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Conserved domains on  [gi|489211173|ref|WP_003119979|]
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MULTISPECIES: TusE/DsrC/DsvC family sulfur relay protein [Gammaproteobacteria]

Protein Classification

TusE/DsrC/DsvC family sulfur relay protein( domain architecture ID 10022376)

TusE/DsrC/DsvC family sulfur relay protein similar to sulfurtransferase TusE that is part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dsrC_tusE_dsvC TIGR03342
sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described ...
 4-111 3.27e-60

sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described as TusE, a partner to TusBCD in a sulfur relay system for 2-thiouridine biosynthesis, a tRNA base modification process. Other members are DsrC, a functionally similar protein in species where the sulfur relay system exists primarily for sulfur metabolism rather than tRNA base modification. Some members of this family are known explicitly as the gamma subunit of sulfite reductases.


:

Pssm-ID: 213798  Cd Length: 108  Bit Score: 179.78  E-value: 3.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173    4 LMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGNS 83
Cdd:TIGR03342   1 LEVNGKEIELDEDGYLLDLDDWSEDVAEALAEEEGIELTEAHWEVINFLRDFYAEYNISPAVRMLVKAMGKKLGEEKGNS 80

                          90       100
                  ....*....|....*....|....*...
gi 489211173   84 LHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:TIGR03342  81 RYLYRLFPKGPAKQACKIAGLPKPTGCL 108
 
Name Accession Description Interval E-value
dsrC_tusE_dsvC TIGR03342
sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described ...
 4-111 3.27e-60

sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described as TusE, a partner to TusBCD in a sulfur relay system for 2-thiouridine biosynthesis, a tRNA base modification process. Other members are DsrC, a functionally similar protein in species where the sulfur relay system exists primarily for sulfur metabolism rather than tRNA base modification. Some members of this family are known explicitly as the gamma subunit of sulfite reductases.


Pssm-ID: 213798  Cd Length: 108  Bit Score: 179.78  E-value: 3.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173    4 LMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGNS 83
Cdd:TIGR03342   1 LEVNGKEIELDEDGYLLDLDDWSEDVAEALAEEEGIELTEAHWEVINFLRDFYAEYNISPAVRMLVKAMGKKLGEEKGNS 80

                          90       100
                  ....*....|....*....|....*...
gi 489211173   84 LHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:TIGR03342  81 RYLYRLFPKGPAKQACKIAGLPKPTGCL 108
DsrC pfam04358
DsrC like protein; Family member Swiss:P45573 has been observed to co-purify with ...
 8-111 1.17e-51

DsrC like protein; Family member Swiss:P45573 has been observed to co-purify with Desulfovibrio vulgaris dissimilatory sulfite reductase, and many members of this family are annotated as the third (gamma) subunit of dissimilatory sulphite reductase. However, this protein appears to be only loosely associated to the sulfite reductase, which suggests that DsrC may not be an integral part of the dissimilatory sulphite reductase. Members of this family are found in organizms such as E. coli and H. influenzae which do not contain dissimilatory sulphite reductases but can synthesize assimilatory sirohaem sulphite and nitrite reductases. It is speculated that DsrC may be involved in the assembly, folding or stabilization of sirohaem proteins. The strictly conserved cysteine in the C terminus suggests that DsrC may have a catalytic function in the metabolism of sulphur compounds.


Pssm-ID: 461273  Cd Length: 107  Bit Score: 158.06  E-value: 1.17e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173    8 GREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGNSLHLN 87
Cdd:pfam04358   4 GKEIETDEEGFLLDPEDWSEEVAEALAAEEGIELTDEHWEVINFLRDYYAEYGIAPAIRVLVKALGKKLGPEKGNSKYLY 83

                          90       100
                  ....*....|....*....|....
gi 489211173   88 HLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:pfam04358  84 ELFPGGPAKQACKIAGLPKPTGCV 107
TusE COG2920
Sulfur transfer complex TusBCD TusE component, DsrC family (tRNA 2-thiouridine synthesizing ...
 4-111 5.98e-49

Sulfur transfer complex TusBCD TusE component, DsrC family (tRNA 2-thiouridine synthesizing protein C) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442164  Cd Length: 108  Bit Score: 151.11  E-value: 5.98e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173   4 LMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPdKGNS 83
Cdd:COG2920    2 LEVNGKTIETDEEGFLLDPEDWSEEVAEALAREEGIELTDEHWEVIRFLREYYAEYGISPAIRELVKALGKKFGP-KGNS 80

