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Conserved domains on  [gi|4885105|ref|NP_005432|]
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chromatin assembly factor 1 subunit B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 381-549 3.71e-98

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


:

Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 295.18  E-value: 3.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    381 GIPLKEKPVLNMRTPDTA-KKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSP 459
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    460 LPGPSEE-KTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGS 538
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVVSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 4885105    539 PPELKRPRLDE 549
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
30-368 9.28e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 9.28e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   30 HRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEpeqiafqde 109
Cdd:COG2319 133 KTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL--------- 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  110 deaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATL 189
Cdd:COG2319 197 ------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  190 SCDRVLRVYSIQKKRVAfnvsKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLTpagcveSGENvmNTTYVF 269
Cdd:COG2319 265 SADGTVRLWDLATGELL----RTLTG-------------HSGGVNS----VAFSPDGKLLAS------GSDD--GTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  270 SRKNlKRPIAHLPCPGKATLAVRCCPvyfelrpvveTGVELmslpyrlvfAVASED-SVLLYDTQQSFPFGYVSNiHYHT 348
Cdd:COG2319 316 DLAT-GKLLRTLTGHTGAVRSVAFSP----------DGKTL---------ASGSDDgTVRLWDLATGELLRTLTG-HTGA 374

                       330       340
                ....*....|....*....|
gi 4885105  349 LSDISWSSDGAFLAISSTDG 368
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADG 394
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 381-549 3.71e-98

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 295.18  E-value: 3.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    381 GIPLKEKPVLNMRTPDTA-KKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSP 459
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    460 LPGPSEE-KTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGS 538
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVVSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 4885105    539 PPELKRPRLDE 549
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
30-368 9.28e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 9.28e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   30 HRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEpeqiafqde 109
Cdd:COG2319 133 KTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL--------- 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  110 deaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATL 189
Cdd:COG2319 197 ------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  190 SCDRVLRVYSIQKKRVAfnvsKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLTpagcveSGENvmNTTYVF 269
Cdd:COG2319 265 SADGTVRLWDLATGELL----RTLTG-------------HSGGVNS----VAFSPDGKLLAS------GSDD--GTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  270 SRKNlKRPIAHLPCPGKATLAVRCCPvyfelrpvveTGVELmslpyrlvfAVASED-SVLLYDTQQSFPFGYVSNiHYHT 348
Cdd:COG2319 316 DLAT-GKLLRTLTGHTGAVRSVAFSP----------DGKTL---------ASGSDDgTVRLWDLATGELLRTLTG-HTGA 374

                       330       340
                ....*....|....*....|
gi 4885105  349 LSDISWSSDGAFLAISSTDG 368
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-251 1.93e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 1.93e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   13 KEPVYSLDFQHgtAGRIhrLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:cd00200  93 TSYVSSVAFSP--DGRI--LSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   93 WkvndnkepeqiafqdedeaqlNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKS 172
Cdd:cd00200 162 W---------------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105  173 YVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRvafnVSKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLT 251
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSG-------------HTNSVTS----LAWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 5.63e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 5.63e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4885105     118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 3.74e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 3.74e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4885105    119 WTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 393-523 1.81e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    393 RTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPseektlQPS 472
Cdd:PHA03247 2879 ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP------AGA 2952

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4885105    473 SQNTKAHPSRRVtlntlqawSKTTPRRINLTPLKTDTPPSSVPTSVISTPS 523
Cdd:PHA03247 2953 GEPSGAVPQPWL--------GALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
PTZ00421 PTZ00421
coronin; Provisional
 142-226 2.56e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   142 NLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVysIQKKRvafnvSKMLSGIGAEGE 221
Cdd:PTZ00421 139 NVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI--IDPRD-----GTIVSSVEAHAS 211


                 ....*
gi 4885105   222 ARSYR 226
Cdd:PTZ00421 212 AKSQR 216
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 381-549 3.71e-98

