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Conserved domains on  [gi|490007402|ref|WP_003910242|]
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MULTISPECIES: YncE family protein [Mycobacterium]

Protein Classification

YncE family protein( domain architecture ID 11465355)

YncE family protein contains repeats resembling the NHL (NCL-1, HT2A and LIN-41) and YVTN-type repeats, similar to DNA-binding beta-propeller protein YncE and Bacillus subtilis uncharacterized protein YwhL

CATH:  2.130.10.10
PubMed:  22120742|10607670
SCOP:  4002745

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
6-108 3.49e-17

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 73.57  E-value: 3.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   6 GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTG 85
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVAT-IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPHG 156

                         90       100
                 ....*....|....*....|...
gi 490007402  86 VAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNTVSVI 179
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
6-108 3.49e-17

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 73.57  E-value: 3.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   6 GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTG 85
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVAT-IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPHG 156

                         90       100
                 ....*....|....*....|...
gi 490007402  86 VAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNTVSVI 179
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1-105 8.24e-11

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 56.45  E-value: 8.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVG 80
Cdd:cd14952  141 VAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGNNRVLKLAAGSTTPTVLPFTGL 219

                         90       100
                 ....*....|....*....|....*
gi 490007402  81 TAPTGVAVNPvTGEVYVTNFAGDTV 105
Cdd:cd14952  220 NGPLGVAVDA-AGNVYVADRGNDRV 243
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 9-108 8.06e-10

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 54.28  E-value: 8.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402    9 VYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTGVAV 88
Cdd:TIGR03866  13 AYVSNEKDNTISVIDTATLKVTRT-FPVGQRPRGITFSKDGKLLYVCASDSDTIQVIDPATGEVLHT-LPSGPDPEQFAL 90

                          90       100
                  ....*....|....*....|
gi 490007402   89 NPVTGEVYVTNFAGDTVSVI 108
Cdd:TIGR03866  91 HPNGKILYIANEDDALVTVI 110
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
6-108 3.49e-17

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 73.57  E-value: 3.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   6 GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTG 85
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVAT-IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPHG 156

                         90       100
                 ....*....|....*....|...
gi 490007402  86 VAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNTVSVI 179
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-106 2.40e-14

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 65.87  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNP-GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVI----DPTTNTVTGS 75
Cdd:COG3391  115 LAVDPdGGRLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPHGIAVDPDGKRLYVANSGSNTVSVIvsviDTATGKVVAT 193

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490007402  76 pITVGTAPTGVAVNPVTGEVYVTNFAGDTVS 106
Cdd:COG3391  194 -IPVGGGPVGVAVSPDGRRLYVANRGSNTSN 223
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2-108 3.87e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.42  E-value: 3.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPI-TVG 80
Cdd:COG4257   23 AVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALpGGG 101

                         90       100
                 ....*....|....*....|....*...
gi 490007402  81 TAPTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:COG4257  102 SNPHGIAFDP-DGNLWFTDQGGNRIGRL 128
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-108 5.45e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.03  E-value: 5.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPI-TIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTG-SPIT 78
Cdd:COG4257  107 IAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLpTGGAGPYGIAVDP-DGNLWVTDFGANAIGRIDPDTGTLTEyALPT 185

                         90       100       110
                 ....*....|....*....|....*....|
gi 490007402  79 VGTAPTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:COG4257  186 PGAGPRGLAVDP-DGNLWVADTGSGRIGRF 214
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-108 6.16e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 59.65  E-value: 6.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTG-SPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPITV 79
Cdd:COG4257  150 IAVDPDGNLWVTDFGANAIGRIDPDTGTLTEyALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKTGTVTEYPLPG 228

                         90       100       110
                 ....*....|....*....|....*....|
gi 490007402  80 GTA-PTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:COG4257  229 GGArPYGVAVDG-DGRVWFAESGANRIVRF 257
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1-105 8.24e-11

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 56.45  E-value: 8.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVG 80
Cdd:cd14952  141 VAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGNNRVLKLAAGSTTPTVLPFTGL 219

