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Conserved domains on  [gi|489499427|ref|WP_003404335|]
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MULTISPECIES: Ni(II)/Co(II)-sensing metalloregulatory transcriptional repressor KmtR [Mycobacterium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-93 3.50e-31

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 106.01  E-value: 3.50e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-93 3.50e-31

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 106.01  E-value: 3.50e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-93 3.83e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.81  E-value: 3.83e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-97 2.47e-22

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 83.03  E-value: 2.47e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427    32 QVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLVIDAV 97
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-96 2.52e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 81.19  E-value: 2.52e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  22 FRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL-ENEHVRQLVIDA 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLtDAERLLALLESL 76
sulf_sens_BigR NF040642
sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is ...
 18-93 5.95e-16

sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.


Pssm-ID: 468610  Cd Length: 95  Bit Score: 67.86  E-value: 5.95e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:NF040642  10 VADLLKTLAHPARLMLVCTLVEGEYSVGELEEKLDIHQPTLSQQLTVLREAGIVETRREGKQIFYRLTEEKAAQLV 85
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 1.07e-15

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 66.67  E-value: 1.07e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489499427  21 VFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-71 1.85e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.45  E-value: 1.85e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489499427   27 DATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLV 71
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 19-84 9.44e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.12  E-value: 9.44e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489499427  19 VEVFRMLADATRVQVLWSLADR-EMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL 84
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-93 3.50e-31

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 106.01  E-value: 3.50e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-93 3.83e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.81  E-value: 3.83e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-97 2.47e-22

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 83.03  E-value: 2.47e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427    32 QVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLVIDAV 97
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-96 2.52e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 81.19  E-value: 2.52e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  22 FRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL-ENEHVRQLVIDA 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLtDAERLLALLESL 76
sulf_sens_BigR NF040642
sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is ...
 18-93 5.95e-16

sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.


Pssm-ID: 468610  Cd Length: 95  Bit Score: 67.86  E-value: 5.95e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLV 93
Cdd:NF040642  10 VADLLKTLAHPARLMLVCTLVEGEYSVGELEEKLDIHQPTLSQQLTVLREAGIVETRREGKQIFYRLTEEKAAQLV 85
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 1.07e-15

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 66.67  E-value: 1.07e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489499427  21 VFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
19-75 1.12e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 61.90  E-value: 1.12e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489499427  19 VEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRR 75
Cdd:COG4189   10 LEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-71 1.85e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.45  E-value: 1.85e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489499427   27 DATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLV 71
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
18-90 9.08e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 55.04  E-value: 9.08e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489499427  18 VVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTI-----FYRLENEHVR 90
Cdd:COG1777    7 LDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDgrarkYYRLSAFRLE 84
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 20-77 1.30e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 50.62  E-value: 1.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489499427   20 EVFRMLADATRVQVLWSLADRE-MSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDG 77
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
21-87 7.42e-09

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 50.65  E-value: 7.42e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489499427  21 VFRMLADATRVQVLWSLADRE-MSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENE 87
Cdd:COG3398   90 ILAYLRRETPRRILLYLLENPgATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 19-84 9.44e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.12  E-value: 9.44e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489499427  19 VEVFRMLADATRVQVLWSLADR-EMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRL 84
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
30-84 4.03e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.34  E-value: 4.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489499427  30 RVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVrTRRDGTtifYRL 84
Cdd:COG4742   18 RKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLI-ERDDGE---YEL 68
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-78 6.37e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.64  E-value: 6.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489499427   27 DATRVQVLWSLADRE-MSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGT 78
Cdd:pfam12802   4 TPAQFRVLLALARNPgLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
25-75 1.08e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.21  E-value: 1.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489499427  25 LADATRVQVLWSL-ADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRR 75
Cdd:COG2345   10 LADPTRRRILELLkRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 39-75 4.54e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 34.84  E-value: 4.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 489499427   39 DREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRR 75
Cdd:pfam02082  21 GEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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