|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
4-450 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 631.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 4 DSYTKPNNTLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIF 83
Cdd:PRK09243 2 LMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGIF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 84 KEEFLRYLKNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGT 163
Cdd:PRK09243 82 DEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 164 RRAHGSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYNY-KQG 242
Cdd:PRK09243 162 RRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETYPDNTVLLVDTYDTlKSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 243 LENAVKAFKKF--KIKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLIT 320
Cdd:PRK09243 242 VPNAIKVAKELgdGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 321 ASSDPIFGCVYKLVAIEEDKLITPKIKISEDKQKITLPHFKKLFRIYDKNTqKMLFDELYIYNEKL-------------- 386
Cdd:PRK09243 322 GSDAPALGGVYKLVAIEGEGGMIPKIKLSNSPEKVTTPGRKQVYRIYDKGG-KAEADVITLADEEEeeplkmfhpvhtyk 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488879799 387 PKLDENLERKELLKCVFKEGKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDL 450
Cdd:PRK09243 401 SKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
12-450 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 564.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 12 TLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYL 91
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 92 KNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGSEA 171
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 172 ALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYN-YKQGLENAVKAF 250
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKATVLLVDTYDtLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 251 KKFK--IKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIFG 328
Cdd:TIGR01513 241 KELGeqGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 329 CVYKLVAIEEdkliTPKIKISEDKQKITLPHFKKLFRIYDkNTQKMLFDELYIYNEklPKLDENLERKE--------LLK 400
Cdd:TIGR01513 321 GVYKLVAYEG----RPVMKLSENPEKSTLPGRKQVFRLYD-ATGKFLGDELTLADE--PIEDLNQEKCTpvfapvepLLR 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 488879799 401 CVFKEGKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDL 450
Cdd:TIGR01513 394 LVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
8-456 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 563.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 8 KPNNTLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEF 87
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 88 LRYLKNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAH 167
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 168 GSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYNYKQGLENAV 247
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDGTTLLVDTYDTLSGVPNAI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 248 KAFKKFKIKQ--CGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDP 325
Cdd:COG1488 241 ELAKELLARGglLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 326 IFGCVYKLVAIEEDKLITPKIKISEDKQKITLPHFKKLFRIYDKNtqKMLFDELYIYNEKLPkldenLERKELLKCVFKE 405
Cdd:COG1488 321 TLGFVYKLVAVEGDGEWRPVIKLSETPGKKSKPGRKQVYRRDEDG--KATADLVALEDEPLP-----GEPEPLLVPVFRD 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 488879799 406 GKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDLTKLRQN 456
Cdd:COG1488 394 GKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
13-334 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 514.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 13 LLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYLK 92
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 93 NFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGSEAA 172
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 173 LKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYN-YKQGLENAVKAFK 251
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDNFTLLVDTYDtLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 252 KFK---IKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIFG 328
Cdd:cd01570 242 ELGalgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 488879799 329 CVYKLV 334
Cdd:cd01570 322 GVYKLV 327
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
13-137 |
4.00e-44 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 150.74 E-value: 4.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 13 LLCDFYELTMMQGYFLNGFeNKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYL-HSQGIFKEEFLRYL 91
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLrRSLPYFKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488879799 92 KNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSIN 137
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
4-450 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 631.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 4 DSYTKPNNTLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIF 83
Cdd:PRK09243 2 LMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGIF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 84 KEEFLRYLKNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGT 163
Cdd:PRK09243 82 DEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 164 RRAHGSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYNY-KQG 242
Cdd:PRK09243 162 RRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETYPDNTVLLVDTYDTlKSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 243 LENAVKAFKKF--KIKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLIT 320
Cdd:PRK09243 242 VPNAIKVAKELgdGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 321 ASSDPIFGCVYKLVAIEEDKLITPKIKISEDKQKITLPHFKKLFRIYDKNTqKMLFDELYIYNEKL-------------- 386
Cdd:PRK09243 322 GSDAPALGGVYKLVAIEGEGGMIPKIKLSNSPEKVTTPGRKQVYRIYDKGG-KAEADVITLADEEEeeplkmfhpvhtyk 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488879799 387 PKLDENLERKELLKCVFKEGKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDL 450
Cdd:PRK09243 401 SKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
12-450 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 564.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 12 TLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYL 91
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 92 KNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGSEA 171
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 172 ALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYN-YKQGLENAVKAF 250
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKATVLLVDTYDtLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 251 KKFK--IKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIFG 328
Cdd:TIGR01513 241 KELGeqGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 329 CVYKLVAIEEdkliTPKIKISEDKQKITLPHFKKLFRIYDkNTQKMLFDELYIYNEklPKLDENLERKE--------LLK 400
Cdd:TIGR01513 321 GVYKLVAYEG----RPVMKLSENPEKSTLPGRKQVFRLYD-ATGKFLGDELTLADE--PIEDLNQEKCTpvfapvepLLR 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 488879799 401 CVFKEGKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDL 450
Cdd:TIGR01513 394 LVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
8-456 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 563.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 8 KPNNTLLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEF 87
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 88 LRYLKNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAH 167
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 168 GSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYNYKQGLENAV 247
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDGTTLLVDTYDTLSGVPNAI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 248 KAFKKFKIKQ--CGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDP 325
Cdd:COG1488 241 ELAKELLARGglLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 326 IFGCVYKLVAIEEDKLITPKIKISEDKQKITLPHFKKLFRIYDKNtqKMLFDELYIYNEKLPkldenLERKELLKCVFKE 405
Cdd:COG1488 321 TLGFVYKLVAVEGDGEWRPVIKLSETPGKKSKPGRKQVYRRDEDG--KATADLVALEDEPLP-----GEPEPLLVPVFRD 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 488879799 406 GKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDLTKLRQN 456
Cdd:COG1488 394 GKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
13-334 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 514.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 13 LLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYLK 92
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 93 NFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGSEAA 172
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 173 LKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYN-YKQGLENAVKAFK 251
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDNFTLLVDTYDtLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 252 KFK---IKQCGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIFG 328
Cdd:cd01570 242 ELGalgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 488879799 329 CVYKLV 334
Cdd:cd01570 322 GVYKLV 327
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
10-458 |
3.14e-157 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 452.66 E-value: 3.14e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 10 NNTLLCDFYELTMMQGYFLNGFENKiAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLR 89
Cdd:PRK12484 3 NLALLTDLYEVTMANAYLREGMSAP-ATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEFLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 90 YLKNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGS 169
Cdd:PRK12484 82 WLAGLRFTGDVRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAHGT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 170 EAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQNPTLLIDTYNYKQGLENAVKA 249
Cdd:PRK12484 162 DAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYPDATTLLVDTYDTLRGVRNAIEV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 250 FKKFKIKQ--CGVRIDSGNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIF 327
Cdd:PRK12484 242 AKELGNRFdpRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 328 GCVYKLVAIEEDklitPKIKISedKQKITLPHFKKLFRIYDKNTQkmLFDELYIYNEKLPKldenlERKELLKCVFKEGK 407
Cdd:PRK12484 322 DSAYKLVAYEGR----GVTKLS--SGKVTYPGRKQVFRLYEHGTA--CGDVIGLHTENIPD-----GREPLLVPVMTNGR 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 488879799 408 ILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDLTKLRQNFT 458
Cdd:PRK12484 389 RIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADT 439
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
13-332 |
4.54e-115 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 341.56 E-value: 4.54e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 13 LLCDFYELTMMQGYfLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYLK 92
Cdd:cd01567 2 LDTDLYKLTMMQAY-LYPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLIFGEFFLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 93 NFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNL------------SVLE 160
Cdd:cd01567 81 LGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLletkdnleelgfKLHD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 161 FGTRRAHGSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMF-DDELSAFCHYLELYPQNP----TLLID 235
Cdd:cd01567 161 FGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFgALEEAAFEAFARWLPQFGgglgIALID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 236 TYNYKQGLENAVKAFKKFKIKQ--CGVRIDSGNLEILSKEIRTILDKN--DLKECKIIVSNSLD-EKSINKLLK-NDAPI 309
Cdd:cd01567 241 TYDTDNGFLNALKLAKALGAGGglLGVRLDSGDPVELIKKVRKHLDELgiDLNKKKIIISGDLDtEEAIELLLEqGASPN 320
|
330 340
....*....|....*....|...