                         90       100
                 ....*....|....*....|....*
gi 490007402  81 TAPTGVAVNPvTGEVYVTNFAGDTV 105
Cdd:cd14952  220 NGPLGVAVDA-AGNVYVADRGNDRV 243
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2-109 9.42e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.56  E-value: 9.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVT-----GSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDP-----TTNT 71
Cdd:cd05819   14 AVDSSGNIYVADTGNNRIQVFDPDGNFITsfgsfGSGDGQFNEPAGVAVDS-DGNLYVADTGNHRIQKFDPdgnflASFG 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 490007402  72 VTGSPITVGTAPTGVAVNPvTGEVYVTNFAGDTVSVIS 109
Cdd:cd05819   93 GSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFD 129
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 2-105 1.11e-10

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 56.06  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVtGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGT 81
Cdd:cd14952  100 AVDAAGNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLN 178

                         90       100
                 ....*....|....*....|....
gi 490007402  82 APTGVAVNPvTGEVYVTNFAGDTV 105
Cdd:cd14952  179 SPSGVAVDT-AGNVYVTDHGNNRV 201
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1-109 6.97e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 6.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTV-----TGSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGS 75
Cdd:cd05819   60 VAVDSDGNLYVADTGNHRIQKFDPDGNFLasfggSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTF 138

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 490007402  76 PITVGTA-----PTGVAVNPvTGEVYVTNFAGDTVSVIS 109
Cdd:cd05819  139 GSGGSGPgqfngPTGVAVDS-DGNIYVADTGNHRIQVFD 176
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 9-108 8.06e-10

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 54.28  E-value: 8.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402    9 VYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTGVAV 88
Cdd:TIGR03866  13 AYVSNEKDNTISVIDTATLKVTRT-FPVGQRPRGITFSKDGKLLYVCASDSDTIQVIDPATGEVLHT-LPSGPDPEQFAL 90

                          90       100
                  ....*....|....*....|
gi 490007402   89 NPVTGEVYVTNFAGDTVSVI 108
Cdd:TIGR03866  91 HPNGKILYIANEDDALVTVI 110
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-105 1.33e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.48  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPI-TIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPITV 79
Cdd:COG4257   64 IAVDPDGNLWFTDNGNNRIGRIDPKTGEITTFALpGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRLDPATGEVTEFPLPT 142

                         90       100
                 ....*....|....*....|....*..
gi 490007402  80 GTA-PTGVAVNPvTGEVYVTNFAGDTV 105
Cdd:COG4257  143 GGAgPYGIAVDP-DGNLWVTDFGANAI 168
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 2-105 3.69e-09

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.82  E-value: 3.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVtGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGT 81
Cdd:cd14952   16 AVDAAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLN 94

                         90       100
                 ....*....|....*....|....
gi 490007402  82 APTGVAVNPVtGEVYVTNFAGDTV 105
Cdd:cd14952   95 DPTGVAVDAA-GNVYVADTGNNRV 117
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1-100 9.26e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.17  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVT--GSPITIG---NGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVT-- 73
Cdd:cd05819  107 IAVDSSGNIYVADTGNHRIQKFDPDGEFLTtfGSGGSGPgqfNGPTGVAVDS-DGNIYVADTGNHRIQVFDPDGNFLTtf 185

                         90       100       110
                 ....*....|....*....|....*....|
gi 490007402  74 GSPITVGT---APTGVAVNPvTGEVYVTNF 100
Cdd:cd05819  186 GSTGTGPGqfnYPTGIAVDS-DGNIYVADS 214
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 2-105 1.53e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 50.28  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVtGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGT 81
Cdd:cd14952   58 AVDAAGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDAA-GNVYVADTGNNRVLKLAAGSNTQTVLPFTGLS 136

                         90       100
                 ....*....|....*....|....
gi 490007402  82 APTGVAVNPVtGEVYVTNFAGDTV 105
Cdd:cd14952  137 NPDGVAVDGA-GNVYVTDTGNNRV 159
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1-108 2.40e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.01  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVT-----GSPITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDP--TTNTVT 73
Cdd:cd05819  154 VAVDSDGNIYVADTGNHRIQVFDPDGNFLTtfgstGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRVQVFDPdgAGFGGN 232

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 490007402  74 GSPITVGTA---PTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:cd05819  233 GNFLGSDGQfnrPSGLAVDS-DGNLYVADTGNNRIQVF 269
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-108 4.19e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 4.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGT 81
Cdd:COG3391   32 GGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT-IPVGG 110

