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Conserved domains on  [gi|488404267|ref|WP_002473652|]
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nucleotide exchange factor GrpE [Staphylococcus epidermidis]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793973)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-210 2.61e-87

heat shock protein GrpE; Provisional


:

Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 255.31  E-value: 2.61e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNteedfnvETEDNQNDTNIENSVSstdnseanasdsENNSEESIKDEESESQDTKIKELEKLANDNEEKYL 80
Cdd:PRK14140   1 MEEKNEQVEE-------EVEETEVEEAVEDEVE------------EETVEEESEAELLDEEQAKIAELEAKLDELEERYL 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILA 160
Cdd:PRK14140  62 RLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEA 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488404267 161 EGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14140 142 VGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
 
Name Accession Description Interval E-value
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-210 2.61e-87

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 255.31  E-value: 2.61e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNteedfnvETEDNQNDTNIENSVSstdnseanasdsENNSEESIKDEESESQDTKIKELEKLANDNEEKYL 80
Cdd:PRK14140   1 MEEKNEQVEE-------EVEETEVEEAVEDEVE------------EETVEEESEAELLDEEQAKIAELEAKLDELEERYL 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILA 160
Cdd:PRK14140  62 RLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEA 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488404267 161 EGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14140 142 VGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-210 9.34e-60

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 183.82  E-value: 9.34e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  66 KELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHES 145
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKSLLEGVEMTLKQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488404267 146 LLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:COG0576   82 LLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 74-208 1.45e-54

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 170.38  E-value: 1.45e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  74 DNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDN 153
Cdd:cd00446    2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKNLLEGVEMTLKQLLKVLEKH 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488404267 154 GLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:cd00446   82 GVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
46-210 2.21e-48

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 155.84  E-value: 2.21e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   46 ENNSEESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQI 125
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  126 EGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSM 205
Cdd:pfam01025  81 APENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAM 160


                  ....*
gi 488404267  206 VKVNQ 210
Cdd:pfam01025 161 VVVSK 165
 
Name Accession Description Interval E-value
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-210 2.61e-87

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 255.31  E-value: 2.61e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNteedfnvETEDNQNDTNIENSVSstdnseanasdsENNSEESIKDEESESQDTKIKELEKLANDNEEKYL 80
Cdd:PRK14140   1 MEEKNEQVEE-------EVEETEVEEAVEDEVE------------EETVEEESEAELLDEEQAKIAELEAKLDELEERYL 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILA 160
Cdd:PRK14140  62 RLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEA 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488404267 161 EGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14140 142 VGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-210 9.34e-60

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 183.82  E-value: 9.34e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  66 KELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHES 145
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKSLLEGVEMTLKQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488404267 146 LLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:COG0576   82 LLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 74-208 1.45e-54

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 170.38  E-value: 1.45e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  74 DNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDN 153
Cdd:cd00446    2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKNLLEGVEMTLKQLLKVLEKH 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488404267 154 GLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:cd00446   82 GVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
46-210 2.21e-48

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 155.84  E-value: 2.21e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   46 ENNSEESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQI 125
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  126 EGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSM 205
Cdd:pfam01025  81 APENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAM 160


                  ....*
gi 488404267  206 VKVNQ 210
Cdd:pfam01025 161 VVVSK 165
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 11-210 6.25e-45

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 148.06  E-value: 6.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  11 TEEDFNVETEDNQNDTniensvssTDNSEANASDSENNSEESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYK 90
Cdd:PRK14162   2 SKEEFPSEKDLPQEET--------TDEAPKKEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  91 RRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLH 170
Cdd:PRK14162  74 NRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVKADDEAAKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLH 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 488404267 171 QAV--VQDDNpDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14162 154 QAVqtVAAEN-DDQKDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 1-208 1.89e-36

