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Conserved domains on  [gi|488734078|ref|WP_002657480|]
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penicillin-binding protein 1A [Borreliella burgdorferi]

Protein Classification

penicillin-binding protein 1A( domain architecture ID 11472030)

penicillin-binding protein 1A is a bifunctional transpeptidases/transglycosylase that catalyzes synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation

CATH:  3.40.710.10|3.40.710.10|2.40.50.140
CAZY:  GT51
EC:  2.4.99.28|3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0008955|GO:0009002|GO:0006508
PubMed:  18266856|18248419
SCOP:  4005091|4002510|4002685

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
15-786 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 688.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  15 KLLIYLTYFAVSFSIITLSLAVSKTINIQKD----KNFGYVNPAVPSRLLDINGKQITQFiSDENRELMPLRKMPDNLIN 90
Cdd:COG5009    2 RLLKILLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKDYQPPTPSRVYSADGKLIAEF-GEERRIPVPIEEIPPLLIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  91 TLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLY-TNQarRSILRKLHEIWWAIQLEKKLSKYE 168
Cdd:COG5009   81 AFLAAEDKRFYEHPGVDPIGIARAAVvNLRTGRRVQGGSTITQQVAKNFLlSPE--RTLTRKIKEAILALRIEQELSKDE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 169 ILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQRAVLNQVVSNGIVKAE 248
Cdd:COG5009  159 ILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 249 IAEKEFNEYwqnYDWTRMADTSAisnkkDQAPYFSEYIRQKILKYLPDgANIYKDGYSIYSTLDLEAQKYADKVTNDMIN 328
Cdd:COG5009  239 EYEAAKAEP---LTARYHGASAE-----VDAPYFAEMVRRELVERYGE-DALYTGGLKVYTTLDPRLQEAAEKALRDGLL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 329 KARTMHNLnRSSETIIiNSEIVPVVDAISDLLGIKNLRI----------------NG-------------RQYKKLRKRK 379
Cdd:COG5009  310 AYDRRHGY-RGPEAHL-DLAEEDWDEALAEVPDVGDLRPavvlevddksarvglrDGetgtlpleglkwaRPYINDNRRG 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 380 FYEDNIDLIASFGAILGIDKIDKatkeyiikNKLTPKLIAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQ 459
Cdd:COG5009  388 PAPKSASDVLKPGDVIRVRPVAD--------GGWRLRQIPEVQGALVALDPHTGAVLALVGGFDFEQ-SKFNRATQAKRQ 458

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 460 PGSAFKALYFAAAIDlKKITAATMFSDSPVAFLN-KNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSA 538
Cdd:COG5009  459 PGSSFKPFVYAAALD-NGYTPATIINDAPIVFDDgGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYV 537

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 539 ISYSSKLlGITDPkeiektFPKVYPLALGVISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRII-----------T 607
Cdd:COG5009  538 IDYAERF-GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIyradparacedC 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 608 NEEASILAKIKNKEHQTQIVSPQTAYIITDMMKSTIQYGTLanqryTNLKNFKSDIAGKSGTTQNWADGWAIGYSPYITT 687
Cdd:COG5009  611 DAAEWDGAEPRLPDPAEQVIDPRTAYQMTSMLRGVVQRGTG-----RRARALGRDIAGKTGTTNDSKDAWFVGFTPDLVA 685

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 688 AFWVGFDKKGySLGISGTGTGLAGPSWGEFMAEYHKNLPKKVFVKPAGIISIPVQAETGLLPEEiADEKIINELFISGTQ 767
Cdd:COG5009  686 GVWVGFDDPR-SLGRGETGGRAALPIWIDFMKAALKDKPEKPFPVPEGIVTVRIDPKTGLLASP-GDPDAIFEAFKPGTE 763

                        810
                 ....*....|....*....
gi 488734078 768 PVEKSKYYENKQEFKNTIE 786
Cdd:COG5009  764 PTESASEDLGPDASEGTGE 782
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
 776-902 7.21e-03

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.15  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  776 ENKQE-FKNTIEFNIYGIDEINNND-EINFDTPEFEYLDNNLESFNNNSNNDNNLESFNNNNNDLESINDNEENKNEDEI 853
Cdd:PTZ00341 1005 ENVEEnVEENIEENVEEYDEENVEEvEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENV 1084

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 488734078  854 EMNIEEPLNEIEnKNPQQDLVNN--NNNQEMLIENTKEIKDEViVNETNIE 902
Cdd:PTZ00341 1085 EENVEENVEEIE-ENVEENVEENaeENAEENAEENAEEYDDEN-PEEHNEE 1133
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
15-786 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 688.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  15 KLLIYLTYFAVSFSIITLSLAVSKTINIQKD----KNFGYVNPAVPSRLLDINGKQITQFiSDENRELMPLRKMPDNLIN 90
Cdd:COG5009    2 RLLKILLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKDYQPPTPSRVYSADGKLIAEF-GEERRIPVPIEEIPPLLIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  91 TLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLY-TNQarRSILRKLHEIWWAIQLEKKLSKYE 168
Cdd:COG5009   81 AFLAAEDKRFYEHPGVDPIGIARAAVvNLRTGRRVQGGSTITQQVAKNFLlSPE--RTLTRKIKEAILALRIEQELSKDE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 169 ILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQRAVLNQVVSNGIVKAE 248
Cdd:COG5009  159 ILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 249 IAEKEFNEYwqnYDWTRMADTSAisnkkDQAPYFSEYIRQKILKYLPDgANIYKDGYSIYSTLDLEAQKYADKVTNDMIN 328
Cdd:COG5009  239 EYEAAKAEP---LTARYHGASAE-----VDAPYFAEMVRRELVERYGE-DALYTGGLKVYTTLDPRLQEAAEKALRDGLL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 329 KARTMHNLnRSSETIIiNSEIVPVVDAISDLLGIKNLRI----------------NG-------------RQYKKLRKRK 379
Cdd:COG5009  310 AYDRRHGY-RGPEAHL-DLAEEDWDEALAEVPDVGDLRPavvlevddksarvglrDGetgtlpleglkwaRPYINDNRRG 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 380 FYEDNIDLIASFGAILGIDKIDKatkeyiikNKLTPKLIAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQ 459
Cdd:COG5009  388 PAPKSASDVLKPGDVIRVRPVAD--------GGWRLRQIPEVQGALVALDPHTGAVLALVGGFDFEQ-SKFNRATQAKRQ 458

