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Conserved domains on  [gi|489993422|ref|WP_003896479|]
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anti-sigma E factor RseA [Mycolicibacterium smegmatis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
anti_sig_RseA super family cl49451
anti-sigma E factor RseA;
1-132 8.38e-88

anti-sigma E factor RseA;


The actual alignment was detected with superfamily member NF041468:

Pssm-ID: 469356  Cd Length: 134  Bit Score: 251.23  E-value: 8.38e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489993422   1 MADPGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSVEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQA 80
Cdd:NF041468   1 MADRGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSTEAIAAFVDGELRMNAHLRAAHHLSLCPQCAAEVEDQSRA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489993422  81 RTALRESCPIAIPNSLLGMLSQIPHRTPEV--TPDVSEQAKFADDPTRGRRKRR 132
Cdd:NF041468  81 RAALRDSHPIRIPSTLLGLLSQIPHCPPDPppGPTSPLSDRFADGDARDRRKRR 134
 
Name Accession Description Interval E-value
anti_sig_RseA NF041468
anti-sigma E factor RseA;
1-132 8.38e-88

anti-sigma E factor RseA;


Pssm-ID: 469356  Cd Length: 134  Bit Score: 251.23  E-value: 8.38e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489993422   1 MADPGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSVEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQA 80
Cdd:NF041468   1 MADRGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSTEAIAAFVDGELRMNAHLRAAHHLSLCPQCAAEVEDQSRA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489993422  81 RTALRESCPIAIPNSLLGMLSQIPHRTPEV--TPDVSEQAKFADDPTRGRRKRR 132
Cdd:NF041468  81 RAALRDSHPIRIPSTLLGLLSQIPHCPPDPppGPTSPLSDRFADGDARDRRKRR 134
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
41-93 4.70e-05

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 40.60  E-value: 4.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489993422  41 VEAIAAFVDGELrmSAHLRAA--HHLSLCPECAAEVDAQSQARTALRESCPIAIP 93
Cdd:COG5662    7 EELLHAYLDGEL--SPEERAEveAHLATCPACAARLAELRRLRAALRAALAPDEP 59
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 42-107 1.47e-04

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 37.67  E-value: 1.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489993422   42 EAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQARTALRESC-----PIAIPNSLLGMLSQIPHRT 107
Cdd:TIGR03988   7 AEVYEYLDGELDDEDCARLRAHLDECPPCLEQYGLEEEVKSLVARCCggesaPEELRARILARIREIRVII 77
cupin_ChrR cd20301
anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ...
 38-104 8.67e-03

anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ChrR from the photosynthetic bacterium Rhodobacter sphaeroides (Rsp) and similar proteins. ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. ChrR comprises two structural and functional modules; the N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen, a potent oxidant that damages cellular biomolecules and can kill cells. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380435 [Multi-domain]  Cd Length: 161  Bit Score: 34.42  E-value: 8.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489993422  38 HLSVEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEV-DAQSQARTALRESCPIAIPNSLLG-MLSQIP 104
Cdd:cd20301    3 HPDDELLLAYAAGALPEALALLVATHLELCPECRARVaALEAVGGALLEALEPVALSDDALDaVLARLD 71
 
Name Accession Description Interval E-value
anti_sig_RseA NF041468
anti-sigma E factor RseA;
1-132 8.38e-88

anti-sigma E factor RseA;


Pssm-ID: 469356  Cd Length: 134  Bit Score: 251.23  E-value: 8.38e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489993422   1 MADPGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSVEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQA 80
Cdd:NF041468   1 MADRGHVFRRAFSWLPSQFASQSDAPVGAPRQFGSTEHLSTEAIAAFVDGELRMNAHLRAAHHLSLCPQCAAEVEDQSRA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489993422  81 RTALRESCPIAIPNSLLGMLSQIPHRTPEV--TPDVSEQAKFADDPTRGRRKRR 132
Cdd:NF041468  81 RAALRDSHPIRIPSTLLGLLSQIPHCPPDPppGPTSPLSDRFADGDARDRRKRR 134
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
41-93 4.70e-05

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 40.60  E-value: 4.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489993422  41 VEAIAAFVDGELrmSAHLRAA--HHLSLCPECAAEVDAQSQARTALRESCPIAIP 93
Cdd:COG5662    7 EELLHAYLDGEL--SPEERAEveAHLATCPACAARLAELRRLRAALRAALAPDEP 59
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 42-107 1.47e-04

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 37.67  E-value: 1.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489993422   42 EAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQARTALRESC-----PIAIPNSLLGMLSQIPHRT 107
Cdd:TIGR03988   7 AEVYEYLDGELDDEDCARLRAHLDECPPCLEQYGLEEEVKSLVARCCggesaPEELRARILARIREIRVII 77
anti_SigH_actin TIGR02949
anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an ...
 44-88 6.55e-03

anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors]


Pssm-ID: 188261  Cd Length: 84  Bit Score: 33.58  E-value: 6.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489993422   44 IAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQARTALRESC 88
Cdd:TIGR02949  16 LYEFLDGECTEDDAERLRRHLAACPECLREYDLEQAVRKLLKRCC 60
cupin_ChrR cd20301
anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ...
 38-104 8.67e-03

anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ChrR from the photosynthetic bacterium Rhodobacter sphaeroides (Rsp) and similar proteins. ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. ChrR comprises two structural and functional modules; the N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen, a potent oxidant that damages cellular biomolecules and can kill cells. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380435 [Multi-domain]  Cd Length: 161  Bit Score: 34.42  E-value: 8.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489993422  38 HLSVEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEV-DAQSQARTALRESCPIAIPNSLLG-MLSQIP 104
Cdd:cd20301    3 HPDDELLLAYAAGALPEALALLVATHLELCPECRARVaALEAVGGALLEALEPVALSDDALDaVLARLD 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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