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 295.18  E-value: 3.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    381 GIPLKEKPVLNMRTPDTA-KKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSP 459
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    460 LPGPSEE-KTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGS 538
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVVSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 4885105    539 PPELKRPRLDE 549
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
30-368 9.28e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 9.28e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   30 HRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEpeqiafqde 109
Cdd:COG2319 133 KTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL--------- 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  110 deaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATL 189
Cdd:COG2319 197 ------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  190 SCDRVLRVYSIQKKRVAfnvsKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLTpagcveSGENvmNTTYVF 269
Cdd:COG2319 265 SADGTVRLWDLATGELL----RTLTG-------------HSGGVNS----VAFSPDGKLLAS------GSDD--GTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  270 SRKNlKRPIAHLPCPGKATLAVRCCPvyfelrpvveTGVELmslpyrlvfAVASED-SVLLYDTQQSFPFGYVSNiHYHT 348
Cdd:COG2319 316 DLAT-GKLLRTLTGHTGAVRSVAFSP----------DGKTL---------ASGSDDgTVRLWDLATGELLRTLTG-HTGA 374

                       330       340
                ....*....|....*....|
gi 4885105  349 LSDISWSSDGAFLAISSTDG 368
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
13-251 1.15e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 1.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   13 KEPVYSLDFQHGtaGRihRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:COG2319 204 TGAVRSVAFSPD--GK--LLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   93 WKVNDNKEpeqiafqdedeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKS 172
Cdd:COG2319 273 WDLATGEL---------------------LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105  173 YVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAfnvsKMLSGigaegearsyrmfHDDSmksfFRRLSFTPDGSLLLT 251
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL----RTLTG-------------HTGA----VTSVAFSPDGRTLAS 389
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-251 1.93e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 1.93e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   13 KEPVYSLDFQHgtAGRIhrLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:cd00200  93 TSYVSSVAFSP--DGRI--LSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   93 WkvndnkepeqiafqdedeaqlNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKS 172
Cdd:cd00200 162 W---------------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105  173 YVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRvafnVSKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLT 251
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSG-------------HTNSVTS----LAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
11-201 2.04e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 2.04e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   11 HNKEPVYSLDFQHGtaGRihRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
Cdd:COG2319 244 GHSGSVRSVAFSPD--GR--LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   91 LLWKVNDNKEpeqiafqdedeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEH 170
Cdd:COG2319 313 RLWDLATGKL---------------------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                       170       180       190
                ....*....|....*....|....*....|.
gi 4885105  171 KSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ 201
Cdd:COG2319 372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-368 6.04e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 6.04e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   11 HNKePVYSLDF-QHGtagriHRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAV 89
Cdd:cd00200   8 HTG-GVTCVAFsPDG-----KLLATGSGDGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   90 ILLWKVNDNKepeqiafqdedeaqlnkenwtVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNE 169
Cdd:cd00200  75 IRLWDLETGE---------------------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  170 HKSYVQGVTWDPLGQYVATLSCDRVLRVYSIqkkrVAFNVSKMLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLL 249
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDL----RTGKCVATLTG-------------HTGEVNS----VAFSPDGEKL 192

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  250 LTpagcveSGENvmNTTYVF---SRKNLKRPIAHlpcpgkaTLAVRCCpvyfelrpvvetgvelMSLPYRLVFAVASEDS 326
Cdd:cd00200 193 LS------SSSD--GTIKLWdlsTGKCLGTLRGH-------ENGVNSV----------------AFSPDGYLLASGSEDG 241

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 4885105  327 VL-LYDTQQsfpfGYVSNI---HYHTLSDISWSSDGAFLAISSTDG 368
Cdd:cd00200 242 TIrVWDLRT----GECVQTlsgHTNSVTSLAWSPDGKRLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-368 3.15e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 3.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ 201
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  202 KKRVafnvskmlsgigaegeARSYRMfHDDSMKSffrrLSFTPDGSLLLTpagcveSGENvmNTTYVF---SRKNLKRPI 278
Cdd:cd00200  82 TGEC----------------VRTLTG-HTSYVSS----VAFSPDGRILSS------SSRD--KTIKVWdveTGKCLTTLR 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  279 AHlpcpgkaTLAVRCCPVyfelrpvvetgvelmsLPYRLVFAVASED-SVLLYDTqQSFPFGYVSNIHYHTLSDISWSSD 357
Cdd:cd00200 133 GH-------TDWVNSVAF----------------SPDGTFVASSSQDgTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPD 188

