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Conserved domains on  [gi|491056471|ref|WP_004918114|]
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endonuclease III [Riemerella anatipestifer]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 7.97e-100

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 287.38  E-value: 7.97e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  11 IQELERLYPETPIPLDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  91 KAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVTETEKDAKKIFPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180
                 ....*....|....*....|.
gi 491056471 171 DKWNSLHLQIIFYGREYSPAR 191
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKAR 181
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 7.97e-100

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 287.38  E-value: 7.97e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  11 IQELERLYPETPIPLDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  91 KAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVTETEKDAKKIFPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180
                 ....*....|....*....|.
gi 491056471 171 DKWNSLHLQIIFYGREYSPAR 191
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKAR 181
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-191 2.50e-78

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 232.66  E-value: 2.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471    4 KQRAEIIIQELERLYPETPIPLDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLS 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   84 NTKAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVTETEKD 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180
                  ....*....|....*....|....*...
gi 491056471  164 AKKIFPKDKWNSLHLQIIFYGREYSPAR 191
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKAR 188
PRK10702 PRK10702
endonuclease III; Provisional
 1-191 2.15e-50

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 162.49  E-value: 2.15e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   1 MTKKQRAEIiiqeLERLYPETPIP---LDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLI 77
Cdd:PRK10702   1 MNKAKRLEI----LTRLRDNNPHPtteLNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  78 KEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNV 157
Cdd:PRK10702  77 KTIGLYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNV 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 491056471 158 TETEKDAKKIFPKDKWNSLHLQIIFYGREYSPAR 191
Cdd:PRK10702 157 EQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIAR 190
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 1.80e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 157.81  E-value: 1.80e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471    39 LSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELEALPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491056471   119 GHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVT-ETEKDAKKIFPKDKWNSLHLQIIFYGRE 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPeEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 3.68e-47

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 152.40  E-value: 3.68e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  31 YTLLVAVALSAQTTDKKVNEVTPQLFA-VADTPFKMKELEVDEIKNLIKEIGlSNTKAKNLKAMAELLVERHQGIV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491056471 107 QSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKL-TSGKNVTETEKDAKKIFPKDKWNSLHLQIIFYG 184
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 1.25e-36

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 124.70  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   35 VAVALSAQTTDKKVNEVTPQLFA-VADTPFKMKELEVDEIKNLIKEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELE 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEkFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491056471  114 A-LPGVGHKTASVVMSQAFGV--PAFPVDTHIHRLMTQWKLTSGKNVT-ETEKDAKKIFPK 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGRpdPLPVVDTHVRRVLKRLGLIKEKPTPkEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 7.97e-100

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 287.38  E-value: 7.97e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  11 IQELERLYPETPIPLDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  91 KAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVTETEKDAKKIFPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180
                 ....*....|....*....|.
gi 491056471 171 DKWNSLHLQIIFYGREYSPAR 191
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKAR 181
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-191 2.50e-78

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 232.66  E-value: 2.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471    4 KQRAEIIIQELERLYPETPIPLDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLS 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   84 NTKAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVTETEKD 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180
                  ....*....|....*....|....*...
gi 491056471  164 AKKIFPKDKWNSLHLQIIFYGREYSPAR 191
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKAR 188
PRK10702 PRK10702
endonuclease III; Provisional
 1-191 2.15e-50

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 162.49  E-value: 2.15e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   1 MTKKQRAEIiiqeLERLYPETPIP---LDHKDPYTLLVAVALSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLI 77
Cdd:PRK10702   1 MNKAKRLEI----LTRLRDNNPHPtteLNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  78 KEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNV 157
Cdd:PRK10702  77 KTIGLYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNV 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 491056471 158 TETEKDAKKIFPKDKWNSLHLQIIFYGREYSPAR 191
Cdd:PRK10702 157 EQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIAR 190
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 1.80e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 157.81  E-value: 1.80e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471    39 LSAQTTDKKVNEVTPQLFAVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELEALPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491056471   119 GHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKLTSGKNVT-ETEKDAKKIFPKDKWNSLHLQIIFYGRE 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPeEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 3.68e-47

