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Conserved domains on  [gi|489518052|ref|WP_003422862|]
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glycosyltransferase family 2 protein [Clostridioides difficile]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-209 5.06e-51

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 165.26  E-value: 5.06e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKAT 84
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  85 GQFIAFLDSDDQWNSSKLEKQVNFMLENDYVISFTSYeLMDENDKKLNKVIKVPPNVdYRRLLKGNILGCLTVVIDKSKL 164
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNL-VRLLTNLPDSTSGFRLFRREVL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489518052 165 DfEIRMSGVRHEDYVLwLSILKKGhiaHGINEVLALYRKSSNSLS 209
Cdd:COG0463  161 E-ELGFDEGFLEDTEL-LRALRHG---FRIAEVPVRYRAGESKLN 200
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-209 5.06e-51

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 165.26  E-value: 5.06e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKAT 84
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  85 GQFIAFLDSDDQWNSSKLEKQVNFMLENDYVISFTSYeLMDENDKKLNKVIKVPPNVdYRRLLKGNILGCLTVVIDKSKL 164
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNL-VRLLTNLPDSTSGFRLFRREVL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489518052 165 DfEIRMSGVRHEDYVLwLSILKKGhiaHGINEVLALYRKSSNSLS 209
Cdd:COG0463  161 E-ELGFDEGFLEDTEL-LRALRHG---FRIAEVPVRYRAGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 7-164 1.22e-42

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 142.53  E-value: 1.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    7 SIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQ 86
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489518052   87 FIAFLDSDDQWNSSKLEKQVNFMLENDYVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNILGCLTVVIDKSKL 164
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFAL 158
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 7-212 2.84e-36

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 127.75  E-value: 2.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRI-KCIKTETNKGVsnARN--LALSKA 83
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIiILIRNGKNLGV--ARNfeSLLQAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  84 TGQFIAFLDSDDQWNSSKLEKQVNFMLEND-YVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNIL-----GClTV 157
Cdd:cd04196   79 DGDYVFFCDQDDIWLPDKLERLLKAFLKDDkPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFqnvvtGC-TM 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489518052 158 VIDKSKLD----FEIRMSGVrHeDYVLWLSILKKGHIAHgINEVLALYRKSSNSLSGNK 212
Cdd:cd04196  158 AFNRELLElalpFPDADVIM-H-DWWLALLASAFGKVVF-LDEPLILYRQHGNNVVGAN 213
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-95 6.26e-26

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 103.20  E-value: 6.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   3 KNLVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTEtNKGVSNARNLALSK 82
Cdd:PRK10073   5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQA-NAGVSVARNTGLAV 83

                         90
                 ....*....|...
gi 489518052  83 ATGQFIAFLDSDD 95
Cdd:PRK10073  84 ATGKYVAFPDADD 96
WcaA TIGR04017
colanic acid biosynthesis glycosyl transferase WcaA; This gene is one of the glycosyl ...
 5-115 4.38e-21

colanic acid biosynthesis glycosyl transferase WcaA; This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.


Pssm-ID: 274920  Cd Length: 279  Bit Score: 89.32  E-value: 4.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTdnSPNIVKSYMQQ--DSRIKCIKTETNKGVSNARNLALSK 82
Cdd:TIGR04017   6 LISIYMPTWNRQQLAIRAIKSVLRQDYDNWEMIIVDDCSS--SYEQLQQFVEAlnDPRVRYTHNDINSGACAVRNQAIMQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489518052   83 ATGQFIAFLDSDDQWNSSKL------EKQVN---FMLENDYV 115
Cdd:TIGR04017  84 AKGEYITGIDDDDEWTPNRLsvflahKHQLVthaFLYANDYV 125
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-209 5.06e-51

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 165.26  E-value: 5.06e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKAT 84
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  85 GQFIAFLDSDDQWNSSKLEKQVNFMLENDYVISFTSYeLMDENDKKLNKVIKVPPNVdYRRLLKGNILGCLTVVIDKSKL 164
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNL-VRLLTNLPDSTSGFRLFRREVL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489518052 165 DfEIRMSGVRHEDYVLwLSILKKGhiaHGINEVLALYRKSSNSLS 209
Cdd:COG0463  161 E-ELGFDEGFLEDTEL-LRALRHG---FRIAEVPVRYRAGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 7-164 1.22e-42

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 142.53  E-value: 1.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    7 SIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQ 86
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489518052   87 FIAFLDSDDQWNSSKLEKQVNFMLENDYVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNILGCLTVVIDKSKL 164
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFAL 158
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 7-212 2.84e-36

