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Conserved domains on  [gi|490183090|ref|WP_004081704|]
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MULTISPECIES: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA [Thermotoga]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-254 1.08e-111

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 322.07  E-value: 1.08e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   8 KKYGVRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPN 87
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  88 VELRFEDFLKAK--NVPEGA--ICVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQT 161
Cdd:COG0030   85 LTVIEGDALKVDlpALAAGEplKVVGNLPYNISTPILFKLLEARppIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 162 FYEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDL----DFEKFKKFVSMIFAKKRKTLKNNLRPFLS------IFE--G 229
Cdd:COG0030  165 YADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLvpvaDEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerleeALEaaG 244

                        250       260
                 ....*....|....*....|....*
gi 490183090 230 VDLSRRAEQLTVEEIVELYEKWRRA 254
Cdd:COG0030  245 IDPTARAEELSVEEFARLANALKKR 269
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-254 1.08e-111

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 322.07  E-value: 1.08e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   8 KKYGVRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPN 87
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  88 VELRFEDFLKAK--NVPEGA--ICVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQT 161
Cdd:COG0030   85 LTVIEGDALKVDlpALAAGEplKVVGNLPYNISTPILFKLLEARppIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 162 FYEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDL----DFEKFKKFVSMIFAKKRKTLKNNLRPFLS------IFE--G 229
Cdd:COG0030  165 YADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLvpvaDEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerleeALEaaG 244

                        250       260
                 ....*....|....*....|....*
gi 490183090 230 VDLSRRAEQLTVEEIVELYEKWRRA 254
Cdd:COG0030  245 IDPTARAEELSVEEFARLANALKKR 269
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 12-249 9.10e-87

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 258.31  E-value: 9.10e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   12 VRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELR 91
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   92 FEDFLK---AKNVPEGAICVSNIPYNITGPLMEKIIE--WKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVK 166
Cdd:TIGR00755  81 EGDALKfdlNELAKDLTKVVGNLPYNISSPLIFKLLKekDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  167 KLFDVSRSCFVPNPEVDSTVVDL---KRKPVDLDFEKFKKFVSMIFAKKRKTLKNNLRPFLSI------FEGVDLSRRAE 237
Cdd:TIGR00755 161 IVFKVPPSAFYPPPKVDSAVVRLvplKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSElvelleELGIDPDKRVE 240

                         250
                  ....*....|..
gi 490183090  238 QLTVEEIVELYE 249
Cdd:TIGR00755 241 QLSPEDFLRLAN 252
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
12-250 7.07e-80

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 240.96  E-value: 7.07e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  12 VRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELR 91
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  92 FEDFLKAkNVPEGAICVSNIPYNITGPLMEKIIEWKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVKKLFDV 171
Cdd:PRK14896  81 EGDALKV-DLPEFNKVVSNLPYQISSPITFKLLKHGFEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 172 SRSCFVPNPEVDSTVVDLKRKPVDLDFEK---FKKFVSMIFAKKRKTLKNNLRPFLSIFE------------GVDLSRRA 236
Cdd:PRK14896 160 PPGAFSPKPKVDSAVVRLTPREPKYEVYDedfFDDFVKALFQHRRKTLRNALKNSAHISGkedikavvealpEELLNKRV 239

                        250
                 ....*....|....
gi 490183090 237 EQLTVEEIVELYEK 250
Cdd:PRK14896 240 FQLSPEEIAELANL 253
rADc smart00650
Ribosomal RNA adenine dimethylases;
28-193 3.67e-73

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 220.85  E-value: 3.67e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090    28 IAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELRFEDFLKAKNVPEGAI- 106
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKLQPYk 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   107 CVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVKKLFDVSRSCFVPNPEVDS 184
Cdd:smart00650  81 VVGNLPYNISTPILFKLLEEPpaFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDS 160


                   ....*....
gi 490183090   185 TVVDLKRKP 193
Cdd:smart00650 161 AVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
13-249 1.09e-58

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 187.19  E-value: 1.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   13 RLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELRF 92
Cdd:pfam00398   3 KFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   93 EDFLKAkNVPEGAI-------CVSNIPYNITGPLMEKIIE---WKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTF 162
Cdd:pfam00398  83 QDFLKF-EFPSLVThihqeflVVGNLPYNISTPIVKQLLFesrFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  163 YEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDL----DFEKFKKFVSMIFAKKRKTLKNNLRPFLS-------IFEGVD 231
Cdd:pfam00398 162 TDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPhpvkDLDVYDSVVRKLFNRKRKTLSTSLKSLFPggqlqafSSHGIN 241

