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Conserved domains on  [gi|491048030|ref|WP_004909683|]
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MULTISPECIES: heavy-metal-associated domain-containing protein [Lactobacillaceae]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10006509)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; similar to heavy metal-associated isoprenylated plant protein (HIPP), Synechocystis Pcc6803 zinc-transporting ATPase, and Salmonella enterica gold resistance metallochaperone GolB which exhibits selectivity toward the Au(I) cation

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098|8091505|9437429

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-73 1.36e-18

Copper chaperone CopZ [Inorganic ion transport and metabolism];


:

Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 71.86  E-value: 1.36e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048030  1 MTKATLKLETLTCPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPVISSK 73
Cdd:COG2608   1 MKTVTLKVEGMTCGHCVARVEKALKALDGVAS--VEVDLATGTATVTYDPEKVSLEDIKAAIEEAGYEVEKAE 71
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-73 1.36e-18

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 71.86  E-value: 1.36e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048030  1 MTKATLKLETLTCPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPVISSK 73
Cdd:COG2608   1 MKTVTLKVEGMTCGHCVARVEKALKALDGVAS--VEVDLATGTATVTYDPEKVSLEDIKAAIEEAGYEVEKAE 71
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-69 4.06e-12

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 55.30  E-value: 4.06e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491048030  5 TLKLETLTCPSCLQKIERGLKQTAGVKkdSVKVLFNASKVKVDFDENqVNLNTIEKAIEDLGYPV 69
Cdd:cd00371   1 ELSVEGMTCAGCVSKIEKALEKLPGVE--SVEVDLETGKATVEYDPE-VSPEELLEAIEDAGYKA 62
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
 13-72 1.10e-09

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 52.69  E-value: 1.10e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048030  13 CPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQvnLNTIEKAIEDLGYPVISS 72
Cdd:PRK11033  64 CPSCARKVENAVRQLAGVNQ--VQVLFATEKLVVDADNDI--RAQVESAVQKAGFSLRDE 119
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 3-69 8.18e-09

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 46.77  E-value: 8.18e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491048030   3 KATLKLETLTCPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPV 69
Cdd:TIGR00003  1 KQTFQVKGMSCNHCVDKIEKFVGEIEGVSK--VKVQLEKEKVVVEFDAPNVSATEICEAILDAGYEV 65
HMA pfam00403
Heavy-metal-associated domain;
5-64 1.36e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 43.76  E-value: 1.36e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048030   5 TLKLETLTCPSCLQKIERGLKQTAGVkkDSVKVLFNASKVKVDFDENQVNLNTIEKAIED 64
Cdd:pfam00403  1 TFRVSGMHCGGCAAKVEKALSELPGV--LSVSVDLATKTVTVTGDAESTKLEKLVEAIEK 58
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-73 1.36e-18

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 71.86  E-value: 1.36e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048030  1 MTKATLKLETLTCPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPVISSK 73
Cdd:COG2608   1 MKTVTLKVEGMTCGHCVARVEKALKALDGVAS--VEVDLATGTATVTYDPEKVSLEDIKAAIEEAGYEVEKAE 71
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
2-69 5.06e-14

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 64.78  E-value: 5.06e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491048030   2 TKATLKLETLTCPSCLQKIERGLKQTAGVKkdSVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPV 69
Cdd:COG2217    1 ERVRLRIEGMTCAACAWLIEKALRKLPGVL--SARVNLATERARVEYDPGKVSLEELIAAVEKAGYEA 66
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-69 4.06e-12

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 55.30  E-value: 4.06e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491048030  5 TLKLETLTCPSCLQKIERGLKQTAGVKkdSVKVLFNASKVKVDFDENqVNLNTIEKAIEDLGYPV 69
Cdd:cd00371   1 ELSVEGMTCAGCVSKIEKALEKLPGVE--SVEVDLETGKATVEYDPE-VSPEELLEAIEDAGYKA 62
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
 13-72 1.10e-09

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 52.69  E-value: 1.10e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048030  13 CPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQvnLNTIEKAIEDLGYPVISS 72
Cdd:PRK11033  64 CPSCARKVENAVRQLAGVNQ--VQVLFATEKLVVDADNDI--RAQVESAVQKAGFSLRDE 119
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 3-69 8.18e-09

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 46.77  E-value: 8.18e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491048030   3 KATLKLETLTCPSCLQKIERGLKQTAGVKKdsVKVLFNASKVKVDFDENQVNLNTIEKAIEDLGYPV 69
Cdd:TIGR00003  1 KQTFQVKGMSCNHCVDKIEKFVGEIEGVSK--VKVQLEKEKVVVEFDAPNVSATEICEAILDAGYEV 65
HMA pfam00403
Heavy-metal-associated domain;
5-64 1.36e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 43.76  E-value: 1.36e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491048030   5 TLKLETLTCPSCLQKIERGLKQTAGVkkDSVKVLFNASKVKVDFDENQVNLNTIEKAIED 64
Cdd:pfam00403  1 TFRVSGMHCGGCAAKVEKALSELPGV--LSVSVDLATKTVTVTGDAESTKLEKLVEAIEK 58
PRK13748 PRK13748
putative mercuric reductase; Provisional
 5-67 1.30e-05

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 40.91  E-value: 1.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491048030   5 TLKLETLTCPSCLQKIERGLKQTAGVKKDSVKVLFNASKVKVDFDenqVNLNTIEKAIEDLGY 67
Cdd:PRK13748   3 TLKITGMTCDSCAAHVKDALEKVPGVQSADVSYPKGSAQLAIEVG---TSPDALTAAVAGLGY 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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