VDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILY---IVYLLFLVKNERWvKYDTYTEENLDENNRRPQIFFS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  178 LFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAV 257
Cdd:TIGR00367 172 LVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVG 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491559916  258 MGIPALINPSEISPDLMGRDFYVMLGVSILLLIMALgKSRSINRIEGGILVTCFCVY 314
Cdd:TIGR00367 252 LGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFK-TSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
19-146 1.17e-29

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 114.46  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:COG0530  165 VVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIP 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 491559916  99 ISSAIIRRELPLMLMVTLLAGGIMF-NNYLGFYEGLLLIGLFACFIIAM 146
Cdd:COG0530  245 VDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
192-319 1.25e-29

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 114.46  E-value: 1.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916 192 ANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAVMGIPALINPSEISP 271
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491559916 272 DLMGRDFYVMLGVSILLLIMALGksRSINRIEGGILVTCFCVYQGYLF 319
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLD--GTLSRIDGVILLLLYVLYLYYLI 126
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 176-314 5.17e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 89.97  E-value: 5.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  176 KALFWVVVGLILLPVGANMLIDNAVVIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNIL 255
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916  256 AVMGIPALINPSEISPDLMGRDFYVMLGVSILLLIMAL----GKSRSINRIEGGILVTCFCVY 314
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLllllPLFGRLSRFEGLVLLLLYIVY 143
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 19-148 9.23e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 84.19  E-value: 9.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   19 VWGADKLVFGSAALARNYGISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKPLA 98
Cdd:pfam01699  14 SVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGPVK 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 491559916   99 ISSAIIRRELPLMLMVTLLAGGIMFNNY------LGFYEGLLLIGLFACFIIAMLY 148
Cdd:pfam01699  94 VDSLLLKLDLGVLLLVALLLLLLLLLLLlplfgrLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 207-320 7.13e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 60.01  E-value: 7.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916   207 GMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAVMGIP----ALIN---PSEISPDLMgrdF- 278
Cdd:TIGR00927  964 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPwllfSLINglqPVPVSSNGL---Fc 1040

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 491559916   279 -YVMLGVSILLLI--MALGKSRsINRIEGgilVTCFCVYqgYLFL 320
Cdd:TIGR00927 1041 aIVLLFLMLLFVIssIASCKWR-MNKILG---FTMFLLY--FVFL 1079
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 37-147 7.69e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 53.85  E-value: 7.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916    37 GISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITAL-------IKPLAISS-----AII 104
Cdd:TIGR00927  964 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLlfslingLQPVPVSSnglfcAIV 1043

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 491559916   105 RRELPLMLMVTLLAG-GIMFNNYLGFYEGLLligLFACFIIAML 147
Cdd:TIGR00927 1044 LLFLMLLFVISSIAScKWRMNKILGFTMFLL---YFVFLIISVM 1084
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 201-263 2.10e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 52.69  E-value: 2.10e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916   201 VIAKYFGMSDLVIGLTIIALGTSLPELAASVAGVLKGEDDMAAGNIIGSNVFNILAVMGIPAL 263
Cdd:TIGR00927  485 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCAL 547
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 38-178 1.77e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.53  E-value: 1.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916    38 ISPLVIGMTILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALILGITALIKplaissaiirREL------PLM 111
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFS----------REIlnltwwPLF 561

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491559916   112 LMVTL----LAGGIMF--NNYLGFYEGLLLIGLFACFIIAMLYiskNEQQngDILLEEQESEIPegVANGKAL 178
Cdd:TIGR00927  562 RDVSFyildLMMLILFflDSLIAWWESLLLLLAYALYVFTMKW---NKQI--ELWVKEQLSRRP--VAKVMAL 627
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 37-90 4.29e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 42.09  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 491559916   37 GISPLVIGMTILAMGSSAPEMMVSAAAAL-DGKTDTAVGNVIGSNIANIALILGI 90
Cdd:TIGR00845 785 GLKDSVTAVVFVALGTSVPDTFASKVAATqDQYADASIGNVTGSNAVNVFLGIGV 839
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 169-260 5.06e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 41.70  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  169 PEGVANGKALFWV---VVGLILLPVGAnmlidnavvIAKYFG----MSDLVIGLTIIALGTSLPELAAS-VAGVLKGEDD 240
Cdd:TIGR00845 749 PTEYWGGWACFVVsilMIGVLTAFIGD---------LASHFGctigLKDSVTAVVFVALGTSVPDTFASkVAATQDQYAD 819

                          90       100
                  ....*....|....*....|
gi 491559916  241 MAAGNIIGSNVFNILAVMGI 260
Cdd:TIGR00845 820 ASIGNVTGSNAVNVFLGIGV 839
ChaA COG0387
Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];
19-148 2.87e-03

Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];


Pssm-ID: 440156 [Multi-domain]  Cd Length: 362  Bit Score: 38.99  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491559916  19 VWGADKLVFGSAALARNYGISPLVIGMtILAMGSSAPEMMVSAAAALDGKTDTAVGNVIGSNIANIALIlgitalIKPLA 98
Cdd:COG0387  230 VLLSEILVGSIEEAVEALGLPEAFVGV-IIAILVLAPEGLTAVRAARKNRLQLSLNIALGSALASIGLT------IPALV 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491559916  99 ISSAIIRRELPL--------MLMVTLLAGGIMFN----NYLgfyEGLLLIGLFACFIIAMLY 148
Cdd:COG0387  303 LISLLTGQPLTLgfnpfelvLLALTVLVSNLTFSdgrtNWL---EGAVHLALFAIYAFLFFF 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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