                         250
                  ....*....|....*...
gi 490183090  232 LSRRAEQLTVEEIVELYE 249
Cdd:pfam00398 242 DNALVKKLSPEQTLDIFN 259
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 44-125 1.30e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  44 VVEIGAGAGTLTEELAKT-GARVIAYEIDESLAPILQE--RLSKYPNVELRFEDFLKAKNVPEGA--ICVSNIPYNITGP 118
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKaaAALLADNVEVLKGDAEELPPEADESfdVIISDPPLHHLVE 81


                 ....*..
gi 490183090 119 LMEKIIE 125
Cdd:cd02440   82 DLARFLE 88
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-254 1.08e-111

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 322.07  E-value: 1.08e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   8 KKYGVRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPN 87
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  88 VELRFEDFLKAK--NVPEGA--ICVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQT 161
Cdd:COG0030   85 LTVIEGDALKVDlpALAAGEplKVVGNLPYNISTPILFKLLEARppIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 162 FYEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDL----DFEKFKKFVSMIFAKKRKTLKNNLRPFLS------IFE--G 229
Cdd:COG0030  165 YADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLvpvaDEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerleeALEaaG 244

                        250       260
                 ....*....|....*....|....*
gi 490183090 230 VDLSRRAEQLTVEEIVELYEKWRRA 254
Cdd:COG0030  245 IDPTARAEELSVEEFARLANALKKR 269
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 12-249 9.10e-87

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 258.31  E-value: 9.10e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   12 VRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELR 91
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   92 FEDFLK---AKNVPEGAICVSNIPYNITGPLMEKIIE--WKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVK 166
Cdd:TIGR00755  81 EGDALKfdlNELAKDLTKVVGNLPYNISSPLIFKLLKekDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  167 KLFDVSRSCFVPNPEVDSTVVDL---KRKPVDLDFEKFKKFVSMIFAKKRKTLKNNLRPFLSI------FEGVDLSRRAE 237
Cdd:TIGR00755 161 IVFKVPPSAFYPPPKVDSAVVRLvplKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSElvelleELGIDPDKRVE 240

                         250
                  ....*....|..
gi 490183090  238 QLTVEEIVELYE 249
Cdd:TIGR00755 241 QLSPEDFLRLAN 252
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
12-250 7.07e-80

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 240.96  E-value: 7.07e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  12 VRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELR 91
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  92 FEDFLKAkNVPEGAICVSNIPYNITGPLMEKIIEWKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVKKLFDV 171
Cdd:PRK14896  81 EGDALKV-DLPEFNKVVSNLPYQISSPITFKLLKHGFEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 172 SRSCFVPNPEVDSTVVDLKRKPVDLDFEK---FKKFVSMIFAKKRKTLKNNLRPFLSIFE------------GVDLSRRA 236
Cdd:PRK14896 160 PPGAFSPKPKVDSAVVRLTPREPKYEVYDedfFDDFVKALFQHRRKTLRNALKNSAHISGkedikavvealpEELLNKRV 239

                        250
                 ....*....|....
gi 490183090 237 EQLTVEEIVELYEK 250
Cdd:PRK14896 240 FQLSPEEIAELANL 253
rADc smart00650
Ribosomal RNA adenine dimethylases;
28-193 3.67e-73

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 220.85  E-value: 3.67e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090    28 IAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELRFEDFLKAKNVPEGAI- 106
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKLQPYk 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   107 CVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFYEVKKLFDVSRSCFVPNPEVDS 184
Cdd:smart00650  81 VVGNLPYNISTPILFKLLEEPpaFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDS 160


                   ....*....
gi 490183090   185 TVVDLKRKP 193
Cdd:smart00650 161 AVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
13-249 1.09e-58

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 187.19  E-value: 1.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   13 RLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYPNVELRF 92
Cdd:pfam00398   3 KFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   93 EDFLKAkNVPEGAI-------CVSNIPYNITGPLMEKIIE---WKFKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTF 162
Cdd:pfam00398  83 QDFLKF-EFPSLVThihqeflVVGNLPYNISTPIVKQLLFesrFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  163 YEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDL----DFEKFKKFVSMIFAKKRKTLKNNLRPFLS-------IFEGVD 231
Cdd:pfam00398 162 TDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPhpvkDLDVYDSVVRKLFNRKRKTLSTSLKSLFPggqlqafSSHGIN 241