                         90       100
                 ....*....|....*....|....*..
gi 490007402  82 APTGVAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:COG3391  111 GPRGLAVDPDGGRLYVADSGNGRVSVI 137
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-72 5.22e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.17  E-value: 5.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNG-PSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTV 72
Cdd:COG4257  193 LAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGArPYGVAVDG-DGRVWFAESGANRIVRFDPDTELT 264
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1-107 5.43e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.12  E-value: 5.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPatntvTGSPITIG----------NGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTN 70
Cdd:cd14956   65 LAVDKDGWLYVADYWGDRIQVFTL-----TGELQTIGgssgsgpgqfNAPRGVAVDA-DGNLYVADFGNQRIQKFDPDGS 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 490007402  71 TVTGSPITVG-----TAPTGVAVNPVtGEVYVTNFAGDTVSV 107
Cdd:cd14956  139 FLRQWGGTGIepgsfNYPRGVAVDPD-GTLYVADTYNDRIQV 179
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 6-90 8.55e-07

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.42  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402    6 GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTG 85
Cdd:TIGR03866  52 GKLLYVCASDSDTIQVIDPATGEVLHT-LPSGPDPEQFALHPNGKILYIANEDDALVTVIDIETRKVLAQ-IDVGVEPEG 129


                  ....*
gi 490007402   86 VAVNP 90
Cdd:TIGR03866 130 MAVSP 134
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1-107 1.30e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTV-----TGSPITIGNGPSGVAVSPVtGLVFVTNFDSNTVSVIDPTTNTVT-- 73
Cdd:cd14956  112 VAVDADGNLYVADFGNQRIQKFDPDGSFLrqwggTGIEPGSFNYPRGVAVDPD-GTLYVADTYNDRIQVFDNDGAFLRkw 190

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490007402  74 GSPITVG---TAPTGVAVNPVtGEVYVTNFAGDTVSV 107
Cdd:cd14956  191 GGRGTGPgqfNYPYGIAIDPD-GNVFVADFGNNRIQK 226
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
1-107 2.34e-06

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 44.13  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGN-VYVTNFGSGTVSVINPATNTVTGSPITI----------GNGPSGVAVSPVTGLVFVTNFDSNTVSV--IDP 67
Cdd:COG2706  203 LAFHPNGRfAYVINELDSTVSVYAYDAATGTLTLIQTvstlpedftgENWAADIHISPDGRFLYVSNRGHNSIAVfaIDA 282

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 490007402  68 TTNTVT--GSPITVGTAPTGVAVNPvTGE-VYVTNFAGDTVSV 107
Cdd:COG2706  283 DGGKLTlvGHVPTGGKWPRDFAIDP-DGRfLLVANQKSDNITV 324
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 2-108 8.76e-06

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 42.72  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402    2 AVNPGGN-VYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVG 80
Cdd:TIGR03866  89 ALHPNGKiLYIANEDDALVTVIDIETRKVLAQ-IDVGVEPEGMAVSPDGKIVVNTSETTNMAHWIDTATYEIVDN-TLVD 166

                          90       100
                  ....*....|....*....|....*...
gi 490007402   81 TAPTGVAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:TIGR03866 167 ARPRFAEFTADGKELWVSSEIGGTVTVI 194
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-70 9.07e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGN-VYVTNFGSGTVSVI----NPATNTVTGSpITIGNGPSGVAVSPVTGLVFVTNFDSN-------TVSVIDPT 68
Cdd:COG3391  157 IAVDPDGKrLYVANSGSNTVSVIvsviDTATGKVVAT-IPVGGGPVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLA 235


                 ..
gi 490007402  69 TN 70
Cdd:COG3391  236 TL 237
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
9-109 1.82e-05

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 41.82  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   9 VYV---TNFGSGTVSV--INPATNTVTG-SPITIGNGPSGVAVSPVTGLVFVTNF-DSNTVSV--IDPTTNTVT--GSPI 77
Cdd:COG2706   10 VYVgtyTSGESEGIYVfrLDTATGELTLlGLVAALGNPSFLALSPDGRFLYAVNEvDDGGVSAfrIDPADGTLTllNTVS 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490007402  78 TVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS 109
Cdd:COG2706   90 SGGASPCHLSVDPDGRFLFVANYGGGSVSVFP 121
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-108 2.20e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.51  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATN---TVTGSPITIG--NGPSGVAVSPVTGLVFVTNFdSNTVSVIDPTTNTVT--- 73
Cdd:cd14963  154 AVDEDGNIYVADSGNGRIQVFDKNGKfikELNGSPDGKSgfVNPRGIAVDPDGNLYVVDNL-SHRVYVFDEQGKELFtfg 232

