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Conserved domains on  [gi|491074719|ref|WP_004936341|]
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MULTISPECIES: LytTR family DNA-binding domain-containing protein [Serratia]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 7.96e-83

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 247.04  E-value: 7.96e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAPSRgshsINLIKDERIIVTDINDIYYAAA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----IFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 161 DEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTyiLRLSDLEfEVPVSRSKVKEFRK 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKNGE-EIPVSRRYKKEFKE 234


                 .
gi 491074719 241 L 241
Cdd:COG3279  235 W 235
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 7.96e-83

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 247.04  E-value: 7.96e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAPSRgshsINLIKDERIIVTDINDIYYAAA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----IFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 161 DEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTyiLRLSDLEfEVPVSRSKVKEFRK 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKNGE-EIPVSRRYKKEFKE 234


                 .
gi 491074719 241 L 241
Cdd:COG3279  235 W 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-119 3.25e-55

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 172.72  E-value: 3.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   3 AIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491074719  83 YKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALH 119
Cdd:cd17532   81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRL 117
PRK14084 PRK14084
DNA-binding response regulator;
1-244 1.91e-45

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 152.21  E-value: 1.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAPSRGSHSINL-IK-DERIIVTDINDIYYA 158
Cdd:PRK14084  81 TAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLpIEiDDKIHMLNQQDIIAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 159 AADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDlEFEVPVSRSKVKEF 238
Cdd:PRK14084 161 GVHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVEQWFNYTYQVILTN-GVKMQVSRSFMKDF 239


                 ....*.
gi 491074719 239 RKLMRL 244
Cdd:PRK14084 240 KASIGL 245
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-242 1.25e-33

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 116.92  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  145 ERIIVTDINDIYYAAADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDl 224
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKN- 79

                          90
                  ....*....|....*...
gi 491074719  225 EFEVPVSRSKVKEFRKLM 242
Cdd:pfam04397  80 GEKIPVSRRYLKELKELL 97
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-241 8.67e-31

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 109.59  E-value: 8.67e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   145 ERIIVTDINDIYYAAADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDL 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....*..
gi 491074719   225 EfEVPVSRSKVKEFRKL 241
Cdd:smart00850  81 E-EVPVSRRYLKELKER 96
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 9-141 6.07e-09

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 54.80  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719    9 EFLAQEElsylikkhsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFA--HRPSIVFITAYKEH 86
Cdd:TIGR02875  20 EYLAAQP---------DMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIElsARPRVIMLSAFGQE 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 491074719   87 AV--EAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAP-SRGSHSINL 141
Cdd:TIGR02875  91 KItqRAVALGADYYVLKPFDLEILAARIRQLAWGTNADILADSPTVPPaSHAAKTKDL 148
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 7.96e-83

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 247.04  E-value: 7.96e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAPSRgshsINLIKDERIIVTDINDIYYAAA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----IFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 161 DEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTyiLRLSDLEfEVPVSRSKVKEFRK 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKNGE-EIPVSRRYKKEFKE 234


                 .
gi 491074719 241 L 241
Cdd:COG3279  235 W 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-119 3.25e-55

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 172.72  E-value: 3.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   3 AIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491074719  83 YKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALH 119
Cdd:cd17532   81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRL 117
PRK14084 PRK14084
DNA-binding response regulator;
1-244 1.91e-45

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 152.21  E-value: 1.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAPSRGSHSINL-IK-DERIIVTDINDIYYA 158
Cdd:PRK14084  81 TAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLpIEiDDKIHMLNQQDIIAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 159 AADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDlEFEVPVSRSKVKEF 238
Cdd:PRK14084 161 GVHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVEQWFNYTYQVILTN-GVKMQVSRSFMKDF 239


                 ....*.
gi 491074719 239 RKLMRL 244
Cdd:PRK14084 240 KASIGL 245
PRK11697 PRK11697
two-component system response regulator BtsR;
1-241 1.91e-39

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 136.51  E-value: 1.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKfAHRPSIVFI 80
Cdd:PRK11697   2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDP-EHMPYIVFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHH----RPAGAAEP-TSAPSRGSHSINLIKDERI--IVTDIN 153
Cdd:PRK11697  81 TAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSpqdvLLPEAQPPlKHIPCTGHNRIKLLPLEEVefVSSRLS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719 154 DIYYAAADEKVTrvytrreefvmpmnlTEFYGRLPEEH--FFRCHRSYCVNLAKIREIVPWFN-NTYILRLSDleFEVPV 230
Cdd:PRK11697 161 GVHVVSAEGKGF---------------TELTLKTLEEKtpLLRCHRQYLVNPAAIQEIRLLDNgQAEIITRSG--HTVPV 223

                        250
                 ....*....|.
gi 491074719 231 SRSKVKEFRKL 241
Cdd:PRK11697 224 SRRYLKSLKEA 234
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-242 1.25e-33

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 116.92  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  145 ERIIVTDINDIYYAAADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDl 224
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKN- 79

                          90
                  ....*....|....*...
gi 491074719  225 EFEVPVSRSKVKEFRKLM 242
Cdd:pfam04397  80 GEKIPVSRRYLKELKELL 97
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-241 8.67e-31

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 109.59  E-value: 8.67e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   145 ERIIVTDINDIYYAAADEKVTRVYTRREEFVMPMNLTEFYGRLPEEHFFRCHRSYCVNLAKIREIVPWFNNTYILRLSDL 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....*..
gi 491074719   225 EfEVPVSRSKVKEFRKL 241
Cdd:smart00850  81 E-EVPVSRRYLKELKER 96
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-115 1.14e-27