                         250
                  ....*....|....*...
gi 490183090  232 LSRRAEQLTVEEIVELYE 249
Cdd:pfam00398 242 DNALVKKLSPEQTLDIFN 259
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 9-221 3.03e-49

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 164.02  E-value: 3.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   9 KYGVRLKKHLGQVFLSDDRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQER---LSKY 85
Cdd:PTZ00338   5 KSGMVFNKKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRfqnSPLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  86 PNVELRFEDFLKAkNVPEGAICVSNIPYNITGPLMEKIIEWK--FKRAIVMIQKEVGERILAKPGKKTYGYLSVVVQTFY 163
Cdd:PTZ00338  85 SKLEVIEGDALKT-EFPYFDVCVANVPYQISSPLVFKLLAHRplFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQLLC 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 164 EVKKLFDVSRSCFVPNPEVDSTVVDL--KRKPVDLDFEKFKKFVSMIFAKKRKTLKNNLR 221
Cdd:PTZ00338 164 RVTHLMKVSKNSFNPPPKVESSVVRIepKNPPPDVDFEEWDGLLRICFSRKNKTLSAIFK 223
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
29-178 5.48e-11

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 60.22  E-value: 5.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  29 AKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTG---ARVIAYEIDESLAPILQERlskYPNVEL------RFEDFLKAK 99
Cdd:COG3963   34 ARAMASEVDWSGAGPVVELGPGTGVFTRAILARGvpdARLLAVEINPEFAEHLRRR---FPRVTVvngdaeDLAELLAEH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090 100 NVPE-GAIcVSNIPYNItgplmekiiewkfkraivmIQKEVGERILA------KPGKK----TYGYLSVVVQTFYEvkKL 168
Cdd:COG3963  111 GIGKvDAV-VSGLPLLS-------------------FPPELRRAILDaafrvlAPGGVfvqfTYSPRSPVPRKLLR--RG 168

                        170
                 ....*....|
gi 490183090 169 FDVSRSCFVP 178
Cdd:COG3963  169 FEAVRSGFVW 178
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 31-105 1.11e-08

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 53.55  E-value: 1.11e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490183090  31 RIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSK--YPNVELRFEDFlkAKNVPEGA 105
Cdd:COG2518   57 RMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLAAlgYDNVTVRVGDG--ALGWPEHA 131
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-91 2.68e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 51.53  E-value: 2.68e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490183090  26 DRIA------KRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYP-NVELR 91
Cdd:COG2226    2 DRVAarydgrEALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGlNVEFV 74
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 25-96 7.17e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 7.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490183090  25 DDRIAKRIvkAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYpNVELRFEDFL 96
Cdd:COG2227   11 DRRLAALL--ARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL-NVDFVQGDLE 79
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 44-125 1.30e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  44 VVEIGAGAGTLTEELAKT-GARVIAYEIDESLAPILQE--RLSKYPNVELRFEDFLKAKNVPEGA--ICVSNIPYNITGP 118
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKaaAALLADNVEVLKGDAEELPPEADESfdVIISDPPLHHLVE 81


                 ....*..
gi 490183090 119 LMEKIIE 125
Cdd:cd02440   82 DLARFLE 88
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 8-106 2.74e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 47.08  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090   8 KKYGVRLKKHLGQVF------LSDD-RIAKR------------IVKAAELTPEDVVVEIGAGAGTLTEELAK----TGaR 64
Cdd:COG2519   40 KPEGSVVTTSKGKEFlvlrptLYDYvLSMKRgtqiiypkdagyIIARLDIFPGARVLEAGTGSGALTLALARavgpEG-K 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 490183090  65 VIAYEIDESLAPILQERLSKY---PNVELRFEDFlkAKNVPEGAI 106
Cdd:COG2519  119 VYSYERREDFAEIARKNLERFglpDNVELKLGDI--REGIDEGDV 161
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 26-95 7.85e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.92  E-value: 7.85e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490183090  26 DRIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAK-TGARVIAYEIDESLAPILQERLSKY---PNVELRFEDF 95
Cdd:COG2230   37 EAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARrYGVRVTGVTLSPEQLEYARERAAEAglaDRVEVRLADY 110
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
40-89 1.39e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.03  E-value: 1.39e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490183090  40 PEDVVVEIGAGAGTLTEELAKTGAR-VIAYEIDESLAPILQERLSKYPNVE 89
Cdd:COG4076   35 PGDVVLDIGTGSGLLSMLAARAGAKkVYAVEVNPDIAAVARRIIAANGLSD 85
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 44-97 2.91e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.78  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 490183090   44 VVEIGAGAGTLTEELAK-TGARVIAYEIDESLAPILQERLSKY-PNVELRFEDFLK 97
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAgLNVEFVQGDAED 56
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
40-95 3.02e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 41.73  E-value: 3.02e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490183090  40 PEDVVVEIGAGAGTLTEELAK--TGARVIAYEIDESLAPILQERLskyPNVELRFEDF 95
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARL---PNVRFVVADL 55
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 27-73 4.63e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 44.01  E-value: 4.63e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 490183090  27 RIAKRIVKAAELTPEDVVVEIGAGAGTLTEELAKTGARVIAYEIDES 73
Cdd:COG2265  220 ALYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPE 266
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 44-111 7.39e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.60  E-value: 7.39e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490183090  44 VVEIGAGAGTLTEELAK-TGARVIAYEIDESLAPILQERLSKY--PNVELRFEDFLKAKNVPEG---AICVSNI 111
Cdd:COG0500   30 VLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARARAAKAglGNVEFLVADLAELDPLPAEsfdLVVAFGV 103
MDR_enoyl_red cd08244
Possible enoyl reductase; Member identified as possible enoyl reductase of the MDR family. ...
 23-67 1.35e-03