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 127.75  E-value: 2.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRI-KCIKTETNKGVsnARN--LALSKA 83
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIiILIRNGKNLGV--ARNfeSLLQAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  84 TGQFIAFLDSDDQWNSSKLEKQVNFMLEND-YVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNIL-----GClTV 157
Cdd:cd04196   79 DGDYVFFCDQDDIWLPDKLERLLKAFLKDDkPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFqnvvtGC-TM 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489518052 158 VIDKSKLD----FEIRMSGVrHeDYVLWLSILKKGHIAHgINEVLALYRKSSNSLSGNK 212
Cdd:cd04196  158 AFNRELLElalpFPDADVIM-H-DWWLALLASAFGKVVF-LDEPLILYRQHGNNVVGAN 213
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 8-113 6.49e-35

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 122.23  E-value: 6.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQF 87
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                         90       100
                 ....*....|....*....|....*.
gi 489518052  88 IAFLDSDDQWNSSKLEKQVNFMLEND 113
Cdd:cd00761   81 ILFLDADDLLLPDWLERLVAELLADP 106
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 7-202 6.22e-34

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 121.11  E-value: 6.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYmqQDSRIKCIkTETNKGVSNARNLALSKATGQ 86
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKY--EDKITYWI-SEPDKGIYDAMNKGIALATGD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  87 FIAFLDSDDQWNSSKLEKQVNFMLEN---DYVISFTsyELMDENDKKlnKVIKVPPNVDYRRLLKGNILGCLTVVIDKS- 162
Cdd:cd06433   78 IIGFLNSDDTLLPGALLAVVAAFAEHpevDVVYGDV--LLVDENGRV--IGRRRPPPFLDKFLLYGMPICHQATFFRRSl 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489518052 163 -----KLDFEIRMSGvrheDYVLWLSILKKGHIAHGINEVLALYR 202
Cdd:cd06433  154 fekygGFDESYRIAA----DYDLLLRLLLAGKIFKYLPEVLAAFR 194
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 5-198 2.14e-32

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 117.30  E-value: 2.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNS-EKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSP-NIVKSYMQQDSRIKCIKTETNKGVSNARNLALSK 82
Cdd:cd04184    2 LISIVMPVYNTpEKYLREAIESVRAQTYPNWELCIADDASTDPEVkRVLKKYAAQDPRIKVVFREENGGISAATNSALEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  83 ATGQFIAFLDSDDQ-------WNSSKLEKqvnfmlENDYVISFTSYELMDENDKKLNKVIKVPPNVDYrrLLKGNILGCL 155
Cdd:cd04184   82 ATGEFVALLDHDDElaphalyEVVKALNE------HPDADLIYSDEDKIDEGGKRSEPFFKPDWSPDL--LLSQNYIGHL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489518052 156 TVViDKSKLDfeiRMSGVRHE-----DYVLWLSILKKG-HIAHgINEVL 198
Cdd:cd04184  154 LVY-RRSLVR---QVGGFREGfegaqDYDLVLRVSEHTdRIAH-IPRVL 197
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 6-117 2.67e-29

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 111.76  E-value: 2.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   6 VSIITPMYNSEKFIEATIKSVLNQTY--QEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKA 83
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSLLAQDYpkEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGLKAA 110

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489518052  84 TGQFIAFLDSDDQWNSSKLEKQVNFMLENDYVIS 117
Cdd:COG1215  111 RGDIVVFLDADTVLDPDWLRRLVAAFADPGVGAS 144
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
6-108 3.12e-26

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 101.22  E-value: 3.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   6 VSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYmqQDSRIKCIKTETNKGVSNARNLALSKATG 85
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAAL--AFPRVRVIRNPENLGFAAARNLGLRAAGG 82

                         90       100
                 ....*....|....*....|...
gi 489518052  86 QFIAFLDSDDQWNSSKLEKQVNF 108
Cdd:COG1216   83 DYLLFLDDDTVVEPDWLERLLAA 105
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-95 6.26e-26

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 103.20  E-value: 6.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   3 KNLVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTEtNKGVSNARNLALSK 82
Cdd:PRK10073   5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQA-NAGVSVARNTGLAV 83

                         90
                 ....*....|...
gi 489518052  83 ATGQFIAFLDSDD 95
Cdd:PRK10073  84 ATGKYVAFPDADD 96
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-113 8.14e-22

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 90.75  E-value: 8.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNSEKFIEATIKSVLNQTYQE--WEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKtetNKG--VSNARNLAL 80
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQSYPKdlIEIIVVDGGSTDGTREIVQEYAAKDPRIRLID---NPKriQSAGLNIGI 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489518052  81 SKATGQFIAFLDSDDQWNSSKLEKQVNFMLEND 113
Cdd:cd02525   78 RNSRGDIIIRVDAHAVYPKDYILELVEALKRTG 110
WcaA TIGR04017
colanic acid biosynthesis glycosyl transferase WcaA; This gene is one of the glycosyl ...
 5-115 4.38e-21

colanic acid biosynthesis glycosyl transferase WcaA; This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.