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 102.42  E-value: 1.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHS-NIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd17536    2 LIVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILSG 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491074719  83 YKEH--AVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17536   82 YDDFeyAQKAIRLGVVDYLLKPVDEEELEEALEKA 116
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 3.25e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 95.68  E-value: 3.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719    4 IIVEDEFLAQEELSYLIKKHSNIdiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYV--VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 491074719   84 --KEHAVEAFEIEAFDYILKPYHEARIVTMLQ 113
Cdd:pfam00072  80 gdEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-102 1.16e-24

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 94.07  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT 81
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 491074719  82 AY--KEHAVEAFEIEAFDYILKP 102
Cdd:COG4753   81 GYsdFEYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-121 1.41e-22

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 89.64  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491074719  81 TAYKEHAV--EAFEIEAFDYILKPYHEARIVTMLQKLEALHHR 121
Cdd:COG4565   84 TAARDPETvrEALRAGVVDYLIKPFTFERLREALERYLEYRRL 126
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-102 9.26e-19

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 78.42  E-value: 9.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSniDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY- 83
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKa 79

                         90       100
                 ....*....|....*....|
gi 491074719  84 -KEHAVEAFEIEAFDYILKP 102
Cdd:cd00156   80 dEEDAVRALELGADDYLVKP 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-115 1.83e-17

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 75.66  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPS--IV 78
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLPDipII 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491074719  79 FITAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:COG0784   84 ALTAYadEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-105 3.83e-17

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 74.75  E-value: 3.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIP-SLDGVLLAQNISKFAHRPsIVF 79
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESL-GYEVVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFDIP-VIF 78

                         90       100
                 ....*....|....*....|....*...
gi 491074719  80 ITAYKEHAV--EAFEIEAFDYILKPYHE 105
Cdd:cd17534   79 LTAYSDEETleRAKETNPYGYLVKPFNE 106
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-101 2.48e-16

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 72.54  E-value: 2.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY 83
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100
                 ....*....|....*....|
gi 491074719  84 KEHAV--EAFEIEAFDYILK 101
Cdd:cd17535   82 DDPEYvlRALKAGAAGYLLK 101
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-121 8.61e-16

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 75.77  E-value: 8.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERA-GYE-VETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491074719  81 TAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKleALHHR 121
Cdd:COG2204   81 TGYgdVETAVEAIKAGAFDYLTKPFDLEELLAAVER--ALERR 121
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-112 1.57e-15

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 71.86  E-value: 1.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPsI 77
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEAA-GYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradPRTADIP-I 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491074719  78 VFITAY--KEHAVEAFEIEAFDYILKPYHEARIVTML 112
Cdd:COG3706   79 IFLTALddEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-114 3.62e-15

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 69.58  E-value: 3.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK 84
Cdd:cd19925    5 IVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTAAN 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491074719  85 EHAV--EAFEIEAFDYILKPYHEARIVTMLQK 114
Cdd:cd19925   85 DVETvrEALRLGVVDYLIKPFTFERLRQRLER 116
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-121 1.93e-14

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 67.61  E-value: 1.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEF-LAQEELSYLIKKHSNIDIVATfedGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd17572    2 LLVEDSPsLAALYQEYLSDEGYKVTHVET---GKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491074719  83 Y--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKleALHHR 121
Cdd:cd17572   79 HgsVDIAVEAMRLGAYDFLEKPFDADRLRVTVRN--ALKHR 117
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-125 2.00e-14

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 69.60  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHsNIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY- 83
Cdd:COG0745    6 VVEDDPDIRELLADALERE-GYE-VDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTARd 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491074719  84 -KEHAVEAFEIEAFDYILKPYHEARIvtmLQKLEALHHRPAGA 125
Cdd:COG0745   84 dEEDRVRGLEAGADDYLTKPFDPEEL---LARIRALLRRRAAE 123
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-120 2.07e-14

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 69.81  E-value: 2.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPsI 77
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTL-GYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLradPSTRDIP-V 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 491074719  78 VFITAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHH 120
Cdd:COG3437   84 IFLTALadPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-102 6.56e-13

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 62.81  E-value: 6.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHsNIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY- 83
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKE-GYE-VDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKd 79

                         90       100
                 ....*....|....*....|
gi 491074719  84 -KEHAVEAFEIEAFDYILKP 102
Cdd:cd17574   80 eEEDKVLGLELGADDYITKP 99
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 29-106 1.30e-12

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 62.68  E-value: 1.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDG-VLLAQNISKFAHRPSIVfITAYK--EHAVEAFEIEAFDYILKPY-- 103
Cdd:cd19919   27 VTSFENAQEALAALASSQPDVLISDIRMPGMDGlALLAQIKQRHPDLPVII-MTAHSdlDSAVSAYQGGAFEYLPKPFdi 105


                 ...
gi 491074719 104 HEA 106
Cdd:cd19919  106 DEA 108
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-103 1.51e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 62.46  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGV-LLAQ--NISKFAHRPsI 77
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSAGYLEVV-SFTDPREALAWCRENPPDLILLDYMMPGMDGLeFIRRlrALPGLEDVP-I 78

                         90       100
                 ....*....|....*....|....*...
gi 491074719  78 VFITAYKEHAV--EAFEIEAFDYILKPY 103
Cdd:cd17551   79 VMITADTDREVrlRALEAGATDFLTKPF 106
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-121 3.26e-11

