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Conserved domains on  [gi|490071246|ref|WP_003973421|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Streptomyces]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 3.13e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.97  E-value: 3.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 490071246  96 ALGHEVAGRLLALIECVEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 3.13e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.97  E-value: 3.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 490071246  96 ALGHEVAGRLLALIECVEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 31-119 1.39e-25

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 92.37  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246   31 VTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGHEVAGRLLALIE 110
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 490071246  111 CVEGRMDEV 119
Cdd:pfam01638  82 WGEEYLEPE 90
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 3.13e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.97  E-value: 3.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 490071246  96 ALGHEVAGRLLALIECVEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 31-119 1.39e-25

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 92.37  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246   31 VTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGHEVAGRLLALIE 110
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 490071246  111 CVEGRMDEV 119
Cdd:pfam01638  82 WGEEYLEPE 90
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
52-107 4.17e-04

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 37.22  E-value: 4.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490071246  52 ELRRRVDG---VSEKMLAQTLHALERDGLV--HREAQPTNPPRVDYELTALGHEVAGRLLA 107
Cdd:COG1695   31 ELEERSGGfwkVSEGTLYPALKRLEKEGLVesEWEESEGGPRRKYYRLTEAGREELAEWLE 91
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
39-125 2.92e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490071246  39 TLGALYE-GSFRFNELRRRVdGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGHEVAGRLLALIECVEGRMD 117
Cdd:COG1846   43 VLAALAEaGGLTQSELAERL-GLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL 121


                 ....*...
gi 490071246 118 EVLASRER 125
Cdd:COG1846  122 AGLSEEEL 129
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 40-101 3.82e-03

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 34.15  E-value: 3.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490071246   40 LGALYEGSFRFNELRrrvdgvsekmLAQTLHALERDGLV--HREAQPTNPPRVDYELTALGHEV 101
Cdd:pfam03551  19 LEELSGGFWRPSEGT----------LYPILKRLEKEGLVesEWVDSGGGPPRKYYRLTDAGRRE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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