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Conserved domains on  [gi|490219853|ref|WP_004118228|]
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MULTISPECIES: ABC transporter permease [Bacteria]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 7-275 1.18e-99

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 292.79  E-value: 1.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   7 FLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQfveglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGV 86
Cdd:COG1173   12 LRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  87 VANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSA 166
Cdd:COG1173   87 LAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 167 LSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAP 246
Cdd:COG1173  167 LREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAP 246

                        250       260
                 ....*....|....*....|....*....
gi 490219853 247 WLVFFPGAAIVLLSLSFNIAGDALRDALD 275
Cdd:COG1173  247 WLALFPGLAIVLTVLAFNLLGDGLRDALD 275
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 7-275 1.18e-99

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 292.79  E-value: 1.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   7 FLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQfveglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGV 86
Cdd:COG1173   12 LRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  87 VANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSA 166
Cdd:COG1173   87 LAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 167 LSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAP 246
Cdd:COG1173  167 LREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAP 246

                        250       260
                 ....*....|....*....|....*....
gi 490219853 247 WLVFFPGAAIVLLSLSFNIAGDALRDALD 275
Cdd:COG1173  247 WLALFPGLAIVLTVLAFNLLGDGLRDALD 275
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 23-275 1.78e-67

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 210.32  E-value: 1.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   23 VVMSALFAPWLTPFDPDEQfveglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLVGLS 102
Cdd:TIGR02790  11 LFLLAIFAPWIAPHDPLAQ-----NLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  103 AGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTLGAG 182
Cdd:TIGR02790  86 AGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGAS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  183 TLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWLVFFPGAAIVLLSLS 262
Cdd:TIGR02790 166 HWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMA 245

                         250
                  ....*....|...
gi 490219853  263 FNIAGDALRDALD 275
Cdd:TIGR02790 246 FNLLGDALRDHLG 258
nikC PRK10417
nickel transporter permease NikC; Provisional
 9-280 1.95e-60

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 192.96  E-value: 1.95e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   9 RRPALLLSLLFILLVVMSALFAPWLTPFDPdeqfvEGLSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVA 88
Cdd:PRK10417   2 SRWSVRLALIIIALLALIALTSQWWLPYDP-----QAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMAC 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  89 NGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALS 168
Cdd:PRK10417  77 LLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 169 ARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWL 248
Cdd:PRK10417 157 QREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLL 236

                        250       260       270
                 ....*....|....*....|....*....|..
gi 490219853 249 VFFPGAAIVLLSLSFNIAGDALRDALDPGLKG 280
Cdd:PRK10417 237 MFWPGLALFISVMAFNLLGDALRDHLDPHLVT 268
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-251 1.08e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.52  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  78 ARTSLLIGVVANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPA--------LLLAIALAAIFQPSVWIVSLVIA 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSlvlglllvLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 150 MVNWVQIARVIYAETSALSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVqPPTP 229
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180
                 ....*....|....*....|..
gi 490219853 230 SWGNIIFESQSYFTSAPWLVFF 251
Cdd:cd06261  160 GTGLLLIFAILFPGDLGVAAAV 181
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 96-279 2.58e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   96 GVLVGLSAGYLQGRIG-GLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVS----LVIAMVNWVQIARVIYAETSALSAR 170
Cdd:pfam00528   1 GIPLGIIAALRRGRRLdRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGilpaIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  171 DFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFL----GVGVQPPTPSWGNIIFESQSYFtsap 246
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPEIQGPV---- 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490219853  247 wlvffpgAAIVLLSLSFNIAGDALRDALDPGLK 279
Cdd:pfam00528 157 -------LAAALILLLLNLLVDILQRLLDPRVR 182
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 7-275 1.18e-99

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 292.79  E-value: 1.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   7 FLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQfveglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGV 86
Cdd:COG1173   12 LRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  87 VANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSA 166
Cdd:COG1173   87 LAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 167 LSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAP 246
Cdd:COG1173  167 LREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAP 246

                        250       260
                 ....*....|....*....|....*....
gi 490219853 247 WLVFFPGAAIVLLSLSFNIAGDALRDALD 275
Cdd:COG1173  247 WLALFPGLAIVLTVLAFNLLGDGLRDALD 275
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 23-275 1.78e-67

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 210.32  E-value: 1.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   23 VVMSALFAPWLTPFDPDEQfveglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLVGLS 102
Cdd:TIGR02790  11 LFLLAIFAPWIAPHDPLAQ-----NLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  103 AGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTLGAG 182
Cdd:TIGR02790  86 AGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGAS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  183 TLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWLVFFPGAAIVLLSLS 262
Cdd:TIGR02790 166 HWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMA 245

