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Conserved domains on  [gi|491009350|ref|WP_004871062|]
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MULTISPECIES: ISC system 2Fe-2S type ferredoxin [Acidithiobacillus]

Protein Classification

2Fe-2S iron-sulfur cluster-binding family protein( domain architecture ID 1376)

2Fe-2S iron-sulfur cluster-binding family protein such as ferredoxin, an iron-sulfur protein transfering electrons in a wide variety of metabolic reactions

Gene Ontology:  GO:0051536

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fer2 super family cl00159
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 4-110 1.69e-54

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


The actual alignment was detected with superfamily member TIGR02007:

Pssm-ID: 444718 [Multi-domain]  Cd Length: 110  Bit Score: 165.35  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350    4 IRVLPHHELCPEGAEFDAEPGESIIEAALRNGVHIEHACEMSCACTTCHVILREGFDSLEPAEEKEEDLLDKAWGLEPTS 83
Cdd:TIGR02007   3 IVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEPDS 82

                          90       100
                  ....*....|....*....|....*..
gi 491009350   84 RLSCQAKVGDADLVIEIPKYTINLEKE 110
Cdd:TIGR02007  83 RLSCQAVVADEDLVVEIPKYTINHARE 109
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 4-110 1.69e-54

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 165.35  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350    4 IRVLPHHELCPEGAEFDAEPGESIIEAALRNGVHIEHACEMSCACTTCHVILREGFDSLEPAEEKEEDLLDKAWGLEPTS 83
Cdd:TIGR02007   3 IVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEPDS 82

                          90       100
                  ....*....|....*....|....*..
gi 491009350   84 RLSCQAKVGDADLVIEIPKYTINLEKE 110
Cdd:TIGR02007  83 RLSCQAVVADEDLVVEIPKYTINHARE 109
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 6.26e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 89.91  E-value: 6.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350   1 MTHIRVLPhhelcpEGAEFDAEPGESIIEAALRNGVHIEHACEMsCACTTCHVILREGFdslepAEEKEEDLLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIP------EGHTVEVPAGESLLEAALRAGIDLPYSCRS-GACGTCHVRVLEGE-----VDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 491009350  81 PTSRLSCQAKVGDaDLVIEIP 101
Cdd:COG0633   68 AGSRLACQARPTS-DLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 21-106 1.14e-23

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 87.47  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  21 AEPGESIIEAALRNGVHIEHACEMSCACTTCHVIL--REGFDSLEPAEEKEEDLLDKAWGLEPTSRLSCQAKVGD--ADL 96
Cdd:PLN02593  17 APVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQVIAKPelDGM 96

                         90
                 ....*....|
gi 491009350  97 VIEIPKYTIN 106
Cdd:PLN02593  97 RLALPAATRN 106
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 6.65e-16

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 66.65  E-value: 6.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  14 PEGAEFDAEPGESIIEAALRNGVHIEHACEMScACTTCHVILREGFDSLEPAEekeedlLDKAWGLEPTSRLSCQAKVGD 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEGEVDQSDPS------LLDEEEAEGGYVLACQTRVTD 79


                 ....*.
gi 491009350  94 aDLVIE 99
Cdd:cd00207   80 -GLVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-91 1.30e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 52.91  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350   11 ELCPEGAEFDAEPGESII-EAALRNGVHIEHACEMSCaCTTCHVILREGFDSLEPaEEKEEDLLDKAWGLeptsrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETTLlDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQ-SFLEDDELAAGYVV-----LACQT 74


                  ..
gi 491009350   90 KV 91
Cdd:pfam00111  75 YP 76
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 4-110 1.69e-54

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 165.35  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350    4 IRVLPHHELCPEGAEFDAEPGESIIEAALRNGVHIEHACEMSCACTTCHVILREGFDSLEPAEEKEEDLLDKAWGLEPTS 83
Cdd:TIGR02007   3 IVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEPDS 82

                          90       100
                  ....*....|....*....|....*..
gi 491009350   84 RLSCQAKVGDADLVIEIPKYTINLEKE 110
Cdd:TIGR02007  83 RLSCQAVVADEDLVVEIPKYTINHARE 109
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 6.26e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 89.91  E-value: 6.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350   1 MTHIRVLPhhelcpEGAEFDAEPGESIIEAALRNGVHIEHACEMsCACTTCHVILREGFdslepAEEKEEDLLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIP------EGHTVEVPAGESLLEAALRAGIDLPYSCRS-GACGTCHVRVLEGE-----VDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 491009350  81 PTSRLSCQAKVGDaDLVIEIP 101
Cdd:COG0633   68 AGSRLACQARPTS-DLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 21-106 1.14e-23

