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Conserved domains on  [gi|489631312|ref|WP_003535752|]
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MULTISPECIES: amino acid ABC transporter permease [Sinorhizobium]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 5-218 1.84e-81

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 242.29  E-value: 1.84e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   5 LQLMADSLPaLLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGI 84
Cdd:COG0765    5 FSVLLDYLP-LLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  85 LLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLA 164
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489631312 165 AAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARY 218
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 5-218 1.84e-81

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 242.29  E-value: 1.84e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   5 LQLMADSLPaLLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGI 84
Cdd:COG0765    5 FSVLLDYLP-LLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  85 LLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLA 164
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489631312 165 AAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARY 218
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
1-217 8.47e-81

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 240.81  E-value: 8.47e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   1 MPHWLQLMADSLPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLP 80
Cdd:PRK15100   1 MQESIQLVIDSAPFLL-KGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  81 SMGILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKD 160
Cdd:PRK15100  80 QFGIELDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489631312 161 TSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:PRK15100 160 TSLAATIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNR 216
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 12-215 1.56e-39

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 135.37  E-value: 1.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   12 LPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGILLDAFPA 91
Cdd:TIGR03003  10 LPTLI-EGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   92 ALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPE 171
Cdd:TIGR03003  89 GVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLE 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 489631312  172 LFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRF 215
Cdd:TIGR03003 169 LMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-205 4.33e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.77  E-value: 4.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  20 LIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMG---ILLDAFPAALIGF 96
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  97 TLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPELFQTA 176
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*....
gi 489631312 177 QRIVATSYEPLILYIEAALIYLVMSSVLS 205
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-217 1.02e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.55  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   34 GLALGLVTAVVRlfaPAPFAAVARFYVWVIRGTPLLVQLFVIFYgLPSMGILLDAFPAALIGFTLNIGAYSSEIIRAVIS 113
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  114 SVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPELFQTAQRIVATSY---EPLILY 190
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYdypEIQGPV 156

                         170       180
                  ....*....|....*....|....*..
gi 489631312  191 IEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 5-218 1.84e-81

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 242.29  E-value: 1.84e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   5 LQLMADSLPaLLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGI 84
Cdd:COG0765    5 FSVLLDYLP-LLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  85 LLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLA 164
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489631312 165 AAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARY 218
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
1-217 8.47e-81

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 240.81  E-value: 8.47e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   1 MPHWLQLMADSLPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLP 80
Cdd:PRK15100   1 MQESIQLVIDSAPFLL-KGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  81 SMGILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKD 160
Cdd:PRK15100  80 QFGIELDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489631312 161 TSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:PRK15100 160 TSLAATIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNR 216
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 5-218 2.51e-63

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 196.47  E-value: 2.51e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   5 LQLMADSLPaLLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMG- 83
Cdd:COG4160    3 LDLLFEYLP-LLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEw 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  84 --------ILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFI 155
Cdd:COG4160   82 vreswlwpLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489631312 156 SLVKDTSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARY 218
Cdd:COG4160  162 LMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRH 224
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
5-217 1.53e-44

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 148.73  E-value: 1.53e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   5 LQLMADSLP---ALLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPS 81
Cdd:COG4215    4 LTLLMFGLQgwgPALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  82 M------------GILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPP 149
Cdd:COG4215   84 LlnaladlfgydgFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPG 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489631312 150 LSNTFISLVKDTSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:COG4215  164 LGNNWLVLLKDTALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAALIYLALTTVSELVLARLERRASR 231
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 12-215 1.56e-39

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 135.37  E-value: 1.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   12 LPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGILLDAFPA 91
Cdd:TIGR03003  10 LPTLI-EGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   92 ALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPE 171
Cdd:TIGR03003  89 GVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLE 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 489631312  172 LFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRF 215
Cdd:TIGR03003 169 LMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 8-214 3.35e-35

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 124.40  E-value: 3.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   8 MADSLPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSM--GIL 85
Cdd:PRK09494   8 IWPAIPLLL-EGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfnDLR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  86 LDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAA 165
Cdd:PRK09494  87 IDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFI 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489631312 166 AITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQR 214
Cdd:PRK09494 167 VIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
PRK15069 PRK15069
histidine ABC transporter permease HisM;
14-218 1.01e-34