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 127.54  E-value: 1.89e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNTEEDFNVETEDNQNDTNIENSVSSTDNSEAnASDSENNSEESIKDEESESQDTKiKELEKLandnEEKYL 80
Cdd:PRK14143  18 SEAEDNSPESSEEVTEQEAELTNPEGDAAEAESSPDSGSA-ASETAADNAARLAQLEQELESLK-QELEEL----NSQYM 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERA---LQIEGDDEsfKSLQKGVQMVHESLLRALKDNGLEE 157
Cdd:PRK14143  92 RIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERArqqLKPEGEEA--QALHRSYQGLYKQLVDVLKRLGVSP 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488404267 158 ILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14143 170 MRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKV 220
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 20-208 3.07e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 125.94  E-value: 3.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  20 EDNQNDTN------IENSVSSTDNSEANASDSENNSEESIKDEESESQDtkikeleklandneeKYLRLYAEFENYKRRI 93
Cdd:PRK14141   4 EKNKNGNPadaardANNPVDREAKPYEMEDDPEPDPLEALKAENAELKD---------------RMLRLAAEMENLRKRT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  94 QKENQINATYKAQGVLTDILPSIDNIERALQI------EGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDP 167
Cdd:PRK14141  69 QRDVADARAYGIAGFARDMLSVSDNLRRALDAipaearAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDP 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 488404267 168 NLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14141 149 NFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 31-208 5.13e-33

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 117.34  E-value: 5.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  31 SVSSTDNSEANASDSENNSEESIKDEESESQDTKIKELEKL-------ANDNEEKYLRLYAEFENYKRRIQKENQINATY 103
Cdd:PRK14158   8 SHQIAEALKAKAAKEAEAAQGKPEAAQPVAAADRIKELEEAlaakeaeAAANWDKYLRERADLENYRKRVQKEKEELLKY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 104 KAQGVLTDILPSIDNIERALQiEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAE-GKEFDPNLHQAVVQDDNPDFK 182
Cdd:PRK14158  88 GNESLILEILPAVDNMERALD-HADEESMSAIIEGIRMTLSMLLSTLKKFGVTPVEAEkGTPFDPAYHQAMCQVESAEQE 166

                        170       180
                 ....*....|....*....|....*.
gi 488404267 183 SGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14158 167 PNTVVAVFQKGYLLNERLLRPAMVSV 192
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 37-208 5.43e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 109.15  E-value: 5.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  37 NSEANASDSENNSEESIKDEESES-QDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPS 115
Cdd:PRK14156   7 NEEVEEEVEATETEETVEEVVEETpEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 116 IDNIERALQIEGDDESFKslqKGVQMVHESLLRALKDNGLEEILAEgkEFDPNLHQAV----VQDDNPdfkSGEVTQELQ 191
Cdd:PRK14156  87 LDNLERALAVEGLTDDVK---KGLEMVQESLIQALKEEGVEEVAVD--SFDHNLHMAVqtlpADDEHP---ADSIAQVFQ 158

                        170
                 ....*....|....*..
gi 488404267 192 KGYKLKDRVLRPSMVKV 208
Cdd:PRK14156 159 KGYKLHERLLRPAMVVV 175
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-210 1.04e-28

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 106.16  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNTEEDFNVETEDNQNDTNIENSVsstdnseanasdsennseesikDEESESQDTKIKELEK--LANDNEEK 78
Cdd:PRK14150   1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAEL----------------------EDELDEADARIAELEAqlAEAQAEER 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  79 --YLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQI-EGDDESFKSLQKGVQMVHESLLRALKDNGL 155
Cdd:PRK14150  59 dsVLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVIDNLERALQAaDKENEALKALIEGVELTLKSLLDTVAKFGV 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488404267 156 EEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14150 139 EVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 1-208 2.69e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 105.61  E-value: 2.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   1 MSEKDQSVNNTEEDFNVETEDNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESESQDTKIKELEKLANDNE---E 77
Cdd:PRK14160   3 KECKDAKHENMEEDCCKENENKEEDKGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEENKKLENELEalkD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  78 KYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKslqKGVQMVHESLLRALKDNGLEE 157
Cdd:PRK14160  83 RLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAAVEGSVEDLK---KGIEMTVKQFKTSLEKLGVEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488404267 158 ILAEGkEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14160 160 ISTEG-EFDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKV 209
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 36-208 5.17e-28