gi 488879799 310 DAFGVGEKLITASSDPIFGCVYK 332
Cdd:cd01567 321 DAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
9-450 |
1.23e-89 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 283.09 E-value: 1.23e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 9 PNNT----LLCDFYELTMMQGYFLNGFENKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQ--GI 82
Cdd:PLN02885 5 PTNPmvtpLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVmpSG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 83 FKEEFLRYLKNFKF-KGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAA-KNLSVLE 160
Cdd:PLN02885 85 CEDAFFDYLRGLDCsDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAgKSKVLLE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 161 FGTRRAHGSEAALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMF---------------------------- 212
Cdd:PLN02885 165 FGLRRAQGPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYmgldeivdktlrsadgssvcedfvslvq 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 213 --------------------DDELSAFCHYLELYPQNPTLLIDTYN-YKQGLEN--AVK-AFKKFKIKQCGVRIDSGNLE 268
Cdd:PLN02885 245 ewlsklqessslrgvfsetnQSELAAFTSYALAFPNSFLALVDTYDvMKSGIPNfcAVAlALNDLGYKAVGIRLDSGDLA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 269 ILSKEIRTI-------LDKNDLKECKIIVSNSLDEKSINKLLKNDAPIDAFGVGEKLITASSDPIFGCVYKLVAIEEdkl 341
Cdd:PLN02885 325 YLSLEARKFfrtieeeLGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEING--- 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 342 iTPKIKISEDKQKITLPHFKKLFRIYDKNTQKmLFDELYIYNEKLPKLDENL-------ERK----------ELLKCVFK 404
Cdd:PLN02885 402 -QPRIKLSEDVEKVTIPCKKRCYRLYGKEGYP-LVDLMTGENEPPPKVGERIlcrhpfnESKrayvvpqrveELLKCYWD 479
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 488879799 405 --EGKILNKQKNVEEIALYAKSQISKLDEKFLNFNNKEKYKIKLSKDL 450
Cdd:PLN02885 480 gsSGKPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
16-332 |
1.78e-70 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 224.81 E-value: 1.78e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 16 DFYELTMMQGYflnGFENKIAYFDIFFRKIPdhgsFAIFAGLEDILDFVSCLHFdeddiaylhsqgifkeeflrylknfK 95
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDP----YGVLAGLEEALELLELLRF-------------------------P 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 96 FKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAK--NLSVLEFGTRRAHgSEAAL 173
Cdd:cd00516 49 GPLVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKgaNTKVHDFGTRKTT-PGLRL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 174 KGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFdDELSAFCHYLELYPQNPTLLIDTYNYKqgLENAVKAFKKF 253
Cdd:cd00516 128 LEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-GELAAVKALRRWLPELFIALIDVEVDT--LEEALEAAKAG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 254 KIkqCGVRIDSGNLE-----ILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLKndAPIDAFGVGEKLItasSDPIFG 328
Cdd:cd00516 205 GA--DGIRLDSGSPEeldpaVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYAE--TGVDVFGVGTLLH---SAPPLD 277
|
....
gi 488879799 329 CVYK 332
Cdd:cd00516 278 IVLK 281
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
85-323 |
2.32e-47 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 165.14 E-value: 2.32e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 85 EEFLRYLKNFKFKgeIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTR 164
Cdd:cd01571 42 EEVLALLEGLPVK--VYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 165 RAHGSEAALKGaRAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCH-YLELYPQNP--TLLIDTYNykQ 241
Cdd:cd01571 120 RDHPAIQPMDG-RAAYIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQVEAWKaFDETYPEDVprIALIDTFN--D 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 242 GLENAVKAFKKFKIKQCGVRIDS-----GNLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLlkNDAPIDAFGVGE 316
Cdd:cd01571 197 EKEEALKAAKALGDKLDGVRLDTpssrrGVFRYLIREVRWALDIRGYKHVKIFVSGGLDEEDIKEL--EDVGVDAFGVGT 274
|
....*..