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 460 PGSAFKALYFAAAIDlKKITAATMFSDSPVAFLN-KNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSA 538
Cdd:COG5009  459 PGSSFKPFVYAAALD-NGYTPATIINDAPIVFDDgGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYV 537

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 539 ISYSSKLlGITDPkeiektFPKVYPLALGVISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRII-----------T 607
Cdd:COG5009  538 IDYAERF-GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIyradparacedC 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 608 NEEASILAKIKNKEHQTQIVSPQTAYIITDMMKSTIQYGTLanqryTNLKNFKSDIAGKSGTTQNWADGWAIGYSPYITT 687
Cdd:COG5009  611 DAAEWDGAEPRLPDPAEQVIDPRTAYQMTSMLRGVVQRGTG-----RRARALGRDIAGKTGTTNDSKDAWFVGFTPDLVA 685

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 688 AFWVGFDKKGySLGISGTGTGLAGPSWGEFMAEYHKNLPKKVFVKPAGIISIPVQAETGLLPEEiADEKIINELFISGTQ 767
Cdd:COG5009  686 GVWVGFDDPR-SLGRGETGGRAALPIWIDFMKAALKDKPEKPFPVPEGIVTVRIDPKTGLLASP-GDPDAIFEAFKPGTE 763

                        810
                 ....*....|....*....
gi 488734078 768 PVEKSKYYENKQEFKNTIE 786
Cdd:COG5009  764 PTESASEDLGPDASEGTGE 782
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 75-724 0e+00

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 683.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078   75 NRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTNQaRRSILRKLHE 153
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVaNITSGRVLEGGSTITQQLAKNLYLTN-ERTITRKIQE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  154 IWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQR 233
Cdd:TIGR02074  80 ALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  234 AVLNQVVSNGIVKAEIAEKEFNEYWQNYDWTRMAdtsaisnKKDQAPYFSEYIRQKILKYLpdGANIYKDGYSIYSTLDL 313
Cdd:TIGR02074 160 LVLSNMVENGYITAEEAEEAINEPIQLYLQTKKS-------EQYKAPYFVDYVIQELEEEY--GEELYTGGLKIYTTLDL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  314 EAQKYADKVTNDMINKARTMHNlnrssetiiinseivpvvdaisdllgiknlringrqykklrkrkfyednidliasfga 393
Cdd:TIGR02074 231 DAQKAAEKVLNTGLRVAGRRDG---------------------------------------------------------- 252

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  394 ilgidkidkatkeyiiknkltpkliAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQPGSAFKALYFAAAI 473
Cdd:TIGR02074 253 -------------------------DDLQAALVAIDPDTGAVRALVGGRDYGK-SQFNRATQAKRQPGSTFKPFVYAAAL 306

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  474 DlKKITAATMFSDSPVAFlnKNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSAISYSsKLLGITDPKe 553
Cdd:TIGR02074 307 E-KGLTPATIVNDEPITY--NGNGPWSPKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALA-KRFGITSPL- 381

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  554 iektfPKVYPLALGVISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRIITNeeasilakikNKEHQTQIVSPQTAY 633
Cdd:TIGR02074 382 -----DPVLSLALGTVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYE----------NKPKTTQVISPATAY 446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  634 IITDMMKSTIQYGTLANQRytnlkNFKSDIAGKSGTTQNWADGWAIGYSPYITTAFWVGFDKKGySLGISGTGTGLAGPS 713
Cdd:TIGR02074 447 IMTDMLKGVVESGTGRSAR-----LPGRPVAGKTGTTQNWRDAWFVGYTPYYVTAVWVGYDDKK-TLGKSGTGGGLAAPI 520

                         650
                  ....*....|.
gi 488734078  714 WGEFMAEYHKN 724
Cdd:TIGR02074 521 WRDFMAEALKN 531
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 55-772 6.67e-79

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 274.32  E-value: 6.67e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  55 VPSRLLDINGKQITQFisDENREL-MPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAfNIVL--GRYFSGGSTLT 131
Cdd:PRK11636  46 TPMQVYSADGELIAQY--GEKRRIpLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAA-SVALfsGHASQGASTIT 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 132 QQLAKLLYTNqARRSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAEsVMMII 211
Cdd:PRK11636 123 QQLARNFFLS-PERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSE-MAVIA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 212 QLPNA-KLYSPLYNPEFSKKIQRAVLNQVVSNG-IVKAEIAEKEFNEYWQNYDWTRMADTsaisnkkdqAPYFSEYIRQK 289
Cdd:PRK11636 201 GLPKApSTFNPLYSMDRAVARRNVVLSRMLDEGyITQAQYDQARSEPIVANYHAPEIAFS---------APYLSEMVRQE 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 290 ILK-YlpdGANIYKDGYSIYSTLDLEAQKYA-DKVTN-----DMINKARTMHN-LNRSSETIIINSEIV----------- 350
Cdd:PRK11636 272 MYNrY---GENAYEDGYRVYTTITRKVQQAAqQAVRNnvldyDMRHGYRGPANvLWKVGESAWDNKKITdtlkalptygp 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 351 --PVV--------------DAISDLLGIKNLRInGRQYKKLRKRKFYEDNIDLIASFGAILGIDKIDKATkeyiiknklt 414
Cdd:PRK11636 349 llPAVvtsanpqeatamlaDGSSVALPMEGVRW-ARPYRSDTQQGPTPRKVTDVVQTGQQIWVRQVDDAW---------- 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 415 pkLIAQ-PE--GAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQPGSAFKALYFAAAIDlKKITAATMFSDSPVAF 491
Cdd:PRK11636 418 --WLAQvPDvnSALVSINPQNGAVMALVGGFDFNQ-SKFNRATQALRQVGSNIKPFLYTAAMD-KGLTLASMLNDVPISR 493