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 123.62  E-value: 1.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  14 ALLW------AGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGI--- 84
Cdd:PRK15069  11 ALLWtdgyrfTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIvrg 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  85 --LLDAF-----PAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISL 157
Cdd:PRK15069  91 tdLLDAFfrsglNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILM 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489631312 158 VKDTSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARY 218
Cdd:PRK15069 171 LHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAH 231
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 15-217 1.00e-32

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 117.64  E-value: 1.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   15 LLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGILLDAFPAALI 94
Cdd:TIGR03004   6 LLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   95 GFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPELFQ 174
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 489631312  175 TAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
8-219 2.85e-27

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 103.99  E-value: 2.85e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   8 MADSLPALLWAGLifTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTP-LLVQLFVIFYGLPSMGILL 86
Cdd:PRK11123   1 MNEFFPLASAAGM--TVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeILVVLFIYFGSSQLLLTLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  87 DAFPAALIGFTLNI-----------------------GAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAG 143
Cdd:PRK11123  79 DGFTLNLGFVQIPVqmdienfevspflcgvialsllyAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMW 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489631312 144 RVAVPPLSNTFISLVKDTSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFARYG 219
Cdd:PRK11123 159 RHALPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATRFE 234
artM PRK11122
arginine ABC transporter permease ArtM;
8-214 5.65e-27

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 103.11  E-value: 5.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   8 MADSLPALLwAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYG---LPSM-- 82
Cdd:PRK11122   1 MLEYLPELL-KGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqFPWLqe 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  83 -----GILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMrRTILPQAGRVAVPPLSNTFISL 157
Cdd:PRK11122  80 ypwlwHLLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLV 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489631312 158 VKDTSLAAAITVPELFQTAQRIVATSYEPLIlYIEAALIYLVMSSVLSALQGKLEQR 214
Cdd:PRK11122 159 FKSTSLAYTITLMDVMGYSQLLYGRTYDVMV-FGAAGIIYLVVNGLLTLLMRLIERK 214
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-110 4.44e-24

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 91.83  E-value: 4.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   14 ALLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMGILLDAFPAAL 93
Cdd:TIGR01726   3 PFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAAV 82

                          90
                  ....*....|....*..
gi 489631312   94 IGFTLNIGAYSSEIIRA 110
Cdd:TIGR01726  83 IALTLFYGAYLAEIFRG 99
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 89-207 8.89e-24

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 97.52  E-value: 8.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  89 FPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAIT 168
Cdd:COG4597  265 FVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIG 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489631312 169 VPELF---------QTAQRIvatsyePLILYIeaALIYLVMSSVLSAL 207
Cdd:COG4597  345 YPDLVsvfagttlnQTGQAI------EIIAIT--MAVYLTISLLISLL 384
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
11-214 1.77e-22

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 91.04  E-value: 1.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  11 SLPaLLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPS-MGILLDAF 89
Cdd:PRK15107  12 SLP-YLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGfLQNVLGLS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  90 P-------AALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTS 162
Cdd:PRK15107  91 PktdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTS 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489631312 163 LAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQR 214
Cdd:PRK15107 171 LVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
8-216 1.56e-20

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 86.00  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   8 MADSLPALLWAGLIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLP------- 80
Cdd:PRK15135   1 MLYGFSGVILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQialnsvt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  81 -SMG---ILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFIS 156
Cdd:PRK15135  81 eALGvgqIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312 157 LVKDTSLAAAITVPELFQTAQRIVATSYEPLILYIEAALIYLVMSSVLSALQGKLEQRFA 216
Cdd:PRK15135 161 ILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERRYS 220
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-205 4.33e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.77  E-value: 4.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  20 LIFTIPLTLLSFTLGLALGLVTAVVRLFAPAPFAAVARFYVWVIRGTPLLVQLFVIFYGLPSMG---ILLDAFPAALIGF 96
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  97 TLNIGAYSSEIIRAVISSVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPELFQTA 176
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*....
gi 489631312 177 QRIVATSYEPLILYIEAALIYLVMSSVLS 205
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-217 1.02e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.55  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312   34 GLALGLVTAVVRlfaPAPFAAVARFYVWVIRGTPLLVQLFVIFYgLPSMGILLDAFPAALIGFTLNIGAYSSEIIRAVIS 113
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489631312  114 SVPRGQWEAAYSIGMSWSQAMRRTILPQAGRVAVPPLSNTFISLVKDTSLAAAITVPELFQTAQRIVATSY---EPLILY 190
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYdypEIQGPV 156

                         170       180
                  ....*....|....*....|....*..
gi 489631312  191 IEAALIYLVMSSVLSALQGKLEQRFAR 217
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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