                       250
                ....*....|.
gi 4885105  358 GAFLAISSTDG 368
Cdd:cd00200 189 GEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
26-368 2.12e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 2.12e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   26 AGRIHRLASAGVDTNVRIWKVEKGPdgkaiveFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDnkepeqia 105
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGA-------LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  106 fqdedeaqlnkenWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQY 185
Cdd:COG2319  68 -------------GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  186 VATLSCDRVLRVYSIQKKRVAFNvskmLSGigaegearsyrmfHDDSMKSffrrLSFTPDGSLLLTpagcveSGENvmNT 265
Cdd:COG2319 135 LASGSADGTVRLWDLATGKLLRT----LTG-------------HSGAVTS----VAFSPDGKLLAS------GSDD--GT 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105  266 TYVFSRKNLKrPIAHLPCPGKATLAVRCCPvyfelrpvveTGvelmslpyRLVfAVASED-SVLLYDTQQSfPFGYVSNI 344
Cdd:COG2319 186 VRLWDLATGK-LLRTLTGHTGAVRSVAFSP----------DG--------KLL-ASGSADgTVRLWDLATG-KLLRTLTG 244

                       330       340
                ....*....|....*....|....
gi 4885105  345 HYHTLSDISWSSDGAFLAISSTDG 368
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
30-97 2.80e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 2.80e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4885105   30 HRLASAGVDTNVRIWKVEKGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVND 97
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 5.63e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 5.63e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4885105     118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 3.74e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 3.74e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4885105    119 WTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-94 2.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4885105      57 EFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWK 94
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 393-523 1.81e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    393 RTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPseektlQPS 472
Cdd:PHA03247 2879 ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP------AGA 2952

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4885105    473 SQNTKAHPSRRVtlntlqawSKTTPRRINLTPLKTDTPPSSVPTSVISTPS 523
Cdd:PHA03247 2953 GEPSGAVPQPWL--------GALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
PTZ00421 PTZ00421
coronin; Provisional
 142-226 2.56e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   142 NLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVysIQKKRvafnvSKMLSGIGAEGE 221
Cdd:PTZ00421 139 NVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI--IDPRD-----GTIVSSVEAHAS 211


                 ....*
gi 4885105   222 ARSYR 226
Cdd:PTZ00421 212 AKSQR 216
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 160-199 3.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4885105     160 KGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 359-541 3.50e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    359 AFLAISSTDGYCSfVTFEKDELGIPLKEKPVLNmrTPDTAKKTKSQTHRGSSP---GPRPVEGTPASRTQD---PSSPGT 432
Cdd:pfam05109 438 GFAAPNTTTGLPS-STHVPTNLTAPASTGPTVS--TADVTSPTPAGTTSGASPvtpSPSPRDNGTESKAPDmtsPTSAVT 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    433 TPPQARQAPAPTVIrdppSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQA----WSKTTPRRINLTPLKTD 508
Cdd:pfam05109 515 TPTPNATSPTPAVT----TPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAtiptLGKTSPTSAVTTPTPNA 590

                         170       180       190
                  ....*....|....*....|....*....|...
gi 4885105    509 TPPSSVPTSVISTPSTEEIQSETPGDAQGSPPE 541
Cdd:pfam05109 591 TSPTVGETSPQANTTNHTLGGTSSTPVVTSPPK 623
WD40 pfam00400
WD domain, G-beta repeat;
57-93 3.92e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4885105     57 EFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 31-209 7.78e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 7.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE-ILASGGDDAVILLWKVNDNKepeqiafqde 109
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGK---------- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   110 deaqlnkenwtVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKS-YVQGVTWDPLGQYVAT 188
Cdd:PTZ00421 160 -----------AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaKSQRCLWAKRKDLIIT 228