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 492 LNKN-GEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSAISYsskLLGITDPKE-IEKTfpkvYPLALGVI 569
Cdd:PRK11636 494 WDAGaGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEY---LQRFGFPAQnIVHT----ESLALGSA 566

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 570 SVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRII------------------------------------TNEEA-- 611
Cdd:PRK11636 567 SFTPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIfeakpkvacpecdipviygdtqksnvlenddvenvaTSQEQqn 646

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 612 -------------SILAKIKNKEHQTQIVSPQTAYIITDMMKSTI-----QYGTlANQRYTNLKnfKSDIAGKSGTTQNW 673
Cdd:PRK11636 647 ssvpmpqleqanqALVAQNGAQEYAPHVINTPLAFLIKSALNTNIfgepgWMGT-GWRAGRDLK--RRDIGGKTGTTNSS 723

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 674 ADGWAIGYSPYITTAFWVGFDKKGYSLG-----------ISGT--GTGLAGPSWGEFMAEYHKNLPKKVFVKPAGIISIP 740
Cdd:PRK11636 724 KDAWFSGYGPGVVTSVWIGFDDHRRDLGrttasgaikdqISGYegGAKSAQPAWDDYMKAALEGVPEQPLTPPPGIVTVN 803

                        810       820       830
                 ....*....|....*....|....*....|..
gi 488734078 741 VQAETGLLPEEIADEKiinELFISGTQPVEKS 772
Cdd:PRK11636 804 IDRSTGKLANGGNSRE---EYFIEGTQPTQQA 832
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 63-240 6.23e-66

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 218.55  E-value: 6.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078   63 NGKQITQFiSDENRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTN 141
Cdd:pfam00912   1 DGTLLAEL-GEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLsNLRSGRIVQGGSTITQQLAKNLFLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  142 QARrSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSP 221
Cdd:pfam00912  80 PER-TLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNP 158

                         170
                  ....*....|....*....
gi 488734078  222 LYNPEFSKKIQRAVLNQVV 240
Cdd:pfam00912 159 LRNPERAKRRRNLVLDRMV 177
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 776-902 7.21e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.15  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  776 ENKQE-FKNTIEFNIYGIDEINNND-EINFDTPEFEYLDNNLESFNNNSNNDNNLESFNNNNNDLESINDNEENKNEDEI 853
Cdd:PTZ00341 1005 ENVEEnVEENIEENVEEYDEENVEEvEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENV 1084

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 488734078  854 EMNIEEPLNEIEnKNPQQDLVNN--NNNQEMLIENTKEIKDEViVNETNIE 902
Cdd:PTZ00341 1085 EENVEENVEEIE-ENVEENVEENaeENAEENAEENAEEYDDEN-PEEHNEE 1133
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
15-786 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 688.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  15 KLLIYLTYFAVSFSIITLSLAVSKTINIQKD----KNFGYVNPAVPSRLLDINGKQITQFiSDENRELMPLRKMPDNLIN 90
Cdd:COG5009    2 RLLKILLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKDYQPPTPSRVYSADGKLIAEF-GEERRIPVPIEEIPPLLIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  91 TLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLY-TNQarRSILRKLHEIWWAIQLEKKLSKYE 168
Cdd:COG5009   81 AFLAAEDKRFYEHPGVDPIGIARAAVvNLRTGRRVQGGSTITQQVAKNFLlSPE--RTLTRKIKEAILALRIEQELSKDE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 169 ILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQRAVLNQVVSNGIVKAE 248
Cdd:COG5009  159 ILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 249 IAEKEFNEYwqnYDWTRMADTSAisnkkDQAPYFSEYIRQKILKYLPDgANIYKDGYSIYSTLDLEAQKYADKVTNDMIN 328
Cdd:COG5009  239 EYEAAKAEP---LTARYHGASAE-----VDAPYFAEMVRRELVERYGE-DALYTGGLKVYTTLDPRLQEAAEKALRDGLL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 329 KARTMHNLnRSSETIIiNSEIVPVVDAISDLLGIKNLRI----------------NG-------------RQYKKLRKRK 379
Cdd:COG5009  310 AYDRRHGY-RGPEAHL-DLAEEDWDEALAEVPDVGDLRPavvlevddksarvglrDGetgtlpleglkwaRPYINDNRRG 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 380 FYEDNIDLIASFGAILGIDKIDKatkeyiikNKLTPKLIAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQ 459
Cdd:COG5009  388 PAPKSASDVLKPGDVIRVRPVAD--------GGWRLRQIPEVQGALVALDPHTGAVLALVGGFDFEQ-SKFNRATQAKRQ 458

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 460 PGSAFKALYFAAAIDlKKITAATMFSDSPVAFLN-KNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSA 538
Cdd:COG5009  459 PGSSFKPFVYAAALD-NGYTPATIINDAPIVFDDgGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYV 537

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 539 ISYSSKLlGITDPkeiektFPKVYPLALGVISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRII-----------T 607
Cdd:COG5009  538 IDYAERF-GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIyradparacedC 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 608 NEEASILAKIKNKEHQTQIVSPQTAYIITDMMKSTIQYGTLanqryTNLKNFKSDIAGKSGTTQNWADGWAIGYSPYITT 687
Cdd:COG5009  611 DAAEWDGAEPRLPDPAEQVIDPRTAYQMTSMLRGVVQRGTG-----RRARALGRDIAGKTGTTNDSKDAWFVGFTPDLVA 685

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 688 AFWVGFDKKGySLGISGTGTGLAGPSWGEFMAEYHKNLPKKVFVKPAGIISIPVQAETGLLPEEiADEKIINELFISGTQ 767
Cdd:COG5009  686 GVWVGFDDPR-SLGRGETGGRAALPIWIDFMKAALKDKPEKPFPVPEGIVTVRIDPKTGLLASP-GDPDAIFEAFKPGTE 763

