protein phosphatase 2C domain-containing protein may be a PP2C family serine/threonine-protein phosphatase with a catalytic mechanism similar to that of the PP1, PP2A, PP2B families of protein Ser/Thr phosphatases, but no sequence similarity
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein ...
6-239
2.79e-121
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.
The actual alignment was detected with superfamily member NF033484:
Pssm-ID: 468046 [Multi-domain] Cd Length: 232 Bit Score: 344.41 E-value: 2.79e-121
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein ...
6-239
2.79e-121
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.
Pssm-ID: 468046 [Multi-domain] Cd Length: 232 Bit Score: 344.41 E-value: 2.79e-121
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
7-239
3.31e-62
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 238083 [Multi-domain] Cd Length: 254 Bit Score: 195.24 E-value: 3.31e-62
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
3-238
1.11e-28
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 214625 [Multi-domain] Cd Length: 252 Bit Score: 109.00 E-value: 1.11e-28
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein ...
6-239
2.79e-121
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.
Pssm-ID: 468046 [Multi-domain] Cd Length: 232 Bit Score: 344.41 E-value: 2.79e-121
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
7-239
3.31e-62
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 238083 [Multi-domain] Cd Length: 254 Bit Score: 195.24 E-value: 3.31e-62
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
3-238
1.11e-28
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 214625 [Multi-domain] Cd Length: 252 Bit Score: 109.00 E-value: 1.11e-28
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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