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Conserved domains on  [gi|489911416|ref|WP_003814827|]
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MULTISPECIES: urease subunit beta [Bordetella]

Protein Classification

urease subunit beta( domain architecture ID 10793751)

urease subunit beta (UreB) is a component of the urease enzyme complex that catalyzes the hydrolysis of urea into carbon dioxide and ammonia

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 3.79e-66

urease subunit beta; Reviewed


:

Pssm-ID: 237303  Cd Length: 102  Bit Score: 193.89  E-value: 3.79e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PRK13203   1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:PRK13203  81 LVPLAGARRVYGFRGKVMGKL 101
 
Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 3.79e-66

urease subunit beta; Reviewed


Pssm-ID: 237303  Cd Length: 102  Bit Score: 193.89  E-value: 3.79e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PRK13203   1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:PRK13203  81 LVPLAGARRVYGFRGKVMGKL 101
UreB COG0832
Urease beta subunit [Amino acid transport and metabolism];
4-101 1.58e-63

Urease beta subunit [Amino acid transport and metabolism];


Pssm-ID: 440594  Cd Length: 101  Bit Score: 187.19  E-value: 1.58e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   4 GEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELVA 83
Cdd:COG0832    1 GEIIVADGDIELNAGRETITLTVANTGDRPIQVGSHYHFFEVNPALEFDREAARGMRLDIPAGTAVRFEPGQTREVELVP 80

                         90
                 ....*....|....*...
gi 489911416  84 VGGERRIFGFQGKVMGAL 101
Cdd:COG0832   81 IGGARRVYGFNGLVNGPL 98
Urease_beta pfam00699
Urease beta subunit; This subunit is known as alpha in Heliobacter.
 3-100 6.09e-63

Urease beta subunit; This subunit is known as alpha in Heliobacter.


Pssm-ID: 459909  Cd Length: 98  Bit Score: 185.66  E-value: 6.09e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416    3 PGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELV 82
Cdd:pfam00699   1 PGEIITGDGDIELNAGRETITLTVTNTGDRPIQVGSHYHFFEVNPALEFDREAAYGMRLDIPAGTAVRFEPGDTKTVTLV 80

                          90
                  ....*....|....*...
gi 489911416   83 AVGGERRIFGFQGKVMGA 100
Cdd:pfam00699  81 PIGGARVVYGFNGLVNGP 98
Urease_beta cd00407
Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis ...
 1-101 6.57e-58

Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The alpha-beta-gamma heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel center complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers.


Pssm-ID: 238238  Cd Length: 101  Bit Score: 173.09  E-value: 6.57e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:cd00407    1 MIPGEIILKEGDIELNAGREAVTLKVKNTGDRPIQVGSHYHFFEVNPALKFDREKAYGMRLDIPAGTAVRFEPGEEKEVE 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:cd00407   81 LVPIGGKRRVYGFNGLVNGPL 101
urease_beta TIGR00192
urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and ...
 1-101 1.45e-47

urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and Haemophilus influenzae, urease subunits beta and gamma are encoded as separate polypeptides. In Helicobacter pylori UreA and in the fission yeast Schizosaccharomyces pombe, beta subunit-like sequence follows gamma subunit-like sequence in a single chain; the fission yeast protein contains additional C-terminal regions. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129296  Cd Length: 101  Bit Score: 147.28  E-value: 1.45e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416    1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:TIGR00192   1 MIPGELQLAEGDITINEGRKTVSVKVKNTGDRPIQVGSHFHFFEVNRALDFDRELAFGMRLDIPSGTAVRFEPGEEKSVE 80

                          90       100
                  ....*....|....*....|.
gi 489911416   81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:TIGR00192  81 LVAIGGNRRIYGFNGLVDGQL 101
 
Name Accession Description Interval E-value
ureB PRK13203
urease subunit beta; Reviewed
 1-101 3.79e-66

urease subunit beta; Reviewed


Pssm-ID: 237303  Cd Length: 102  Bit Score: 193.89  E-value: 3.79e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PRK13203   1 MIPGEYITADGEIELNAGRETVTLTVANTGDRPIQVGSHYHFFEVNPALSFDREAARGMRLNIPAGTAVRFEPGQTREVE 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:PRK13203  81 LVPLAGARRVYGFRGKVMGKL 101
UreB COG0832
Urease beta subunit [Amino acid transport and metabolism];
4-101 1.58e-63