Possible enoyl reductase; Member identified as possible enoyl reductase of the MDR family. 2-enoyl thioester reductase (ETR) catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.


Pssm-ID: 176206 [Multi-domain]  Cd Length: 324  Bit Score: 39.27  E-value: 1.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 490183090  23 LSDDRIAKRIVKAAELTPEDVVVEIGA--GAGTLTEELAKT-GARVIA 67
Cdd:cd08244  125 VHDGRTALGLLDLATLTPGDVVLVTAAagGLGSLLVQLAKAaGATVVG 172
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 28-90 1.82e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 38.99  E-value: 1.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490183090  28 IAKRIVKAA-----ELTPEDVVVEIGAGAGTLTEELAKT--GARVIAYEIDESLAPILQERLSKY--PNVEL 90
Cdd:COG2242  230 ITKREVRALtlaklALRPGDVLWDIGAGSGSVSIEAARLapGGRVYAIERDPERAALIRANARRFgvPNVEV 301
Methyltransf_33 pfam10017
Histidine-specific methyltransferase, SAM-dependent; The mycobacterial members of this family ...
 36-98 2.10e-03

Histidine-specific methyltransferase, SAM-dependent; The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.


Pssm-ID: 462944  Cd Length: 304  Bit Score: 38.61  E-value: 2.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490183090   36 AELTPEDVVVEIGAGAGT----LTEELAKTGARVIAYEID---ESLAPILQERLSKYPNVELR-----FEDFLKA 98
Cdd:pfam10017  57 AALIPAAVLVELGSGSSRktrlLLDALPAAGKPVTYVPIDisaEALEESAAALAADYPGLTVHglvgdYEDGLAR 131
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-86 2.25e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.49  E-value: 2.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 490183090   45 VEIGAGAGTLTEELAKTGARVIAYEIDESLAPILQERLSKYP 86
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREG 42
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
32-89 3.43e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 37.67  E-value: 3.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490183090  32 IVKAAELTPEDVVVEIGAGAGTLTEELAK--TGARVIAYEIDESLAPILQERLSKY--PNVE 89
Cdd:PRK07402  32 LISQLRLEPDSVLWDIGAGTGTIPVEAGLlcPKGRVIAIERDEEVVNLIRRNCDRFgvKNVE 93
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-95 3.48e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.19  E-value: 3.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490183090   45 VEIGAGAGTLTEELAK--TGARVIAYEIDESLAPILQERLSKYPNVELRFEDF 95
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALGLLNAVRVEL 53
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
15-112 5.11e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 37.19  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490183090  15 KKHLGQvFLSDDRIAKRIVKAAEL---TPEDVVVEIGAGAGTLTEELAKTGA-RVIAYEIDESLAPILQERLSKY-PNVE 89
Cdd:COG2263   18 KVELEQ-YPTPAELAAELLHLAYLrgdIEGKTVLDLGCGTGMLAIGAALLGAkKVVGVDIDPEALEIARENAERLgVRVD 96

                         90       100
                 ....*....|....*....|...
gi 490183090  90 LRFEDFLKAKNVPEGAICVSNIP 112
Cdd:COG2263   97 FIRADVTRIPLGGSVDTVVMNPP 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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