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Conserved domains on  [gi|490004081|ref|WP_003906988|]
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MULTISPECIES: PPE domain-containing protein [Mycobacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPE super family cl35037
PPE-repeat protein [Function unknown];
1-111 4.37e-17

PPE-repeat protein [Function unknown];


The actual alignment was detected with superfamily member COG5651:

Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 75.70  E-value: 4.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490004081   1 MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTA 80
Cdd:COG5651    1 MDFMALPPEVNSARMYAGPGSGPLLAAAAAWDGLAAELASAAASLESVLSGLTGGSWQGPAAAAMAAAAAPYVAWLTAAA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490004081  81 AQTKQTATQARAAAAAFEQAHAMTVPPALVT 111
Cdd:COG5651   81 AQAEQAAAQAEAAAAAYEAALAAMVPPAEVA 111
 
Name Accession Description Interval E-value
PPE COG5651
PPE-repeat protein [Function unknown];
1-111 4.37e-17

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 75.70  E-value: 4.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490004081   1 MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTA 80
Cdd:COG5651    1 MDFMALPPEVNSARMYAGPGSGPLLAAAAAWDGLAAELASAAASLESVLSGLTGGSWQGPAAAAMAAAAAPYVAWLTAAA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490004081  81 AQTKQTATQARAAAAAFEQAHAMTVPPALVT 111
Cdd:COG5651   81 AQAEQAAAQAEAAAAAYEAALAAMVPPAEVA 111
PPE pfam00823
PPE family; This family named after a PPE motif near to the amino terminus of the domain. The ...
 6-132 9.59e-17

PPE family; This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.


Pssm-ID: 425887  Cd Length: 158  Bit Score: 71.46  E-value: 9.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490004081    6 LPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQ 85
Cdd:pfam00823   2 LPPEVNSARLYAGPGSGPLLAAAAAWDGLAAELASAAASYSSVLAGLTGGAWQGPSSAAMAAAAAPYVAWLTAAAAQAEQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 490004081   86 TATQARAAAAAFEQAHAMTVPPALVTGIRgaIVVETASASNTAG--TPP 132
Cdd:pfam00823  82 AAAQAEAAAAAYEAALAAMVPPAEIAANR--AELAVLVATNFFGqnTPA 128
 
Name Accession Description Interval E-value
PPE COG5651
PPE-repeat protein [Function unknown];
1-111 4.37e-17

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 75.70  E-value: 4.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490004081   1 MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTA 80
Cdd:COG5651    1 MDFMALPPEVNSARMYAGPGSGPLLAAAAAWDGLAAELASAAASLESVLSGLTGGSWQGPAAAAMAAAAAPYVAWLTAAA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490004081  81 AQTKQTATQARAAAAAFEQAHAMTVPPALVT 111
Cdd:COG5651   81 AQAEQAAAQAEAAAAAYEAALAAMVPPAEVA 111
PPE pfam00823
PPE family; This family named after a PPE motif near to the amino terminus of the domain. The ...
 6-132 9.59e-17

PPE family; This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.


Pssm-ID: 425887  Cd Length: 158  Bit Score: 71.46  E-value: 9.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490004081    6 LPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQ 85
Cdd:pfam00823   2 LPPEVNSARLYAGPGSGPLLAAAAAWDGLAAELASAAASYSSVLAGLTGGAWQGPSSAAMAAAAAPYVAWLTAAAAQAEQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 490004081   86 TATQARAAAAAFEQAHAMTVPPALVTGIRgaIVVETASASNTAG--TPP 132
Cdd:pfam00823  82 AAAQAEAAAAAYEAALAAMVPPAEIAANR--AELAVLVATNFFGqnTPA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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