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Conserved domains on  [gi|48976089|ref|NP_001001744|]
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iroquois-class homeodomain protein IRX-4 [Gallus gallus]

Protein Classification

homeodomain and IRO domain-containing protein( domain architecture ID 13432725)

homeodomain and IRO domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 160-198 1.06e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 73.32  E-value: 1.06e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48976089   160 LQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 198
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
144-245 3.02e-06

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 47.05  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48976089 144 RRKNaTRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMtwpprnkcSDEKRPYEEE 223
Cdd:COG5576  52 KSKR-RRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG--------KVEQRPGEEE 122

                        90       100
                ....*....|....*....|..
gi 48976089 224 EEEEEECSQEDAMKSEKAEEPT 245
Cdd:COG5576 123 ADLAKIGSLSTGQISIIETLEF 144
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
347-363 9.92e-04

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


:

Pssm-ID: 214716  Cd Length: 18  Bit Score: 36.40  E-value: 9.92e-04
                           10
                   ....*....|....*..
gi 48976089    347 LLEAKPRIWSLAHTATS 363
Cdd:smart00548   1 SPAAKPKIWSLADTATS 17
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 160-198 1.06e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 73.32  E-value: 1.06e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48976089   160 LQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 198
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 144-203 2.87e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.19  E-value: 2.87e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48976089 144 RRKNATRETTSTLKAWLQehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 203
Cdd:cd00086   3 KRTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 144-200 7.02e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 7.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 48976089    144 RRKNATRETTSTLKAWLQehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 200
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
144-245 3.02e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 47.05  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48976089 144 RRKNaTRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMtwpprnkcSDEKRPYEEE 223
Cdd:COG5576  52 KSKR-RRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG--------KVEQRPGEEE 122

                        90       100
                ....*....|....*....|..
gi 48976089 224 EEEEEECSQEDAMKSEKAEEPT 245
Cdd:COG5576 123 ADLAKIGSLSTGQISIIETLEF 144
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
347-363 9.92e-04

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 36.40  E-value: 9.92e-04
                           10
                   ....*....|....*..
gi 48976089    347 LLEAKPRIWSLAHTATS 363
Cdd:smart00548   1 SPAAKPKIWSLADTATS 17
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 160-198 1.06e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 73.32  E-value: 1.06e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48976089   160 LQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 198
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 144-203 2.87e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.19  E-value: 2.87e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48976089 144 RRKNATRETTSTLKAWLQehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 203
Cdd:cd00086   3 KRTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 144-200 7.02e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 7.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 48976089    144 RRKNATRETTSTLKAWLQehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 200
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
144-201 1.43e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 45.18  E-value: 1.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 48976089   144 RRKNATRETTSTLKAwlqEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK 201
Cdd:pfam00046   3 KRTTFTPEQLEELEK---EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
144-245 3.02e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 47.05  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48976089 144 RRKNaTRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMtwpprnkcSDEKRPYEEE 223
Cdd:COG5576  52 KSKR-RRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG--------KVEQRPGEEE 122

                        90       100
                ....*....|....*....|..
gi 48976089 224 EEEEEECSQEDAMKSEKAEEPT 245
Cdd:COG5576 123 ADLAKIGSLSTGQISIIETLEF 144
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
347-363 9.92e-04

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 36.40  E-value: 9.92e-04
                           10
                   ....*....|....*..
gi 48976089    347 LLEAKPRIWSLAHTATS 363
Cdd:smart00548   1 SPAAKPKIWSLADTATS 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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