MULTISPECIES: helix-turn-helix domain-containing protein [Staphylococcus]
helix-turn-helix domain-containing protein( domain architecture ID 18527876)
helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator similar to cytoskeleton protein RodZ, an inner membrane protein which functions in cell-shape control through regulation of the length of the long axis; also contains a DUF4115 domain
List of domain hits
Name | Accession | Description | Interval | E-value | |||
HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
5-72 | 2.59e-14 | |||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; : Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 65.40 E-value: 2.59e-14
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Voltage_gated_ClC super family | cl02915 | CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of ... |
72-200 | 6.42e-03 | |||
CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function. The actual alignment was detected with superfamily member PRK05277: Pssm-ID: 445960 [Multi-domain] Cd Length: 438 Bit Score: 36.79 E-value: 6.42e-03
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Name | Accession | Description | Interval | E-value | |||
HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
5-72 | 2.59e-14 | |||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 65.40 E-value: 2.59e-14
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HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
5-59 | 2.73e-09 | |||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 50.98 E-value: 2.73e-09
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HTH_XRE | cd00093 | Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ... |
4-59 | 7.23e-09 | |||
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators. Pssm-ID: 238045 [Multi-domain] Cd Length: 58 Bit Score: 50.24 E-value: 7.23e-09
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HTH_3 | pfam01381 | Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ... |
6-59 | 7.62e-09 | |||
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family. Pssm-ID: 460181 [Multi-domain] Cd Length: 55 Bit Score: 49.85 E-value: 7.62e-09
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couple_hipB | TIGR03070 | transcriptional regulator, y4mF family; Members of this family belong to a clade of ... |
10-54 | 1.78e-03 | |||
transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions] Pssm-ID: 213767 [Multi-domain] Cd Length: 58 Bit Score: 35.33 E-value: 1.78e-03
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PRK05277 | PRK05277 | H(+)/Cl(-) exchange transporter ClcA; |
72-200 | 6.42e-03 | |||
H(+)/Cl(-) exchange transporter ClcA; Pssm-ID: 235385 [Multi-domain] Cd Length: 438 Bit Score: 36.79 E-value: 6.42e-03
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Name | Accession | Description | Interval | E-value | |||
HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
5-72 | 2.59e-14 | |||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 65.40 E-value: 2.59e-14
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XRE | COG1476 | DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; |
3-61 | 2.34e-11 | |||
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; Pssm-ID: 441085 [Multi-domain] Cd Length: 68 Bit Score: 57.17 E-value: 2.34e-11
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HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
5-59 | 2.73e-09 | |||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 50.98 E-value: 2.73e-09
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HTH_XRE | cd00093 | Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ... |
4-59 | 7.23e-09 | |||
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators. Pssm-ID: 238045 [Multi-domain] Cd Length: 58 Bit Score: 50.24 E-value: 7.23e-09
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HTH_3 | pfam01381 | Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ... |
6-59 | 7.62e-09 | |||
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family. Pssm-ID: 460181 [Multi-domain] Cd Length: 55 Bit Score: 49.85 E-value: 7.62e-09
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aMBF1 | COG1813 | Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ... |
4-58 | 7.35e-08 | |||
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441418 [Multi-domain] Cd Length: 70 Bit Score: 47.63 E-value: 7.35e-08
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AF2118 | COG3620 | Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ... |
6-59 | 5.10e-06 | |||
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription]; Pssm-ID: 442838 [Multi-domain] Cd Length: 95 Bit Score: 43.47 E-value: 5.10e-06
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YozG | COG3655 | DNA-binding transcriptional regulator, XRE family [Transcription]; |
1-67 | 4.80e-05 | |||
DNA-binding transcriptional regulator, XRE family [Transcription]; Pssm-ID: 442872 [Multi-domain] Cd Length: 69 Bit Score: 40.13 E-value: 4.80e-05
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RodZ | COG1426 | Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ... |
8-60 | 5.04e-04 | |||
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 441035 [Multi-domain] Cd Length: 71 Bit Score: 37.09 E-value: 5.04e-04
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HTH_26 | pfam13443 | Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ... |
5-61 | 8.26e-04 | |||
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA. Pssm-ID: 433211 [Multi-domain] Cd Length: 63 Bit Score: 36.36 E-value: 8.26e-04
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YiaG | COG2944 | DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription]; |
6-38 | 1.37e-03 | |||
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription]; Pssm-ID: 442187 [Multi-domain] Cd Length: 64 Bit Score: 36.07 E-value: 1.37e-03
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couple_hipB | TIGR03070 | transcriptional regulator, y4mF family; Members of this family belong to a clade of ... |
10-54 | 1.78e-03 | |||
transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions] Pssm-ID: 213767 [Multi-domain] Cd Length: 58 Bit Score: 35.33 E-value: 1.78e-03
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HTH_19 | pfam12844 | Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ... |
5-60 | 4.51e-03 | |||
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains. Pssm-ID: 463728 [Multi-domain] Cd Length: 64 Bit Score: 34.57 E-value: 4.51e-03
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PRK05277 | PRK05277 | H(+)/Cl(-) exchange transporter ClcA; |
72-200 | 6.42e-03 | |||
H(+)/Cl(-) exchange transporter ClcA; Pssm-ID: 235385 [Multi-domain] Cd Length: 438 Bit Score: 36.79 E-value: 6.42e-03
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Blast search parameters | ||||
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