                        810
                 ....*....|....*....
gi 488734078 768 PVEKSKYYENKQEFKNTIE 786
Cdd:COG5009  764 PTESASEDLGPDASEGTGE 782
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 75-724 0e+00

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 683.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078   75 NRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTNQaRRSILRKLHE 153
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVaNITSGRVLEGGSTITQQLAKNLYLTN-ERTITRKIQE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  154 IWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQR 233
Cdd:TIGR02074  80 ALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  234 AVLNQVVSNGIVKAEIAEKEFNEYWQNYDWTRMAdtsaisnKKDQAPYFSEYIRQKILKYLpdGANIYKDGYSIYSTLDL 313
Cdd:TIGR02074 160 LVLSNMVENGYITAEEAEEAINEPIQLYLQTKKS-------EQYKAPYFVDYVIQELEEEY--GEELYTGGLKIYTTLDL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  314 EAQKYADKVTNDMINKARTMHNlnrssetiiinseivpvvdaisdllgiknlringrqykklrkrkfyednidliasfga 393
Cdd:TIGR02074 231 DAQKAAEKVLNTGLRVAGRRDG---------------------------------------------------------- 252

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  394 ilgidkidkatkeyiiknkltpkliAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQPGSAFKALYFAAAI 473
Cdd:TIGR02074 253 -------------------------DDLQAALVAIDPDTGAVRALVGGRDYGK-SQFNRATQAKRQPGSTFKPFVYAAAL 306

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  474 DlKKITAATMFSDSPVAFlnKNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSAISYSsKLLGITDPKe 553
Cdd:TIGR02074 307 E-KGLTPATIVNDEPITY--NGNGPWSPKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALA-KRFGITSPL- 381

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  554 iektfPKVYPLALGVISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRIITNeeasilakikNKEHQTQIVSPQTAY 633
Cdd:TIGR02074 382 -----DPVLSLALGTVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYE----------NKPKTTQVISPATAY 446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  634 IITDMMKSTIQYGTLANQRytnlkNFKSDIAGKSGTTQNWADGWAIGYSPYITTAFWVGFDKKGySLGISGTGTGLAGPS 713
Cdd:TIGR02074 447 IMTDMLKGVVESGTGRSAR-----LPGRPVAGKTGTTQNWRDAWFVGYTPYYVTAVWVGYDDKK-TLGKSGTGGGLAAPI 520

                         650
                  ....*....|.
gi 488734078  714 WGEFMAEYHKN 724
Cdd:TIGR02074 521 WRDFMAEALKN 531
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 16-753 1.11e-178

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 531.42  E-value: 1.11e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  16 LLIYLTYFAVSFSIITLSLAVSKTINIQKDKNFgyvNPAVPSRLLDINGKQITQFiSDENRELMPLRKMPDNLINTLLIR 95
Cdd:COG0744   18 LLLLLAVLVLAALAGLVALYVADLPDPEELEDL---ALPQTSTIYDRDGTLIATL-GDENREWVPLDQIPPHLKDAVVAI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  96 EDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTNQaRRSILRKLHEIWWAIQLEKKLSKYEILEKYL 174
Cdd:COG0744   94 EDRRFYEHGGVDPKGIARALVaNLTAGGVVQGGSTITQQLVKNLFLSN-ERTLSRKLKEALLALKLERKYSKDEILELYL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 175 NKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMM--IIQLPNAklYSPLYNPEFSKKIQRAVLNQVVSNGIvkaeIAEK 252
Cdd:COG0744  173 NTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLagLVKAPSY--YDPYRNPEAAKERRNLVLDRMVEQGY----ITQA 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 253 EFNEYwQNYDWTRMADTSAISNKKdqAPYFSEYIRQKILKYLPDgANIYKDGYSIYSTLDLEAQKYADKVtndminkart 332
Cdd:COG0744  247 EADAA-KAEPLTLVPPPNGAAAGK--YPYFVDYVRRELEELLGE-DDLYRGGLKIYTTLDPKLQKAAEKA---------- 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 333 mhnlnrssetiiinseivpvvdaisdllgiknlringrqykklrkrkfyednidliasfgailgidkidkatkeyiIKNK 412
Cdd:COG0744  313 ----------------------------------------------------------------------------VKNV 316

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 413 LTPKLIAQPEGAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQPGSAFKALYFAAAIDlKKITAATMFSDSPVAFl 492
Cdd:COG0744  317 LPEGKPGGLQAALVVVDPKTGEVLAMVGGRDYGK-SQFNRATQAKRQPGSTFKPFVYAAALE-QGYTPATTVDDEPVTF- 393

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 493 nkNGEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSAISYSSKLlGITDPkeiektFPKVYPLALGVISVS 572
Cdd:COG0744  394 --PGGGWSPKNYDGRYRGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRL-GITSP------LDPNPSLALGTSEVS 464

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 573 PIQMARAFAILGNSGSEIEPYGIRYIEDRAGRIITneeasilakiKNKEHQTQIVSPQTAYIITDMMKSTIQYGTLANQR 652
Cdd:COG0744  465 PLEMASAYATFANGGVYVEPHAITKVTDADGKVLY----------EAKPKCEQVISPEVAYLMTDMLQDVVTSGTGRAAR 534

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 653 YTNLknfksDIAGKSGTTQNWADGWAIGYSPYITTAFWVGFDkKGYSLGIsGTGTGLAGPSWGEFMAEYHKNLPKKVFVK 732
Cdd:COG0744  535 LPGR-----PVAGKTGTTNDNRDAWFVGYTPQLVTAVWVGND-DNSPMGY-VTGGSLPAPIWRDFMEAALEGLPVEDFPK 607

                        730       740
                 ....*....|....*....|...
gi 488734078 733 PAGIISIPVQ--AETGLLPEEIA 753
Cdd:COG0744  608 PSGVVRIDEPspTPSGTEPTETS 630
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 55-772 6.67e-79