Pssm-ID: 274920  Cd Length: 279  Bit Score: 89.32  E-value: 4.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTdnSPNIVKSYMQQ--DSRIKCIKTETNKGVSNARNLALSK 82
Cdd:TIGR04017   6 LISIYMPTWNRQQLAIRAIKSVLRQDYDNWEMIIVDDCSS--SYEQLQQFVEAlnDPRVRYTHNDINSGACAVRNQAIMQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489518052   83 ATGQFIAFLDSDDQWNSSKL------EKQVN---FMLENDYV 115
Cdd:TIGR04017  84 AKGEYITGIDDDDEWTPNRLsvflahKHQLVthaFLYANDYV 125
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
5-115 8.77e-20

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 85.81  E-value: 8.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   5 LVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTdnSPNIVKSYMQQ--DSRIKCIKTETNKGVSNARNLALSK 82
Cdd:PRK10018   6 LISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCST--SWEQLQQYVTAlnDPRITYIHNDINSGACAVRNQAIML 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489518052  83 ATGQFIAFLDSDDQWNSSKL------EKQVN---FMLENDYV 115
Cdd:PRK10018  84 AQGEYITGIDDDDEWTPNRLsvflahKQQLVthaFLYANDYV 125
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 8-114 1.52e-19

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 83.01  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLN--QTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATG 85
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvlEEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRAGFKAARG 80

                         90       100
                 ....*....|....*....|....*....
gi 489518052  86 QFIAFLDSDDQWNSSKLEKQVNFMLENDY 114
Cdd:cd04179   81 DIVVTMDADLQHPPEDIPKLLEKLLEGGA 109
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-94 2.24e-18

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 79.53  E-value: 2.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQqdsRIKCIKTETNKGVSNARNLALSKATGQF 87
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELFP---EVRLIRNGENLGFGAGNNQGIREAKGDY 77


                 ....*..
gi 489518052  88 IAFLDSD 94
Cdd:cd04186   78 VLLLNPD 84
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 7-202 1.63e-17

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 78.13  E-value: 1.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSEK--FIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKAT 84
Cdd:cd04195    1 SVLMSVYIKEKpeFLREALESILKQTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEGLKHCT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  85 GQFIAFLDSDDQWNSSKLEKQVNFMLENDYV-ISFTSYELMDENDKKLNKVIKVPPNVD-YRRLLKGNILGCLTVVIDKS 162
Cdd:cd04195   81 YDWVARMDTDDISLPDRFEKQLDFIEKNPEIdIVGGGVLEFDSDGNDIGKRRLPTSHDDiLKFARRRSPFNHPTVMFRKS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 489518052 163 KLdfeIRMSGVRH----EDYVLWLSILKKGHIAHGINEVLALYR 202
Cdd:cd04195  161 KV---LAVGGYQDlplvEDYALWARMLANGARFANLPEILVKAR 201
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 8-116 2.23e-17

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 77.27  E-value: 2.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSY-MQQDSRIKCIKTETNKGVSNARNLALSKATGQ 86
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELaALYIRRVLVVRDKENGGKAGALNAGLRHAKGD 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 489518052  87 FIAFLDSDDQWNSSKLEKQVNFMLENDYVI 116
Cdd:cd06423   81 IVVVLDADTILEPDALKRLVVPFFADPKVG 110
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 8-96 4.23e-17

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 76.36  E-value: 4.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEAT---IKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIkciktetnKGVSNARN------- 77
Cdd:cd04187    1 IVVPVYNEEENLPELyerLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRV--------KVIRLSRNfgqqaal 72

                         90       100
                 ....*....|....*....|
gi 489518052  78 LA-LSKATGQFIAFLDSDDQ 96
Cdd:cd04187   73 LAgLDHARGDAVITMDADLQ 92
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 6-104 2.44e-16

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 75.70  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   6 VSIITPMYNSEKFIEATIKSVLNQTY--QEWEMLIIDDCSTDNSPNIVKSYMQQdsRIKCIKTETNKGVSNARNLALSKA 83
Cdd:cd06439   31 VTIIIPAYNEEAVIEAKLENLLALDYprDRLEIIVVSDGSTDGTAEIAREYADK--GVKLLRFPERRGKAAALNRALALA 108