                         250
                  ....*....|...
gi 490219853  263 FNIAGDALRDALD 275
Cdd:TIGR02790 246 FNLLGDALRDHLG 258
nikC PRK10417
nickel transporter permease NikC; Provisional
 9-280 1.95e-60

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 192.96  E-value: 1.95e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   9 RRPALLLSLLFILLVVMSALFAPWLTPFDPdeqfvEGLSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVA 88
Cdd:PRK10417   2 SRWSVRLALIIIALLALIALTSQWWLPYDP-----QAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMAC 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  89 NGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALS 168
Cdd:PRK10417  77 LLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 169 ARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWL 248
Cdd:PRK10417 157 QREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLL 236

                        250       260       270
                 ....*....|....*....|....*....|..
gi 490219853 249 VFFPGAAIVLLSLSFNIAGDALRDALDPGLKG 280
Cdd:PRK10417 237 MFWPGLALFISVMAFNLLGDALRDHLDPHLVT 268
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
6-279 1.11e-56

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 184.22  E-value: 1.11e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   6 YFLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQFVEGLSLEGAPLSPNS-TYWLGTDLLGRDLFSRLIYGARTSLLI 84
Cdd:PRK10913  25 YFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAEQFRDALLAPPVWQEGGSwAHILGTDDVGRDVLSRLMYGARLSLLV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  85 GVVANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAET 164
Cdd:PRK10913 105 GCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVNAALALTFVALPHYVRLTRAAV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 165 SALSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTS 244
Cdd:PRK10913 185 LVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQS 264

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 490219853 245 APWLVFFPGAAIVLLSLSFNIAGDALRDALDPGLK 279
Cdd:PRK10913 265 AWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKLK 299
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
3-281 1.98e-55

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 180.78  E-value: 1.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   3 RVGYFLRR-PALLLSLLFILLVVMSALFAPWLTPFDPDeqfveGLSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTS 81
Cdd:PRK09881  22 KLVWMLKGsPLTVTGAVIIVLMLLMMIFSPWLATHDPN-----AIDLTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  82 LLIGVVANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIY 161
Cdd:PRK09881  97 ILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSLVLTMALAAALGPSLFNAMLAIAIVRIPFYVRLAR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 162 AETSALSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSY 241
Cdd:PRK09881 177 GQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLGAQQPSAEWGAMVANGRNY 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490219853 242 FTSAPWLVFFPGAAIVLLSLSFNIAGDALRDALDPGLKGR 281
Cdd:PRK09881 257 VLDQWWYCAFPGAAILLTAVGFNLFGDGIRDLLDPKAGGK 296
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 7-280 1.49e-52

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 173.38  E-value: 1.49e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   7 FLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQFVEGLSLEGaplsPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGV 86
Cdd:PRK15082  32 FRRQHVALVAGLFVLLLIVVAIFAPWIAPYDAENYFDYDALNAG----PSLQHWFGVDSLGRDIFSRILVGARISLAAGF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  87 VANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSA 166
Cdd:PRK15082 108 FSVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAILGSGMANVIIAVAIFSIPAFARLVRGNTLV 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 167 LSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAP 246
Cdd:PRK15082 188 LKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAASLSFLGLGAQPPTPEWGAMLNEARADMVIAP 267

                        250       260       270
                 ....*....|....*....|....*....|....
gi 490219853 247 WLVFFPGAAIVLLSLSFNIAGDALRDALDPGLKG 280
Cdd:PRK15082 268 HVALFPSLAIFLTVLAFNLLGDGLRDALDPKIKG 301
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 7-276 1.86e-47

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 160.39  E-value: 1.86e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   7 FLRRPALLLSLLFILLVVMSALFAPWLTPFDPDEQFVEGLSlegAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGV 86
Cdd:PRK15406  33 FMHNRAAVASLIVLVLIALFVILAPMLSQFAYDDTDWGMMS---SAPDMESGHYFGTDSSGRDLLVRVAIGGRISLMVGV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  87 VANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSA 166
Cdd:PRK15406 110 AAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 167 LSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAP 246
Cdd:PRK15406 190 LKRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSP 269

                        250       260       270
                 ....*....|....*....|....*....|
gi 490219853 247 WLVFFPGAAIVLLSLSFNIAGDALRDALDP 276
Cdd:PRK15406 270 WLLLFPAGFLVVTLFCFNFIGDGLRDALDP 299
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
27-279 1.57e-42