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 152.40  E-value: 3.68e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  31 YTLLVAVALSAQTTDKKVNEVTPQLFA-VADTPFKMKELEVDEIKNLIKEIGlSNTKAKNLKAMAELLVERHQGIV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491056471 107 QSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMTQWKL-TSGKNVTETEKDAKKIFPKDKWNSLHLQIIFYG 184
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 1.25e-36

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 124.70  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   35 VAVALSAQTTDKKVNEVTPQLFA-VADTPFKMKELEVDEIKNLIKEIGLSNTKAKNLKAMAELLVERHQGIVPQSFEELE 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEkFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491056471  114 A-LPGVGHKTASVVMSQAFGV--PAFPVDTHIHRLMTQWKLTSGKNVT-ETEKDAKKIFPK 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGRpdPLPVVDTHVRRVLKRLGLIKEKPTPkEVERELEELWPP 141
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 57-187 1.42e-14

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 69.49  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  57 AVADTPFKMKELEVDEIKNLIKEIGLSNTKAKNLKAMAELLVERHQG----IVPQSFEELE----ALPGVGHKTASVVMS 128
Cdd:COG2231   57 AGLLDPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGGglekLKALPTEELReellSLKGIGPETADSILL 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491056471 129 QAFGVPAFPVDTHIHRLMTQWKLTSGknvTETEKDAKKIF----PKD--KWNSLHLQIIFYGREY 187
Cdd:COG2231  137 YAFNRPVFVVDAYTRRIFSRLGLIEE---DASYDELQRLFeenlPPDvaLYNEFHALIVEHGKEY 198
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 87-139 5.41e-14

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 69.40  E-value: 5.41e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491056471  87 AKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVD 139
Cdd:COG1194   85 ARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVD 137
PRK10880 PRK10880
adenine DNA glycosylase;
86-146 2.91e-11

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 61.65  E-value: 2.91e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491056471  86 KAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPaFPV-DTHIHRLM 146
Cdd:PRK10880  85 RARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKH-FPIlDGNVKRVL 145
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 10-161 7.12e-09

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 54.12  E-value: 7.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  10 IIQELERLYPETPIPLdHKDPYTLLVAVALSAQTTDK--------------KVNEVTPQLFAVADTPFKMKELEVDEIKn 75
Cdd:COG0122   65 VLAPLIERYPGLRLPR-RPDPFEALVRAILGQQVSVAaartiwrrlvalfgEPIEGPGGGLYAFPTPEALAAASEEELR- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471  76 likEIGLSNTKAKNLKAMAELLVE---RHQGIVPQSFEE----LEALPGVGHKTASVVMSQAFGVP-AFPV-DTHIHRLM 146
Cdd:COG0122  143 ---ACGLSRRKARYLRALARAVADgelDLEALAGLDDEEaiarLTALPGIGPWTAEMVLLFALGRPdAFPAgDLGLRRAL 219

                        170
                 ....*....|....*
gi 491056471 147 tQWKLTSGKNVTETE 161
Cdd:COG0122  220 -GRLYGLGERPTPKE 233
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 100-128 7.91e-07

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 43.94  E-value: 7.91e-07
                          10        20
                  ....*....|....*....|....*....
gi 491056471  100 RHQGIVPQSFEELEALPGVGHKTASVVMS 128
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILS 29
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 69-146 4.24e-05

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 4.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491056471  69 EVDEIKNLIKEIGLSnTKAKNLKAMAELLVERHQGIVPQSFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLM 146
Cdd:PRK13910  32 PLEEVLLLWRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRVL 108
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 67-175 3.88e-04

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 40.28  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491056471   67 ELEVDEIKNLIKEIGLSnTKAKNLKAMAELLVERH------QGIVPQSFEE----LEALPGVGHKTASVVMSQAFGVP-A 135
Cdd:TIGR00588 168 ALTGPEAEAHLRKLGLG-YRARYIRETARALLEEQggrawlQQIRGASYEDareaLCELPGVGPKVADCICLMGLDKPqA 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 491056471  136 FPVDTHIHRLMT---QWKLTS--GKNVTETEKDAKKIFPKDKWNS 175
Cdd:TIGR00588 247 VPVDVHVWRIANrdyPWHPKTsrAKGPSPFARKELGNFFRSLWGP 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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