                        170       180
                 ....*....|....*....|....*
gi 4885105   189 LSCD----RVLRVYSIQKKRVAFNV 209
Cdd:PTZ00421 229 LGCSksqqRQIMLWDTRKMASPYST 253
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 402-522 9.47e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 9.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   402 KSQTHRGSSPGPRPVegtPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNtkAHPS 481
Cdd:PRK14951 378 KKTPARPEAAAPAAA---PVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA--PAPP 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 4885105   482 RRVTLNTLQAWSKTTPrRINLTPLKTDTPPSSVPTSVISTP 522
Cdd:PRK14951 453 AQAAPETVAIPVRVAP-EPAVASAAPAPAAAPAAARLTPTE 492
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-523 1.48e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    394 TPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQdPSSPGT-TPPQARQAPAptvirDPPSITPAvKSPLPGPSEEKTLQPS 472
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGpARPARPPTTA-----GPPAPAPP-AAPAAGPPRRLTRPAV 2788

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4885105    473 SQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPS 523
Cdd:PHA03247 2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 400-545 1.54e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    400 KTKSQTHRGSSPG-PRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPS--SQNT 476
Cdd:pfam03154 135 KDIDQDNRSTSPSiPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqgSPAT 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4885105    477 KAHPSRRVT----LNTLQAWSKTTPRRI-----NLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRP 545
Cdd:pfam03154 215 SQPPNQTQStaapHTLIQQTPTLHPQRLpsphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP 292
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 383-558 1.91e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   383 PLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGT--PAS--RTQDPSSPGTTPPQARqapaPTVIRDPPSiTPAVKS 458
Cdd:PTZ00449 582 PKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLdiPKSpkRPESPKSPKRPPPPQR----PSSPERPEG-PKIIKS 656

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   459 PLPGPSEEKTLQPS-------SQNTKAHPSR--RVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVistPSTEEIQS 529
Cdd:PTZ00449 657 PKPPKSPKPPFDPKfkekfydDYLDAAAKSKetKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKL---PRDEEFPF 733

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 4885105   530 ETPGDA---QGS------PPELKRPRLDENKGGTESLD 558
Cdd:PTZ00449 734 EPIGDPdaeQPDdiefftPPEEERTFFHETPADTPLPD 771
PHA03247 PHA03247
large tegument protein UL36; Provisional
 383-558 2.27e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    383 PLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTPAsRTQDPSSPgTTPPQARQAPAPTViRDP------PSITPAV 456
Cdd:PHA03247 2899 ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-RPQPPLAP-TTDPAGAGEPSGAV-PQPwlgalvPGRVAVP 2975

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    457 KS--PLPGPSEEkTLQPSSQNTKAHPSRRVT--LNTLQAWSKTTPRRINLtpLKT-----DTPPSSVPTSVISTPSTEEI 527
Cdd:PHA03247 2976 RFrvPQPAPSRE-APASSTPPLTGHSLSRVSswASSLALHEETDPPPVSL--KQTlwppdDTEDSDADSLFDSDSERSDL 3052

                         170       180       190
                  ....*....|....*....|....*....|.
gi 4885105    528 QSETPgdaqgSPPELKRPRLDENKGGTESLD 558
Cdd:PHA03247 3053 EALDP-----LPPEPHDPFAHEPDPATPEAG 3078
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 392-559 2.34e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    392 MRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKtlqp 471
Cdd:PHA03307  151 SPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR---- 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    472 sSQNTKAHPSRRVTLNTLQAWSKTTPRriNLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPElKRPRLDENK 551
Cdd:PHA03307  227 -SAADDAGASSSDSSSSESSGCGWGPE--NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRE-RSPSPSPSS 302


                  ....*...
gi 4885105    552 GGTESLDP 559
Cdd:PHA03307  303 PGSGPAPS 310
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 379-542 3.66e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    379 ELGIPLKEKPVLNMRTPDTAKKTKSQThrgsSPGPRPVEGTPASRTQD--PSSPGTTPPQA-RQAPAPTVIRDPPSITPA 455
Cdd:pfam03154 283 QTGPSHMQHPVPPQPFPLTPQSSQSQV----PPGPSPAAPGQSQQRIHtpPSQSQLQSQQPpREQPLPPAPLSMPHIKPP 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    456 VKSPLPGpseektlQPSSQNTKaHPSRRVTLNTLQAWSKTTPRRI--NLTPLKTDTPPSSVPTSVISTPSTEEIQsetPG 533
Cdd:pfam03154 359 PTTPIPQ-------LPNPQSHK-HPPHLSGPSPFQMNSNLPPPPAlkPLSSLSTHHPPSAHPPPLQLMPQSQQLP---PP 427