                         90       100
                 ....*....|....*....|.
gi 489518052  84 TGQFIAFLDSDDQWNSSKLEK 104
Cdd:cd06439  109 TGEIVVFTDANALLDPDALRL 129
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 8-105 1.31e-14

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 70.56  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTY-QEWEMLIIDDCSTDNSPNIVKSYMQ--QDSRIKCIKTETN----KGVSNARNLAL 80
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFeGTLELSVFNDASTDKSAEIIEKWRKklEDSGVIVLVGSHNspspKGVGYAKNQAI 80

                         90       100
                 ....*....|....*....|....*
gi 489518052  81 SKATGQFIAFLDSDDQWNSSKLEKQ 105
Cdd:cd06913   81 AQSSGRYLCFLDSDDVMMPQRIRLQ 105
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 8-120 1.49e-12

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 64.51  E-value: 1.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSV---LNQTYQ-EWEMLIIDDCSTDNSPNIVKSY-MQQDSRIKCIKTETNKGVSNARNLALSK 82
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAveyLEERPSfSYEIIVVDDGSKDGTAEVARKLaRKNPALIRVLTLPKNRGKGGAVRAGMLA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489518052  83 ATGQFIAFLDSDdqwNSSK---LEKQVNFMLENDYVISFTS 120
Cdd:cd04188   81 ARGDYILFADAD---LATPfeeLEKLEEALKTSGYDIAIGS 118
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 7-134 2.51e-11

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 62.29  E-value: 2.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    7 SIITPMYNSEK--FIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCI-KTETNKGVSNARNLALSKA 83
Cdd:pfam10111   1 SVVIPVYNGEKthWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLQVYYPnAPDTTYSLAASRNRGTSHA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489518052   84 TGQFIAFLDSDDQWNSSKLEKQVNF-----MLEN-DYVISFTSYELMDENDKKLNKV 134
Cdd:pfam10111  81 IGEYISFIDGDCLWSPDKFEKQLKIatslaLQENiQAAVVLPVTDLNDESSNFLRRG 137
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 8-94 3.36e-10

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 58.45  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITpmYNSEKFIEATIKSVLNQTYqewEMLIIDDCSTDNSPNIVKSYMQQdsrikcIKTETNKGVSNARNLALSKATGQF 87
Cdd:cd02511    6 IIT--KNEERNIERCLESVKWAVD---EIIVVDSGSTDRTVEIAKEYGAK------VYQRWWDGFGAQRNFALELATNDW 74


                 ....*..
gi 489518052  88 IAFLDSD 94
Cdd:cd02511   75 VLSLDAD 81
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 8-94 6.98e-10

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 56.82  E-value: 6.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDS-RIKCIKTEtNKG--VSNARNLALSKAT 84
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFPiPIKHVWQE-DEGfrKAKIRNKAIAAAK 79

                         90
                 ....*....|
gi 489518052  85 GQFIAFLDSD 94
Cdd:cd06420   80 GDYLIFIDGD 89
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 8-94 1.85e-09

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 56.00  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTYQ-EWEMLIIDDCSTDNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQ 86
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKGiDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAARGD 80


                 ....*...
gi 489518052  87 FIAFLDSD 94
Cdd:cd06442   81 VIVVMDAD 88
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 7-128 2.16e-09

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 56.70  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSE-----------KFIEATIKSVLNQTYqewEMLIIDDCSTDNSPNIVKSYMQQ----DSRIKCIKTETNKG 71
Cdd:PTZ00260  73 SIVIPAYNEEdrlpkmlketiKYLESRSRKDPKFKY---EIIIVNDGSKDKTLKVAKDFWRQninpNIDIRLLSLLRNKG 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052  72 VSNARNLALSKATGQFIAFLDSD---DQWNSSKLEKQVNFMLENDYVISFTSYELMDEND 128
Cdd:PTZ00260 150 KGGAVRIGMLASRGKYILMVDADgatDIDDFDKLEDIMLKIEQNGLGIVFGSRNHLVDSD 209
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-114 3.67e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 55.37  E-value: 3.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   8 IITPMYNSEKFIEATIKSVLNQTY--QEWEMLIIDDCSTDNSPNIVKSYMQQDS-RIKCI--KTETNKGVSNARNLALSK 82
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDYpkEKFEVILVDDHSTDGTVQILEFAAAKPNfQLKILnnSRVSISGKKNALTTAIKA 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489518052  83 ATGQFIAFLDSDDQWNSSKLEKQVNFMLENDY 114
Cdd:cd04192   81 AKGDWIVTTDADCVVPSNWLLTFVAFIQKEQI 112
mycofact_glyco TIGR03965
mycofactocin system glycosyltransferase; Members of this protein family are putative ...
 6-94 2.84e-08