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 60.36  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKhSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFI 80
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLRE-AGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAP-VILL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491074719  81 TAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKLEALHHR 121
Cdd:COG3707   82 TAYsdPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRE 124
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 5-112 3.28e-11

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 58.63  E-value: 3.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHsNIDIVaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPSIVFIT 81
Cdd:cd17546    3 VVDDNPVNRKVLKKLLEKL-GYEVD-VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIrelEGGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491074719  82 AY--KEHAVEAFEIEAFDYILKPYHEARIVTML 112
Cdd:cd17546   81 ANalEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-113 7.92e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 57.81  E-value: 7.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNiDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKfaHRPS-IVF 79
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGY-EVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITS--ENIApIVL 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491074719  80 ITAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQ 113
Cdd:cd19932   78 LTAYsqQDLVERAKEAGAMAYLVKPFSESDLIPAIE 113
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 4-114 1.98e-10

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 58.93  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDE-FLAQEELSYLIKKHSNIDIVAtfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITA 82
Cdd:PRK10710  14 LIVEDEpKLGQLLIDYLQAASYATTLLS---HGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIP-IVMVTA 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491074719  83 YKEHA--VEAFEIEAFDYILKPYHE----ARIVTMLQK 114
Cdd:PRK10710  90 KIEEIdrLLGLEIGADDYICKPYSPrevvARVKTILRR 127
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 16-103 3.30e-10

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 55.69  E-value: 3.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  16 LSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDG--VLLAQNISKFAHRPSIVFITAYKEHAV--EAF 91
Cdd:cd17561   17 LEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGigVLEKLRRMRLEKRPKIIMLTAFGQEDItqRAV 96

                         90
                 ....*....|..
gi 491074719  92 EIEAFDYILKPY 103
Cdd:cd17561   97 ELGASYYILKPF 108
orf27 CHL00148
Ycf27; Reviewed
 29-152 3.54e-10

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 58.19  E-value: 3.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAYKEHA--VEAFEIEAFDYILKPYH-- 104
Cdd:CHL00148  33 VITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVP-IIMLTALGDVSdrITGLELGADDYVVKPFSpk 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491074719 105 --EARIVTMLQKLEALHHRPagaAEPTSAPSR-GSHSINLIK------DERIIVTDI 152
Cdd:CHL00148 112 elEARIRSVLRRTNKKSFSS---KIPNSSIIRiGFLKIDLNKkqvyknNERIRLTGM 165
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 1-102 3.70e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 55.86  E-value: 3.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKfAHRPSIVFI 80
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMA-ERPTPVVMV 79

                         90       100
                 ....*....|....*....|....*.
gi 491074719  81 TAY----KEHAVEAFEIEAFDYILKP 102
Cdd:cd17541   80 SSLteegAEITLEALELGAVDFIAKP 105
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-115 3.74e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 55.75  E-value: 3.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKA-GYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491074719  81 TAYKEHA--VEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17542   80 SAMGQEEmvKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 2-114 4.15e-10

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 55.84  E-value: 4.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEF-LAQEELSYLIKkhsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFI 80
Cdd:cd19939    1 RILIVEDELeLARLTRDYLIK---AGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVP-ILML 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491074719  81 TAYKEHA--VEAFEIEAFDYILKPYHE----ARIVTMLQK 114
Cdd:cd19939   77 TARTEEMdrVLGLEMGADDYLCKPFSPrellARVRALLRR 116
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-152 8.65e-10

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 57.50  E-value: 8.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVED--EFLaqEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDG--VLLAQNISKFAHRPS 76
Cdd:COG5801    5 IKVLIADDnrEFC--ELLEEYLSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGlgVLEKLREMNLEKRPK 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491074719  77 IVFITAYKEHAV--EAFEIEAFDYILKPYheaRIVTMLQKLEALHHRPAGAAEPTSAPSRGSHSINLIKDERIIVTDI 152
Cdd:COG5801   83 VIMLTAFGQEDItqRAVELGADYYILKPF---DLDVLAERIRQLAGGKAESETSKKKSSPETASVDKARDLEAEVTNI 157
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 29-114 9.01e-10

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 54.81  E-value: 9.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT--AYKEHAVEAFEIEAFDYILKPYHEA 106
Cdd:cd17550   25 VDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISghGTIETAVKATKLGAYDFIEKPLSLD 104


                 ....*...
gi 491074719 107 RIVTMLQK 114
Cdd:cd17550  105 RLLLTIER 112
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-114 1.34e-09

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 57.55  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY 83
Cdd:PRK11361   8 LIVDDEDNVRRMLSTAFALQGFETHCAN--NGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAY 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491074719  84 KE--HAVEAFEIEAFDYILKPYHEARIVTMLQK 114
Cdd:PRK11361  86 AEveTAVEALRCGAFDYVIKPFDLDELNLIVQR 118
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-90 1.76e-09

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 54.20  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT-- 81
Cdd:cd19930    2 LIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTtf 81

                         90
                 ....*....|..
gi 491074719  82 ---AYKEHAVEA 90
Cdd:cd19930   82 grpGYFRRALAA 93
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 5-113 2.15e-09

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 53.82  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELS-YLIKKHSNIDIVATFEDGLDVLKylqTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAY 83
Cdd:cd18159    3 IVEDDETIASLLKkHLEKWGYEVVLIEDFEDVLEEFL---QFKPDLVLLDINLPYFDGFYWCREIRQISNVP-IIFISSR 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491074719  84 KEHA--VEAFEIEAFDYILKPYHEARIVTMLQ 113
Cdd:cd18159   79 DDNMdqVMAINMGGDDYITKPFDLDVLLAKIK 110
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 5-114 2.18e-09

