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Conserved domains on  [gi|490423292|ref|WP_004295507|]
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MULTISPECIES: hypothetical protein [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhdYeFM_antitox super family cl46529
Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins ...
 1-66 9.69e-04

Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.


The actual alignment was detected with superfamily member COG2161:

Pssm-ID: 480869  Cd Length: 83  Bit Score: 34.38  E-value: 9.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490423292  1 MEALSVREYRNNLAASFTKA-DNGEQVLIRRKNEIYAlVKVGRED---------LMITPELQARIDKAREEIKSGK 66
Cdd:COG2161   1 MTTISYSEARKNLASLLDQVvEDHEPVIITRRNGPAA-VLISAEDyeslqetlyLLSSPANAERLLESLAELEAGE 75
 
Name Accession Description Interval E-value
StbD COG2161
Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family [Defense ...
 1-66 9.69e-04

Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family [Defense mechanisms];


Pssm-ID: 441764  Cd Length: 83  Bit Score: 34.38  E-value: 9.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490423292  1 MEALSVREYRNNLAASFTKA-DNGEQVLIRRKNEIYAlVKVGRED---------LMITPELQARIDKAREEIKSGK 66
Cdd:COG2161   1 MTTISYSEARKNLASLLDQVvEDHEPVIITRRNGPAA-VLISAEDyeslqetlyLLSSPANAERLLESLAELEAGE 75
 
Name Accession Description Interval E-value
StbD COG2161
Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family [Defense ...
 1-66 9.69e-04

Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family [Defense mechanisms];


Pssm-ID: 441764  Cd Length: 83  Bit Score: 34.38  E-value: 9.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490423292  1 MEALSVREYRNNLAASFTKA-DNGEQVLIRRKNEIYAlVKVGRED---------LMITPELQARIDKAREEIKSGK 66
Cdd:COG2161   1 MTTISYSEARKNLASLLDQVvEDHEPVIITRRNGPAA-VLISAEDyeslqetlyLLSSPANAERLLESLAELEAGE 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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