Urease beta subunit [Amino acid transport and metabolism];


Pssm-ID: 440594  Cd Length: 101  Bit Score: 187.19  E-value: 1.58e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   4 GEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELVA 83
Cdd:COG0832    1 GEIIVADGDIELNAGRETITLTVANTGDRPIQVGSHYHFFEVNPALEFDREAARGMRLDIPAGTAVRFEPGQTREVELVP 80

                         90
                 ....*....|....*...
gi 489911416  84 VGGERRIFGFQGKVMGAL 101
Cdd:COG0832   81 IGGARRVYGFNGLVNGPL 98
Urease_beta pfam00699
Urease beta subunit; This subunit is known as alpha in Heliobacter.
 3-100 6.09e-63

Urease beta subunit; This subunit is known as alpha in Heliobacter.


Pssm-ID: 459909  Cd Length: 98  Bit Score: 185.66  E-value: 6.09e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416    3 PGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELV 82
Cdd:pfam00699   1 PGEIITGDGDIELNAGRETITLTVTNTGDRPIQVGSHYHFFEVNPALEFDREAAYGMRLDIPAGTAVRFEPGDTKTVTLV 80

                          90
                  ....*....|....*...
gi 489911416   83 AVGGERRIFGFQGKVMGA 100
Cdd:pfam00699  81 PIGGARVVYGFNGLVNGP 98
Urease_beta cd00407
Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis ...
 1-101 6.57e-58

Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The alpha-beta-gamma heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel center complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers.


Pssm-ID: 238238  Cd Length: 101  Bit Score: 173.09  E-value: 6.57e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:cd00407    1 MIPGEIILKEGDIELNAGREAVTLKVKNTGDRPIQVGSHYHFFEVNPALKFDREKAYGMRLDIPAGTAVRFEPGEEKEVE 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:cd00407   81 LVPIGGKRRVYGFNGLVNGPL 101
urease_beta TIGR00192
urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and ...
 1-101 1.45e-47

urease, beta subunit; In a number of species, including B.subtilis, Synechocystis, and Haemophilus influenzae, urease subunits beta and gamma are encoded as separate polypeptides. In Helicobacter pylori UreA and in the fission yeast Schizosaccharomyces pombe, beta subunit-like sequence follows gamma subunit-like sequence in a single chain; the fission yeast protein contains additional C-terminal regions. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129296  Cd Length: 101  Bit Score: 147.28  E-value: 1.45e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416    1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:TIGR00192   1 MIPGELQLAEGDITINEGRKTVSVKVKNTGDRPIQVGSHFHFFEVNRALDFDRELAFGMRLDIPSGTAVRFEPGEEKSVE 80

                          90       100
                  ....*....|....*....|.
gi 489911416   81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:TIGR00192  81 LVAIGGNRRIYGFNGLVDGQL 101
PRK13192 PRK13192
bifunctional urease subunit gamma/beta; Reviewed
 2-99 1.69e-46

bifunctional urease subunit gamma/beta; Reviewed


Pssm-ID: 183886 [Multi-domain]  Cd Length: 208  Bit Score: 147.82  E-value: 1.69e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   2 IPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVEL 81
Cdd:PRK13192 111 YPGEILPGDGEIELNAGRPAVTLDVTNTGDRPIQVGSHFHFFEVNRALRFDRAAAYGMRLDIPAGTAVRFEPGETKEVRL 190

                         90
                 ....*....|....*...
gi 489911416  82 VAVGGERRIFGFQGKVMG 99
Cdd:PRK13192 191 VPIGGARVVIGFNGLTNG 208
PLN02303 PLN02303
urease
 1-99 1.29e-40

urease


Pssm-ID: 215172 [Multi-domain]  Cd Length: 837  Bit Score: 141.81  E-value: 1.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PLN02303 131 PIPGEIITGDGSIIINAGRKAVKLKVTNTGDRPIQVGSHYHFIETNPYLVFDRRKAYGMRLNIPAGTAVRFEPGETKTVT 210