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490007402  74 --GSPITVGTAPTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:cd14963  233 grGKDDGQFNLPNGLFIDD-DGRLYVTDRENNRVAVY 268
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 44-108 3.07e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 41.18  E-value: 3.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490007402   44 AVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVI 108
Cdd:TIGR03866   5 AGSAAAETAYVSNEKDNTISVIDTATLKVTRT-FPVGQRPRGITFSKDGKLLYVCASDSDTIQVI 68
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-99 7.58e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.97  E-value: 7.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATN----TVTGSPITIGNGPSGVAVSpvTGLVFVTNFDSNTVSVIDPTTNTV--TGS 75
Cdd:cd14963   62 AVDSDGNIYVADLYNGRIQVFDPDGKflkyFPEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLleFGK 139

                         90       100       110
                 ....*....|....*....|....*....|
gi 490007402  76 PitvGT------APTGVAVNPvTGEVYVTN 99
Cdd:cd14963  140 P---GSepgelsYPNGIAVDE-DGNIYVAD 165
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
1-107 7.58e-05

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.89  E-value: 7.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGN-VYVTNF-GSGTVSV--INPATNTVT--GSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTG 74
Cdd:COG2706   50 LALSPDGRfLYAVNEvDDGGVSAfrIDPADGTLTllNTVSSGGASPCHLSVDPDGRFLFVANYGGGSVSVFPIDADGSLG 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490007402  75 SPITV--------------GTAPTGVAVNPVTGEVYVTNFAGDTVSV 107
Cdd:COG2706  130 EPVQViqhegsgpnperqeGPHAHSVVFDPDGRFLYVPDLGTDRIYV 176
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-108 9.60e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.57  E-value: 9.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVT--GSPITiGNG----PSGVAVSPVtGLVFVTNFDSNTVSVIDP--TTNTVT 73
Cdd:cd14956  160 AVDPDGTLYVADTYNDRIQVFDNDGAFLRkwGGRGT-GPGqfnyPYGIAIDPD-GNVFVADFGNNRIQKFTAdgTFLTSW 237

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 490007402  74 GSPITV---GTAPTGVAVNPvTGEVYVTNFAGDTVSVI 108
Cdd:cd14956  238 GSPGTGpgqFKNPWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1-109 3.84e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   1 MAVNPGGNVYVTNFGSGTVSVINPATNTVTgspiTIGNG-------PSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVT 73
Cdd:cd14962   17 VAADGRGRIYVADTGRGAVFVFDLPNGKVF----VIGNAgpnrfvsPIGVAIDA-NGNLYVSDAELGKVFVFDRDGKFLR 91

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 490007402  74 gsPITVG---TAPTGVAVNPVTGEVYVTNFAGDTVSVIS 109
Cdd:cd14962   92 --AIGAGalfKRPTGIAVDPAGKRLYVVDTLAHKVKVFD 128
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 33-105 6.04e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.19  E-value: 6.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490007402  33 PITIGNGPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVtGEVYVTNFAGDTV 105
Cdd:cd14952    5 PFTGLDGPGGVAVDA-AGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRV 75
beta_rpt_yvtn TIGR02276
40-residue YVTN family beta-propeller repeat; This repeat of about 40 amino acids is found in ...
 47-89 8.21e-04

40-residue YVTN family beta-propeller repeat; This repeat of about 40 amino acids is found in up to 14 copies per protein. Archaea Methanosarcina mazei and Methanosarcina acetivorans each have over 10 genes that encode tandem copies of this repeat, which is also found in other species. PSIPRED predicts with high confidence that each 40-residue repeats contains four beta strands. This model overlaps somewhat with the NHL repeat (pfam01436) and also shows sequence similarity to the WD domain, G-beta repeat (pfam00400).