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 53.75  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSnIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK 84
Cdd:cd17537    5 VVDDDEAVRDSLAFLLRSVG-LA-VKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHG 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491074719  85 E--HAVEAFEIEAFDYILKPYHEARIVTMLQK 114
Cdd:cd17537   83 DvpMAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-116 2.19e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 54.16  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEEL-----SYLIKKHSNIDIvATFEDGLDVLKY---LQTHQVDAIFLDINIPSLDGVLLAQNISKFA 72
Cdd:cd17533    1 MNIFILEDDKIQRVRLeeiieNILKIENIEYVI-ELTGKTEELLEKikeRGKNGIYFLDIDIKMEEKNGLEVAQKIRKYD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491074719  73 HRPSIVFITAYKEHAVEAFE--IEAFDYILKPYHEA----RIVTMLQKLE 116
Cdd:cd17533   80 PYAIIIFVTTHSEFAPLTFEykVAALDFILKPLKLEefkkRIEECIKYAQ 129
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-68 2.82e-09

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 53.74  E-value: 2.82e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI 68
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 29-103 3.10e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 52.90  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGV----LLAQNiSKFAHRPsIVFITAY--KEHAVEAFEIEAFDYILKP 102
Cdd:cd19920   25 VLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFevcrRLKAD-PATRHIP-VIFLTALtdTEDKVKGFELGAVDYITKP 102


                 .
gi 491074719 103 Y 103
Cdd:cd19920  103 F 103
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 9-141 6.07e-09

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 54.80  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719    9 EFLAQEElsylikkhsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFA--HRPSIVFITAYKEH 86
Cdd:TIGR02875  20 EYLAAQP---------DMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIElsARPRVIMLSAFGQE 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 491074719   87 AV--EAFEIEAFDYILKPYHEARIVTMLQKLEALHHRPAGAAEPTSAP-SRGSHSINL 141
Cdd:TIGR02875  91 KItqRAVALGADYYVLKPFDLEILAARIRQLAWGTNADILADSPTVPPaSHAAKTKDL 148
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 4-112 8.30e-09

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 52.00  E-value: 8.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDE-FLAQEELSYLIKKHSNIDIVAtfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITA 82
Cdd:cd19938    3 LIVEDEpKLAQLLIDYLRAAGYAPTLLA---HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVP-IIMVTA 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491074719  83 YKEHA--VEAFEIEAFDYILKPYHE----ARIVTML 112
Cdd:cd19938   79 RVEEIdrLLGLELGADDYICKPYSPrevvARVKAIL 114
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-103 9.50e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 51.89  E-value: 9.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIdiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPsIVFIT 81
Cdd:cd19937    2 VVDDEEDIVELLKYNLEKEGYE--VVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILrsdPKTSSIP-IIMLT 78

                         90       100
                 ....*....|....*....|....
gi 491074719  82 AYKEHA--VEAFEIEAFDYILKPY 103
Cdd:cd19937   79 AKGEEFdkVLGLELGADDYITKPF 102
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-116 1.36e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 51.57  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKK--HSNIDIVatfEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRP 75
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKElgFNNVEEA---EDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIradGALSHLP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491074719  76 sIVFIT--AYKEHAVEAFEIEAFDYILKPYHEArivTMLQKLE 116
Cdd:cd19923   78 -VLMVTaeAKKENVIAAAQAGVNNYIVKPFTAA---TLKEKLE 116
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 30-170 2.07e-08

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 54.11  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  30 ATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK--EHAVEAFEIEAFDYILKPYHEAR 107
Cdd:PRK10923  31 TTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSdlDAAVSAYQQGAFDYLPKPFDIDE 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491074719 108 IVTMLQKleALHHRPAgAAEPTSAPSRGShsinlikderiiVTDIndIYYAAADEKVTRVYTR 170
Cdd:PRK10923 111 AVALVER--AISHYQE-QQQPRNIQVNGP------------TTDI--IGEAPAMQDVFRIIGR 156
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 29-127 3.15e-08

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 52.02  E-value: 3.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY--KEHAVEAFEIEAFDYILKPYHEA 106
Cdd:COG4566   26 VETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHgdVPMAVRAMKAGAVDFLEKPFDDQ 105

                         90       100
                 ....*....|....*....|..
gi 491074719 107 RIVTMLQK-LEALHHRPAGAAE 127
Cdd:COG4566  106 ALLDAVRRaLARDRARRAERAR 127
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
29-131 4.57e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 53.11  E-value: 4.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK--EHAVEAFEIEAFDYILKPYHEA 106
Cdd:PRK10365  32 VALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSsvETAVEALKTGALDYLIKPLDFD 111

                         90       100
                 ....*....|....*....|....*
gi 491074719 107 RIVTMLQKleALHHRPAGAAEPTSA 131
Cdd:PRK10365 112 NLQATLEK--ALAHTHSIDAETPAV 134
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-102 7.00e-08

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 48.98  E-value: 7.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDE-----FLAQ--EELSYlikkhsNIDIVAtfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPS 76
Cdd:cd19935    2 LVVEDEkklaeYLKKglTEEGY------AVDVAY---DGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTP 72

                         90       100
                 ....*....|....*....|....*...
gi 491074719  77 IVFITAYK--EHAVEAFEIEAFDYILKP 102
Cdd:cd19935   73 VLMLTARDsvEDRVKGLDLGADDYLVKP 100
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-103 1.29e-07

