NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488369341|ref|WP_002438726|]
View 

MULTISPECIES: C1q-binding complement inhibitor VraX [Staphylococcus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VraX super family cl38692
Family of unknown function; This domain family is found in VraX proteins from Staphylococcus ...
 1-55 1.52e-29

Family of unknown function; This domain family is found in VraX proteins from Staphylococcus aureus. The vraX gene belongs to the vra operon together with the vraA gene encoding for a long chain fatty acid-CoA ligase, which is up-regulated in the VISA (vancomycin-intermediate S. aureus). The gene product, a 55-amino acids protein,is upregulated in the stress response to cell wall-active antibiotics and other surface-interactive molecules. VraX harbors a putative phosphorylation site, and could therefore be involved in regulatory processes within the cell. However, no exact function has been demonstrated.


The actual alignment was detected with superfamily member pfam17412:

Pssm-ID: 407486  Cd Length: 55  Bit Score: 98.09  E-value: 1.52e-29
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488369341   1 MIIYRRNIENGTPIYEIITKTFKTITIKCDETFNKYEIYQLLSLLENDVDNMPTS 55
Cdd:pfam17412  1 MIIYRQNHEEGAPVYEIITKTFKHISIKCDDSFNDTEIFKLLSLLEDDIDHMKTS 55
 
Name Accession Description Interval E-value
VraX pfam17412
Family of unknown function; This domain family is found in VraX proteins from Staphylococcus ...
 1-55 1.52e-29

Family of unknown function; This domain family is found in VraX proteins from Staphylococcus aureus. The vraX gene belongs to the vra operon together with the vraA gene encoding for a long chain fatty acid-CoA ligase, which is up-regulated in the VISA (vancomycin-intermediate S. aureus). The gene product, a 55-amino acids protein,is upregulated in the stress response to cell wall-active antibiotics and other surface-interactive molecules. VraX harbors a putative phosphorylation site, and could therefore be involved in regulatory processes within the cell. However, no exact function has been demonstrated.


Pssm-ID: 407486  Cd Length: 55  Bit Score: 98.09  E-value: 1.52e-29
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488369341   1 MIIYRRNIENGTPIYEIITKTFKTITIKCDETFNKYEIYQLLSLLENDVDNMPTS 55
Cdd:pfam17412  1 MIIYRQNHEEGAPVYEIITKTFKHISIKCDDSFNDTEIFKLLSLLEDDIDHMKTS 55
 
Name Accession Description Interval E-value
VraX pfam17412
Family of unknown function; This domain family is found in VraX proteins from Staphylococcus ...
 1-55 1.52e-29

Family of unknown function; This domain family is found in VraX proteins from Staphylococcus aureus. The vraX gene belongs to the vra operon together with the vraA gene encoding for a long chain fatty acid-CoA ligase, which is up-regulated in the VISA (vancomycin-intermediate S. aureus). The gene product, a 55-amino acids protein,is upregulated in the stress response to cell wall-active antibiotics and other surface-interactive molecules. VraX harbors a putative phosphorylation site, and could therefore be involved in regulatory processes within the cell. However, no exact function has been demonstrated.


Pssm-ID: 407486  Cd Length: 55  Bit Score: 98.09  E-value: 1.52e-29
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488369341   1 MIIYRRNIENGTPIYEIITKTFKTITIKCDETFNKYEIYQLLSLLENDVDNMPTS 55
Cdd:pfam17412  1 MIIYRQNHEEGAPVYEIITKTFKHISIKCDDSFNDTEIFKLLSLLEDDIDHMKTS 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH