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Conserved domains on  [gi|489336223|ref|WP_003243443|]
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MULTISPECIES: 50S ribosomal protein L25/general stress protein Ctc [Bacillus]

Protein Classification

50S ribosomal protein L25( domain architecture ID 11489537)

50S ribosomal protein L25 is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bL25_bact_ctc TIGR00731
ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length ...
 4-179 1.00e-80

ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length homology to the general stress protein Ctc of Bacillus subtilis, a mesophile, and ribosomal protein TL5 of Thermus thermophilus, a thermophile. Ribosomal protein L25 of Escherichia coli and H. influenzae appear to be orthologous but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this family bind the E-loop of bacterial 5S rRNA. This protein appears to be restricted to bacteria and organelles, and consists of at most one copy per prokaryotic genome.Ctc of Bacillus subtilis has now been localized to ribosomes and can be viewed as the long form, or Ctc form, of L25. The C-terminal domain of sll1824, an apparent L25 of Synechocystis PCC6803, matches the N-terminal domain of this family. Examples of L25 and Ctc are not separated by a UPGMA tree built on the region of shared homology. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 273237 [Multi-domain]  Cd Length: 176  Bit Score: 238.03  E-value: 1.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223    4 LTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKN 83
Cdd:TIGR00731   1 LEVKSRTSFGKSAARRIRKEGRIPAVVYGKGKENVNLELKSKEFIKYLRKGATSTVLTLEIGGKEFKVLVKDYQYNPVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   84 EITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGD 163
Cdd:TIGR00731  81 EVIHVDFLEVVEGVKLKVEVPIKLIGTPIGVKNGGILTQVKRRIEVECKPKDIPDFLELDVSSLGVGESLKLSDLELPAG 160

                         170
                  ....*....|....*.
gi 489336223  164 YSFNHESDEVVASILP 179
Cdd:TIGR00731 161 VSFITDDDEVVVTVIK 176
 
Name Accession Description Interval E-value
bL25_bact_ctc TIGR00731
ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length ...
 4-179 1.00e-80

ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length homology to the general stress protein Ctc of Bacillus subtilis, a mesophile, and ribosomal protein TL5 of Thermus thermophilus, a thermophile. Ribosomal protein L25 of Escherichia coli and H. influenzae appear to be orthologous but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this family bind the E-loop of bacterial 5S rRNA. This protein appears to be restricted to bacteria and organelles, and consists of at most one copy per prokaryotic genome.Ctc of Bacillus subtilis has now been localized to ribosomes and can be viewed as the long form, or Ctc form, of L25. The C-terminal domain of sll1824, an apparent L25 of Synechocystis PCC6803, matches the N-terminal domain of this family. Examples of L25 and Ctc are not separated by a UPGMA tree built on the region of shared homology. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273237 [Multi-domain]  Cd Length: 176  Bit Score: 238.03  E-value: 1.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223    4 LTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKN 83
Cdd:TIGR00731   1 LEVKSRTSFGKSAARRIRKEGRIPAVVYGKGKENVNLELKSKEFIKYLRKGATSTVLTLEIGGKEFKVLVKDYQYNPVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   84 EITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGD 163
Cdd:TIGR00731  81 EVIHVDFLEVVEGVKLKVEVPIKLIGTPIGVKNGGILTQVKRRIEVECKPKDIPDFLELDVSSLGVGESLKLSDLELPAG 160

                         170
                  ....*....|....*.
gi 489336223  164 YSFNHESDEVVASILP 179
Cdd:TIGR00731 161 VSFITDDDEVVVTVIK 176
PRK05618 PRK05618
50S ribosomal protein L25/general stress protein Ctc; Reviewed
 1-192 8.42e-68

50S ribosomal protein L25/general stress protein Ctc; Reviewed


Pssm-ID: 235534 [Multi-domain]  Cd Length: 197  Bit Score: 205.82  E-value: 8.42e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   1 MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDE-GKNAVITLEVSGEKHSVMVTDLQTD 79
Cdd:PRK05618   3 TITLEAEVREEFGKGAARRLRRAGKVPAVIYGKGKEPVSISVDEKELIKALKKGaFLSTLLDLEVGGKKQKVLVKDVQRH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223  80 PLKNEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKN--GGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIAD 157
Cdd:PRK05618  83 PVKDFILHVDFLRVDAGEKVKVEVPVHFVGEAKGVGVklGGVLNQVLHELEVECLPEDIPEFIEVDVSGLEIGDSIHVSD 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489336223 158 LPAGGDYSFNHESDEVVASILPPQQQEAAEVDEEE 192
Cdd:PRK05618 163 LKLPEGVKLLDDPDEVVATVVAPRGEEEEEEEEAA 197
RplY COG1825
Ribosomal protein L25 (general stress protein Ctc) [Translation, ribosomal structure and ...
 3-180 2.20e-59