gi 488879799 317 KLITASS 323
Cdd:cd01571 275 AISKAPP 281
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
33-326 |
3.79e-45 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 160.43 E-value: 3.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 33 NKIAYFDIFFRKIPDhGSFAIFAGLEDILdfvsclhfdeddiaylhsqgifkeEFLRYLKnfkfkGEIYAMQEGEIIFPN 112
Cdd:PRK08662 35 NPKVVAEVTASSLPK-GEWGVFAGLEEVL------------------------ELLEGKP-----VDVYALPEGTLFDPK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 113 EPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEFGTRRAHGSEAALKgARAAIIGGCKASSCTLA 192
Cdd:PRK08662 85 EPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGARHVHPAIAPMM-DRAAYIGGCDGVSGVLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 193 GKNYSIMTSGTMAHSWVQMFDDELSAFCHYLELYPQN-P-TLLIDTynYKQGLENAVKAFKKFKIKQCGVRIDS-----G 265
Cdd:PRK08662 164 AELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDvPrIALVDT--FKDEREEALRAAEALGDRLDGVRLDTpssrrG 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488879799 266 NLEILSKEIRTILDKNDLKECKIIVSNSLDEKSINKLLknDApIDAFGVGEKLitASSDPI 326
Cdd:PRK08662 242 NFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELR--DV-VDGFGVGTYI--SFAPPV 297
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
13-137 |
4.00e-44 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 150.74 E-value: 4.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 13 LLCDFYELTMMQGYFLNGFeNKIAYFDIFFRKIPDHGSFAIFAGLEDILDFVSCLHFDEDDIAYL-HSQGIFKEEFLRYL 91
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLrRSLPYFKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488879799 92 KNFKFKGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSIN 137
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
85-319 |
2.71e-26 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 109.27 E-value: 2.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 85 EEFLRYLKNFKF---KGEIYAMQEGEIIFPNEPLMIIKANAIEAQILESFLLLSINHQSLIATKANRIVRAAKNLSVLEF 161
Cdd:PRK07188 56 DEVIALLKTFAKdpsKLKIRYLKDGDIINPFETVLEIEGPYENFGFLEGIIDGILARRTSVATNAYNVVQAANEKPVIFM 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 162 GTRRAHGSEAALKGaRAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMFDDELSAFCH-YLELYPQNP-TLLIDTYNy 239
Cdd:PRK07188 136 GDRADHYLQQAGDG-YAAYIGGISAFSTHAQNEWWGKSGFGTMPHALIQMFNGDVVEACKaYHKTFPEDElIALVDYNN- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 240 kQGLENAVKAFKKFKIKQCGVRID-SGNL---------------------EILSKEIRTILDKNDLKECKIIVSNSLDEK 297
Cdd:PRK07188 214 -DVITDSLKVAREFGDKLKGVRVDtSKNMidkyfirhpevlgtfdprgvnPELIKALRKALDENGGKHVKIIVSSGFDAK 292
|
250 260
....*....|....*....|..
gi 488879799 298 SINKLLKNDAPIDAFGVGEKLI 319
Cdd:PRK07188 293 KIREFEAQNVPVDIYGVGSSLL 314
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
16-265 |
1.32e-14 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 75.18 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 16 DFYELTMMQGYFLNgFENKIAYFDIFFRKipDHGSFAIFAG-LEDILDFVSCLHFDEDDIAYLHSQGIFKEEFLRYLKNF 94