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 48.92  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEEL-SYLIKKHSNIDIVAtfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITA 82
Cdd:cd17619    4 LIVEDEPVTRATLkSYFEQEGYDVSEAG---DGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVG-IILVTG 79

                         90       100
                 ....*....|....*....|...
gi 491074719  83 YKEHA--VEAFEIEAFDYILKPY 103
Cdd:cd17619   80 RDDEVdrIVGLEIGADDYVTKPF 102
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 5-102 1.82e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 48.22  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIdiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI--TA 82
Cdd:cd17580    3 VVDDNEDAAEMLALLLELEGAE--VTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAIalTG 80

                         90       100
                 ....*....|....*....|....*.
gi 491074719  83 Y-----KEHAVEAfeieAFD-YILKP 102
Cdd:cd17580   81 YgqpedRERALEA----GFDaHLVKP 102
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-103 2.13e-07

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 48.19  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSnIDIVATFeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAY 83
Cdd:cd17614    2 LVVDDEKPISDILKFNLTKEG-YEVVTAY-DGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVP-IIMLTAK 78

                         90       100
                 ....*....|....*....|..
gi 491074719  84 KEH--AVEAFEIEAFDYILKPY 103
Cdd:cd17614   79 DSEvdKVLGLELGADDYVTKPF 100
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-86 2.36e-07

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 49.89  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHsNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLLIKN-DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIV 79


                 ....*.
gi 491074719  81 TAYKEH 86
Cdd:PRK09958  80 SAKNDH 85
PRK10610 PRK10610
chemotaxis protein CheY;
5-115 2.45e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 48.43  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPSI-VFI 80
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIradGAMSALPVLmVTA 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:PRK10610  89 EAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKI 123
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 28-114 6.26e-07

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 46.99  E-value: 6.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  28 IVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYKEHA--VEAFEIEAFDYILKPY-- 103
Cdd:cd17627   24 EVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARDSVSdrVAGLDAGADDYLVKPFal 103

                         90
                 ....*....|...
gi 491074719 104 HE--ARIVTMLQK 114
Cdd:cd17627  104 EEllARVRALLRR 116
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-121 6.39e-07

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 46.89  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELS-YLIKKHSNIDIVATFEDGLDvlkYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd19934    2 LLVEDDALLAAQLKeQLSDAGYVVDVAEDGEEALF---QGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491074719  83 YKEHA--VEAFEIEAFDYILKPYHearIVTMLQKLEALHHR 121
Cdd:cd19934   79 RDSWQdkVEGLDAGADDYLTKPFH---IEELLARLRALIRR 116
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 2-115 8.12e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 8.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEflaqEELSYLIK---KHSNIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIV 78
Cdd:cd17622    2 RILLVEDD----PKLARLIAdflESHGFN-VVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGP-IL 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491074719  79 FITAY--KEHAVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17622   76 LLTALdsDIDHILGLELGADDYVVKPVEPAVLLARLRAL 114
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
4-85 9.10e-07

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 47.95  E-value: 9.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY 83
Cdd:PRK09935   7 IIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSK 86


                 ..
gi 491074719  84 KE 85
Cdd:PRK09935  87 SE 88
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 1-115 1.42e-06

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 45.99  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIvaTF-EDGLDVLKYLQTHQVDAIFLDINIPSLDG--VLlaQNISKFAHRPSI 77
Cdd:cd17593    1 MKVLICDDSSMARKQLARALPADWDVEI--TFaENGEEALEILREGRIDVLFLDLTMPVMDGyeVL--EALPVEQLETKV 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491074719  78 VFITA-YKEHAVE-AFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17593   77 IVVSGdVQPEAKErVLELGALAFLKKPFDPEKLAQLLEEL 116
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 29-121 1.73e-06

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 45.94  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAykeH-----AVEAFEIEAFDYILKPY 103
Cdd:cd17549   25 VRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITG---HgdvpmAVEAMRAGAYDFLEKPF 101

                         90
                 ....*....|....*...
gi 491074719 104 HEARIVTMLQKleALHHR 121
Cdd:cd17549  102 DPERLLDVVRR--ALEKR 117
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
29-82 1.97e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 48.43  E-value: 1.97e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:PRK10841 828 CKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVTA 881
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-102 2.05e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 45.27  E-value: 2.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAY 83
Cdd:cd17621    2 LVVEDEESFSDPLAYLLRKEGFEVTVAT--DGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVP-VIMVTAK 78

                         90       100
                 ....*....|....*....|.
gi 491074719  84 KEH--AVEAFEIEAFDYILKP 102
Cdd:cd17621   79 DSEidKVVGLELGADDYVTKP 99
fixJ PRK09390
response regulator FixJ; Provisional
 5-127 2.21e-06

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 46.92  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKkhSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK 84
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLD--SAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 491074719  85 E--HAVEAFEIEAFDYILKPYHEARIVTMLQKleALHHRPAGAAE 127
Cdd:PRK09390  86 DvpLAVEAMKLGAVDFIEKPFEDERLIGAIER--ALAQAPEAAKS 128
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-114 2.69e-06

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 46.84  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEelsYLIKKHSNIDIVATFED-GLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVF 79
Cdd:PRK09836   1 MKLLIVEDEKKTGE---YLTKGLTEAGFVVDLADnGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491074719  80 ITAYK--EHAVEAFEIEAFDYILKPYH----EARIVTMLQK 114
Cdd:PRK09836  78 LTALGtiEHRVKGLELGADDYLVKPFAfaelLARVRTLLRR 118
PRK13435 PRK13435
response regulator; Provisional
 1-117 4.12e-06