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 147.27  E-value: 1.57e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  27 ALFAPWLTPFDPDEQFVeglsleGAPLSPNS-------TYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLV 99
Cdd:COG4171   43 ALFGPLLAPYSPDQQFI------GALLLPPSwddngdvSFFLGTDDLGRDILSRLLYGARYTFGSALLVVLAAAIIGGII 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 100 GLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTL 179
Cdd:COG4171  117 GILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLGPGLENAMLAITLALLPQFIHAIYQAVHQELKKEYVLAARLD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 180 GAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWLVFFPGAAIVLL 259
Cdd:COG4171  197 GASNWQLLRYSILPNILEVLVTELTRALSIAILDISALGFLGLGAQLPSPEWGAMLGDSLELIYLAPWTVILPGLAIMFS 276

                        250       260
                 ....*....|....*....|
gi 490219853 260 SLSFNIAGDALRDALDPGLK 279
Cdd:COG4171  277 VLIVNLVGDGLRRALNKGVE 296
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 27-276 5.62e-37

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 133.74  E-value: 5.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  27 ALFAPwlTPFDPDEQFVEglSLEGAPLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLVGLSAGYL 106
Cdd:COG4239   93 ALWPP--IPYSYDTINYD--LPSPAPSPPSAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQGYF 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 107 QGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTLGAGTLRI 186
Cdd:COG4239  169 GGRVDLLFQRFIEIWSSMPELYLLIILSSIFQPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRI 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 187 LGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTsAPWLVFFPGAAIVL-LSLSFNI 265
Cdd:COG4239  249 MFRHILPNAMVATLTFLPFILSGAITTLTSLDFLGFGLPPGSPSLGELLAQGKNNLQ-APWLGLSAFVVLALmLSLLVFI 327

                        250
                 ....*....|.
gi 490219853 266 aGDALRDALDP 276
Cdd:COG4239  328 -GEAVRDAFDP 337
PRK15111 PRK15111
peptide ABC transporter permease SapC;
27-279 1.81e-27

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 107.48  E-value: 1.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  27 ALFAPWLTPFDPDEQFVeglsleGAPLSPNS-------TYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLV 99
Cdd:PRK15111  43 CLFGGWLAPYGIDQQFL------GYQLLPPSwsrygevSFFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATLCGLVL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 100 GLSAGYLQGRIGGLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTL 179
Cdd:PRK15111 117 GVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSAVHDELEKEYVIAARLD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 180 GAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVQPPTPSWGNIIFESQSYFTSAPWLVFFPGAAIVLL 259
Cdd:PRK15111 197 GASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDSLELIYVAPWTVMLPGAAIMLS 276

                        250       260
                 ....*....|....*....|
gi 490219853 260 SLSFNIAGDALRDALDPGLK 279
Cdd:PRK15111 277 VLLVNLLGDGIRRAIIAGVE 296
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 52-276 3.28e-26

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 105.07  E-value: 3.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  52 PLSPNSTYWLGTDLLGRDLFSRLIYGARTSLLIGVVANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPALLLAI 131
Cdd:PRK15021 114 PSPPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLII 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 132 ALAAIFQPSVWIVSLVIAMVNWVQIARVIYAETSALSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTV 211
Cdd:PRK15021 194 LLSSVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSI 273

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490219853 212 LLEATLSFLGVGVQPPTPSWGNIIFESQSYFtSAPWL--VFFPGAAIVLLSLSFniAGDALRDALDP 276
Cdd:PRK15021 274 TTLTSLDFLGFGLPLGSPSLGELLLQGKNNL-QAPWLgiTAFLSVAILLSLLIF--IGEAVRDAFDP 337
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-251 1.08e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.52  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  78 ARTSLLIGVVANGTAVLIGVLVGLSAGYLQGRIGGLLMRFTDLMMAFPA--------LLLAIALAAIFQPSVWIVSLVIA 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSlvlglllvLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853 150 MVNWVQIARVIYAETSALSARDFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFLGVGVqPPTP 229
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180
                 ....*....|....*....|..
gi 490219853 230 SWGNIIFESQSYFTSAPWLVFF 251
Cdd:cd06261  160 GTGLLLIFAILFPGDLGVAAAV 181
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 96-279 2.58e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853   96 GVLVGLSAGYLQGRIG-GLLMRFTDLMMAFPALLLAIALAAIFQPSVWIVS----LVIAMVNWVQIARVIYAETSALSAR 170
Cdd:pfam00528   1 GIPLGIIAALRRGRRLdRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGilpaIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490219853  171 DFIAVERTLGAGTLRILGVHLIPHLAPTVLVWATLGISTTVLLEATLSFL----GVGVQPPTPSWGNIIFESQSYFtsap 246
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPEIQGPV---- 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490219853  247 wlvffpgAAIVLLSLSFNIAGDALRDALDPGLK 279
Cdd:pfam00528 157 -------LAAALILLLLNLLVDILQRLLDPRVR 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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