mycofactocin system glycosyltransferase; Members of this protein family are putative glycosyltransferases, members of pfam00535 (glycosyl transferase family 2). Members appear mostly in the Actinobacteria, where they appear to be part of a system for converting a precursor peptide (TIGR03969) into a novel redox carrier designated mycofactocin. A radical SAM enzyme, TIGR03962, is a proposed to be a key maturase for mycofactocin.


Pssm-ID: 274884 [Multi-domain]  Cd Length: 466  Bit Score: 53.61  E-value: 2.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    6 VSIITPMYNSEKFIEATIKSVLNQTYQ--EWEMLIIDDCSTDNSPNIVKSYMQQDSRIkcIKTETNKGVSNARNLALSKA 83
Cdd:TIGR03965  76 VTVVVPVRNRPAGLARLLAALLALDYPrdRLEVIVVDDGSEDPVPTRAARGARLPVRV--IRHPRRQGPAAARNAGARAA 153

                          90
                  ....*....|.
gi 489518052   84 TGQFIAFLDSD 94
Cdd:TIGR03965 154 RTEFVAFTDSD 164
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 7-93 5.21e-08

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 52.59  E-value: 5.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   7 SIITPMYNSEK-FIEATIKSVLNQTYQEW--EMLIIDDCSTD---NSPNIVKsYMQQDSRIKCIKTETNKGVSNARNLAL 80
Cdd:cd02510    1 SVIIIFHNEALsTLLRTVHSVINRTPPELlkEIILVDDFSDKpelKLLLEEY-YKKYLPKVKVLRLKKREGLIRARIAGA 79

                         90
                 ....*....|...
gi 489518052  81 SKATGQFIAFLDS 93
Cdd:cd02510   80 RAATGDVLVFLDS 92
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 6-96 2.18e-07

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 50.89  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   6 VSIITPMYNSEK----FIEATIKSVlNQTYQEWEMLIIDDCSTDNSPNI-VKSYMQQDSRIKCIKTETNKGVSNARNLAL 80
Cdd:PRK10714   8 VSVVIPVYNEQEslpeLIRRTTAAC-ESLGKEYEILLIDDGSSDNSAEMlVEAAQAPDSHIVAILLNRNYGQHSAIMAGF 86

                         90
                 ....*....|....*.
gi 489518052  81 SKATGQFIAFLDSDDQ 96
Cdd:PRK10714  87 SHVTGDLIITLDADLQ 102
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 2-94 3.64e-07

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 49.70  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   2 KKNLVSIITPMYNSEKFIeATIKSVLNQTYQE---WEMLIIDDCSTDNSPNIVKSyMQQ---DSRIKCIKTETNKGVSNA 75
Cdd:PLN02726   7 GAMKYSIIVPTYNERLNI-ALIVYLIFKALQDvkdFEIIVVDDGSPDGTQDVVKQ-LQKvygEDRILLRPRPGKLGLGTA 84

                         90
                 ....*....|....*....
gi 489518052  76 RNLALSKATGQFIAFLDSD 94
Cdd:PLN02726  85 YIHGLKHASGDFVVIMDAD 103
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 6-94 4.38e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 49.11  E-value: 4.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052   6 VSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYmqqdsRIKCIKTEtnKGVSNARNLALSKATG 85
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGTVAIARSA-----GVVVISSP--KGRARQMNAGAAAARG 73


                 ....*....
gi 489518052  86 QFIAFLDSD 94
Cdd:cd02522   74 DWLLFLHAD 82
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 13-71 5.60e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 45.70  E-value: 5.60e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489518052  13 YNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQQDsRIKCIKTETNKG 71
Cdd:cd04185    6 YNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWLTSLGDLD-NIVYLRLPENLG 63
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 6-108 1.61e-03

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 38.89  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518052    6 VSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCSTDNSPNIVKSYMQ--QDSRIKCIKTETNKGV---SNARNLAL 80
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAArfPDVRLRVIRNARLLGPtgkSRGLNHGF 83

                          90       100
                  ....*....|....*....|....*...
gi 489518052   81 SKATGQFIAFLDSDDQWNSSKLEKQVNF 108
Cdd:pfam13641  84 RAVKSDLVVLHDDDSVLHPGTLKKYVQY 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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