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 45.43  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKK--HSNIDIVATFEDGLDvlkYLQTHQVDAIFLDINIP-SLDGVLLAQNISKfAHRPSI 77
Cdd:PRK13435   6 LKVLIVEDEALIALELEKLVEEagHEVVGIAMSSEQAIA---LGRRRQPDVALVDVHLAdGPTGVEVARRLSA-DGGVEV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491074719  78 VFITAYKEHAVEAFeIEAFDYILKPYHEARIVTMLQKLEA 117
Cdd:PRK13435  82 VFMTGNPERVPHDF-AGALGVIAKPYSPRGVARALSYLSA 120
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 5-134 5.16e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 46.11  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIdiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAYK 84
Cdd:PRK11083   8 LVEDEQAIADTLVYALQSEGFT--VEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTARS 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491074719  85 EHA--VEAFEIEAFDYILKPYHE----ARIVTMLQKLealhhRPAGAAEPTSAPSR 134
Cdd:PRK11083  86 DEVdrLVGLEIGADDYVAKPFSPrevaARVRTILRRV-----KKFAAPSPVIRIGH 136
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-101 6.21e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 44.13  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDE----FLAQEELS---YlikkhsnidIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAH 73
Cdd:cd17554    1 KKILVVDDEenirELYKEELEdegY---------EVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKP 71

                         90       100
                 ....*....|....*....|....*...
gi 491074719  74 RPSIVFITAYKEHAVEAFEIEAFDYILK 101
Cdd:cd17554   72 DLPVIICTAYSEYKSDFSSWAADAYVVK 99
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-114 6.45e-06

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 44.13  E-value: 6.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEflaqEELSYLIKKHSN-----IDIVATFEDGLDvlkYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVF 79
Cdd:cd17625    2 VVEDE----KDLSEAITKHLKkegytVDVCFDGEEGLE---YALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491074719  80 ITAYKEHA--VEAFEIEAFDYILKPYH----EARIVTMLQK 114
Cdd:cd17625   75 LTALDAVEdrVKGLDLGADDYLPKPFSlaelLARIRALLRR 115
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 5-102 6.86e-06

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 43.80  E-value: 6.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT--A 82
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISqvS 82

                         90       100
                 ....*....|....*....|
gi 491074719  83 YKEHAVEAFEIEAFDYILKP 102
Cdd:cd17565   83 DKEMIGKAYQAGIEFFINKP 102
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 4-120 8.44e-06

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 43.73  E-value: 8.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLikKHSNIDIVATfEDGLDVLKYLQTHQVDAIFLDINIPSLDGV-LLAQNISKFAHRPSIVFITA 82
Cdd:cd17555    5 VIDDDEVVRESIAAYL--EDSGFQVLQA-ADGRQGLELFRSEQPDLVLCDLRMPEMDGLeVLKQITKESPDTPVIVVSGA 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491074719  83 -YKEHAVEAFEIEAFDYILKPyhearivtmLQKLEALHH 120
Cdd:cd17555   82 gVMSDAVEALRLGAWDYLTKP---------IEDLAVLEH 111
PRK15369 PRK15369
two component system response regulator;
2-101 1.22e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 44.68  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT 81
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                         90       100
                 ....*....|....*....|..
gi 491074719  82 AYKE--HAVEAFEIEAFDYILK 101
Cdd:PRK15369  85 ARQEehMASRTLAAGALGYVLK 106
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-138 1.50e-05

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 45.26  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNIskFAHRP-SIVF 79
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRI--MAERPcPILI 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491074719  80 ITAYKEHAV----EAFEIEAFDYILKP------YHEARIVTMLQKLEA---LHHRPAGAAEPTSAPSRGSHS 138
Cdd:PRK12555  79 VTSLTERNAsrvfEAMGAGALDAVDTPtlgigaGLEEYAAELLAKIDQigrLLGRRLAPAAAPAAASAAPFR 150
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-115 1.65e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 43.08  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVAtfEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNIS---KFAHRPSIVFI 80
Cdd:cd17598    2 LIVEDSPTQAEQLKHILEEQGYKVQVA--RNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKsdpDLKDIPVILLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491074719  81 T-AYKEHAVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17598   80 TlSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYI 115
PRK10336 PRK10336
two-component system response regulator QseB;
1-126 2.17e-05

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 44.12  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEEL-SYLIKKHSNIDivaTFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVF 79
Cdd:PRK10336   1 MRILLIEDDMLIGDGIkTGLSKMGFSVD---WFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 491074719  80 ITAYK--EHAVEAFEIEAFDYILKPYheaRIVTMLQKLEALHHRPAGAA 126
Cdd:PRK10336  78 LTARDalAERVEGLRLGADDYLCKPF---ALIEVAARLEALMRRTNGQA 123
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-139 2.38e-05

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 44.76  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNIskFAHRPSIV-- 78
Cdd:PRK00742   4 IRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKI--MRLRPTPVvm 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491074719  79 FITAYKEHA---VEAFEIEAFDYILKPyhEARIVT--------MLQKLEALHHRPAGAAEPTSAPSRGSHSI 139
Cdd:PRK00742  82 VSSLTERGAeitLRALELGAVDFVTKP--FLGISLgmdeykeeLAEKVRAAARARVRALPPRAAAAARAAAA 151
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-108 2.86e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 42.09  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHS-NIDIVATFEDGLDVLkylQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITA 82
Cdd:cd17624    2 LLVEDDALLGDGLKTGLRKAGyAVDWVRTGAEAEAAL---ASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491074719  83 YK--EHAVEAFEIEAFDYILKPYH----EARI 108
Cdd:cd17624   79 RDgvDDRVAGLDAGADDYLVKPFAleelLARL 110
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 29-132 5.48e-05