Ribosomal protein L25 (general stress protein Ctc) [Translation, ribosomal structure and biogenesis]; Ribosomal protein L25 (general stress protein Ctc) is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441430 [Multi-domain]  Cd Length: 182  Bit Score: 183.95  E-value: 2.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   3 TLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLK 82
Cdd:COG1825    5 TLKAEKREETGKGAARRLRREGKVPAVIYGGGKEPVSISVDAKELRKLLRKEGENTLITLDIDGKKEKVLIKDVQRHPVK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223  83 NEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGG 162
Cdd:COG1825   85 DEILHVDFLRVSAGEKVTVEVPVHFVGEAAGVKVGGGLVLTLHELEVEALPPDIPEPIEVDVSDLGLGDSISVHDLDLPL 164

                        170
                 ....*....|....*...
gi 489336223 163 DYSFNHESDEVVASILPP 180
Cdd:COG1825  165 LVGVVEDPDVVVVVVVTP 182
Ribosomal_L25_TL5_CTC cd00495
Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; L25 is a single-domain protein, ...
 3-91 7.08e-34

Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC. CTC is a known stress protein, and proteins of this family are believed to have two functions, acting as both ribosomal and stress proteins. In Escherichia coli, cells deleted for L25 were found to be viable; however, these cells grew slowly and had impaired protein synthesis capability. In Bacillus subtilis, CTC is induced under stress conditions and located in the ribosome; it has been proposed that CTC may be necessary for accurate translation under stress conditions. Ribosomal_L25_TL5_CTC is mostly found in bacteria, with a few exceptions such as plants or stramenopiles. Due to its limited taxonomic diversity and the viability of cells deleted for L25, this protein is not believed to be necessary for ribosomal assembly. Eukaryotes contain a protein called L25, which is not homologous to bacterial L25, but rather to bacterial L23.


Pssm-ID: 198379  Cd Length: 90  Bit Score: 116.03  E-value: 7.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   3 TLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLK 82
Cdd:cd00495    1 TLKAEKREETGKGAARRLRREGKVPAVIYGKGEEPIPISVDAKELEKLLRKEGENTVIELEIDGKKENVLIKDVQRHPVK 80


                 ....*....
gi 489336223  83 NEITHADFQ 91
Cdd:cd00495   81 DEILHVDFL 89
Ribosomal_L25p pfam01386
Ribosomal L25p family; Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. ...
 4-90 1.87e-32

Ribosomal L25p family; Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis, which is induced by stress.


Pssm-ID: 460185  Cd Length: 87  Bit Score: 112.15  E-value: 1.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223    4 LTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKN 83
Cdd:pfam01386   1 LKAEKRTEFGKGAARRLRREGKVPAVLYGGGKEPISISVDAKELRKLLRTEGENTVIELDIDGKKYKVLIKDVQRHPVKD 80


                  ....*..
gi 489336223   84 EITHADF 90
Cdd:pfam01386  81 EILHVDF 87
 
Name Accession Description Interval E-value
bL25_bact_ctc TIGR00731
ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length ...
 4-179 1.00e-80

ribosomal protein bL25, Ctc-form; This model models a family of proteins with full-length homology to the general stress protein Ctc of Bacillus subtilis, a mesophile, and ribosomal protein TL5 of Thermus thermophilus, a thermophile. Ribosomal protein L25 of Escherichia coli and H. influenzae appear to be orthologous but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this family bind the E-loop of bacterial 5S rRNA. This protein appears to be restricted to bacteria and organelles, and consists of at most one copy per prokaryotic genome.Ctc of Bacillus subtilis has now been localized to ribosomes and can be viewed as the long form, or Ctc form, of L25. The C-terminal domain of sll1824, an apparent L25 of Synechocystis PCC6803, matches the N-terminal domain of this family. Examples of L25 and Ctc are not separated by a UPGMA tree built on the region of shared homology. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273237 [Multi-domain]  Cd Length: 176  Bit Score: 238.03  E-value: 1.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223    4 LTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKN 83
Cdd:TIGR00731   1 LEVKSRTSFGKSAARRIRKEGRIPAVVYGKGKENVNLELKSKEFIKYLRKGATSTVLTLEIGGKEFKVLVKDYQYNPVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   84 EITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGD 163
Cdd:TIGR00731  81 EVIHVDFLEVVEGVKLKVEVPIKLIGTPIGVKNGGILTQVKRRIEVECKPKDIPDFLELDVSSLGVGESLKLSDLELPAG 160

                         170
                  ....*....|....*.
gi 489336223  164 YSFNHESDEVVASILP 179
Cdd:TIGR00731 161 VSFITDDDEVVVTVIK 176
PRK05618 PRK05618
50S ribosomal protein L25/general stress protein Ctc; Reviewed
 1-192 8.42e-68

50S ribosomal protein L25/general stress protein Ctc; Reviewed


Pssm-ID: 235534 [Multi-domain]  Cd Length: 197  Bit Score: 205.82  E-value: 8.42e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   1 MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDE-GKNAVITLEVSGEKHSVMVTDLQTD 79
Cdd:PRK05618   3 TITLEAEVREEFGKGAARRLRRAGKVPAVIYGKGKEPVSISVDEKELIKALKKGaFLSTLLDLEVGGKKQKVLVKDVQRH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223  80 PLKNEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKN--GGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIAD 157
Cdd:PRK05618  83 PVKDFILHVDFLRVDAGEKVKVEVPVHFVGEAKGVGVklGGVLNQVLHELEVECLPEDIPEFIEVDVSGLEIGDSIHVSD 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489336223 158 LPAGGDYSFNHESDEVVASILPPQQQEAAEVDEEE 192
Cdd:PRK05618 163 LKLPEGVKLLDDPDEVVATVVAPRGEEEEEEEEAA 197
RplY COG1825
Ribosomal protein L25 (general stress protein Ctc) [Translation, ribosomal structure and ...
 3-180 2.20e-59