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 274.32  E-value: 6.67e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  55 VPSRLLDINGKQITQFisDENREL-MPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAfNIVL--GRYFSGGSTLT 131
Cdd:PRK11636  46 TPMQVYSADGELIAQY--GEKRRIpLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAA-SVALfsGHASQGASTIT 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 132 QQLAKLLYTNqARRSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAEsVMMII 211
Cdd:PRK11636 123 QQLARNFFLS-PERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSE-MAVIA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 212 QLPNA-KLYSPLYNPEFSKKIQRAVLNQVVSNG-IVKAEIAEKEFNEYWQNYDWTRMADTsaisnkkdqAPYFSEYIRQK 289
Cdd:PRK11636 201 GLPKApSTFNPLYSMDRAVARRNVVLSRMLDEGyITQAQYDQARSEPIVANYHAPEIAFS---------APYLSEMVRQE 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 290 ILK-YlpdGANIYKDGYSIYSTLDLEAQKYA-DKVTN-----DMINKARTMHN-LNRSSETIIINSEIV----------- 350
Cdd:PRK11636 272 MYNrY---GENAYEDGYRVYTTITRKVQQAAqQAVRNnvldyDMRHGYRGPANvLWKVGESAWDNKKITdtlkalptygp 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 351 --PVV--------------DAISDLLGIKNLRInGRQYKKLRKRKFYEDNIDLIASFGAILGIDKIDKATkeyiiknklt 414
Cdd:PRK11636 349 llPAVvtsanpqeatamlaDGSSVALPMEGVRW-ARPYRSDTQQGPTPRKVTDVVQTGQQIWVRQVDDAW---------- 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 415 pkLIAQ-PE--GAMIAIDTTSGAIRAMVGGSGHTKdNEFNRATQAKVQPGSAFKALYFAAAIDlKKITAATMFSDSPVAF 491
Cdd:PRK11636 418 --WLAQvPDvnSALVSINPQNGAVMALVGGFDFNQ-SKFNRATQALRQVGSNIKPFLYTAAMD-KGLTLASMLNDVPISR 493

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 492 LNKN-GEVYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDSAISYsskLLGITDPKE-IEKTfpkvYPLALGVI 569
Cdd:PRK11636 494 WDAGaGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEY---LQRFGFPAQnIVHT----ESLALGSA 566

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 570 SVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRII------------------------------------TNEEA-- 611
Cdd:PRK11636 567 SFTPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIfeakpkvacpecdipviygdtqksnvlenddvenvaTSQEQqn 646

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 612 -------------SILAKIKNKEHQTQIVSPQTAYIITDMMKSTI-----QYGTlANQRYTNLKnfKSDIAGKSGTTQNW 673
Cdd:PRK11636 647 ssvpmpqleqanqALVAQNGAQEYAPHVINTPLAFLIKSALNTNIfgepgWMGT-GWRAGRDLK--RRDIGGKTGTTNSS 723

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 674 ADGWAIGYSPYITTAFWVGFDKKGYSLG-----------ISGT--GTGLAGPSWGEFMAEYHKNLPKKVFVKPAGIISIP 740
Cdd:PRK11636 724 KDAWFSGYGPGVVTSVWIGFDDHRRDLGrttasgaikdqISGYegGAKSAQPAWDDYMKAALEGVPEQPLTPPPGIVTVN 803

                        810       820       830
                 ....*....|....*....|....*....|..
gi 488734078 741 VQAETGLLPEEIADEKiinELFISGTQPVEKS 772
Cdd:PRK11636 804 IDRSTGKLANGGNSRE---EYFIEGTQPTQQA 832
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 80-775 1.39e-78

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 271.71  E-value: 1.39e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  80 PLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTNqaRRSILRKLHEIWWAI 158
Cdd:COG4953   69 PLDEVSPRYLQALLAYEDRRFYYHPGVNPLALLRAAWqNLRSGRIVSGGSTLTMQVARLLEPR--PRTLSGKLRQILRAL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 159 QLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIqLPNA-KLYSPLYNPEFSKKIQRAVLN 237
Cdd:COG4953  147 QLERRYSKDEILELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAV-LPQApSRRRPDRNPERARAARDRVLA 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 238 QVVSNGIVKAEIAEkefneywqnydwtrMADTSAISNKKDQ----APYFSEYIRQKilkyLPDGAniykdgySIYSTLDL 313
Cdd:COG4953  226 RLAEAGVIDAEEAA--------------LALLEPVPARRRPlpqlAPHLARRLLRQ----LPGGT-------RIRTTLDA 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 314 EAQkyadkvtndminkartmhnlnRSSETIiinseivpVVDAISdllgikNLRINGRQykklrkrkfyednidliasfga 393
Cdd:COG4953  281 GLQ---------------------RRLERL--------VRRYVR------RLKQNGIH---------------------- 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 394 ilgidkidkatkeyiiknkltpkliaqpEGAMIAIDTTSGAIRAMVGGSGHTkDNE---FNRATQAKVQPGSAFKALYFA 470
Cdd:COG4953  304 ----------------------------NAAVLVVDNRTGEVLAYVGSADFF-DASrqgQVDMVRALRSPGSTLKPFLYG 354

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 471 AAIDLKKITAATMFSDSPVAFlnkNGevYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGFDsaiSYSSKL--LGI 548
Cdd:COG4953  355 LALDQGLIHPETLLADVPTSF---GG--YRPENFDGTFQGPVSAREALARSLNIPAVRLLEALGPA---RFYARLrrAGL 426

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 549 TDPKEIEKTfpkvY--PLALGVISVSPIQMARAFAILGNSGseiEPYGIRYIEDRAgriitneeasilakiknKEHQTQI 626
Cdd:COG4953  427 RLLLPPAEH----YglSLILGGAEVTLEELVGLYAALARGG---EARPLRLLAGEP-----------------ASPGRRL 482

