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Conserved domains on  [gi|4894370|gb|AAD32452|]
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NADH-ubiquinone oxidoreductase B22 subunit homolog [Homo sapiens]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9( domain architecture ID 14448744)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis

Gene Ontology:  GO:0006120|GO:0008137|GO:0032981|GO:0005747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 6.91e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380758  Cd Length: 77  Bit Score: 135.00  E-value: 6.91e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4894370   12 HQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 6.91e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 135.00  E-value: 6.91e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4894370   12 HQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 14-72 9.62e-11

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 54.51  E-value: 9.62e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4894370     14 QKVLRLYKRALRHLESWCVqRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFW 72
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPD-YNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELE 58
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 6.91e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 135.00  E-value: 6.91e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4894370   12 HQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 14-72 9.62e-11

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 54.51  E-value: 9.62e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4894370     14 QKVLRLYKRALRHLESWCVqRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFW 72
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPD-YNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELE 58
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 16-73 1.36e-09

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 51.78  E-value: 1.36e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4894370   16 VLRLYKRALRHLESwCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWY 73
Cdd:cd20251   1 VLKLYRDLLRLARK-GLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 16-69 6.39e-05

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 39.47  E-value: 6.39e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4894370   16 VLRLYKRALRhLESWCVQRDKYRYFACLMRAR--FEEHKNEKDMAKATQLLKEAEE 69
Cdd:cd20267   1 VLSAYRELLR-ARRWVFKGDTPALKAARQKIReeFEKNRNETDPEKIAELLKEARE 55
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 16-69 1.17e-03

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 36.17  E-value: 1.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4894370     16 VLRLYKRALRHLESwcVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEE 69
Cdd:pfam13233   1 VLSLYRALLRELRE--LPPNGRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWRE 52
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 15-68 2.51e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 34.91  E-value: 2.51e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4894370   15 KVLRLYKRALRHLESWCVQRDKYR-YFACLMRARFEEHKNEKDMAKATQLLKEAE 68
Cdd:cd20261   1 EVLSLYRRILRLARTWPADTEEEReYILNEARSLFRKNKNLTDPEEIEEKIQEAE 55
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
 16-70 3.96e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 34.42  E-value: 3.96e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4894370   16 VLRLYKRALRhlESwcvQRDK---YR-YFacLMRAR--FEEHKNEKDMAKATQLLKEAEEE 70
Cdd:cd20264   2 VLSLYRALLR--EA---RKFPdynFReYF--LRRIRdaFRENKNLKDPEEIKKLYEEGEEQ 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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