                  ....*....
gi 4885105    534 DAQgsPPEL 542
Cdd:pfam03154 428 PAQ--PPVL 434
PHA03247 PHA03247
large tegument protein UL36; Provisional
 405-532 4.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    405 THRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNT-----KAH 479
Cdd:PHA03247 2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgRVS 2662

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4885105    480 PSRRVTLNTLQAWSKTTPRRinltPLKTDTPPSSVPTSVISTPSTEEIQSETP 532
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPPPPPPTPEPA 2711
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
388-537 4.40e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 42.73  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    388 PVLNMRTPDTakKTKSQTHRGSSPGPRpVEGTPASRTQDPSSPGTTPPQARQAPA---PTVIRDPPSITPAVKSPLPGPS 464
Cdd:pfam05539 188 TYPSQVTPQS--QPATQGHQTATANQR-LSSTEPVGTQGTTTSSNPEPQTEPPPSqrgPSGSPQHPPSTTSQDQSTTGDG 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    465 EEKTLQPSSQNTKAHPsrRVTLNTLQAWSKT--------TPRRINLTPLKTdTPPSSVPTSVISTPSTEEIQSETPGDAQ 536
Cdd:pfam05539 265 QEHTQRRKTPPATSNR--RSPHSTATPPPTTkrqetgrpTPRPTATTQSGS-SPPHSSPPGVQANPTTQNLVDCKELDPP 341


                  .
gi 4885105    537 G 537
Cdd:pfam05539 342 K 342
PHA03247 PHA03247
large tegument protein UL36; Provisional
 395-546 4.40e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    395 PDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPgttpPQARQAPAPTVIRDPPSITPAvksPLPGPSEEKTLQPSSQ 474
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAP----PQSARPRAPVDDRGDPRGPAP---PSPLPPDTHAPDPPPP 2629

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4885105    475 NTKAHPSRRVTLNTLQAWSKTTPRRinltplktDTPPSSVptsviSTPSTEEIQSETPGDAqgSPPELKRPR 546
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTVPPPERPRD--------DPAPGRV-----SRPRRARRLGRAAQAS--SPPQRPRRR 2686
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 390-558 5.63e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    390 LNMRTPDTAKKTKSQTHRGSSPGPrpvegtPASRTQDPSSPGTTPPQARQAPAPTVIR-DPPSITPAVKSPLPGPSEEKT 468
Cdd:PHA03307   92 LSTLAPASPAREGSPTPPGPSSPD------PPPPTPPPASPPPSPAPDLSEMLRPVGSpGPPPAASPPAAGASPAAVASD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    469 LQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRinlTPLKTDTPPSSVPTSVISTPSTEeiqsetPGDAQGSPPELKRPRLD 548
Cdd:PHA03307  166 AASSRQAALPLSSPEETARAPSSPPAEPPPS---TPPAAASPRPPRRSSPISASASS------PAPAPGRSAADDAGASS 236

                         170
                  ....*....|
gi 4885105    549 ENKGGTESLD 558
Cdd:PHA03307  237 SDSSSSESSG 246
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 366-539 5.78e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    366 TDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTksqTHRGS-SPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPT 444
Cdd:pfam05109 380 SGAFASNRTFDITVSGLGTAPKTLIITRTATNATTT---THKVIfSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPT 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    445 VIRDPPSITPAVK----------------SPL-PGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAwskTTPRRINLTPLKT 507
Cdd:pfam05109 457 NLTAPASTGPTVStadvtsptpagttsgaSPVtPSPSPRDNGTESKAPDMTSPTSAVTTPTPNA---TSPTPAVTTPTPN 533