Cdd:PRK05321 16 DFYKLTMQQAVLHH-YPDAQVEYEFICRN--DEVDLAEYIDeIREQLDHLCTLRLTDDELDYLRGLPFFKPDFLDWLRLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 95 KFKgeiyaMQEGEIIFPNEPLMI-IKANAIEAQILESFLLLSIN-------HQSLIATKANRIVRA----------AKNL 156
Cdd:PRK05321 93 RLN-----PYEVTVSIDDGQLDIrIEGPWLETILWEVPLLAIISelyfrarSPEVLYAQAKRRLWEkiellkalpdLSGF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 157 SVLEFGTRRAHGSEA------ALK-GARAAIIGgckASSCTLAgKNYSIMTSGTMAHSWV---QMFDDELS-----AFCH 221
Cdd:PRK05321 168 KIADFGTRRRFSFEWqeevveALKeGLPGAFVG---TSNVHLA-MKLGLTPIGTMAHEWFmahQALGPRLRdsqyaALED 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 488879799 222 YLELYPQNptLLI---DTYNYKQGLENA----VKAFKkfkikqcGVRIDSG 265
Cdd:PRK05321 244 WVREYRGD--LGIaltDTIGMDAFLRDFdlyfAKLFD-------GLRHDSG 285
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
16-356 |
2.19e-14 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 74.59 E-value: 2.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 16 DFYELTMMQGYFLNgFENKIAYFDifFRKIPDHGSFAIFAG-LEDILDFVSCLHFDEDDIAYLH-SQGIFKEEFLRYLKN 93
Cdd:cd01401 7 DLYKLTMQQAVLHH-YPDVQVTYE--FTNRSPEDFLEEAAEaLREQIDHLANLRFSEEELAYLRrSLPFLKPDYLDYLEL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 94 FKFK------------GEIYAMQEG---EIIFPNEPLMiikanAIEAQILESFLLLSINHQSLIA---TKANRIVRAAK- 154
Cdd:cd01401 84 FRLNpeevvvrldtgkGQLDIRISGpwkDTILYEVPLL-----AIVSEVYFRFRDADWDYEEQLEkleEKLERLLEEAKr 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 155 ----NLSVLEFGTRRAHGSEA---ALKGARAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMF--------DDELSAF 219
Cdd:cd01401 159 rdlnGFRFSDFGTRRRFSYEVqetVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHqaltgdlkDSQKAAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 220 CHYLELYPQNPTL-LIDTYnykqGLENAVKAFKKFKIKQ-CGVRIDSGNLEILSKEIRTILDK--NDLKECKIIVSNSLD 295
Cdd:cd01401 239 ERWVREYGGDLGIaLTDTF----GTDAFLRDFDLYFAKLfDGVRHDSGDPFEWGEKAIAHYEKlgIDPKTKTLVFSDGLD 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488879799 296 -EKSIN--KLLKNDAPIdAFGVGEKL-----ITASSDPIfGCVYKLVAIEEdkliTPKIKISEDKQKIT 356
Cdd:cd01401 315 vEKALElyEYFKGRIKV-SFGIGTNLtndfgNKEKSTPL-NIVIKLVECNG----RPVAKISDSPGKNM 377
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
360-454 |
9.19e-12 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 61.81 E-value: 9.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 360 FKKLFRIYDKNTqKMLFDELYIYNEKLPKLDENL-----------------ERKELLKCVFKEGKILNKQKNVEEIALYA 422
Cdd:pfam17956 1 RKQVYRLYDKDG-KAIADLITLADEPPPDPGEEIlcfhpfdewkrktvtpfTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79
|
90 100 110
....*....|....*....|....*....|..
gi 488879799 423 KSQISKLDEKFLNFNNKEKYKIKLSKDLTKLR 454
Cdd:pfam17956 80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQLK 111
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
160-365 |
2.98e-10 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 60.09 E-value: 2.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 160 EFGTRRAHGSEAALKGArAAIIGGCKASSCTLAGKNYSIMTSGTMAHSWVQMfDDELSA----FCH-----YLELYP-QN 229