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 87.47  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  21 AEPGESIIEAALRNGVHIEHACEMSCACTTCHVIL--REGFDSLEPAEEKEEDLLDKAWGLEPTSRLSCQAKVGD--ADL 96
Cdd:PLN02593  17 APVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQVIAKPelDGM 96

                         90
                 ....*....|
gi 491009350  97 VIEIPKYTIN 106
Cdd:PLN02593  97 RLALPAATRN 106
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 6.65e-16

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 66.65  E-value: 6.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  14 PEGAEFDAEPGESIIEAALRNGVHIEHACEMScACTTCHVILREGFDSLEPAEekeedlLDKAWGLEPTSRLSCQAKVGD 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEGEVDQSDPS------LLDEEEAEGGYVLACQTRVTD 79


                 ....*.
gi 491009350  94 aDLVIE 99
Cdd:cd00207   80 -GLVIE 84
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 1-101 1.77e-15

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 70.60  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350   1 MTHIRVLphheLCPEGAEFDAEPGESIIEAALRNGVHIEHACEMSCACTTCHVILREGfdSLEPAEEKEEDLLDKAwGLE 80
Cdd:COG3894    1 MPKVKVT----FLPSGKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEG--EFSPVTEEERRLLSPE-ELA 73

                         90       100
                 ....*....|....*....|.
gi 491009350  81 PTSRLSCQAKVgDADLVIEIP 101
Cdd:COG3894   74 EGYRLACQARV-LGDLVVEVP 93
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-109 3.17e-13

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 64.11  E-value: 3.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  14 PEGAEFDAEPGESIIEAALRNGVHIEHACEMSCACTTCHVILREGFDSLEPAEE----KEEdlLDKAWgleptsRLSCQA 89
Cdd:COG2871   41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGGGDILPTETfhlsDRE--RKEGY------RLACQV 112

                         90       100
                 ....*....|....*....|
gi 491009350  90 KVgDADLVIEIPKYTINLEK 109
Cdd:COG2871  113 KV-KSDMEIEVPEEVFGVKK 131
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 18-107 2.75e-12

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 59.11  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  18 EFDAEPGESIIEAaLRN--GVHIEHACEMSCACTTCHVILREG-FDSLEPAEEKEEDLLDKAWGLEPTSRLSCQAKVGDA 94
Cdd:PTZ00490  49 DVEVPVGMSLMHA-LRDvaKLDVEGTCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLTPE 127

                         90
                 ....*....|....*
gi 491009350  95 --DLVIEIPKYTINL 107
Cdd:PTZ00490 128 mdGLEVELPSYVTNR 142
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-91 1.30e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 52.91  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350   11 ELCPEGAEFDAEPGESII-EAALRNGVHIEHACEMSCaCTTCHVILREGFDSLEPaEEKEEDLLDKAWGLeptsrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETTLlDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQ-SFLEDDELAAGYVV-----LACQT 74


                  ..
gi 491009350   90 KV 91
Cdd:pfam00111  75 YP 76
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-104 3.12e-10

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 55.26  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  14 PEGAEFDAEPGESIIEAALRNGVHIEHACEmSCACTTCHVILREG-------FDSLEPAEEKEEDLLdkawgleptsrLS 86
Cdd:PRK07609   9 PSGRQFTAEPDETILDAALRQGIHLPYGCK-NGACGSCKGRLLEGeveqgphQASALSGEERAAGEA-----------LT 76

                         90
                 ....*....|....*...
gi 491009350  87 CQAKvGDADLVIEIPKYT 104
Cdd:PRK07609  77 CCAK-PLSDLVLEAREVP 93
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
16-111 1.22e-03

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 36.99  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491009350  16 GAEFDAEPGESIIEAALRNGVHIEHACEMSC-----ACTTCHVilregfdslepaeekEEDlldkawglepTSR-LSCQA 89
Cdd:PRK08493   8 GKECEAQEGEYILNVARRNGIFIPAICYLSGcsptlACRLCMV---------------EAD----------GKRvYSCNT 62

                         90       100
                 ....*....|....*....|..
gi 491009350  90 KVGDAdlvIEIPKYTINLEKER 111
Cdd:PRK08493  63 KAKEG---MNILTNTPNLMDER 81
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 15-42 7.30e-03

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 32.90  E-value: 7.30e-03
                          10        20
                  ....*....|....*....|....*...
gi 491009350   15 EGAEFDAEPGESIIEAALRNGVHIEHAC 42
Cdd:pfam13510   9 DGRPVTAPEGDTIAAALLANGVRVPRSC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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