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 4885105    508 DTPPS---SVPTSVISTPsTEEIQSETPGDAQGSP 539
Cdd:pfam05109 534 ATSPTlgkTSPTSAVTTP-TPNATSPTPAVTTPTP 567
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 104-179 9.15e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 9.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105    104 IAFQDED-EAQLNKENWTVVKTLRGHLED--VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTW 179
Cdd:pfam12894  10 IALATEDgELLLHRLNWQRVWTLSPDKEDleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 393-545 1.31e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    393 RTPDTAKKTKSQTHRGSSPGPRPVEGtPASRTQDPSSPGTTP-----PQARQAPAPTVIRDPPSITPAVK-SPLPGPSEE 466
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVG-SLTSLADPPPPPPTPepaphALVSATPLPPGPAAARQASPALPaAPAPPAVPA 2746

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105    467 KTLQPSSQNTKAHPSrrvtlNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSViSTPSTEEIQSETPGDAQGSPPELKRP 545
Cdd:PHA03247 2747 GPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE-SRESLPSPWDPADPPAAVLAPAAALP 2819
WD40 pfam00400
WD domain, G-beta repeat;
161-199 1.54e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4885105    161 GQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 44-206 1.85e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105    44 WKVEKGpdGKAIVEFLSNLAR---------HTKAVNVVRFSPT-GEILASGGDDAVILLWK-------VNDNKEPEQIaf 106
Cdd:PTZ00420  45 WEVEGG--GLIGAIRLENQMRkppviklkgHTSSILDLQFNPCfSEILASGSEDLTIRVWEiphndesVKEIKDPQCI-- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   107 qdedeaqlnkenwtvvktLRGHLEDVYDICW-ATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSyVQGVTWDPLGQY 185
Cdd:PTZ00420 121 ------------------LKGHKKKISIIDWnPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNL 181

                        170       180
                 ....*....|....*....|.
gi 4885105   186 VATLSCDRVLRVYSIQKKRVA 206
Cdd:PTZ00420 182 LSGTCVGKHMHIIDPRKQEIA 202
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 398-481 4.20e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.79  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   398 AKKTKSQTHRGSSPGPRPVEGTPAsrtqdPSSPGTTPPQARQAPAPTV--IRDPPSITP-AVKSPLPGPSEektlQPSSQ 474
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTPA-----PSTRPKAAAAANIPPKEPVreTATPPPVPPrPVAPPVPHTPE----SAPKL 431


                 ....*..
gi 4885105   475 NTKAHPS 481
Cdd:PRK14950 432 TRAAIPV 438
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 407-540 5.69e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   407 RGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRrvtl 486
Cdd:PRK07764 383 RRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP---- 458

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4885105   487 ntlQAWSKTTPRRINLTPLKTDTPPSSVPTSViSTPSTEEIQSETPGDAQGSPP 540
Cdd:PRK07764 459 ---AAAPSAQPAPAPAAAPEPTAAPAPAPPAA-PAPAAAPAAPAAPAAPAGADD 508
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 393-471 6.10e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.33  E-value: 6.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885105   393 RTPDTAKKTKSQTHRGSSPGPRPVegTPASRTQDPSSPGTTPPQARQAPAPTvirdppSITPAVKSPLPGPSEEKTLQP 471
Cdd:PHA03269  80 EKFDPAPAPHQAASRAPDPAVAPQ--LAAAPKPDAAEAFTSAAQAHEAPADA------GTSAASKKPDPAAHTQHSPPP 150
PRK12757 PRK12757
cell division protein FtsN; Provisional
 382-468 9.58e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 38.10  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885105   382 IPLKEKPvLNMRTPDTAKKTkSQTHRGSSPGPRPVEGTPASRTQDPSSpgTTPPQARQAPAPTVIRDPPSITPAVKSPLP 461
Cdd:PRK12757 100 TQLSEVP-YNEQTPQVPRST-VQIQQQAQQQQPPATTAQPQPVTPPRQ--TTAPVQPQTPAPVRTQPAAPVTQAVEAPKV 175


                 ....*..
gi 4885105   462 GPSEEKT 468
Cdd:PRK12757 176 EAEKEKE 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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