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 42.60  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISkfAHRPS--IVFITAYK--EHAVEAFEIEAFDYILKPYH 104
Cdd:COG4567   31 VTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALR--ERDPDarIVVLTGYAsiATAVEAIKLGADDYLAKPAD 108

                         90       100
                 ....*....|....*....|....*...
gi 491074719 105 EARIvtmlqkLEALHHRPAGAAEPTSAP 132
Cdd:COG4567  109 ADDL------LAALERAEGDAPAPPENP 130
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 29-102 5.58e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 40.89  E-value: 5.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAYKEHAVEAFEIE--AFDYILKP 102
Cdd:cd19936   25 VETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLP-VIFLTSKDDEIDEVFGLRmgADDYITKP 99
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 34-115 7.41e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 41.13  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  34 DGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPSIVFIT----AYKEHAVEAfeiEAFDYILKPYHEA 106
Cdd:cd17562   32 DGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELrklPAYKFTPILMLTTessdEKKQEGKAA---GATGWLVKPFDPE 108


                 ....*....
gi 491074719 107 RIVTMLQKL 115
Cdd:cd17562  109 QLLEVVKKV 117
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-145 8.13e-05

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 42.58  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSY-LIKKHSNIDIVAtfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNIsKFAHRPSIVF 79
Cdd:PRK11517   1 MKILLIEDNQRTQEWVTQgLSEAGYVIDAVS---DGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL-RTAKQTPVIC 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491074719  80 ITAYK--EHAVEAFEIEAFDYILKPYHEARIVTMLqKLEALHHRPAGAAEPTS---------APSRGSHSINLIKDE 145
Cdd:PRK11517  77 LTARDsvDDRVRGLDSGANDYLVKPFSFSELLARV-RAQLRQHHALNSTLEISglrmdsvsqSVSRDNISITLTRKE 152
PRK15479 PRK15479
transcriptional regulator TctD;
1-114 9.61e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 42.40  E-value: 9.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDeflaQEELSYLIKK--HSNIDIVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIV 78
Cdd:PRK15479   1 MRLLLAED----NRELAHWLEKalVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491074719  79 FITAYKEHA--VEAFEIEAFDYILKPYH----EARIVTMLQK 114
Cdd:PRK15479  77 LLTARSAVAdrVKGLNVGADDYLPKPFEleelDARLRALLRR 118
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-108 1.09e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 40.70  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKkHSNIDIVATfEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPsIV 78
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLE-RAGFDVVEA-EDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLkrdEMTRDIP-II 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491074719  79 FITAY--KEHAVEAFEIEAFDYILKPY--HE--ARI 108
Cdd:cd17618   79 MLTARgeEEDKVRGLEAGADDYITKPFspRElvARI 114
PRK11173 PRK11173
two-component response regulator; Provisional
 4-103 1.12e-04

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 42.31  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIVATfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAy 83
Cdd:PRK11173   7 LIVEDELVTRNTLKSIFEAEGYDVFEAT--DGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVA-LMFLTG- 82

                         90       100
                 ....*....|....*....|...
gi 491074719  84 KEHAVE---AFEIEAFDYILKPY 103
Cdd:PRK11173  83 RDNEVDkilGLEIGADDYITKPF 105
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 2-103 1.72e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 40.23  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKKHSnidiVATFE--DGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVF 79
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEG----YQTFQaaNGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVII 77

                         90       100
                 ....*....|....*....|....*.
gi 491074719  80 ITAYKEHAV--EAFEIEAFDYILKPY 103
Cdd:cd17553   78 MTAYGELDMiqESKELGALTHFAKPF 103
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-113 2.21e-04

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 39.70  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHS-NIDIVATFEDGLDVLKylqTHQVDAIFLDINIPSLDG--VLLAQNISKFAHRPSIVFI 80
Cdd:cd17616    2 LLIEDDSATAQSIELMLKSEGfNVYTTDLGEEGLDLGK---LYDYDIILLDLNLPDMSGyeVLRTLRLAKVKTPILILSG 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491074719  81 TAYKEHAVEAFEIEAFDYILKPYHEARIVTMLQ 113
Cdd:cd17616   79 LADIEDKVKGLGFGADDYMTKPFHKDELVARIH 111
PRK10816 PRK10816
two-component system response regulator PhoP;
1-126 2.55e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 40.88  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHSNIdiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFI 80
Cdd:PRK10816   1 MRVLVVEDNALLRHHLKVQLQDAGHQ--VDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491074719  81 TAYK--EHAVEAFEIEAFDYILKPYHEARIVTMLQkleALHHRPAGAA 126
Cdd:PRK10816  79 TAREswQDKVEVLSAGADDYVTKPFHIEEVMARMQ---ALMRRNSGLA 123
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 3-102 3.29e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 39.28  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   3 AIIVEDEFLAQEELSYLIKKhSNIDIvATFEDGLDVLKYLQ---------THQVDAIFLDINIPSLDGVLLAQNIS---K 70
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKN-LGFEI-AEAVDGEEALNKLEnlakegndlSKELDLIITDIEMPKMDGYELTFELRddpR 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491074719  71 FAHRPSIVF---ITAYKEHAVEafEIEAFDYILKP 102
Cdd:cd19924   79 LANIPVILNsslSGEFSRARGK--KVGADAYLAKF 111
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 5-102 7.32e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 38.29  E-value: 7.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDEFLAQEELSYLIKKHSNIDIVATfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISK---FAHRPsIVFIT 81
Cdd:cd17548    4 IVEDNPLNMKLARDLLESAGYEVLEAA--DGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpaTRDIP-VIALT 80