Cdd:pfam04095 5 DFGTRRRSSLESQEIVG-LAHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGA-HQELDAnlrqFQKdaldlWHAEYRgNL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 230 PTLLIDTYNYKQGLENAVKAFKKFKIkqcGVRIDSGN----LEILSKEIRTILdkNDLKECKIIV-SNSLDEKSINKLLK 304
Cdd:pfam04095 83 GIALTDTVTMDAFLKDFDLYFAKLYL---GVRPDSGDpvewGEKLIAHYGSTL--NIDGYTKRLIfSDGLDVEKIIELLE 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488879799 305 NDAPID---AFGVGEKLITASSDPIFGCVYKLVAIE-EDKLI----TPKIKISEDKQKITL--PHFKKLFR 365
Cdd:pfam04095 158 YFKGKGfniAFGIGTNLTQDLNRDTLGFAVKATPLNiVIKLVevngDPVAKISDSSGKGRCgdPAFVALLR 228
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
10-418 |
2.04e-08 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 56.44 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 10 NNTLLCDFYELTmmqgYFL---NGFENKIAYFDiffRKIPDHGSFAIFAGLEDIL-----DFVSCLHFDEDDIAYLHSQG 81
Cdd:PRK09198 6 NPILNTDSYKAS----HRLqypPGTTYLYSYLE---SRSGGRYDKVVFFGLQYFLkeyliQPITEAFIDEAKALLVAHGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 82 IFKEEFLRYLKNfKFKG----EIYAMQEGEIIFPNEPLMIIKANAIE----AQILESFLLLSINHQSLIATKANRI---- 149
Cdd:PRK09198 79 PFNRAGWRRIVD-KYGGylplRIKAVPEGSVVPVHNVLMTIENTDPEffwlPNYLETLLLRNVWYPSTVATISWEYkqli 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 150 ----VRAAKNLSVL-----EFGTRRAHGSEAALKGARA------------AIIGGCKASSCTLAGknYSI-------MTS 201
Cdd:PRK09198 158 rqylEKTADDLDFLpfqlhDFGARGMSSLESAALGGAAhlvsflgtdtipALLYAERYYNADMAG--FSIpatehsvMTS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 202 GTMAHswvqmfddELSAFCHYLELYPQNPTL--LIDTYNYKQGLENAVKAFKKFKIKQCG----VRIDSGN--------L 267
Cdd:PRK09198 236 WGREG--------ELEAYRNMIEQFYPGGIVsiVSDSYDLWNAITEPWGGELKDEILARGgtlvIRPDSGDpvtiicgtL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 268 EIL---------SKEIRtILDKNdlkeCKIIVSNSLDEKSINKLLKNdapIDA---------FGVGEKLITASSDPIFGC 329
Cdd:PRK09198 308 ELLdeifggtvnSKGYK-VLNPH----VGVIQGDGITLDSIEAILEA---LKAkgfaaenivFGMGGALLQYVNRDTQGF 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 330 VYKLVAIEEDKLitpKIKISedKQKITLPhfkklfriyDKNTQKMLFDELYIYNE----KLPKLDEnlERKELLKCVFKE 405
Cdd:PRK09198 380 AMKASAIEVNGE---WRDIF--KDPITDQ---------GKKSKKGRLKLIKDNGEyrtvDLDEAGD--ENDDLLQTVFEN 443
|
490
....*....|...
gi 488879799 406 GKILNKQkNVEEI 418
Cdd:PRK09198 444 GKLLVEY-SLAEI 455
|
|
| PBEF_like |
cd01569 |
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of ... |
48-337 |
2.24e-08 |
|
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.
Pssm-ID: 238803 [Multi-domain] Cd Length: 407 Bit Score: 56.13 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 48 HGSFAIFAGLEDILDFVSCLHFDEDDIAYLHSQgIFKEEFLRYLKNFKFKG--------------EIYAMQEGEIIFPNE 113
Cdd:cd01569 33 YYDQTVFFGLQYFLKKYLIDPVNRDFFIDEAEA-VFEAHFGMNDLPFNEDGwrhilelhdgylpiEIRAVPEGTVVPTKN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 114 PLMIIKANAIE----AQILESFLLLSINHQSLIATKANRI--------VRAAKNLSVLE-----FGTRRAHGSEAALKGA 176
Cdd:cd01569 112 VLMTVENTDPDffwlTNYLETILLRNVWYPSTVATISREYkkilrkyaKETSDNLEFLPfqlhdFGMRGMSSLESAALGG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 177 RA------------AIIGGCKA-SSCTLAGknYSIMTS--GTMAhSWVQmfDDELSAFCHYLELYPQNP-TLLIDTYNYK 240
