|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-419 |
9.96e-127 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 371.73 E-value: 9.96e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 1 MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGlgrpidapigpieT 80
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANP-------------V 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 81 SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD 160
Cdd:COG0303 68 TLRVVGEIAAGSPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 161 GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR 240
Cdd:COG0303 148 GTRLTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 241 LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLG-EIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSLVIFE 319
Cdd:COG0303 228 LRAALREALAEADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 320 MFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAqtQDYLVEGLGGANgapAHLLAGLAEANAMIKI 399
Cdd:COG0303 306 LFVRPALRKLAGLPPPPPPRVRARLAEDLPKKPGRTEFLRVRLERDD--GELVVEPLGGQG---SGLLSSLAEADGLIVL 380
|
410 420
....*....|....*....|
gi 489947450 400 PEDVNEVRPGDIVEVLFMSQ 419
Cdd:COG0303 381 PEGVEGVEAGEEVEVLLLDG 400
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-417 |
3.37e-120 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 354.88 E-value: 3.37e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 4 VEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERglgrpidapigpieTSLP 83
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGAS--------------VTLR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 84 VVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAI 163
Cdd:cd00887 67 VVGEIPAGEPPDGPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 164 LSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLRE 243
Cdd:cd00887 147 LTPADIGLLASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALRE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 244 IVESQLLRSEIIVIAGAVGGSGSEEIRRILSDL-GEIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSLVIFEMFI 322
Cdd:cd00887 227 ALEEALEEADVVITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFELFV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 323 RPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAqtQDYLVEGLGGANgapAHLLAGLAEANAMIKIPED 402
Cdd:cd00887 305 RPALRKLQGAPEPEPPRVKARLAEDLKSKPGRREFLRVRLERDE--GGLVVAPPGGQG---SGLLSSLARADGLIVIPEG 379
|
410
....*....|....*
gi 489947450 403 VNEVRPGDIVEVLFM 417
Cdd:cd00887 380 VEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
1-416 |
4.17e-68 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 227.40 E-value: 4.17e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 1 MRSVEQQLALVTQ--SAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGlgrpiDAPIgpi 78
Cdd:PRK14498 9 LVSLEEAREILESllSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGASE-----ANPV--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 79 etSLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTD-CGRKRMTAHRPVRSGEFVRHAGDDIRPGDVA 157
Cdd:PRK14498 81 --RLKLGGEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEeVDDDTVEIYRPVAPGENVRPAGEDIVAGELI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 158 VSDGAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGE 237
Cdd:PRK14498 159 LPKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 238 PRRLREIVESQLLRSEIIVIAGavGGS-GSEE-IRRILSDLGEIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSL 315
Cdd:PRK14498 239 EEELEAALRKALKECDLVLLSG--GTSaGAGDvTYRVIEELGEVLVHGVAIKPGKPTILGVIGG--KPVVGLPGYPVSAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 316 VIFEMFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTqdYLVEGLGGANGApahlLAGLAEANA 395
Cdd:PRK14498 315 TIFEEFVAPLLRKLAGLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDG--YVAYPLSRGSGA----ITSLVRADG 388
|
410 420
....*....|....*....|..
gi 489947450 396 MIKIPEDVNEVRPGDIVEV-LF 416
Cdd:PRK14498 389 FIEIPANTEGLEAGEEVEVeLF 410
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-176 |
8.58e-38 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 133.85 E-value: 8.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 17 APEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERglgrpidapigpietslpVVGEVPAGSQRPL 96
Cdd:pfam03453 5 TEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGAS------------------EVNPIAAGEPPGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 97 RLQPKQAVRVHTGAPLPTLSDAVIPLEWT-DCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAAV 175
Cdd:pfam03453 67 LLPGGEAVRIMTGAPLPEGADAVVMVEDTeEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASL 146
|
.