                         90       100
                 ....*....|....*....|....*..
gi 491074719  82 AY-----KEHAVEAfeieAFD-YILKP 102
Cdd:cd17548   81 AYamkgdREKILEA----GCDgYISKP 103
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 4-103 9.38e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 37.80  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHS-NIDIVATFEDGLdvlKYLQTHQVDAIFLDINIPSLDGVLLAQNIsKFAHRPSIVFITA 82
Cdd:cd17573    2 LLIEDDSTLGKEISKGLNEKGyQADVAESLKDGE---YYIDIRNYDLVLVSDKLPDGNGLSIVSRI-KEKHPSIVVIVLS 77

                         90       100
                 ....*....|....*....|....
gi 491074719  83 YK---EHAVEAFEIEAFDYILKPY 103
Cdd:cd17573   78 DNpktEQEIEAFKEGADDYIAKPF 101
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 29-140 9.41e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 40.22  E-value: 9.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPS--IVFITAykeHAVeAFEIEAF------DYIL 100
Cdd:PRK11107 694 VVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQLPHNQNtpIIAVTA---HAM-AGERERLlsagmdDYLA 769

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491074719 101 KPYHEArivtMLQKLeaLHH--------RPAGAAEPTSAPSRGSHSIN 140
Cdd:PRK11107 770 KPIDEA----MLKQV--LLRykpgpkftSRVVAPEPPEPVHFPNATLD 811
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 4-109 1.13e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.83  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEELSYLIKKHSNIDIvATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPsIVFITAY 83
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDP-AFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVP-IVMLTAK 80

                         90       100
                 ....*....|....*....|....*...
gi 491074719  84 KEHA--VEAFEIEAFDYILKPYHEARIV 109
Cdd:cd17626   81 SDTVdvVLGLESGADDYVAKPFKPKELV 108
PRK10766 PRK10766
two-component system response regulator TorR;
4-103 2.15e-03

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 38.10  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   4 IIVEDEFLAQEEL-SYLIKKHSNidiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHrPSIVFITA 82
Cdd:PRK10766   6 LVVEDEPVTRARLqGYFEQEGYT---VSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRST-VGIILVTG 81

                         90       100
                 ....*....|....*....|...
gi 491074719  83 YKEH--AVEAFEIEAFDYILKPY 103
Cdd:PRK10766  82 RTDSidRIVGLEMGADDYVTKPL 104
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 29-103 2.89e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 36.32  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719  29 VATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNI---SKFAHRPsIVFITAYKEHA--VEAFEIEAFDYILKPY 103
Cdd:cd17538   26 VLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLkedPETRHIP-VIMITALDDREdrIRGLEAGADDFLSKPI 104
PRK10643 PRK10643
two-component system response regulator PmrA;
1-103 3.05e-03

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 37.71  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   1 MKAIIVEDEFLAQEELSYLIKKHS-NIDIVATFEDGlDVLkyLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVF 79
Cdd:PRK10643   1 MKILIVEDDTLLLQGLILALQTEGyACDCASTAREA-EAL--LESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77

                         90       100
                 ....*....|....*....|....*.
gi 491074719  80 ITAYK--EHAVEAFEIEAFDYILKPY 103
Cdd:PRK10643  78 LTARDtlEDRVAGLDVGADDYLVKPF 103
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 5-102 3.09e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 36.63  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   5 IVEDE----FLAQEELsylikKHSNIDI-VATFEDGLDVLKYLQTH-------QVDAIFLDINIPSLDG--VL--LAQNi 68
Cdd:cd17557    4 LVEDNpgdaELIQEAF-----KEAGVPNeLHVVRDGEEALDFLRGEgeyadapRPDLILLDLNMPRMDGfeVLreIKAD- 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491074719  69 SKFAHRPSIVFITAYKEHAVE-AFEIEAFDYILKP 102
Cdd:cd17557   78 PDLRRIPVVVLTTSDAEEDIErAYELGANSYIVKP 112
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 42-102 4.64e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 35.59  E-value: 4.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491074719  42 LQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFITAY--KEHAVEAFEIEAFDYILKP 102
Cdd:cd19926   38 LASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYgsLDTAIEALKAGAFDFLTKP 100
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 2-115 5.89e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 35.79  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKkHSNIDiVATFEDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVFIT 81
Cdd:cd17615    1 RVLVVDDEPNITELLSMALR-YEGWD-VETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491074719  82 AYK--EHAVEAFEIEAFDYILKPYHEARIVTMLQKL 115
Cdd:cd17615   79 AKDsvEDRIAGLTAGGDDYVTKPFSLEEVVARLRAL 114
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 2-103 6.95e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 35.50  E-value: 6.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491074719   2 KAIIVEDEFLAQEELSYLIKKHSNIDIVATfeDGLDVLKYLQTHQVDAIFLDINIPSLDGVLLAQNISKFAHRPSIVfIT 81
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTAAA--DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIII-IS 77

                         90       100
                 ....*....|....*....|....*
gi 491074719  82 AYK---EHAVEAFEIEAFDYILKPY 103
Cdd:cd17594   78 GDRrdeIDRVVGLELGADDYLAKPF 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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