Cdd:cd01569 192 AAhlvnfkgtdtipALDAAYAYyYEDPMAG--FSIPAAehSTMT-AWGR--ERELEAFRNLLEQFGPGIvSVVSDSYDFW 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 241 QGLENAVKAFKKFKIKQCG---VRIDSGN-LEILSKEIRTILDK-------------NdlKECKIIVSNSLDEKSINKLL 303
Cdd:cd01569 267 NALTLWGPRLKDEILARGGtlvIRPDSGDpVDIICGVLEILGEIfggtvnskgykvlN--PHVRIIQGDGITLERIEEIL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 488879799 304 KN------DAPIDAFGVGEKLITASSDPIFGCVYKLVAIE 337
Cdd:cd01569 345 ERlkakgfASENIVFGMGGGLLQKVTRDTQGFAMKASAIE 384
|
|
| nadV |
PHA02594 |
nicotinamide phosphoribosyl transferase; Provisional |
10-418 |
5.77e-08 |
|
nicotinamide phosphoribosyl transferase; Provisional
Pssm-ID: 222898 [Multi-domain] Cd Length: 470 Bit Score: 55.04 E-value: 5.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 10 NNTLLCDFYELTMMQGYFLNGfenKIAYFDIFFR--KIPDHgsfAIFAGLE----------------DILDFVSCLHFDE 71
Cdd:PHA02594 9 NIILMTDSYKLSHWSQYPKGT---DYVMFYLEPRggKFFDK---VVVFGIQyfvkkyffepitmevvEEAHELVKAHLGK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 72 DDIAYLHSQGIFKEEFLRYlknfkfkgEIYAMQEGEIIFPNEPLMIIKANAIE----AQILESFLLLSINHQSLIAT--- 144
Cdd:PHA02594 83 DVFNREHWEALHDLGYLPI--------EVRAVPEGTVVPVKVPVLTIENTHPDffwlAGYLETVILRGVWYPSTVATlsr 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 145 KANRIVRAAKNLSVL-----------EFGTRRAHGSEAALKGARAAIIG--GCKASSCTLAGKNYSIMTSGTMA------ 205
Cdd:PHA02594 155 ECKKILKKYLKETSDnedevldfqlhDFGARGMSSGESAALGGLAHLYNfkGTDTVEALYMAKRYYGDDEVEMAgisvpa 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 206 --HSWVQMF--DDELSAFCHYLELYPQNP-TLLIDTYNYKQGLENAVKAFKKFKIKQCG---VRIDSGN--------LEI 269
Cdd:PHA02594 235 reHSTMCSYgaENEDEAFKNSLTLYGTGIySIVSDTYDFKRAVTEILPELKDEIMARGGklvIRPDSGDpvdiicgaLET 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 270 LSKEIRTILDKNDLKE----CKIIVSNSLDEKSINKLLKN------DAPIDAFGVGEKLITASSDPIFGCVYKLVAIE-- 337
Cdd:PHA02594 315 LGEIFGGTVNSKGYKVldehVRLIQGDGITLERINRILTRmkengfASENVAFGMGGGLLQMVTRDTFKFAMKATAIKin 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 338 -EDKLI--TPKikisEDKQKITlpHFKKLFRIYDkntqkmlfDELYIYNEKLPkLDENLERKELLKCVFKEGKILNKQkN 414
Cdd:PHA02594 395 gKWKGVfkNPK----TDEGKKS--KKGRLARVKD--------GGSFKTVDGLE-EQSEADLNDALVTYFDDGKLVRYQ-S 458
|
....
gi 488879799 415 VEEI 418
Cdd:PHA02594 459 LAEI 462
|
|
| QRPTase_C |
pfam01729 |
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl ... |
142-326 |
2.74e-06 |
|
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.
Pssm-ID: 396337 Cd Length: 169 Bit Score: 47.31 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 142 IATKANRIVRAAKNLSVLEFGTRRAH-GSEAALKgaRAAIIGGCkassctlAGKNYSIMTSGTMAHSWVQMFDDELSAFC 220
Cdd:pfam01729 1 IATATRRMVEAARSVKVRIADTRKTTpGLRPLEK--YAVLIGGG-------DNHRLGLSDMVMIKDNHIAAAGSITEAVR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488879799 221 HYLELYPQNPTLLIDTYNYKQgLENAVKAfkkfkiKQCGVRIDSGNLEilskEIRTILDKNDLKECKII--VSNSLDEKS 298
Cdd:pfam01729 72 RARQVAPFAVKIEVEVESLEE-AEEALEA------GADIIMLDNFSPE----EVKKAVEELDERNPRVLleVSGGVTLDN 140
|
170 180
....*....|....*....|....*...
gi 488879799 299 INKLLKNDapIDAFGVGekLITASSDPI 326
Cdd:pfam01729 141 VLEYAKTG--VDVISVG--ALTHSVPPL 164
|
|
| |