                         90
                 ....*....|....*....
gi 489911416  81 LVAVGGERRIFGFQGKVMG 99
Cdd:PLN02303 211 LVSIGGNKVIRGGNGIVDG 229
ureB PRK13201
urease subunit beta; Reviewed
 1-101 1.53e-40

urease subunit beta; Reviewed


Pssm-ID: 237302 [Multi-domain]  Cd Length: 136  Bit Score: 130.34  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PRK13201   1 MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQ 80

                         90       100
                 ....*....|....*....|.
gi 489911416  81 LVAVGGERRIFGFQGKVMGAL 101
Cdd:PRK13201  81 LVEYAGKRKIFGFRGMVNGPI 101
PRK13986 PRK13986
urease subunit beta;
3-95 1.13e-36

urease subunit beta;


Pssm-ID: 184439 [Multi-domain]  Cd Length: 225  Bit Score: 123.40  E-value: 1.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   3 PGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELV 82
Cdd:PRK13986 108 PGELFLKDEDITINAGKKAVSVKVKNVGDRPVQVGSHFHFFEVNRCLEFDREKAFGKRLDIASGTAVRFEPGEEKSVELI 187

                         90
                 ....*....|...
gi 489911416  83 AVGGERRIFGFQG 95
Cdd:PRK13986 188 DIGGNRRIFGFNA 200
ureB PRK13205
urease subunit beta; Reviewed
 1-102 3.85e-35

urease subunit beta; Reviewed


Pssm-ID: 106174 [Multi-domain]  Cd Length: 162  Bit Score: 117.60  E-value: 3.85e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVE 80
Cdd:PRK13205   1 MIPGEYILSSESLTGNVGREAKTIEIINTGDRPVQIGSHFHFAEVNPSISFDRSEGYGFRLDIPSGTAVRLEPGDARTVN 80

                         90       100
                 ....*....|....*....|..
gi 489911416  81 LVAVGGERRIFGFQGKVMGALK 102
Cdd:PRK13205  81 LVAIGGDRIVAGFRDLVDGPLE 102
ureB PRK13204
urease subunit beta; Reviewed
 13-99 7.45e-31

urease subunit beta; Reviewed


Pssm-ID: 171902 [Multi-domain]  Cd Length: 159  Bit Score: 106.78  E-value: 7.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416  13 IELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELVAVGGERRIFG 92
Cdd:PRK13204  36 IEINQGRPRTTLTVRNTGDRPIQIGSHFHFFEVNRYLEFDRSKAFGLRLDIPANTAVRFEPGDEKEVTLVPFAGKRFIFG 115


                 ....*..
gi 489911416  93 FQGKVMG 99
Cdd:PRK13204 116 FNNLVDG 122
ureB PRK13198
urease subunit beta; Reviewed
 13-99 2.25e-29

urease subunit beta; Reviewed


Pssm-ID: 171897 [Multi-domain]  Cd Length: 158  Bit Score: 102.84  E-value: 2.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416  13 IELNVGRPTLTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTVELVAVGGERRIFG 92
Cdd:PRK13198  41 ITFNENKPVTKVKVRNTGDRPIQVGSHFHFFEVNRALEFDRAAAYGKRLNISSTTAIRFEPGDETEVPLIPFGGKQTLYG 120


                 ....*..
gi 489911416  93 FQGKVMG 99
Cdd:PRK13198 121 FNNLVDG 127
ureB PRK13202
urease subunit beta; Reviewed
 1-93 3.18e-29

urease subunit beta; Reviewed


Pssm-ID: 106171  Cd Length: 104  Bit Score: 100.92  E-value: 3.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911416   1 MIPGEILTEPGQIELNVGRPT-LTIAVVNEGDRPIQVGSHYHFAEANNALVFDRELATGYRLNIPAGNAVRFEPGMRRTV 79
Cdd:PRK13202   1 MIPGEIFYGSGDIEMNAAALSrLQMRIINAGDRPVQVGSHVHLPQANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIV 80

                         90
                 ....*....|....
gi 489911416  80 ELVAVGGERRIFGF 93
Cdd:PRK13202  81 GLVPLGGRREVPGL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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