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 104.18  E-value: 5.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  36 DNSEANASDSENNSEESIKDEESESQDTKIKELEKLA------NDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVL 109
Cdd:PRK14149  10 DHLSQKEPESEEKACACKEQQGEEKQEASEKEGEIKEdfelkyKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 110 TDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGkEFDPNLHQAVVQDDNPDFKSGEVTQE 189
Cdd:PRK14149  90 LDLLPVIDALLGALKSAAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLE-EFDPNFHNAIMQVKSEEKENGKIVQV 168

                        170
                 ....*....|....*....
gi 488404267 190 LQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14149 169 LQQGYKYKGRVLRPAMVSI 187
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 17-208 1.05e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 103.85  E-value: 1.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  17 VETEDNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESESQD--TKIKELEKLANDNEEKYLRLYAEFENYKRRIQ 94
Cdd:PRK14145   4 VEKEINKEEEKDVNNLSSNEQMEGPPEDEQAQQNQPQQQTVDEIEElkQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  95 KENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKslqKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVV 174
Cdd:PRK14145  84 KEKSEMVEYGKEQVILELLPVMDNFERALASSGDYNSLK---EGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVM 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 488404267 175 QDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14145 161 QEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKV 194
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 21-210 7.49e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 101.20  E-value: 7.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  21 DNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESEsqdtkIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQIN 100
Cdd:PRK14139   2 ENTQQNPSEQEAEEAGAAAQAAAAAAAAAEDAAPALEAE-----LAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 101 ATYKAQGVLTDILPSIDNIERALQIEgdDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAV--VQDDN 178
Cdd:PRK14139  77 HKFAIESFAESLLPVKDSLEAALADE--SGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAIsmVPAEQ 154

                        170       180       190
                 ....*....|....*....|....*....|..
gi 488404267 179 PdfkSGEVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14139 155 E---PNTVVAVLQKGYTIADRVLRPALVTVAA 183
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 46-210 2.44e-26

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 99.47  E-value: 2.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  46 ENNSEESIKDEESESQD--TKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERAL 123
Cdd:PRK14151   8 DLQAPEAAQAEAAAGDDltARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 124 Q-IEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLR 202
Cdd:PRK14151  88 ElSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYLLNGRLLR 167


                 ....*...
gi 488404267 203 PSMVKVNQ 210
Cdd:PRK14151 168 PAMVVVSK 175
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 43-208 3.40e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 100.04  E-value: 3.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  43 SDSENNSEESIKDEESESQDTKIKELEKLANdnEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERA 122
Cdd:PRK14155   2 TDEQTPAEDGPFEADDAAQEIEALKAEVAAL--KDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 123 LQI---EGDDESFKSLQKGVQMVHESLLRALKDNGLEEIL-AEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKD 198
Cdd:PRK14155  80 TAAspkDSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDpAKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMG 159

                        170
                 ....*....|
gi 488404267 199 RVLRPSMVKV 208
Cdd:PRK14155 160 RLVRPAMVAV 169
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 39-208 3.77e-26

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 98.99  E-value: 3.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  39 EANASDSENNSEESIKDEESESQDTKIKELEKLandnEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDN 118
Cdd:PRK14159  10 NENAENSEHLQDENLQNIEDVEQNKLQKDYDEL----KDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 119 IERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEgKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKD 198
Cdd:PRK14159  86 LEAAVNVECHDEISLKIKEGVQNTLDLFLKKLEKHGVALIKEE-KEFDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIAD 164

                        170
                 ....*....|
gi 488404267 199 RVLRPSMVKV 208
Cdd:PRK14159 165 RVIRPTKVSV 174
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 25-210 1.18e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 93.25  E-value: 1.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  25 DTNIENSVSSTDNSEANASDSENNSEESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYK 104
Cdd:PRK14144  14 DEHKEEHKVENEILEEETDEESQHQEPALGHPSYTALEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 105 AQGVLTDILPSIDNIERALQIeGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSG 184
Cdd:PRK14144  94 VEKLISALLPVVDSLEQALQL-ADKNSDPSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPN 172