Ribosomal protein L25 (general stress protein Ctc) [Translation, ribosomal structure and biogenesis]; Ribosomal protein L25 (general stress protein Ctc) is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441430 [Multi-domain]  Cd Length: 182  Bit Score: 183.95  E-value: 2.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   3 TLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLK 82
Cdd:COG1825    5 TLKAEKREETGKGAARRLRREGKVPAVIYGGGKEPVSISVDAKELRKLLRKEGENTLITLDIDGKKEKVLIKDVQRHPVK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223  83 NEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGG 162
Cdd:COG1825   85 DEILHVDFLRVSAGEKVTVEVPVHFVGEAAGVKVGGGLVLTLHELEVEALPPDIPEPIEVDVSDLGLGDSISVHDLDLPL 164

                        170
                 ....*....|....*...
gi 489336223 163 DYSFNHESDEVVASILPP 180
Cdd:COG1825  165 LVGVVEDPDVVVVVVVTP 182
Ribosomal_L25_TL5_CTC cd00495
Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; L25 is a single-domain protein, ...
 3-91 7.08e-34

Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC. CTC is a known stress protein, and proteins of this family are believed to have two functions, acting as both ribosomal and stress proteins. In Escherichia coli, cells deleted for L25 were found to be viable; however, these cells grew slowly and had impaired protein synthesis capability. In Bacillus subtilis, CTC is induced under stress conditions and located in the ribosome; it has been proposed that CTC may be necessary for accurate translation under stress conditions. Ribosomal_L25_TL5_CTC is mostly found in bacteria, with a few exceptions such as plants or stramenopiles. Due to its limited taxonomic diversity and the viability of cells deleted for L25, this protein is not believed to be necessary for ribosomal assembly. Eukaryotes contain a protein called L25, which is not homologous to bacterial L25, but rather to bacterial L23.


Pssm-ID: 198379  Cd Length: 90  Bit Score: 116.03  E-value: 7.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   3 TLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLK 82
Cdd:cd00495    1 TLKAEKREETGKGAARRLRREGKVPAVIYGKGEEPIPISVDAKELEKLLRKEGENTVIELEIDGKKENVLIKDVQRHPVK 80


                 ....*....
gi 489336223  83 NEITHADFQ 91
Cdd:cd00495   81 DEILHVDFL 89
Ribosomal_L25p pfam01386
Ribosomal L25p family; Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. ...
 4-90 1.87e-32

Ribosomal L25p family; Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis, which is induced by stress.


Pssm-ID: 460185  Cd Length: 87  Bit Score: 112.15  E-value: 1.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223    4 LTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKN 83
Cdd:pfam01386   1 LKAEKRTEFGKGAARRLRREGKVPAVLYGGGKEPISISVDAKELRKLLRTEGENTVIELDIDGKKYKVLIKDVQRHPVKD 80


                  ....*..
gi 489336223   84 EITHADF 90
Cdd:pfam01386  81 EILHVDF 87
Ribosomal_TL5_C pfam14693
Ribosomal protein TL5, C-terminal domain; This family contains the C-terminal domain of ...
 99-181 1.44e-28

Ribosomal protein TL5, C-terminal domain; This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, pfam01386. Full length (N- and C-terminal domain) homologs of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family pfam01386). The function of the C-terminal domain of TLC is at present unknown.


Pssm-ID: 464265  Cd Length: 84  Bit Score: 102.10  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   99 IEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGDYSFNHESDEVVASIL 178
Cdd:pfam14693   2 VTVEVPVHFVGEAPGVKKGGVLNQVLRELEVECLPKDIPEFIEVDVSGLEIGDSIHVSDLKLPEGVELLTDPDTVVVSVV 81


                  ...
gi 489336223  179 PPQ 181
Cdd:pfam14693  82 APR 84
PRK05943 PRK05943
50S ribosomal protein L25; Reviewed
 1-90 1.27e-11

50S ribosomal protein L25; Reviewed


Pssm-ID: 180318  Cd Length: 94  Bit Score: 58.37  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489336223   1 MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGkdtGNK-PVS--LDSVELIKTLRDEG-KNAVITLEVSGEKHSVMVTDL 76
Cdd:PRK05943   1 MFTINAEVRPEQGKGASRRLRRAGKFPAIIYG---GNEaPVSivLDHKDVINLQAKAEfYKEVITLVIDGKEVKVKVQAV 77

                         90
                 ....*....|....
gi 489336223  77 QTDPLKNEITHADF 90
Cdd:PRK05943  78 QRHPFKPKLEHIDF 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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