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 627 VSPQTAYIITDMMKstiqyGTLANQRYTNLKNFKSD--IAGKSGTTQNWADGWAIGYSPYITTAFWVG-FDKKGySLGIS 703
Cdd:COG4953  483 LSPGAAWLVRDILS-----DVPRPDGAFGWRALDSPppIAWKTGTSYGFRDAWAVGFTGRYTVGVWVGnPDGTP-VPGLT 556

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488734078 704 GTGTglAGPSWGEFMAEYHKNLPKKVFVKPAGIISIPVQAETGLLPEEIADEKiINELFISGTQPVEKSKYY 775
Cdd:COG4953  557 GAEA--AAPLLFDIFDLLPASRWPLPFPPPAGLLRVEVCAPSGLLAGPNCPQR-VTEWFIPGTSPPTLCPYH 625
mrcB PRK09506
bifunctional glycosyl transferase/transpeptidase; Reviewed
 41-697 8.16e-67

bifunctional glycosyl transferase/transpeptidase; Reviewed


Pssm-ID: 236544 [Multi-domain]  Cd Length: 830  Bit Score: 240.06  E-value: 8.16e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  41 NIQKDKNFGY--VNPAVPSRLLDINGKQitqfisdenRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-N 117
Cdd:PRK09506 183 NLDNNRQFGFfrLDPRLITMLQSPNGEQ---------RLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLaN 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 118 IVLGRYFSGGSTLTQQLAKLLY-TNQarRSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFG-NGN---YGIVAASKF 192
Cdd:PRK09506 254 LTAGRTVQGGSTLTQQLVKNLFlSNE--RSLWRKANEAYMALIMDARYSKDRILELYLNEVYLGqSGDdqiRGFPLASLY 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 193 FFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQRAVLNQVVSNGIVKAEIaekefneywqnYDW--TRMADTS 270
Cdd:PRK09506 332 YFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALERRNLVLRLLQQQQIIDQEL-----------YDMlsARPLGVQ 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 271 AISNKKDQAPYFSEYIRQKILKYLPDGANIYKdGYSIYSTLDLEAQKYADKVTNDMINKARTMHNLnrssetiiinseiv 350
Cdd:PRK09506 401 PKGGVISPQPAFMQMVRQELQAKLGDKVKDLS-GVKIFTTLDPVSQDAAEKAVEEGIPALKKQRKL-------------- 465

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 351 pvvdaiSDLlgiknlringrqykklrkrkfyednidliasfgailgidkidkatkeyiiknkltpkliaqpEGAMIAIDT 430
Cdd:PRK09506 466 ------SDL--------------------------------------------------------------ETAMVVVDR 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 431 TSGAIRAMVGGSgHTKDNEFNRATQAKVQPGSAFK-ALYFAAAIDLKKITAATMFSDSPVAFLNKNGEVYAPGNYGGKWR 509
Cdd:PRK09506 478 FSGEVRAMVGGS-EPQFAGYNRAMQARRSIGSLAKpATYLTALSQPDKYRLNTWIADAPISLRQPNGQVWSPQNDDRRFS 556

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 510 GNVLTRQALALSLNIPALRILDRLGFDsAISYSSKLLGItdPKEIEKTFPKvypLALGVISVSPIQMARAFAILGNSGSE 589
Cdd:PRK09506 557 GRVMLVDALTRSMNVPTVNLGMALGLP-AVTDTWIKLGV--PKDQLNPVPA---MLLGALNLTPIEVAQAFQTIASGGNR 630

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 590 IEPYGIRYiedragriITNEEASILakIKNKEHQTQIVSPQTAYIITDMMKSTIQYGTlanQRYTNLKNFKSDIAGKSGT 669
Cdd:PRK09506 631 APLSALRS--------VIAEDGKVL--YQSFPQAERAVPAQAAYLTLYTMQQVVQRGT---GRQLGAKYPNLHLAGKTGT 697

                        650       660
                 ....*....|....*....|....*...
gi 488734078 670 TQNWADGWAIGYSPYITTAFWVGFDKKG 697
Cdd:PRK09506 698 TNDLVDSWFAGIDGKEVTITWVGRDNNQ 725
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 63-240 6.23e-66

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 218.55  E-value: 6.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078   63 NGKQITQFiSDENRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLYTN 141
Cdd:pfam00912   1 DGTLLAEL-GEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLsNLRSGRIVQGGSTITQQLAKNLFLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  142 QARrSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQLPNAKLYSP 221
Cdd:pfam00912  80 PER-TLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNP 158

                         170
                  ....*....|....*....
gi 488734078  222 LYNPEFSKKIQRAVLNQVV 240
Cdd:pfam00912 159 LRNPERAKRRRNLVLDRMV 177
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 38-706 1.28e-56

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 209.32  E-value: 1.28e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  38 KTINIQKDKNFGY--VNPAVPSRLLDINGKQitqfisdenRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRAA 115
Cdd:PRK14850 126 RIKNIDNNHDFSFlrLDPKLIAMLYSPEGKK---------RLFIPRNQYPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAF 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 116 F-NIVLGRYFSGGSTLTQQLAKLLYTNQARrSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFG-NGN---YGIVAAS 190
Cdd:PRK14850 197 LvNLMSGHTIQGGSTLTQQLVKNLFLTNTR-SLWRKINEIYMALILDRFYSKDRILELYLNEVYLGqDGNeqiRGFPLAS 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 191 KFFFGKSVNKINTAESVMMIIQLPNAKLYSPLYNPEFSKKIQRAVLNQVVSNGIVKAEIAEKEFneywqnydwTRMADTS 270
Cdd:PRK14850 276 IYYFGRPINELNLDQYALLVGMVKGASLYNPWTNPNLTLKRRNLVLFLLYKQKVITRKLYKDLC---------SRPLNVQ 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 271 AISNKKDQAPYFSEYIRQKILKYLpdgANIYKD--GYSIYSTLDLEAQKYADKVTNdminkartmhnlnrssetiiinse 348
Cdd:PRK14850 347 SKGNIISSHPAFIQLVCEEFHKKI---HYPFKNfsGTKIFTTLDYISQNAAEQAVK------------------------ 399