                         90       100
                 ....*....|....*....|....*...
gi 489211173  84 LHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:COG2920   81 KYLYELFPGGPAKQACKIAGLPKPTGCV 108
PRK11508 PRK11508
sulfurtransferase TusE;
3-111 6.13e-42

sulfurtransferase TusE;


Pssm-ID: 183167  Cd Length: 109  Bit Score: 133.62  E-value: 6.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173   3 LLMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGN 82
Cdd:PRK11508   1 MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGN 80

                         90       100
                 ....*....|....*....|....*....
gi 489211173  83 SLHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:PRK11508  81 SRYLYRLFPKGPAKQATKIAGLPKPVKCI 109
 
Name Accession Description Interval E-value
dsrC_tusE_dsvC TIGR03342
sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described ...
 4-111 3.27e-60

sulfur relay protein, TusE/DsrC/DsvC family; Members of this protein family may be described as TusE, a partner to TusBCD in a sulfur relay system for 2-thiouridine biosynthesis, a tRNA base modification process. Other members are DsrC, a functionally similar protein in species where the sulfur relay system exists primarily for sulfur metabolism rather than tRNA base modification. Some members of this family are known explicitly as the gamma subunit of sulfite reductases.


Pssm-ID: 213798  Cd Length: 108  Bit Score: 179.78  E-value: 3.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173    4 LMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGNS 83
Cdd:TIGR03342   1 LEVNGKEIELDEDGYLLDLDDWSEDVAEALAEEEGIELTEAHWEVINFLRDFYAEYNISPAVRMLVKAMGKKLGEEKGNS 80

                          90       100
                  ....*....|....*....|....*...
gi 489211173   84 LHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:TIGR03342  81 RYLYRLFPKGPAKQACKIAGLPKPTGCL 108
DsrC pfam04358
DsrC like protein; Family member Swiss:P45573 has been observed to co-purify with ...
 8-111 1.17e-51

DsrC like protein; Family member Swiss:P45573 has been observed to co-purify with Desulfovibrio vulgaris dissimilatory sulfite reductase, and many members of this family are annotated as the third (gamma) subunit of dissimilatory sulphite reductase. However, this protein appears to be only loosely associated to the sulfite reductase, which suggests that DsrC may not be an integral part of the dissimilatory sulphite reductase. Members of this family are found in organizms such as E. coli and H. influenzae which do not contain dissimilatory sulphite reductases but can synthesize assimilatory sirohaem sulphite and nitrite reductases. It is speculated that DsrC may be involved in the assembly, folding or stabilization of sirohaem proteins. The strictly conserved cysteine in the C terminus suggests that DsrC may have a catalytic function in the metabolism of sulphur compounds.


Pssm-ID: 461273  Cd Length: 107  Bit Score: 158.06  E-value: 1.17e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173    8 GREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGNSLHLN 87
Cdd:pfam04358   4 GKEIETDEEGFLLDPEDWSEEVAEALAAEEGIELTDEHWEVINFLRDYYAEYGIAPAIRVLVKALGKKLGPEKGNSKYLY 83

                          90       100
                  ....*....|....*....|....
gi 489211173   88 HLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:pfam04358  84 ELFPGGPAKQACKIAGLPKPTGCV 107
TusE COG2920
Sulfur transfer complex TusBCD TusE component, DsrC family (tRNA 2-thiouridine synthesizing ...
 4-111 5.98e-49

Sulfur transfer complex TusBCD TusE component, DsrC family (tRNA 2-thiouridine synthesizing protein C) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442164  Cd Length: 108  Bit Score: 151.11  E-value: 5.98e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173   4 LMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPdKGNS 83
Cdd:COG2920    2 LEVNGKTIETDEEGFLLDPEDWSEEVAEALAREEGIELTDEHWEVIRFLREYYAEYGISPAIRELVKALGKKFGP-KGNS 80

                         90       100
                 ....*....|....*....|....*...
gi 489211173  84 LHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:COG2920   81 KYLYELFPGGPAKQACKIAGLPKPTGCV 108
PRK11508 PRK11508
sulfurtransferase TusE;
3-111 6.13e-42

sulfurtransferase TusE;


Pssm-ID: 183167  Cd Length: 109  Bit Score: 133.62  E-value: 6.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489211173   3 LLMLEGREIRLDKDGYLAALDDWSEPVAEALAAREELALTAEHWEILQLLREFYAEFQLSPANRPLIKYVAQRLGPDKGN 82
Cdd:PRK11508   1 MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGN 80

                         90       100
                 ....*....|....*....|....*....
gi 489211173  83 SLHLNHLFKGAPAKLGAKLAGLPKPSNCL 111
Cdd:PRK11508  81 SRYLYRLFPKGPAKQATKIAGLPKPVKCI 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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