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Conserved domains on  [gi|489995582|ref|WP_003898622|]
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MULTISPECIES: helicase-associated domain-containing protein [Mycobacterium]

Protein Classification

Helicase_C_3 and YafY domain-containing protein( domain architecture ID 12150165)

Helicase_C_3 and YafY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Helicase_C_3 pfam13625
Helicase conserved C-terminal domain; This domain family is found in a wide variety of ...
 479-598 1.11e-40

Helicase conserved C-terminal domain; This domain family is found in a wide variety of helicases and helicase-related proteins.


:

Pssm-ID: 463939 [Multi-domain]  Cd Length: 121  Bit Score: 144.95  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582  479 FLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDD 558
Cdd:pfam13625   1 LIVQADLTILLPGPLAPEARDFLAAFAELESRGHAHTYRLTPLSLRRALDAGLTAEDILDFLERHSKYPVPQALEYLIRD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489995582  559 VARRHGQLRIG-MAASFVRCEDPTLLAQVVAAPEADGLALR 598
Cdd:pfam13625  81 VARRHGRLRLGlGASSYLRSDDPAVLAELLADPRIAPLGLR 121
YobV super family cl28501
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 661-748 3.36e-05

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


The actual alignment was detected with superfamily member COG2378:

Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 46.61  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582 661 SEALKAVVAVLREVTAaPFANVRVDPAVtMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITL--RGGQ--LVAFDSSS 736
Cdd:COG2378  112 PERLRERLEALAERVG-VDPPPEVDPEV-LETLREAIRERRRLRIDYRSGRGEPTERTVEPYGLvfYGGRwyLVAWCELR 189

                         90
                 ....*....|..
gi 489995582 737 GRLRDFAIHRIT 748
Cdd:COG2378  190 DDIRTFRLDRIR 201
 
Name Accession Description Interval E-value
Helicase_C_3 pfam13625
Helicase conserved C-terminal domain; This domain family is found in a wide variety of ...
 479-598 1.11e-40

Helicase conserved C-terminal domain; This domain family is found in a wide variety of helicases and helicase-related proteins.


Pssm-ID: 463939 [Multi-domain]  Cd Length: 121  Bit Score: 144.95  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582  479 FLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDD 558
Cdd:pfam13625   1 LIVQADLTILLPGPLAPEARDFLAAFAELESRGHAHTYRLTPLSLRRALDAGLTAEDILDFLERHSKYPVPQALEYLIRD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489995582  559 VARRHGQLRIG-MAASFVRCEDPTLLAQVVAAPEADGLALR 598
Cdd:pfam13625  81 VARRHGRLRLGlGASSYLRSDDPAVLAELLADPRIAPLGLR 121
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 661-748 3.36e-05

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 46.61  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582 661 SEALKAVVAVLREVTAaPFANVRVDPAVtMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITL--RGGQ--LVAFDSSS 736
Cdd:COG2378  112 PERLRERLEALAERVG-VDPPPEVDPEV-LETLREAIRERRRLRIDYRSGRGEPTERTVEPYGLvfYGGRwyLVAWCELR 189

                         90
                 ....*....|..
gi 489995582 737 GRLRDFAIHRIT 748
Cdd:COG2378  190 DDIRTFRLDRIR 201
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 689-748 1.09e-04

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 43.41  E-value: 1.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489995582  689 TMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITL--RGGQ--LVAFDSSSGRLRDFAIHRIT 748
Cdd:pfam13280   2 VLETLREAILERRRVRFRYRSPRGEGTERTVEPYGLvyKDGRwyLVAYCRLRDDIRTFRLDRIE 65
 
Name Accession Description Interval E-value
Helicase_C_3 pfam13625
Helicase conserved C-terminal domain; This domain family is found in a wide variety of ...
 479-598 1.11e-40

Helicase conserved C-terminal domain; This domain family is found in a wide variety of helicases and helicase-related proteins.


Pssm-ID: 463939 [Multi-domain]  Cd Length: 121  Bit Score: 144.95  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582  479 FLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDD 558
Cdd:pfam13625   1 LIVQADLTILLPGPLAPEARDFLAAFAELESRGHAHTYRLTPLSLRRALDAGLTAEDILDFLERHSKYPVPQALEYLIRD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489995582  559 VARRHGQLRIG-MAASFVRCEDPTLLAQVVAAPEADGLALR 598
Cdd:pfam13625  81 VARRHGRLRLGlGASSYLRSDDPAVLAELLADPRIAPLGLR 121
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 661-748 3.36e-05

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 46.61  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995582 661 SEALKAVVAVLREVTAaPFANVRVDPAVtMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITL--RGGQ--LVAFDSSS 736
Cdd:COG2378  112 PERLRERLEALAERVG-VDPPPEVDPEV-LETLREAIRERRRLRIDYRSGRGEPTERTVEPYGLvfYGGRwyLVAWCELR 189

                         90
                 ....*....|..
gi 489995582 737 GRLRDFAIHRIT 748
Cdd:COG2378  190 DDIRTFRLDRIR 201
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 689-748 1.09e-04

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 43.41  E-value: 1.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489995582  689 TMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITL--RGGQ--LVAFDSSSGRLRDFAIHRIT 748
Cdd:pfam13280   2 VLETLREAILERRRVRFRYRSPRGEGTERTVEPYGLvyKDGRwyLVAYCRLRDDIRTFRLDRIE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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