gi 489947450 176 G 176
Cdd:pfam03453 147 G 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
186-324 |
8.61e-21 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 88.14 E-value: 8.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 186 PRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEIIVIAGAVGGSG 265
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 266 SEEIRRILSDLGEI-----------DTTRVAMHPGSVQGFGLLgeNQTPVFLLPSNTVSSLVIFEMFIRP 324
Cdd:TIGR00177 81 RDVTPEALEELGEKeipgfgefrmlSSLPVLSRPGKPATAGVR--GGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-419 |
9.96e-127 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 371.73 E-value: 9.96e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 1 MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGlgrpidapigpieT 80
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANP-------------V 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 81 SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD 160
Cdd:COG0303 68 TLRVVGEIAAGSPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 161 GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR 240
Cdd:COG0303 148 GTRLTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 241 LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLG-EIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSLVIFE 319
Cdd:COG0303 228 LRAALREALAEADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 320 MFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAqtQDYLVEGLGGANgapAHLLAGLAEANAMIKI 399
Cdd:COG0303 306 LFVRPALRKLAGLPPPPPPRVRARLAEDLPKKPGRTEFLRVRLERDD--GELVVEPLGGQG---SGLLSSLAEADGLIVL 380
|
410 420
....*....|....*....|
gi 489947450 400 PEDVNEVRPGDIVEVLFMSQ 419
Cdd:COG0303 381 PEGVEGVEAGEEVEVLLLDG 400
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-417 |
3.37e-120 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 354.88 E-value: 3.37e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 4 VEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERglgrpidapigpieTSLP 83
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGAS--------------VTLR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 84 VVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAI 163
Cdd:cd00887 67 VVGEIPAGEPPDGPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 164 LSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLRE 243
Cdd:cd00887 147 LTPADIGLLASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALRE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 244 IVESQLLRSEIIVIAGAVGGSGSEEIRRILSDL-GEIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSLVIFEMFI 322
Cdd:cd00887 227 ALEEALEEADVVITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFELFV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 323 RPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAqtQDYLVEGLGGANgapAHLLAGLAEANAMIKIPED 402
Cdd:cd00887 305 RPALRKLQGAPEPEPPRVKARLAEDLKSKPGRREFLRVRLERDE--GGLVVAPPGGQG---SGLLSSLARADGLIVIPEG 379
|
410
....*....|....*
gi 489947450 403 VNEVRPGDIVEVLFM 417
Cdd:cd00887 380 VEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
1-416 |
4.17e-68 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 227.40 E-value: 4.17e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 1 MRSVEQQLALVTQ--SAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGlgrpiDAPIgpi 78
Cdd:PRK14498 9 LVSLEEAREILESllSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGASE-----ANPV--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 79 etSLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTD-CGRKRMTAHRPVRSGEFVRHAGDDIRPGDVA 157
Cdd:PRK14498 81 --RLKLGGEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEeVDDDTVEIYRPVAPGENVRPAGEDIVAGELI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 158 VSDGAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGE 237
Cdd:PRK14498 159 LPKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 238 PRRLREIVESQLLRSEIIVIAGavGGS-GSEE-IRRILSDLGEIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSL 315
Cdd:PRK14498 239 EEELEAALRKALKECDLVLLSG--GTSaGAGDvTYRVIEELGEVLVHGVAIKPGKPTILGVIGG--KPVVGLPGYPVSAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 316 VIFEMFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTqdYLVEGLGGANGApahlLAGLAEANA 395
Cdd:PRK14498 315 TIFEEFVAPLLRKLAGLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDG--YVAYPLSRGSGA----ITSLVRADG 388
|
410 420
....*....|....*....|..