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 349 ivpvvdaisdlLGIKNLringrqykklrKRKFyeDNIDLiasfgailgidkidkatkeyiiknkltpkliaqpEGAMIAI 428
Cdd:PRK14850 400 -----------IGIPIL-----------KRKK--RLKDL----------------------------------EVAMVII 421

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 429 DTTSGAIRAMVGGSgHTKDNEFNRATQAKVQPGSAFK-ALYFAAAIDLKKITAATMFSDSPVAFLNKNGEVYAPGNYGGK 507
Cdd:PRK14850 422 DRFSGEVRALIGSS-KPEFNGYNRALKARRSIGSLSKpITYLTALSQPEKYHLNTWISDTPISIKLDNGQYWTPKNNNFS 500

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 508 WRGNVLTRQALALSLNIPALRILDRLGFDSAISySSKLLGITDpKEIEKtFPKVyplALGVISVSPIQMARAFAILGNSG 587
Cdd:PRK14850 501 FSGKVMLIDALIHSINIPTVHLSINLGLKKLVD-SWILLGISS-NYITP-LPSI---SLGAINLTPMEVAQVFQIIGSGG 574

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 588 SEIEPYGIRYIEDRAGRIItneeasilakIKNKEHQTQIVSPQTAYIITDMMKSTIQYGTlANQRYTNLKNFKsdIAGKS 667
Cdd:PRK14850 575 YKSSLSSIRSIISDDNKVL----------YQNFPQSKHVESSQASYLTLYAMQQVVKSGT-AKSLGTIFKEFS--LAGKT 641

                        650       660       670
                 ....*....|....*....|....*....|....*....
gi 488734078 668 GTTQNWADGWAIGYSPYITTAFWVGFDKKGYSLGISGTG 706
Cdd:PRK14850 642 GTTNNLVDSWFVGIDGKQVVITWIGRDNNHTTKLYGSSG 680
mono_pep_trsgly TIGR02070
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ...
 48-244 8.34e-29

monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273951 [Multi-domain]  Cd Length: 224  Bit Score: 115.25  E-value: 8.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078   48 FGYVNPAVPS--RLLDINGKQITQFISDENRELMPLRKMPDNLINTLLIREDIGFFSHRGFSLIGIFRA-AFNIVLGRYF 124
Cdd:TIGR02070  25 WRFVPPPSTAfmVAEKLALWGQGDPTCGIQHRWRPYDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDAlEKNEKSGKVV 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  125 SGGSTLTQQLAKLLYTNQArRSILRKLHEIWWAIQLEKKLSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTA 204
Cdd:TIGR02070 105 RGGSTISQQLAKNLFLWSG-RSYLRKGLEAWATWMLETWWSKQRILEVYLNSVEWGNGVFGAEAAARYYFKRSASNLTRG 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 488734078  205 ESVMMIIQLPNAKLYSPL-YNPEFSKKiQRAVLNQVVSNGI 244
Cdd:TIGR02070 184 QAARLAAVLPNPKYYDENrPGPYVRRK-ATWILKQMGYLGL 223
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 423-728 2.55e-28

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 121.08  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 423 GAMIAIDTTSGAIRAMVG--------GSGHTKDNEFNRATQAKVQPGSAFKALYFAAAIDLKKITAATMFSDSpvAFLNK 494
Cdd:COG0768  249 GAVVVMDPKTGEILAMASypsfdpnlFVGGPDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTTFDCP--GYYRV 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 495 NGEVYAPGNYGGkwRGNVLTRQALALSLNIPALRILDRLGFDSAISYSSKLlGITDPKEIE---------KTFPKVYPLA 565
Cdd:COG0768  327 GGRTIRDWDRGG--HGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKF-GLGQKTGIDlpgeasgllPSPKRWYPGE 403

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 566 LGV------ISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRIITNEeasilakiknKEHQTQIVSPQTAYIITDMM 639
Cdd:COG0768  404 TATmsigqgLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEE----------PEVLRRVISPETAETVREGM 473

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 640 KSTIQ--YGTlanqrYTNLKNFKSDIAGKSGTTQNwADGWAIGYSPYITTAFWVGF---DKKGYSLGI-------SGTGT 707
Cdd:COG0768  474 EGVVNepGGT-----ARRAAIPGYRVAGKTGTAQV-VDIGNGGYYKGRHIASFVGFapaDNPRYAVAVvvenpggGAYGG 547

                        330       340
                 ....*....|....*....|.
gi 488734078 708 GLAGPSWGEFMAEYHKNLPKK 728
Cdd:COG0768  548 TVAAPVFREIMEAYLRLLGPP 568
PRK11240 PRK11240
penicillin-binding protein 1C; Provisional
 89-692 4.85e-26

penicillin-binding protein 1C; Provisional


Pssm-ID: 183049 [Multi-domain]  Cd Length: 772  Bit Score: 115.18  E-value: 4.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  89 INTLLIREDIGFFSHRGFSLIGIFRAAF-NIVLGRYFSGGSTLTQQLAKLLytNQARRSILRKLHEIWWAIQLEKKLSKY 167
Cdd:PRK11240  75 LEALINYEDRWFWKHPGVNPFSVARAAWqDLTSGRVISGGSTLTMQVARLL--DPHPRTFGGKIRQLWRALQLEWHLSKR 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 168 EILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIqLPNAKlySPLYNPEFSKKIQRA---VLNQVVSNGI 244
Cdd:PRK11240 153 EILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAV-LPQAP--SRLRPDRWPERAEAArnkVLERMAEQGV 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 245 VKAE-IAEKEFNEYWqnydwtrmadtsaisnkkdQAPyfseyiRQkilkyLPDGANIYkdgysiystldleaqkyadkvt 323
Cdd:PRK11240 230 WSAEqVKESREEPVW-------------------LAP------RQ-----MPQLAPLF---------------------- 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 324 ndminkARTMHNLNRSsetiiinSEIVPVVDAisdllGIKnlringRQYKklrkrkfyedniDLIASFgailgidkidka 403
Cdd:PRK11240 258 ------ARMMLGKSKS-------DKIVTTLDA-----GLQ------RRLE------------DLALNW------------ 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 404 tkeyiiKNKLTPKLIAqpegAMIAIDTTSGAIRAMVGGSGHTKDNEFNRA--TQAKVQPGSAFKALYFAAAIDLKKITAA 481
Cdd:PRK11240 290 ------KGRLPPRSSL----AMIVVDHTDMAVRGWVGSVDLNDDSRFGHVdmVNAIRSPGSVLKPFVYGLALDDGLIHPA 359