                        170       180
                 ....*....|....*....|....*.
gi 488404267 185 EVTQELQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14144 173 SVITVFQKGYKLSDRVIRPARVIVST 198
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 30-210 4.90e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 91.44  E-value: 4.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  30 NSVSSTDNSEANASDSENNSEESIKDEESESQDTKIKELEklandneEKYLRLYAEFENYKRRIQKENQINATYKAQGVL 109
Cdd:PRK14153  14 SEARNSGSSAEEAEELKEEPEDSTADSETEKCREEIESLK-------EQLFRLAAEFDNFRKRTAREMEENRKFVLEQVL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 110 TDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQE 189
Cdd:PRK14153  87 LDLLEVTDNFERALESARTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDV 166

                        170       180
                 ....*....|....*....|.
gi 488404267 190 LQKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14153 167 CKPGYALNSKVIRPAMVSVAR 187
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 41-208 1.99e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 86.54  E-value: 1.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  41 NASDSENNSEESIKDeeSESQDTKIKELEKLANDNEE---KYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSID 117
Cdd:PRK14147   2 NQDHPEFDSEDLAQN--PPETDPLKAEVESLRSEIALvkaDALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 118 NIERALQIEGDDESfkSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLK 197
Cdd:PRK14147  80 SLDAGLTAAGTEPS--PLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLN 157

                        170
                 ....*....|.
gi 488404267 198 DRVLRPSMVKV 208
Cdd:PRK14147 158 ERLLRPALVVV 168
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 23-208 5.20e-21

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 86.35  E-value: 5.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  23 QNDTNIENSVSSTDNSEANASDSENNS---EESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQI 99
Cdd:PRK14148   4 QEKSNVEDKSLDIETAAQVETAQESASgalEELSVEEQLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 100 NATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNP 179
Cdd:PRK14148  84 ARKFGIEKFAKELLPVIDSIEQALKHEVKLEEAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNP 163

                        170       180
                 ....*....|....*....|....*....
gi 488404267 180 DFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14148 164 EFEDNTIFDVFQKGYMLNGRIVRAAKVVI 192
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 31-210 2.99e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 84.79  E-value: 2.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  31 SVSSTDNSEANASDSENNSEESIKDEeSESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLT 110
Cdd:PRK14163  16 SGATPDDAEPKAASEEGAAPAGDAAA-TAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 111 DILPSIDNIERAlqiegddESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQEL 190
Cdd:PRK14163  95 ELLPVLDDVGRA-------REHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAIL 167

                        170       180
                 ....*....|....*....|
gi 488404267 191 QKGYKLKDRVLRPSMVKVNQ 210
Cdd:PRK14163 168 QPGYRIGERTIRPARVAVAE 187
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 50-208 1.22e-17

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 77.41  E-value: 1.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  50 EESIKDEESESQDTKIKELE----KLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQI 125
Cdd:PRK10325  29 EPEASAEQVDPRDEKIANLEaqlaEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 126 -EGDDESFKSLQKGVQMVHESLLRALKDNGLEEILAEGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPS 204
Cdd:PRK10325 109 aDKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAA 188


                 ....
gi 488404267 205 MVKV 208
Cdd:PRK10325 189 MVTV 192
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 46-208 7.53e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 74.63  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  46 ENNSEE--SIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERAL 123
Cdd:PRK14161   7 ENNEQTinDIAEEIVETANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 124 QIEGDDESFK--SLQKGVQMVHESLLRALKDNGLEEILAE-GKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKDRV 200
Cdd:PRK14161  87 AHKPANSDVEvtNIIAGVQMTKDELDKVFHKHHIEEIKPEiGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRL 166