gi 489947450 396 MIKIPEDVNEVRPGDIVEV-LF 416
Cdd:PRK14498 389 FIEIPANTEGLEAGEEVEVeLF 410
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
3-415 |
3.53e-50 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 178.65 E-value: 3.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 3 SVEQQLALVTqSAVAP--EPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGErglgrpidapigpiet 80
Cdd:PRK14491 200 SVSQGLDKIL-SLVTPvtETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPE---------------- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 81 SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD 160
Cdd:PRK14491 263 SYTLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAA 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 161 GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR 240
Cdd:PRK14491 343 GTRLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAA 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 241 LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGEnqTPVFLLPSNTVSSLVIFEM 320
Cdd:PRK14491 423 LEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGD--SPFFGLPGNPVAVMVSFLQ 500
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 321 FIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTQDYLVEglGGANGapAHLLAGLAEANAMIKIP 400
Cdd:PRK14491 501 FVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRT--TGKQG--SGILSSMSEANCLIEIG 576
|
410
....*....|....*
gi 489947450 401 EDVNEVRPGDIVEVL 415
Cdd:PRK14491 577 PAAETVNAGETVTIQ 591
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
1-418 |
4.69e-42 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 157.28 E-value: 4.69e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 1 MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGErglgrpidapigpiet 80
Cdd:PLN02699 7 MISVEEALSIVLSVAARLSPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGPGE---------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 81 sLPVVGEVPAGSQ-RPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDC------GRKRMTAHRPVRSGEFVRHAGDDIRP 153
Cdd:PLN02699 71 -YPVITESRAGNDgLGVTLTPGTVAYVTTGGPIPDGADAVVQVEDTEVvedpldGSKRVRILSQASKGQDIRPVGCDIEK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 154 GDVAVSDGAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVE-IDREPSLGQVFDVNSYALAAAGRDAGADVHRVG 232
Cdd:PLN02699 150 DAKVLKAGERLGASEIGLLATVGVTMVKVYPRPTVAILSTGDELVEpTTGTLGRGQIRDSNRAMLLAAAIQQQCKVVDLG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 233 IAAGEPRRLREIVESQLLRS-EIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGENQTP-------V 304
Cdd:PLN02699 230 IARDDEEELERILDEAISSGvDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIDAKSAPsnskkmlA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 305 FLLPSNTVSSLVIFEMFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGR----RGYIRARLMRDAQTQDYLVEGLGgaN 380
Cdd:PLN02699 310 FGLPGNPVSCLVCFNLFVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVRpefhRAIIRWKLNDGSGNPGFVAESTG--H 387
|
410 420 430
....*....|....*....|....*....|....*...
gi 489947450 381 GAPAHLLAgLAEANAMIKIPEDVNEVRPGDIVEVLFMS 418
Cdd:PLN02699 388 QMSSRLLS-MKSANALLELPATGNVLSAGTSVSAIIIS 424
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
16-414 |
1.27e-38 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 146.11 E-value: 1.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 16 VAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGErglgrpidapigpietsLPVVGEVPAGSQRP 95
Cdd:PRK14497 26 FKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSSCTPGE-----------------FKVIDKIGIGEFKE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 96 LRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGR-KRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAA 174
Cdd:PRK14497 89 IHIKECEAVEVDTGSMIPMGADAVIKVENTKVINgNFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIGLLAS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 175 VGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEI 254
Cdd:PRK14497 169 LGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISVADV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 255 IVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQgfgLLGENQ-TPVFLLPSNTVSSLVIFEMFIRPVVRM--SLG 331
Cdd:PRK14497 249 LILTGGTSAGEKDFVHQAIRELGNIIVHGLKIKPGKPT---ILGIVDgKPVIGLPGNIVSTMVVLNMVILEYLKSlyPSR 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 332 KRSSQRRLVRARALNHVGSKVGRRGYIRArlmrdaqtqdYLVEGLGG--ANGAP--AHLLAGLAEANAMIKIPEDvNEVR 407
Cdd:PRK14497 326 KEILGLGKIKARLALRVKADEHRNTLIPV----------YLFKSDNSyyALPVPfdSYMVGTFSLTDGYIMLGPN-EEIE 394
|
....*..
gi 489947450 408 PGDIVEV 414
Cdd:PRK14497 395 EGKEVEV 401
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
23-415 |
6.38e-38 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 141.98 E-value: 6.38e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 23 IAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAvdvggerglGRPIDAPIGPIE-----TSLPVVGEVPAGsqrplr 97
Cdd:PRK14690 45 LDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAG---------AAPEGAQVLPLIegraaAGVPFSGRVPEG------ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 98 lqpkQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAAVGR 177
Cdd:PRK14690 110 ----MALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVGL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 178 SKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEIIVI 257
Cdd:PRK14690 186 TRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAAEADVILT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 258 AGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLgeNQTPVFLLPSNTVSSLVIFEMFIRPVVRMSLGKRSSQR 337
Cdd:PRK14690 266 SGGASAGDEDHVSALLREAGAMQSWRIALKPGRPLALGLW--QGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEGWSEP 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489947450 338 RLVRARALNHVGSKVGRRGYIRARlMRDAQTQDYLVEGLGgangapahLLAGLAEANAMIKIPEDVNEVRPGDIVEVL 415
Cdd:PRK14690 344 QGFTVPAAFEKRKKPGRREYLRAR-LRQGHAEVFRSEGSG--------RISGLSWAEGLVELGDGARRIAPGDPVRFI 412
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-176 |
8.58e-38 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 133.85 E-value: 8.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 17 APEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERglgrpidapigpietslpVVGEVPAGSQRPL 96
Cdd:pfam03453 5 TEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGAS------------------EVNPIAAGEPPGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 97 RLQPKQAVRVHTGAPLPTLSDAVIPLEWT-DCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAAV 175
Cdd:pfam03453 67 LLPGGEAVRIMTGAPLPEGADAVVMVEDTeEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASL 146
|
.