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 482 TMFSDSPVAFlnknGEvYAPGNYGGKWRGNVLTRQALALSLNIPALRILDRLGfdsAISYSSKLLGITDPkeieKTFPkv 561
Cdd:PRK11240 360 SLLQDVPRRT----GD-YRPGNFDSGFHGPVSMSEALVRSLNLPAVQVLEAYG---PKRFAAKLRNVGLP----LYLP-- 425

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078 562 yPLALGVISVspiqmarafaILGNSGSEIEPYGIRYI----EDRAGRIITNEEASILAKiknkehqtQIVSPQTAYIITD 637
Cdd:PRK11240 426 -AGAEPNLSL----------ILGGAGARLEDMVAAYSafarHGKAAKLRLQPDDPLLER--------PLMSPGAAWIIRR 486

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488734078 638 MMKSTIQ---YGTLANQrytnlknfkSDIAGKSGTTQNWADGWAIGYSPYITTAFWVG 692
Cdd:PRK11240 487 IMADEAQplpDAALPRV---------VPLAWKTGTSYGYRDAWAIGVNARYVIGIWTG 535
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 423-684 1.91e-24

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 104.81  E-value: 1.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  423 GAMIAIDTTSGAIRAMVGGSGHTKDNEF----NRATQAKVQPGSAFKALYFAAAIDLKKITAATMFSDSPvaFLNKNGEV 498
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIgplrNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWP--GKQQGGKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  499 YAPGNYGGKWRGNVltRQALALSLNIPALRILDRLGFDSAISYSSKL-----LGITDPKEIEKTFPKVY------PLALG 567
Cdd:pfam00905  79 IGDWNQDQVGIGTL--RQALEYSSNWYMQKLAQKLGADKLRSYLKKFgygnkTGIGLPGENAGYLTPYWlegataSFGIG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  568 vISVSPIQMARAFAILGNSGSEIEPYGIRYIEDragriitneeasilaKIKNKEHQTQIVSPQTAYIITDMMKSTIQYGT 647
Cdd:pfam00905 157 -LTITPLQQAQAYAAIANGGKLVPPHLVKSIED---------------KVDPKVLNKLPISKSTAEKVKDMLRLVVNDGT 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 488734078  648 LANQRYTNLknfkSDIAGKSGTTQ-----------NWADGWAIGYSPY 684
Cdd:pfam00905 221 GTGTAAVPG----YKVAGKTGTAQvagpkgggyydGAQIGWFVGYAPA 264
PRK13481 PRK13481
glycosyltransferase; Provisional
 84-212 3.08e-22

glycosyltransferase; Provisional


Pssm-ID: 184078 [Multi-domain]  Cd Length: 232  Bit Score: 96.41  E-value: 3.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  84 MPDNLINTLLIREDIGFFSHRGFSLIGIFRAAFNIVLGRYFSGGSTLTQQLAKLLYTNQaRRSILRKLHEIWWAIQLEKK 163
Cdd:PRK13481  53 MPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTISDRDVQGGSTITQQVVKNYFYDN-ERSFTRKVKELFVAHRVEKQ 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488734078 164 LSKYEILEKYLNKVYFGNGNYGIVAASKFFFGKSVNKINTAESVMMIIQ 212
Cdd:PRK13481 132 YSKNEILSFYLNNIYFGDNQYTLEGAANHYFGTTVNKNSTTMSHITVLQ 180
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 423-671 5.06e-17

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 85.65  E-value: 5.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  423 GAMIAIDTTSGAIRAMV-----------GGSGHTKDNE---------FNRATQAKVQPGSAFKALYFAAAIDLKKITAAT 482
Cdd:TIGR03423 249 GAVVVMDPRTGEILAMVstpsfdpnlfvDGISSKDYKAllndpdrplLNRAIQGVYPPGSTFKPVVALAALEEGVITPET 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  483 MFSDspvaflnkNGEVYAPGNYGGKWR----GNVLTRQALALSLNIPALRILDRLGFDSAISYSSKL-----LGITDPKE 553
Cdd:TIGR03423 329 RIYC--------PGYFQLGGRRFRCWKrgghGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFgfgqkTGIDLPGE 400

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  554 I----------EKTFPKVY------PLALG--VISVSPIQMARAFAILGNSGSEIEPYGIRYIEDRAGRIITNEEASILA 615
Cdd:TIGR03423 401 KsglvpsrewkRKRFGQPWypgdtlNVSIGqgYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDPDGGVVRRTEPEVLR 480

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 488734078  616 KIKnkehqtqiVSPQTAYIITDMMKSTIQ--YGTLANQRytnlKNFKSDIAGKSGTTQ 671
Cdd:TIGR03423 481 PLP--------ISPENLDVVREGMRDVVNgpGGTARRAR----LGLPYKMAGKTGTAQ 526
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 776-902 7.21e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.15  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488734078  776 ENKQE-FKNTIEFNIYGIDEINNND-EINFDTPEFEYLDNNLESFNNNSNNDNNLESFNNNNNDLESINDNEENKNEDEI 853
Cdd:PTZ00341 1005 ENVEEnVEENIEENVEEYDEENVEEvEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENV 1084

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 488734078  854 EMNIEEPLNEIEnKNPQQDLVNN--NNNQEMLIENTKEIKDEViVNETNIE 902
Cdd:PTZ00341 1085 EENVEENVEEIE-ENVEENVEENaeENAEENAEENAEEYDDEN-PEEHNEE 1133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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