Pssm-ID: 213697 [Multi-domain]  Cd Length: 42  Bit Score: 34.58  E-value: 8.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 490007402   47 PVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTGVAVN 89
Cdd:TIGR02276   1 PDGTKLYVTNSGSNTVSVIDTATNKVIAT-IPVGGYPFGVAVS 42
beta_rpt_yvtn TIGR02276
40-residue YVTN family beta-propeller repeat; This repeat of about 40 amino acids is found in ...
 6-46 1.28e-03

40-residue YVTN family beta-propeller repeat; This repeat of about 40 amino acids is found in up to 14 copies per protein. Archaea Methanosarcina mazei and Methanosarcina acetivorans each have over 10 genes that encode tandem copies of this repeat, which is also found in other species. PSIPRED predicts with high confidence that each 40-residue repeats contains four beta strands. This model overlaps somewhat with the NHL repeat (pfam01436) and also shows sequence similarity to the WD domain, G-beta repeat (pfam00400).


Pssm-ID: 213697 [Multi-domain]  Cd Length: 42  Bit Score: 33.81  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 490007402    6 GGNVYVTNFGSGTVSVINPATNTVTGSpITIGNGPSGVAVS 46
Cdd:TIGR02276   3 GTKLYVTNSGSNTVSVIDTATNKVIAT-IPVGGYPFGVAVS 42
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 2-107 1.82e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 35.99  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVT--GSPITiGNG----PSGVAVSPvTGLVFVTNFDSNTVSVIDPTTN---TV 72
Cdd:cd14954  171 AVNPDGNIVVSDFNNHRLQVFDPDGQFLRffGSEGS-GNGqfkrPRGVAVDD-EGNIIVADSGNHRVQVFSPDGEflcSF 248

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490007402  73 TGSPITVGT--APTGVAVNPvTGEVYVTNFAGDTVSV 107
Cdd:cd14954  249 GTEGNGEGQfdRPSGVAVTP-DGRIVVVDRGNHRIQV 284
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 2-107 2.02e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 35.71  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVTG-SPITIGNG----PSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVtgsp 76
Cdd:cd14961   17 AVTPTGRVVVADDGNKRIQVFDSDGNCLQQfGPKGDAGQdiryPLDVAVTP-DGHIVVTDAGDRSVKVFSFDGRLK---- 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490007402  77 ITVGTA---PTGVAVNPvTGEVYVTNFAGDTVSV 107
Cdd:cd14961   92 LFVRKSfslPWGVAVNP-SGEILVTDSEAGKLFV 124
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 2-107 2.50e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 35.78  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPatntvTGSPIT-IGN----GPSGVAVSPvTGLVFVTNFDSNTVSVIDPTTNTVT--- 73
Cdd:cd14960   70 AVTLNGDIIIADYDNKWVSIFSP-----DGKFKSkIGAgklmGPKGVAVDR-NGHIIVVDNKACCVFIFQPNGKLVTrfg 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490007402  74 --GSPITVGTAPTGVAVNPvTGEVYVTNFAGDTVSV 107
Cdd:cd14960  144 srGNGDRQFAGPHFAAVNN-NNEIIVTDFHNHSVKV 178
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 44-90 4.77e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 35.02  E-value: 4.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 490007402   44 AVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSpITVGTAPTGVAVNP 90
Cdd:TIGR03866 265 AFTPDESRLLTTNGVSNDVSVIDVAALKVIKS-IKVGRLPWGVVVRP 310
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
2-107 5.68e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 34.50  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGN-VYVTNFGSGTVSV--INPATNTVTGSPITI---GNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGS 75
Cdd:COG2706  156 VFDPDGRfLYVPDLGTDRIYVyrLDPATGKLPEPPEVSlppGSGPRHLAFHPNGRFAYVINELDSTVSVYAYDAATGTLT 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 490007402  76 PI-TVGTAPTGVAVNPVTGE---------VYVTNFAGDTVSV 107
Cdd:COG2706  236 LIqTVSTLPEDFTGENWAADihispdgrfLYVSNRGHNSIAV 277
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 2-99 7.22e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 34.47  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490007402   2 AVNPGGNVYVTNFGSGTVSVINPATNTVT--GSPITiGNG----PSGVAVSPVtGLVFVTNFDSNTVSVIDPTTNTVT-- 73
Cdd:cd14955  163 AVDSAGNVYVADTGNNRIQKFTSTGTFLTkwGSEGS-GDGqfnaPYGIAVDSA-GNVYVADTGNNRIQKFDSSGTFITkw 240

                         90       100
                 ....*....|....*....|....*....
gi 490007402  74 ---GSPITVGTAPTGVAVNPvTGEVYVTN 99
Cdd:cd14955  241 gseGSGDGQFNSPSGIAVDS-AGNVYVAD 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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