gi 489947450 176 G 176
Cdd:pfam03453 147 G 147
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
3-414 |
1.05e-37 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 141.38 E-value: 1.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 3 SVEQQLA-LVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGLgrpidaPI-GPIET 80
Cdd:PRK10680 9 SLETALTeMLSRVTPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQPL------PVaGKAFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 81 SLPVVGEVPAGSqrplrlqpkqAVRVHTGAPLPTLSDAVIPLEWTDCGRK--RMTAhrPVRSGEFVRHAGDDIRPGDVAV 158
Cdd:PRK10680 83 GQPFHGEWPAGT----------CIRIMTGAPVPEGCEAVVMQEQTEQTDDgvRFTA--EVRSGQNIRRRGEDISQGAVVF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 159 SDGAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEP 238
Cdd:PRK10680 151 PAGTRLTTAELPVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 239 RRLREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLgenQTPVFL-LPSNTVSSLVI 317
Cdd:PRK10680 231 HALRAAFIEADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKL---SNSWFCgLPGNPVSAALT 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 318 FEMFIRPVVRMSLGKRSSQRRL-VRARALNHVGSKVGRRGYIRARLMRDAQTQdyLVEGLGGANGapAHLLAGLAEANAM 396
Cdd:PRK10680 308 FYQLVQPLLAKLSGNTASGLPPrQRVRTASRLKKTPGRLDFQRGILQRNADGE--LEVTTTGHQG--SHIFSSFSLGNCF 383
|
410
....*....|....*...
gi 489947450 397 IKIPEDVNEVRPGDIVEV 414
Cdd:PRK10680 384 IVLERERGNVEVGEWVEV 401
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
186-324 |
8.61e-21 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 88.14 E-value: 8.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 186 PRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEIIVIAGAVGGSG 265
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 266 SEEIRRILSDLGEI-----------DTTRVAMHPGSVQGFGLLgeNQTPVFLLPSNTVSSLVIFEMFIRP 324
Cdd:TIGR00177 81 RDVTPEALEELGEKeipgfgefrmlSSLPVLSRPGKPATAGVR--GGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
190-327 |
1.10e-11 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 62.27 E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 190 VISVGHELVeidrepsLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEIIVIAGAVGGSGSEEI 269
Cdd:pfam00994 2 IITTGDELL-------PGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVT 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489947450 270 RRILSDLGEIDTT-------RVAMHPGSVQGFG---LLGENQTPVFLLPSNTVSSLVIFEMFIRPVVR 327
Cdd:pfam00994 75 PEALAELGGRELPgfeelfrGVSLKPGKPVGTApgaILSRAGKTVFGLPGSPVAAKVMFELLLLPLLR 142
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
187-326 |
2.62e-08 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 52.35 E-value: 2.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489947450 187 RMSVISVGHELveidrepSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRRLREIVESQLLRSEIIVIAGAVGGSGS 266
Cdd:cd00758 1 RVAIVTVSDEL-------SQGQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRR 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489947450 267 EEIRRILSDLGEIDT--TRVAMHPGSVQGFGLLGenQTPVFLLPSNTVSSLVIFEMFIRPVV 326
Cdd:cd00758 74 DVTPEALAELGEREAhgKGVALAPGSRTAFGIIG--KVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
341-415 |
1.58e-07 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 48.38 E-value: 1.58e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489947450 341 RARALNHVGSKVGRRGYIRARLMRDAQtqDYLVEGLGGANgapAHLLAGLAEANAMIKIPEDVNEVRPGDIVEVL 415
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLHEEDG--RYYAEPIGKQG---SGMLSSLAEANGLIVVPEGTEGLEAGEEVEVI 70
|
|
| |