                 ....*...
gi 488404267 201 LRPSMVKV 208
Cdd:PRK14161 167 LRPATVQV 174
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 7-206 8.95e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 75.61  E-value: 8.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   7 SVNNTEedfNVETEDNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESESQDT-KIKELEKLANDNEEKYLRLYAE 85
Cdd:PRK14164  23 SADRAE---AAAEEAALAQGVPEDDPFGDAVEGEIDPDLEADLEDLLDDVDPELADDgEASTVEAQLAERTEDLQRVTAE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  86 FENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQiEGDdesfksLQKG-VQMVHESLLRALKDNGLEEILAEGKE 164
Cdd:PRK14164 100 YANYRRRTERERQAIIETAKAGVATDLLPILDDLDLAEQ-HGD------LNEGpLKAFSDKLTNVLAGLKVEKFGEEGDA 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488404267 165 FDPNLHQAVvqddnPDFKSGE---VTQELQKGYKLKDRVLRPSMV 206
Cdd:PRK14164 173 FDPEIHEAV-----QDLSSGDekvLGTVLRKGYRMGDRVLRTAMV 212
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 29-208 1.40e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 74.85  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  29 ENSVSSTDNSEANASDSENNSE---ESIKDEESESQDTKIKELEKLANDNEEKYLRLYAEFENYKRRIQKENQINATYKA 105
Cdd:PRK14154  22 EKVMEAEEEQEEGGGDGSQEMEphrEGLEFPSREKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267 106 QGVLTDILPSIDNIERALQIEG-DDESFKSLQKGVQMVHESLLRALKDNGLEEILAE-GKEFDPNLHQAVVQDDNPDFKS 183
Cdd:PRK14154 102 KQLITDLLPVADSLIHGLESPAsEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPNpGDPFDPALHEAMSVQAVPDAKP 181

                        170       180
                 ....*....|....*....|....*
gi 488404267 184 GEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14154 182 DTIIQVLQKGYQLNGRVLRAARVIV 206
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 14-208 1.71e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 74.99  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  14 DFNVETEDNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESESQD--TKIKELEKLANDNEEKYLRLYAEFENYKR 91
Cdd:PRK14157  33 DASAESGEQQDSAAQADANAGADAAPAAAEGEAKAAAEKTGEAQSDSDDtlTPLGQAKKEAAEYLEALQRERAEFINYRN 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  92 RIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSlqkgvqmVHESLLRALKDNGLEEILAEGKEFDPNLHQ 171
Cdd:PRK14157 113 RTQKEQDRFRQHGIIDVLTALLPALDDIDRIREHSEMDDSFKA-------VAAKIDKAFEKFGVEKFGEKGEDFDPTKHD 185

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 488404267 172 AVVQDDNPDFKSGEVTQELQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14157 186 AILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 6-210 4.00e-14

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 68.22  E-value: 4.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267   6 QSVNNTEEDFNVETEDNQNDTNIENSVSSTDNSEANASDSENNSEESIKDEESESQ-----DTKIKELEKLandnEEKYL 80
Cdd:PRK14146   3 ETSNNKTSEEAKANEKKSQSQTLEESKLENMNSEESQTITEETQEQAVEGAETETSlqkelDNAKKEIESL----KDSWA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQIEGDDESFKSLQKGVQMVHESLLRALKDNGLEEILA 160
Cdd:PRK14146  79 RERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDP 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488404267 161 EGKEFDPNLHQAVVQDDNPDFKSGEVTQELQKGYKLKD----RVLRPSMVKVNQ 210
Cdd:PRK14146 159 KGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRIGK 212
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 81-208 3.39e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 65.79  E-value: 3.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488404267  81 RLYAEFENYKRRIQKENQINATYKAQGVLTDILPSIDNIERALQiEGDDESfkslqKGVQMVHESLLRALKDNGLEEILA 160
Cdd:PRK14142  58 RVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARK-HGDLES-----GPLKSVADKLDSALTGLGLVAFGA 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488404267 161 EGKEFDPNLHQAVVQDDNPDFKSGEVTQE-LQKGYKLKDRVLRPSMVKV 208
Cdd:PRK14142 132 EGEDFDPVLHEAVQHEGDGGQGSKPVIGTvMRQGYQLGEQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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